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The map label for this gene is lpxA [H]

Identifier: 194334813

GI number: 194334813

Start: 2212422

End: 2213228

Strand: Reverse

Name: lpxA [H]

Synonym: Paes_2016

Alternate gene names: 194334813

Gene position: 2213228-2212422 (Counterclockwise)

Preceding gene: 194334814

Following gene: 194334812

Centisome position: 88.07

GC content: 50.81

Gene sequence:

>807_bases
ATGTTCATGAGTAGCAGTATGATACATCCAACCGCGATCATCGGTTCCGGTGCTGAAATCGGTGAGGGCGTCAGGATCGG
GCCGTATTCGGTTATCGAAGATGACGTGCAGATCGGCAGCAACACTGAAATCGGTCCGCATGTCCAGATTGCCGATGGAG
CCAGAATCGGGGAATCCTGCAGAATTTTTGCCGGTGCAGTGCTTTCGACAGTCCCGCAGGACCTGAAATTTGAAGGTGAA
AAAACCTCTCTCCATATCGGAGACCGAACGGTTATTCGTGAATGCGTCACCCTGAACCGGGGGACAAAAGCCAGCGGAAA
GACTGTGGTTGGTTCAGATTGTCTGATTATGGCCTATGTTCACGCCGGTCATGACTGCGTCATTGGCAATCATGTCATTA
TTGCCAATTCCGTGCAATTCGGCGGCCATTGCCAGGTCGAGGACTATGCTGTTGTGGGCGGGCTTGCAGGGATTCACCAG
TTTGTCAGGATCGGTCGTTATGCCATGGTCGGAGGCATTTCAAGAGCCTCTCTCGATGTCCCTCCTTTTGTGATGGCAGG
CGGCCATGAGAAGTTCAGGTTTGAAGGGCTCAATATTGTCGGCCTTAAACGGCGCGGTTTTTCTTCAGCACAGCTTGACC
GGATTCGCGCCATATACAGGATTCTTTTTCAGTCCGGGATGCTTCTGGGTAACGCGCTTGACAAAGTTCTGACAGACTGT
GAAGAAAGTCCTGAACGTGACGAGATATTGGCGTTTTTCGATACCAGTTCGGCCAGAAGAAAGTATATCCGACCCTATAA
TTCTTAA

Upstream 100 bases:

>100_bases
CGGCCAGCTCGATGCATCACAAAAGATACTTGAGCAACTGCTCAGGGATGGTGATACGCTGCAGGCGGGTCAGGAGAGAT
ACCAGAACGAAGAAAAGTAA

Downstream 100 bases:

>100_bases
CCGTTAGAGATGCGTATGGCGTGGGCGATAGGTATAGATCTTGGCGGTACTGCGGTAAAAATTGCGCTCATTGATCGTCA
TACCGGTATTGCAGACCACG

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MFMSSSMIHPTAIIGSGAEIGEGVRIGPYSVIEDDVQIGSNTEIGPHVQIADGARIGESCRIFAGAVLSTVPQDLKFEGE
KTSLHIGDRTVIRECVTLNRGTKASGKTVVGSDCLIMAYVHAGHDCVIGNHVIIANSVQFGGHCQVEDYAVVGGLAGIHQ
FVRIGRYAMVGGISRASLDVPPFVMAGGHEKFRFEGLNIVGLKRRGFSSAQLDRIRAIYRILFQSGMLLGNALDKVLTDC
EESPERDEILAFFDTSSARRKYIRPYNS

Sequences:

>Translated_268_residues
MFMSSSMIHPTAIIGSGAEIGEGVRIGPYSVIEDDVQIGSNTEIGPHVQIADGARIGESCRIFAGAVLSTVPQDLKFEGE
KTSLHIGDRTVIRECVTLNRGTKASGKTVVGSDCLIMAYVHAGHDCVIGNHVIIANSVQFGGHCQVEDYAVVGGLAGIHQ
FVRIGRYAMVGGISRASLDVPPFVMAGGHEKFRFEGLNIVGLKRRGFSSAQLDRIRAIYRILFQSGMLLGNALDKVLTDC
EESPERDEILAFFDTSSARRKYIRPYNS
>Mature_268_residues
MFMSSSMIHPTAIIGSGAEIGEGVRIGPYSVIEDDVQIGSNTEIGPHVQIADGARIGESCRIFAGAVLSTVPQDLKFEGE
KTSLHIGDRTVIRECVTLNRGTKASGKTVVGSDCLIMAYVHAGHDCVIGNHVIIANSVQFGGHCQVEDYAVVGGLAGIHQ
FVRIGRYAMVGGISRASLDVPPFVMAGGHEKFRFEGLNIVGLKRRGFSSAQLDRIRAIYRILFQSGMLLGNALDKVLTDC
EESPERDEILAFFDTSSARRKYIRPYNS

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=258, Percent_Identity=42.2480620155039, Blast_Score=206, Evalue=1e-54,
Organism=Escherichia coli, GI1786376, Length=193, Percent_Identity=27.4611398963731, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 28960; Mature: 28960

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFMSSSMIHPTAIIGSGAEIGEGVRIGPYSVIEDDVQIGSNTEIGPHVQIADGARIGESC
CCCCCCCCCCEEEEECCCHHCCCEEECCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCH
RIFAGAVLSTVPQDLKFEGEKTSLHIGDRTVIRECVTLNRGTKASGKTVVGSDCLIMAYV
HHHHHHHHHHCCCCCEECCCCEEEEECCHHHHHHHHHCCCCCCCCCCEEECCCEEEEEEE
HAGHDCVIGNHVIIANSVQFGGHCQVEDYAVVGGLAGIHQFVRIGRYAMVGGISRASLDV
CCCCEEEECCEEEEEECCCCCCCCEECCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PPFVMAGGHEKFRFEGLNIVGLKRRGFSSAQLDRIRAIYRILFQSGMLLGNALDKVLTDC
CCEEEECCCCEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
EESPERDEILAFFDTSSARRKYIRPYNS
HCCCCCCCEEEEEECCHHHHHHCCCCCC
>Mature Secondary Structure
MFMSSSMIHPTAIIGSGAEIGEGVRIGPYSVIEDDVQIGSNTEIGPHVQIADGARIGESC
CCCCCCCCCCEEEEECCCHHCCCEEECCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCH
RIFAGAVLSTVPQDLKFEGEKTSLHIGDRTVIRECVTLNRGTKASGKTVVGSDCLIMAYV
HHHHHHHHHHCCCCCEECCCCEEEEECCHHHHHHHHHCCCCCCCCCCEEECCCEEEEEEE
HAGHDCVIGNHVIIANSVQFGGHCQVEDYAVVGGLAGIHQFVRIGRYAMVGGISRASLDV
CCCCEEEECCEEEEEECCCCCCCCEECCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PPFVMAGGHEKFRFEGLNIVGLKRRGFSSAQLDRIRAIYRILFQSGMLLGNALDKVLTDC
CCEEEECCCCEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
EESPERDEILAFFDTSSARRKYIRPYNS
HCCCCCCCEEEEEECCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA