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The map label for this gene is malY [H]

Identifier: 194733937

GI number: 194733937

Start: 1502619

End: 1503791

Strand: Reverse

Name: malY [H]

Synonym: SeSA_A1562

Alternate gene names: 194733937

Gene position: 1503791-1502619 (Counterclockwise)

Preceding gene: 194738396

Following gene: 194735508

Centisome position: 31.93

GC content: 56.01

Gene sequence:

>1173_bases
ATGTTCGATTTTTCACAGGAAGTTGACCGTCGCGGGACATGGTGTACGCAGTGGGATTATGTCGCCGATCGTTTTGGCGA
AGCCGATCTGCTCCCCTTTACGATCTCGGATATGGATTTTGCCACCGCGCCGTGTATCCTGGAGGCGCTAAACCAGCGCC
TTTCCCACGGTGTGCTGGGCTATAGCCGCTGGAAAAATGAGGCGTTTTTAGGGGCAATTACCCACTGGTTTGCGACACGC
CATCAGACCACGATAGATGCCCACTCCCTCGTATACGGCCCCTCCGTTATCTATATGGCGTCCGAGCTTATCCGCCAGTG
GTCCGACGAAGGCGATGGCGTGGTAGTTCATACCCCCGCTTACGATGCTTTTTATAAAGCGATTGAAGGCAACCATCGCA
TCGTCACTCCCGTCCCGCTGGAGAAAGAAGGCAACGCCTGGTATTGCGATATGGCCAAACTGGAGGCGGCGCTGGCGCGT
CCGGAAAGCAAAATCCTGCTGCTGTGCAGTCCGCAAAATCCCACCGGTAAAGTGTGGACGCGTGACGAGCTGGAAACGAT
GTCAACGCTGTGCGAGCGCCATGGCGTACGGGTGATTTCCGATGAAATTCACATGGATATGGTATGGGGAAACCAGCCGC
ATATTCCCTGGAGCAATGTCGCGCGCGGAGACTGGGCGCTGCTCTCCTCCGGCTCGAAAAGCTTCAATATTCCGGCATTA
ACCGGCGCTTATGGAATCATTGAAAATAGTGAAAGCCGTGAACGCTACCTGGCCGCCTTAAAAGGGCGCGACGGCCTCTC
TTCGCCAGCGGTGCTCTCGCTCACGGCGCATATTGCCGCGTATCAGCACGGCGCGCCGTGGCTGGATGCGTTACGCGCCT
CGCTGGCGGCTAATATGCGCTATATTGAGCAGGCGCTGAATGGCGCCTTTCCGACGTTGAACTGGCAAGCGCCGCCATCG
ACCTATCTGGCCTGGATTGATCTCCGTCCACTCGGCATTGACGATCAAAAATTACAGCACACGCTCATTCATCAGGAGAA
AGTCGCCATTATGCCCGGCGATACCTATGGCGCAGAAGGCCGGGGATTTGTGCGTCTGAATGCCGGATGCCCTCGTCTGA
AACTTGAAAAAGGCGTCAACGGATTGATTAACGCTATCCGCACCGTTCGCTGA

Upstream 100 bases:

>100_bases
CAATCAGCATAATTTGCAGGTGGTTATCGGCCCGCAGGTTCAGTCGGTAAAAGATGAAATGGTTGGTCTGATGAATACCG
TTCAGGCATAAGGAAGAGAT

Downstream 100 bases:

>100_bases
TACCGTCTACAAGCGGGGTGTTGACCCTTTATCCTAAGATGCGATAACAGAGCCCCCCGTGAGCTAACCGGGGCGCGTTA
AAGAGAATGATACAAAATTT

Product: protein MalY

Products: NA

Alternate protein names: Cystathionine beta-lyase MalY; CBL; Beta-cystathionase; Cysteine lyase; Maltose regulon modulator [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MFDFSQEVDRRGTWCTQWDYVADRFGEADLLPFTISDMDFATAPCILEALNQRLSHGVLGYSRWKNEAFLGAITHWFATR
HQTTIDAHSLVYGPSVIYMASELIRQWSDEGDGVVVHTPAYDAFYKAIEGNHRIVTPVPLEKEGNAWYCDMAKLEAALAR
PESKILLLCSPQNPTGKVWTRDELETMSTLCERHGVRVISDEIHMDMVWGNQPHIPWSNVARGDWALLSSGSKSFNIPAL
TGAYGIIENSESRERYLAALKGRDGLSSPAVLSLTAHIAAYQHGAPWLDALRASLAANMRYIEQALNGAFPTLNWQAPPS
TYLAWIDLRPLGIDDQKLQHTLIHQEKVAIMPGDTYGAEGRGFVRLNAGCPRLKLEKGVNGLINAIRTVR

Sequences:

>Translated_390_residues
MFDFSQEVDRRGTWCTQWDYVADRFGEADLLPFTISDMDFATAPCILEALNQRLSHGVLGYSRWKNEAFLGAITHWFATR
HQTTIDAHSLVYGPSVIYMASELIRQWSDEGDGVVVHTPAYDAFYKAIEGNHRIVTPVPLEKEGNAWYCDMAKLEAALAR
PESKILLLCSPQNPTGKVWTRDELETMSTLCERHGVRVISDEIHMDMVWGNQPHIPWSNVARGDWALLSSGSKSFNIPAL
TGAYGIIENSESRERYLAALKGRDGLSSPAVLSLTAHIAAYQHGAPWLDALRASLAANMRYIEQALNGAFPTLNWQAPPS
TYLAWIDLRPLGIDDQKLQHTLIHQEKVAIMPGDTYGAEGRGFVRLNAGCPRLKLEKGVNGLINAIRTVR
>Mature_390_residues
MFDFSQEVDRRGTWCTQWDYVADRFGEADLLPFTISDMDFATAPCILEALNQRLSHGVLGYSRWKNEAFLGAITHWFATR
HQTTIDAHSLVYGPSVIYMASELIRQWSDEGDGVVVHTPAYDAFYKAIEGNHRIVTPVPLEKEGNAWYCDMAKLEAALAR
PESKILLLCSPQNPTGKVWTRDELETMSTLCERHGVRVISDEIHMDMVWGNQPHIPWSNVARGDWALLSSGSKSFNIPAL
TGAYGIIENSESRERYLAALKGRDGLSSPAVLSLTAHIAAYQHGAPWLDALRASLAANMRYIEQALNGAFPTLNWQAPPS
TYLAWIDLRPLGIDDQKLQHTLIHQEKVAIMPGDTYGAEGRGFVRLNAGCPRLKLEKGVNGLINAIRTVR

Specific function: Acts as a beta-cystathionase and as a repressor of the maltose regulon [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=140, Percent_Identity=30, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI169881279, Length=140, Percent_Identity=30, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787909, Length=390, Percent_Identity=80.2564102564103, Blast_Score=669, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71994472, Length=138, Percent_Identity=27.536231884058, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71994476, Length=138, Percent_Identity=27.536231884058, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322401, Length=283, Percent_Identity=26.8551236749117, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI18859735, Length=375, Percent_Identity=24, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43521; Mature: 43521

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDFSQEVDRRGTWCTQWDYVADRFGEADLLPFTISDMDFATAPCILEALNQRLSHGVLG
CCCCHHHHHCCCCCCCCHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCC
YSRWKNEAFLGAITHWFATRHQTTIDAHSLVYGPSVIYMASELIRQWSDEGDGVVVHTPA
HHHHCCCHHHHHHHHHHHHCCCCCCCHHHHEECCHHHHHHHHHHHHHCCCCCEEEEECCC
YDAFYKAIEGNHRIVTPVPLEKEGNAWYCDMAKLEAALARPESKILLLCSPQNPTGKVWT
HHHHHHHHCCCCEEECCCCCCCCCCEEEEEHHHHHHHHHCCCCCEEEEECCCCCCCCCEE
RDELETMSTLCERHGVRVISDEIHMDMVWGNQPHIPWSNVARGDWALLSSGSKSFNIPAL
HHHHHHHHHHHHHCCCEEEECCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCEE
TGAYGIIENSESRERYLAALKGRDGLSSPAVLSLTAHIAAYQHGAPWLDALRASLAANMR
CCCCCEEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
YIEQALNGAFPTLNWQAPPSTYLAWIDLRPLGIDDQKLQHTLIHQEKVAIMPGDTYGAEG
HHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHCCEEEEECCCCCCCCC
RGFVRLNAGCPRLKLEKGVNGLINAIRTVR
CEEEEECCCCCCEEHHHCHHHHHHHHHHCC
>Mature Secondary Structure
MFDFSQEVDRRGTWCTQWDYVADRFGEADLLPFTISDMDFATAPCILEALNQRLSHGVLG
CCCCHHHHHCCCCCCCCHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCC
YSRWKNEAFLGAITHWFATRHQTTIDAHSLVYGPSVIYMASELIRQWSDEGDGVVVHTPA
HHHHCCCHHHHHHHHHHHHCCCCCCCHHHHEECCHHHHHHHHHHHHHCCCCCEEEEECCC
YDAFYKAIEGNHRIVTPVPLEKEGNAWYCDMAKLEAALARPESKILLLCSPQNPTGKVWT
HHHHHHHHCCCCEEECCCCCCCCCCEEEEEHHHHHHHHHCCCCCEEEEECCCCCCCCCEE
RDELETMSTLCERHGVRVISDEIHMDMVWGNQPHIPWSNVARGDWALLSSGSKSFNIPAL
HHHHHHHHHHHHHCCCEEEECCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCEE
TGAYGIIENSESRERYLAALKGRDGLSSPAVLSLTAHIAAYQHGAPWLDALRASLAANMR
CCCCCEEECCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
YIEQALNGAFPTLNWQAPPSTYLAWIDLRPLGIDDQKLQHTLIHQEKVAIMPGDTYGAEG
HHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHCCEEEEECCCCCCCCC
RGFVRLNAGCPRLKLEKGVNGLINAIRTVR
CEEEEECCCCCCEEHHHCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1856179; 9097039; 9278503; 7665481; 10698925 [H]