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The map label for this gene is moaA [H]

Identifier: 194334917

GI number: 194334917

Start: 2303805

End: 2304815

Strand: Reverse

Name: moaA [H]

Synonym: Paes_2126

Alternate gene names: 194334917

Gene position: 2304815-2303805 (Counterclockwise)

Preceding gene: 194334918

Following gene: 194334916

Centisome position: 91.72

GC content: 53.12

Gene sequence:

>1011_bases
ATGAGTCAACCACACAATGCGGTATCTTCGCCCCTGAAGCCTTTATCGGACCGTTACCGGAGGACTGTCGATTATGTCCG
CCTGGCGGTTACGTCGCAGTGCAATCTCCGGTGCATGTACTGTATGCGTGAGGAGCACACGGTCTATAATCCCGAAGGGG
AAGCGTTAAGCGGAGATGAAATAGTATCGATGCTTGCTGTTCTTGCCAGGATGGGTGTCAGCAAGGTTCGTTATACGGGA
GGAGAACCGCTGCTCCGGCAGGACATTGTCAGGCTTGTTCGTGATGCGAAGGCTCTCGAAGGTATCGAGACTGTTTCTCT
GACAACCAATGGGTTGCTGCTTGACCGTTATCTGGATGATCTTGTTGCGGCGGGGATCGATGCGATTAACTTCAGTCTCG
ATACCTTCGATCCGGAGCGTTATCGGGAGATAACCCGCAGAAATCTCTTTGATAAGGTGCACAGCAATCTGCTGCGTCTT
CTGGAGTGTGATGCTCTTCTGGTCAAGATCAATGTTCTGCTTCTGCGCAAGGTCAATATCGACGAGATCACAACGTTTGT
CGAACTGACCCGTGATCGGCCGGTGACGGTCAGGTTTATGGAACTCATGCCGTTCGACGATCACCAGATTTGGCGGACAG
GCAAGTTCATGGGCGCGGACAAGATTCTTGAAACACTTCATGCCTGCTATCCCGATCTTCAACCCATGCAGGGGGATGCT
ACTGAATATTTCAGCTTTTCTCTCCCCGGTTATAAGGGAAAGGTATCCGTCATTCCGGCCTTTACCCGTAATTTCTGCAG
CAAGTGTACGCGTTTGCGCATTACCTCAGCAGGAAAGGCTATCAACTGCCTCTATTCCCGGGAGGGGACCGATCTTCTCG
ATGCGTTGCGGAGCGGAGGACAGGATTCGCTCGAACAATTGCTGCGCAAGTCCGTCGAGGCAAAGCCCCGTGACGGACGT
GAGGCTGGCGGCTCGGCGCTGAGGACCAGTATGTCGGAAATAGGGGGCTGA

Upstream 100 bases:

>100_bases
GAACGAGCGGCAGGTATTGCCGGCTTTGCTGCCGATCGGAAAAATCGTGTATGAAAATGTTACATTAGCCGAATACTTTT
TTCCTGTAGTTATTGCAGTT

Downstream 100 bases:

>100_bases
CAAGACAATTGTTGATCTGTTGAATGCTTTCTGTTTTCCGTTGTCGAGGGTGTATACCGCAATGCAGCACATCAACAGAT
TAAAGACTCTACATCCCGCT

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSQPHNAVSSPLKPLSDRYRRTVDYVRLAVTSQCNLRCMYCMREEHTVYNPEGEALSGDEIVSMLAVLARMGVSKVRYTG
GEPLLRQDIVRLVRDAKALEGIETVSLTTNGLLLDRYLDDLVAAGIDAINFSLDTFDPERYREITRRNLFDKVHSNLLRL
LECDALLVKINVLLLRKVNIDEITTFVELTRDRPVTVRFMELMPFDDHQIWRTGKFMGADKILETLHACYPDLQPMQGDA
TEYFSFSLPGYKGKVSVIPAFTRNFCSKCTRLRITSAGKAINCLYSREGTDLLDALRSGGQDSLEQLLRKSVEAKPRDGR
EAGGSALRTSMSEIGG

Sequences:

>Translated_336_residues
MSQPHNAVSSPLKPLSDRYRRTVDYVRLAVTSQCNLRCMYCMREEHTVYNPEGEALSGDEIVSMLAVLARMGVSKVRYTG
GEPLLRQDIVRLVRDAKALEGIETVSLTTNGLLLDRYLDDLVAAGIDAINFSLDTFDPERYREITRRNLFDKVHSNLLRL
LECDALLVKINVLLLRKVNIDEITTFVELTRDRPVTVRFMELMPFDDHQIWRTGKFMGADKILETLHACYPDLQPMQGDA
TEYFSFSLPGYKGKVSVIPAFTRNFCSKCTRLRITSAGKAINCLYSREGTDLLDALRSGGQDSLEQLLRKSVEAKPRDGR
EAGGSALRTSMSEIGG
>Mature_335_residues
SQPHNAVSSPLKPLSDRYRRTVDYVRLAVTSQCNLRCMYCMREEHTVYNPEGEALSGDEIVSMLAVLARMGVSKVRYTGG
EPLLRQDIVRLVRDAKALEGIETVSLTTNGLLLDRYLDDLVAAGIDAINFSLDTFDPERYREITRRNLFDKVHSNLLRLL
ECDALLVKINVLLLRKVNIDEITTFVELTRDRPVTVRFMELMPFDDHQIWRTGKFMGADKILETLHACYPDLQPMQGDAT
EYFSFSLPGYKGKVSVIPAFTRNFCSKCTRLRITSAGKAINCLYSREGTDLLDALRSGGQDSLEQLLRKSVEAKPRDGRE
AGGSALRTSMSEIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=311, Percent_Identity=37.2990353697749, Blast_Score=228, Evalue=5e-60,
Organism=Homo sapiens, GI22027536, Length=311, Percent_Identity=37.2990353697749, Blast_Score=228, Evalue=6e-60,
Organism=Escherichia coli, GI1786999, Length=332, Percent_Identity=31.0240963855422, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI32566329, Length=332, Percent_Identity=36.7469879518072, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI32566331, Length=318, Percent_Identity=36.4779874213836, Blast_Score=208, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17561210, Length=332, Percent_Identity=35.8433734939759, Blast_Score=207, Evalue=8e-54,
Organism=Drosophila melanogaster, GI28574490, Length=324, Percent_Identity=36.7283950617284, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI28574488, Length=318, Percent_Identity=37.1069182389937, Blast_Score=211, Evalue=6e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37811; Mature: 37680

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPHNAVSSPLKPLSDRYRRTVDYVRLAVTSQCNLRCMYCMREEHTVYNPEGEALSGDE
CCCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEECCCCCCCCHHH
IVSMLAVLARMGVSKVRYTGGEPLLRQDIVRLVRDAKALEGIETVSLTTNGLLLDRYLDD
HHHHHHHHHHHCHHHEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHH
LVAAGIDAINFSLDTFDPERYREITRRNLFDKVHSNLLRLLECDALLVKINVLLLRKVNI
HHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
DEITTFVELTRDRPVTVRFMELMPFDDHQIWRTGKFMGADKILETLHACYPDLQPMQGDA
HHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCC
TEYFSFSLPGYKGKVSVIPAFTRNFCSKCTRLRITSAGKAINCLYSREGTDLLDALRSGG
HHHEEEECCCCCCCEEEEHHHHHHHHHHHHEEEEECCCCEEEEECCCCCHHHHHHHHCCC
QDSLEQLLRKSVEAKPRDGREAGGSALRTSMSEIGG
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SQPHNAVSSPLKPLSDRYRRTVDYVRLAVTSQCNLRCMYCMREEHTVYNPEGEALSGDE
CCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEECCCCCCCCHHH
IVSMLAVLARMGVSKVRYTGGEPLLRQDIVRLVRDAKALEGIETVSLTTNGLLLDRYLDD
HHHHHHHHHHHCHHHEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHH
LVAAGIDAINFSLDTFDPERYREITRRNLFDKVHSNLLRLLECDALLVKINVLLLRKVNI
HHHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
DEITTFVELTRDRPVTVRFMELMPFDDHQIWRTGKFMGADKILETLHACYPDLQPMQGDA
HHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCC
TEYFSFSLPGYKGKVSVIPAFTRNFCSKCTRLRITSAGKAINCLYSREGTDLLDALRSGG
HHHEEEECCCCCCCEEEEHHHHHHHHHHHHEEEEECCCCEEEEECCCCCHHHHHHHHCCC
QDSLEQLLRKSVEAKPRDGREAGGSALRTSMSEIGG
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]