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The map label for this gene is cbs [H]

Identifier: 194334744

GI number: 194334744

Start: 2126227

End: 2127600

Strand: Reverse

Name: cbs [H]

Synonym: Paes_1945

Alternate gene names: 194334744

Gene position: 2127600-2126227 (Counterclockwise)

Preceding gene: 194334748

Following gene: 194334743

Centisome position: 84.67

GC content: 50.58

Gene sequence:

>1374_bases
ATGTTGCAGCAGAATATATTCTCGATGAACGCTCAGGTGCCGATGGTTGCCATCAAGCGGCTGGCAGCCCATATACAGCC
GGAAATAGTTGCACGACTCGAGTATCTCAATCCTTCCGGGACCCATTACTGGTCTGTTGCATCCGTGATTATCGAAAATG
CTGAAAAAGAGGGGCTCATTTCGCCTGGAATGACCCTGGTCGACTGGACATACGGCAGCAGCGGTATTGCACTGGCAATG
GCCGCGATAGCTAAGGGCTATAAGGTTCTGCTTGTCGTGCCGGACAAGATATCACGCGAAAAGCAGCAGGTGCTGAAAGC
CATGGGAGCCGAAGTTGTTATCACGCCTTCTGATGCGCTGCCGGGAGCGCCGAGAAGTTGCGTCAATGTTGCGCAAAATC
TGGTGCAGAACCTCAAGCATGCGTATTTCACCAATATGTATGAAAACCCTCTGAGTTTCAGCGTTCACGCTGAGACCACC
GGCCCTATGATATGGGAGCAGACCGGAGGGGAGGTCACGCATCTTTTTGTTCCTGTGACATCGGGAGCGATGATTTCGGG
TATAGGACAATTTCTGAAGTCGAAACGGCAGAATATCAGGATTATCGGTGTTGAGCCGGAGGGATCGATCTACAGGGAGC
TGTTGCAGCATCGCAAGCTCTCTGCGCCGGCACTGTTCGAGCTGGAGGAGATAGGAGGATTATGGGAATCGAAATACTGG
GATGCTTCGGTGATCGACGATATCGTTCAGGTCAGCGATTTCGATGCCTTTAACTGCGGTCGTGAACTTCTGCGTTCAGA
GGCGATTTTTTCTGGAGGATCATCCGGCGCAGCGATGTTTGCAGCGCTCAGGGCCGGTGCACATCTTGGCCGGGATGCCC
GGATCGTTGTCATGATGAGTGATTTTGGCGGCTACTACCTCAGTAAGATGTACAGCGATGAATGGATGAAGCTCAAAGGG
TTTTACAGAAAAGCGCCATCTTCCAGAGATGAGATTACCGCAGAGGATATTCTCGGGCTCAAAACCCGCAGGGATCTTAT
CTTCGCCCTTCCCGAGCATACGCTTTCGGAAGTGTTTGAAATGATGCGTCAGAACGACGTTTCGCAGCTGCCGATTGTCT
CCTATGGGACAGCGATCGGAAGTATCAGCGAAAACAAGATTCTCTCGATTCTGATTGAAAACGACGATGCCATGAATTCC
AAGGTTGTCGGCTATATGGAACAGCCATTTCCGGTCTGTCCGCCACATGCCACTATTTCGGAGTTGTCTGAAAAACTGCA
GGAAAATGCTTCGGGCGTTCTGATAAGTCTTTCGGATGGTCGATTGCAACTTCTTACGAAATCTGACCTTATAGAAGCGC
TTACACATAAATGA

Upstream 100 bases:

>100_bases
GTTGCCGTTGTCGTGCCGGTTCGGATAATTTGAAACGATGAGCAGAGGTATTACATTGATTAACGACGACAATTCATTTA
ACCCTCTTCCCTATAGAAGA

Downstream 100 bases:

>100_bases
TCCTGATGGGTAATAAGCGGTTGTTTTTCTATTCAGATTTACGTATCTAAGCAAACCTGAAGAACCTTTTCAGTGTGGGC
GAGGTGTATCCTGTAAGGCC

Product: Cysteine synthase

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MLQQNIFSMNAQVPMVAIKRLAAHIQPEIVARLEYLNPSGTHYWSVASVIIENAEKEGLISPGMTLVDWTYGSSGIALAM
AAIAKGYKVLLVVPDKISREKQQVLKAMGAEVVITPSDALPGAPRSCVNVAQNLVQNLKHAYFTNMYENPLSFSVHAETT
GPMIWEQTGGEVTHLFVPVTSGAMISGIGQFLKSKRQNIRIIGVEPEGSIYRELLQHRKLSAPALFELEEIGGLWESKYW
DASVIDDIVQVSDFDAFNCGRELLRSEAIFSGGSSGAAMFAALRAGAHLGRDARIVVMMSDFGGYYLSKMYSDEWMKLKG
FYRKAPSSRDEITAEDILGLKTRRDLIFALPEHTLSEVFEMMRQNDVSQLPIVSYGTAIGSISENKILSILIENDDAMNS
KVVGYMEQPFPVCPPHATISELSEKLQENASGVLISLSDGRLQLLTKSDLIEALTHK

Sequences:

>Translated_457_residues
MLQQNIFSMNAQVPMVAIKRLAAHIQPEIVARLEYLNPSGTHYWSVASVIIENAEKEGLISPGMTLVDWTYGSSGIALAM
AAIAKGYKVLLVVPDKISREKQQVLKAMGAEVVITPSDALPGAPRSCVNVAQNLVQNLKHAYFTNMYENPLSFSVHAETT
GPMIWEQTGGEVTHLFVPVTSGAMISGIGQFLKSKRQNIRIIGVEPEGSIYRELLQHRKLSAPALFELEEIGGLWESKYW
DASVIDDIVQVSDFDAFNCGRELLRSEAIFSGGSSGAAMFAALRAGAHLGRDARIVVMMSDFGGYYLSKMYSDEWMKLKG
FYRKAPSSRDEITAEDILGLKTRRDLIFALPEHTLSEVFEMMRQNDVSQLPIVSYGTAIGSISENKILSILIENDDAMNS
KVVGYMEQPFPVCPPHATISELSEKLQENASGVLISLSDGRLQLLTKSDLIEALTHK
>Mature_457_residues
MLQQNIFSMNAQVPMVAIKRLAAHIQPEIVARLEYLNPSGTHYWSVASVIIENAEKEGLISPGMTLVDWTYGSSGIALAM
AAIAKGYKVLLVVPDKISREKQQVLKAMGAEVVITPSDALPGAPRSCVNVAQNLVQNLKHAYFTNMYENPLSFSVHAETT
GPMIWEQTGGEVTHLFVPVTSGAMISGIGQFLKSKRQNIRIIGVEPEGSIYRELLQHRKLSAPALFELEEIGGLWESKYW
DASVIDDIVQVSDFDAFNCGRELLRSEAIFSGGSSGAAMFAALRAGAHLGRDARIVVMMSDFGGYYLSKMYSDEWMKLKG
FYRKAPSSRDEITAEDILGLKTRRDLIFALPEHTLSEVFEMMRQNDVSQLPIVSYGTAIGSISENKILSILIENDDAMNS
KVVGYMEQPFPVCPPHATISELSEKLQENASGVLISLSDGRLQLLTKSDLIEALTHK

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=396, Percent_Identity=32.0707070707071, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI295821200, Length=396, Percent_Identity=32.0707070707071, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI4557415, Length=396, Percent_Identity=32.0707070707071, Blast_Score=206, Evalue=3e-53,
Organism=Escherichia coli, GI2367138, Length=313, Percent_Identity=33.5463258785943, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1788754, Length=319, Percent_Identity=31.0344827586207, Blast_Score=136, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17534315, Length=331, Percent_Identity=31.1178247734139, Blast_Score=158, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17562970, Length=308, Percent_Identity=33.1168831168831, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17535051, Length=301, Percent_Identity=33.5548172757475, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI32566674, Length=301, Percent_Identity=33.2225913621262, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI115535073, Length=316, Percent_Identity=31.3291139240506, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25147552, Length=334, Percent_Identity=29.940119760479, Blast_Score=145, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17561720, Length=331, Percent_Identity=33.2326283987915, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI32566672, Length=225, Percent_Identity=30.6666666666667, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321594, Length=504, Percent_Identity=28.7698412698413, Blast_Score=183, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6321449, Length=327, Percent_Identity=27.217125382263, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24643623, Length=392, Percent_Identity=30.1020408163265, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI20129101, Length=392, Percent_Identity=30.1020408163265, Blast_Score=184, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 50307; Mature: 50307

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQQNIFSMNAQVPMVAIKRLAAHIQPEIVARLEYLNPSGTHYWSVASVIIENAEKEGLI
CCCCCHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCC
SPGMTLVDWTYGSSGIALAMAAIAKGYKVLLVVPDKISREKQQVLKAMGAEVVITPSDAL
CCCCEEEEEECCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCC
PGAPRSCVNVAQNLVQNLKHAYFTNMYENPLSFSVHAETTGPMIWEQTGGEVTHLFVPVT
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCCCEEEEEEEEC
SGAMISGIGQFLKSKRQNIRIIGVEPEGSIYRELLQHRKLSAPALFELEEIGGLWESKYW
CCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCHHEEHHHHCCHHHCCCC
DASVIDDIVQVSDFDAFNCGRELLRSEAIFSGGSSGAAMFAALRAGAHLGRDARIVVMMS
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEE
DFGGYYLSKMYSDEWMKLKGFYRKAPSSRDEITAEDILGLKTRRDLIFALPEHTLSEVFE
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHCCCEEECCHHHHHHHHH
MMRQNDVSQLPIVSYGTAIGSISENKILSILIENDDAMNSKVVGYMEQPFPVCPPHATIS
HHHHCCCCCCCEEEECCHHCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCCHHH
ELSEKLQENASGVLISLSDGRLQLLTKSDLIEALTHK
HHHHHHHCCCCEEEEEECCCCEEEEEHHHHHHHHHCC
>Mature Secondary Structure
MLQQNIFSMNAQVPMVAIKRLAAHIQPEIVARLEYLNPSGTHYWSVASVIIENAEKEGLI
CCCCCHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCC
SPGMTLVDWTYGSSGIALAMAAIAKGYKVLLVVPDKISREKQQVLKAMGAEVVITPSDAL
CCCCEEEEEECCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCC
PGAPRSCVNVAQNLVQNLKHAYFTNMYENPLSFSVHAETTGPMIWEQTGGEVTHLFVPVT
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCCCEEEEEEEEC
SGAMISGIGQFLKSKRQNIRIIGVEPEGSIYRELLQHRKLSAPALFELEEIGGLWESKYW
CCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCHHEEHHHHCCHHHCCCC
DASVIDDIVQVSDFDAFNCGRELLRSEAIFSGGSSGAAMFAALRAGAHLGRDARIVVMMS
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEE
DFGGYYLSKMYSDEWMKLKGFYRKAPSSRDEITAEDILGLKTRRDLIFALPEHTLSEVFE
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHCCCEEECCHHHHHHHHH
MMRQNDVSQLPIVSYGTAIGSISENKILSILIENDDAMNSKVVGYMEQPFPVCPPHATIS
HHHHCCCCCCCEEEECCHHCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCCCHHH
ELSEKLQENASGVLISLSDGRLQLLTKSDLIEALTHK
HHHHHHHCCCCEEEEEECCCCEEEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]