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The map label for this gene is kbl [C]

Identifier: 194334978

GI number: 194334978

Start: 2361558

End: 2362724

Strand: Reverse

Name: kbl [C]

Synonym: Paes_2189

Alternate gene names: 194334978

Gene position: 2362724-2361558 (Counterclockwise)

Preceding gene: 194334979

Following gene: 194334977

Centisome position: 94.02

GC content: 56.47

Gene sequence:

>1167_bases
ATGCTACCGGTTTTTGAGGCTATGGAGAAAGAGCTTGATGCGCTGCGGCGCCAGGAGCGTTTCAGGCGGCTTCCGGATAC
CGGGGTACGGGACGGGAGATTTCTTGAGTTCGGAGGGGAGAGTCTTCTCAACCTTTCCTCGAACGACTATCTGGGTATCG
GTAGTAACCGCGCCCTTGTTGAGGAGTATTTCGATGGATGTCACCGCTATACCGAGGATTACTGGATGGCATCCTCATCG
TCGCGTCTGTTAACCGGCAATCATCGGCTGTACGGCGCGCTTGAATTGCAGCTTGCGGCACTTTACGGGCGACAGGCCTC
GCTGGTTTTTAATAGCGGTTACCATGCCAATACCGGTATTCTGCCTGCAATCTCTACACGTCAAGATCTTATTCTTTCCG
ACAGGCTCAATCATGCAAGCATCATTGACGGTGGCAGAATTGCCGATGCTGCGTTCAGACGATACCGGCATCTGGATTAC
GCGCATCTCGAGTCGCTGCTTGATTCCTGCAGGAGCAGCTATCGTCAGATTATTATCGTGACCGAGTCGGTGTTCAGTAT
GGACGGTGATATCGCTGATCTGAAACGGCTGGTCGAGCTCAAGGAGCGCTATGGGGCGATGCTTGTTGTCGATGAGGCTC
ACGGAGCCGGTACCTTCGGCACACAAGGGCTTGGGGTGGCTGAAGCTATAGGGGTGATCGGCGGGATCGATATCCTTGTC
GGAACATTCGGCAAGGCGTTCGCATCAACCGGGGCTTATGCGGTGATGGATAGCCTGGTGAGGGATTATCTGGTCAATAC
GATGCGTCCGCTGATCTTTACGACTGCACTGCCGCCGGTGGTGCTCGGCTGGAGCGCCCGGGTGCTGGAGCGTCAGCGAT
GCATGCAGCAGGAGCGTGGTCATCTCCGGGAGATCTCCTCTCTTCTGCGTGAGGGGTTCAGGTCCCGGGGATTGAGAGTA
TACGGTGAGAGCCATATTGTTCCTGTTGTGCTCGGGGAGAATGATCTGGCCGTCAGAAAAGCGGCTGAGCTTCGGGCGCA
TGGTATCCTTGCGCTACCGGTGCGCCCTCCTGCGGTCCCTGAACAGAGCGCCCGTGTACGCTTTTCGCTACGCGCGGATT
TGGCGTGGGAGGACCTCGCCGGAATCCCTGAACTTCTGATACCCTGA

Upstream 100 bases:

>100_bases
ACGGTTTTCTGACAGGTGGTTATCTGACAACAAGGGGACGCGATGTTGGCGACGATCAGGCATTCATGGAGCAGCTCAAA
CATTTTTCGGGGAGGTCCTG

Downstream 100 bases:

>100_bases
GCGAAATGAAGACGATCTGGATAGAACAGCGAAACAACCACCGTGTTCTGGTGTTTTTCAATGGTTGGGGAATGGATGAA
CAGATTGCCCGTTACATCCA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MLPVFEAMEKELDALRRQERFRRLPDTGVRDGRFLEFGGESLLNLSSNDYLGIGSNRALVEEYFDGCHRYTEDYWMASSS
SRLLTGNHRLYGALELQLAALYGRQASLVFNSGYHANTGILPAISTRQDLILSDRLNHASIIDGGRIADAAFRRYRHLDY
AHLESLLDSCRSSYRQIIIVTESVFSMDGDIADLKRLVELKERYGAMLVVDEAHGAGTFGTQGLGVAEAIGVIGGIDILV
GTFGKAFASTGAYAVMDSLVRDYLVNTMRPLIFTTALPPVVLGWSARVLERQRCMQQERGHLREISSLLREGFRSRGLRV
YGESHIVPVVLGENDLAVRKAAELRAHGILALPVRPPAVPEQSARVRFSLRADLAWEDLAGIPELLIP

Sequences:

>Translated_388_residues
MLPVFEAMEKELDALRRQERFRRLPDTGVRDGRFLEFGGESLLNLSSNDYLGIGSNRALVEEYFDGCHRYTEDYWMASSS
SRLLTGNHRLYGALELQLAALYGRQASLVFNSGYHANTGILPAISTRQDLILSDRLNHASIIDGGRIADAAFRRYRHLDY
AHLESLLDSCRSSYRQIIIVTESVFSMDGDIADLKRLVELKERYGAMLVVDEAHGAGTFGTQGLGVAEAIGVIGGIDILV
GTFGKAFASTGAYAVMDSLVRDYLVNTMRPLIFTTALPPVVLGWSARVLERQRCMQQERGHLREISSLLREGFRSRGLRV
YGESHIVPVVLGENDLAVRKAAELRAHGILALPVRPPAVPEQSARVRFSLRADLAWEDLAGIPELLIP
>Mature_388_residues
MLPVFEAMEKELDALRRQERFRRLPDTGVRDGRFLEFGGESLLNLSSNDYLGIGSNRALVEEYFDGCHRYTEDYWMASSS
SRLLTGNHRLYGALELQLAALYGRQASLVFNSGYHANTGILPAISTRQDLILSDRLNHASIIDGGRIADAAFRRYRHLDY
AHLESLLDSCRSSYRQIIIVTESVFSMDGDIADLKRLVELKERYGAMLVVDEAHGAGTFGTQGLGVAEAIGVIGGIDILV
GTFGKAFASTGAYAVMDSLVRDYLVNTMRPLIFTTALPPVVLGWSARVLERQRCMQQERGHLREISSLLREGFRSRGLRV
YGESHIVPVVLGENDLAVRKAAELRAHGILALPVRPPAVPEQSARVRFSLRADLAWEDLAGIPELLIP

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=376, Percent_Identity=32.9787234042553, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI284448556, Length=340, Percent_Identity=34.1176470588235, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI83977444, Length=327, Percent_Identity=33.3333333333333, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI83977442, Length=327, Percent_Identity=33.3333333333333, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI83977440, Length=327, Percent_Identity=33.3333333333333, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI4758668, Length=375, Percent_Identity=29.3333333333333, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI119220554, Length=406, Percent_Identity=28.5714285714286, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4502025, Length=321, Percent_Identity=32.398753894081, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI40316939, Length=321, Percent_Identity=32.398753894081, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI5454084, Length=252, Percent_Identity=25.3968253968254, Blast_Score=89, Evalue=8e-18,
Organism=Escherichia coli, GI1790046, Length=337, Percent_Identity=33.8278931750742, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1786993, Length=360, Percent_Identity=34.4444444444444, Blast_Score=180, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71994529, Length=371, Percent_Identity=34.2318059299191, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI32566772, Length=370, Percent_Identity=32.972972972973, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17560914, Length=315, Percent_Identity=28.5714285714286, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17560912, Length=315, Percent_Identity=28.5714285714286, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71982625, Length=258, Percent_Identity=26.3565891472868, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71982617, Length=258, Percent_Identity=26.3565891472868, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320438, Length=350, Percent_Identity=32, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6320267, Length=408, Percent_Identity=30.6372549019608, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6323954, Length=292, Percent_Identity=26.027397260274, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24662918, Length=335, Percent_Identity=36.1194029850746, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI17137420, Length=296, Percent_Identity=33.7837837837838, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI17136286, Length=359, Percent_Identity=29.5264623955432, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24653280, Length=294, Percent_Identity=25.1700680272109, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24653276, Length=294, Percent_Identity=25.1700680272109, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24653278, Length=294, Percent_Identity=25.1700680272109, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43062; Mature: 43062

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPVFEAMEKELDALRRQERFRRLPDTGVRDGRFLEFGGESLLNLSSNDYLGIGSNRALV
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHEECCCCCEEECCCCHHHH
EEYFDGCHRYTEDYWMASSSSRLLTGNHRLYGALELQLAALYGRQASLVFNSGYHANTGI
HHHHHHHHHHHHHHHCCCCCCCEEECCCEEEEHHHHHHHHHHCCCEEEEEECCCCCCCCC
LPAISTRQDLILSDRLNHASIIDGGRIADAAFRRYRHLDYAHLESLLDSCRSSYRQIIIV
CCCCCCCHHHHHHCCCCCCEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEE
TESVFSMDGDIADLKRLVELKERYGAMLVVDEAHGAGTFGTQGLGVAEAIGVIGGIDILV
EHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHH
GTFGKAFASTGAYAVMDSLVRDYLVNTMRPLIFTTALPPVVLGWSARVLERQRCMQQERG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHH
HLREISSLLREGFRSRGLRVYGESHIVPVVLGENDLAVRKAAELRAHGILALPVRPPAVP
HHHHHHHHHHHHHHHCCEEEECCCCEEEEEECCCCHHHHHHHHHHHCCEEEECCCCCCCC
EQSARVRFSLRADLAWEDLAGIPELLIP
CCCCEEEEEEECCCCHHHHCCCCHHHCC
>Mature Secondary Structure
MLPVFEAMEKELDALRRQERFRRLPDTGVRDGRFLEFGGESLLNLSSNDYLGIGSNRALV
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHEECCCCCEEECCCCHHHH
EEYFDGCHRYTEDYWMASSSSRLLTGNHRLYGALELQLAALYGRQASLVFNSGYHANTGI
HHHHHHHHHHHHHHHCCCCCCCEEECCCEEEEHHHHHHHHHHCCCEEEEEECCCCCCCCC
LPAISTRQDLILSDRLNHASIIDGGRIADAAFRRYRHLDYAHLESLLDSCRSSYRQIIIV
CCCCCCCHHHHHHCCCCCCEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEE
TESVFSMDGDIADLKRLVELKERYGAMLVVDEAHGAGTFGTQGLGVAEAIGVIGGIDILV
EHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHH
GTFGKAFASTGAYAVMDSLVRDYLVNTMRPLIFTTALPPVVLGWSARVLERQRCMQQERG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHH
HLREISSLLREGFRSRGLRVYGESHIVPVVLGENDLAVRKAAELRAHGILALPVRPPAVP
HHHHHHHHHHHHHHHCCEEEECCCCEEEEEECCCCHHHHHHHHHHHCCEEEECCCCCCCC
EQSARVRFSLRADLAWEDLAGIPELLIP
CCCCEEEEEEECCCCHHHHCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA