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The map label for this gene is aroA

Identifier: 194334741

GI number: 194334741

Start: 2123826

End: 2125130

Strand: Reverse

Name: aroA

Synonym: Paes_1942

Alternate gene names: 194334741

Gene position: 2125130-2123826 (Counterclockwise)

Preceding gene: 194334742

Following gene: 194334735

Centisome position: 84.57

GC content: 52.87

Gene sequence:

>1305_bases
ATGACTGCCTATAAAGGGGAAGTTTTCAACCTGCCGCCTGACAAGTCAATTTCTCACCGCGCAGCCCTTATCGGGGCGCT
TGCAGACGGAACGACTGAGATTTCGAATTTTTCCGGCGGGTTCGATAACCAGTCTACGCTTGGCGTGCTTCAGGCATGCG
GCATCAGGCTTTCCCAGGATATTGTTCAGGGGGCCGATGGTCGTCAGACTCGTCATGTTGTTCTTCATTCCAGCGGACTC
TGGAGTTTTTCTGCTCCGGATGCCCCGCTTATGTGCAATAATTCGGGCAGTACTATGCGGATGTTTGCCGGGATACTGGC
AGGACAGCCGTTCGACAGTACGCTTGTCGGGGACAATTCACTGATGAAGCGCCCCATGAAGCGTATTGCCGATCCGTTGC
GTCGTATGGGGGCCGGTATTTCACTCTCACCGGATGGGACCGCCCCTGTCGGCATCAATGGGACACGGGATCTGAAACCG
ATTACCTATGAGCTTCCTATGCCTTCCGCCCAGGTCAAGTCACTTGTTGCGTTTGCGGCTCTGCATGCTGACGGGGAAAG
TCGTGTTATCGAAACCCTGCCTTCGAGAAATCATACTGAACTGATGCTCGATCTGAAGACTGAGGCGTTGTCTGATGGTC
GGCGTGCGGTAATTATTCCTGGCGGAAAATCTCTGGAGGCAAGGCCGTTTCATATTCCGGCAGACCCCTCTGCGGCATGT
TTTATGATCGCGCTCGGCCTGCTTGTTCCCGGCTCCGAAATTCTTCTCAGGGATGTCTGTCTCAATCCGACCCGGGCGGG
CTACATTGAGCTCCTGATCGGTGCCGGCGCCGATATCGGGTTTGAAAACCGACGGGTGATCGGCGGGGAAACGATCGGAG
ATATTGTCGTTCGGTATTCGGGATCGGTCGAACCGCTCAGGATCGATGAGCCTTCAATTGTTGCCAATATCATCGATGAA
ATTCCGATGCTTGCCGTTTTTTCAGCATGTGCAACCGCTGAATTCGAGCTTCACCATGCGGCTGAACTGAGGACAAAGGA
AAGCGACAGGATTTCCGCCGTTGTCAGCAATTTGCAGCGGCTTGGTTTTCTGTGTGAAGAGTTTCCCGATGGTTTTGCGG
TTAAAGGCCGTCAGCGTGTGCCTTCTGGAAAAGTCATTCTCGAAAGCTATGACGACCATCGCATTGCGATGAGTTTCGCT
ATAGCCGACAAGGCGCTGGAGAGTGAGTTGGAAATTTCAGACAGGGAGATCATAGGGGTATCCTTTCCTAACTTCTTCGA
TATTATCGAAAGTCTTCGACAGTAG

Upstream 100 bases:

>100_bases
CAACTCCTGATCGCGTTACAGCAGGAAACATATGAAGCAGCTCCCGTTCGGGGCTGCTTTTTTTATACAGAACCTGTTTC
ACCATTAAAATCTTTTGGAC

Downstream 100 bases:

>100_bases
GGCGCCTGCAACGAATGCGTGAGCACTGTTTGCCTTCCGGCGGACTTGCTTTCGGCGAGCAGGAGTCCGAATAAGCCGAA
CCTCATGGCCCGGAGTTTCA

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTAYKGEVFNLPPDKSISHRAALIGALADGTTEISNFSGGFDNQSTLGVLQACGIRLSQDIVQGADGRQTRHVVLHSSGL
WSFSAPDAPLMCNNSGSTMRMFAGILAGQPFDSTLVGDNSLMKRPMKRIADPLRRMGAGISLSPDGTAPVGINGTRDLKP
ITYELPMPSAQVKSLVAFAALHADGESRVIETLPSRNHTELMLDLKTEALSDGRRAVIIPGGKSLEARPFHIPADPSAAC
FMIALGLLVPGSEILLRDVCLNPTRAGYIELLIGAGADIGFENRRVIGGETIGDIVVRYSGSVEPLRIDEPSIVANIIDE
IPMLAVFSACATAEFELHHAAELRTKESDRISAVVSNLQRLGFLCEEFPDGFAVKGRQRVPSGKVILESYDDHRIAMSFA
IADKALESELEISDREIIGVSFPNFFDIIESLRQ

Sequences:

>Translated_434_residues
MTAYKGEVFNLPPDKSISHRAALIGALADGTTEISNFSGGFDNQSTLGVLQACGIRLSQDIVQGADGRQTRHVVLHSSGL
WSFSAPDAPLMCNNSGSTMRMFAGILAGQPFDSTLVGDNSLMKRPMKRIADPLRRMGAGISLSPDGTAPVGINGTRDLKP
ITYELPMPSAQVKSLVAFAALHADGESRVIETLPSRNHTELMLDLKTEALSDGRRAVIIPGGKSLEARPFHIPADPSAAC
FMIALGLLVPGSEILLRDVCLNPTRAGYIELLIGAGADIGFENRRVIGGETIGDIVVRYSGSVEPLRIDEPSIVANIIDE
IPMLAVFSACATAEFELHHAAELRTKESDRISAVVSNLQRLGFLCEEFPDGFAVKGRQRVPSGKVILESYDDHRIAMSFA
IADKALESELEISDREIIGVSFPNFFDIIESLRQ
>Mature_433_residues
TAYKGEVFNLPPDKSISHRAALIGALADGTTEISNFSGGFDNQSTLGVLQACGIRLSQDIVQGADGRQTRHVVLHSSGLW
SFSAPDAPLMCNNSGSTMRMFAGILAGQPFDSTLVGDNSLMKRPMKRIADPLRRMGAGISLSPDGTAPVGINGTRDLKPI
TYELPMPSAQVKSLVAFAALHADGESRVIETLPSRNHTELMLDLKTEALSDGRRAVIIPGGKSLEARPFHIPADPSAACF
MIALGLLVPGSEILLRDVCLNPTRAGYIELLIGAGADIGFENRRVIGGETIGDIVVRYSGSVEPLRIDEPSIVANIIDEI
PMLAVFSACATAEFELHHAAELRTKESDRISAVVSNLQRLGFLCEEFPDGFAVKGRQRVPSGKVILESYDDHRIAMSFAI
ADKALESELEISDREIIGVSFPNFFDIIESLRQ

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family

Homologues:

Organism=Escherichia coli, GI1787137, Length=439, Percent_Identity=24.373576309795, Blast_Score=82, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320332, Length=467, Percent_Identity=24.1970021413276, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROA_PROA2 (B4S4Q8)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002016601.1
- GeneID:   6460004
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_1942
- HOGENOM:   HBG646626
- OMA:   LSRNHTE
- ProtClustDB:   PRK02427
- GO:   GO:0005737
- HAMAP:   MF_00210
- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792
- Gene3D:   G3DSA:3.65.10.10
- PIRSF:   PIRSF000505
- TIGRFAMs:   TIGR01356

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.19

Molecular weight: Translated: 46697; Mature: 46566

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00104 EPSP_SYNTHASE_1; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAYKGEVFNLPPDKSISHRAALIGALADGTTEISNFSGGFDNQSTLGVLQACGIRLSQD
CCCCCCCEECCCCCCCCHHHHHHHHHHCCCCHHHCCCCCCCCCCHHHHHHHHHCCHHHHH
IVQGADGRQTRHVVLHSSGLWSFSAPDAPLMCNNSGSTMRMFAGILAGQPFDSTLVGDNS
HHCCCCCCCEEEEEEECCCCEECCCCCCCEEECCCCCHHHHHHHHHCCCCCCCEEECCHH
LMKRPMKRIADPLRRMGAGISLSPDGTAPVGINGTRDLKPITYELPMPSAQVKSLVAFAA
HHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHH
LHADGESRVIETLPSRNHTELMLDLKTEALSDGRRAVIIPGGKSLEARPFHIPADPSAAC
HHCCCCHHHHHHCCCCCCCEEEEEEEHHHHCCCCEEEEECCCCCCCCCCEECCCCCCHHH
FMIALGLLVPGSEILLRDVCLNPTRAGYIELLIGAGADIGFENRRVIGGETIGDIVVRYS
HHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCEEECCCCCEEEEEEEC
GSVEPLRIDEPSIVANIIDEIPMLAVFSACATAEFELHHAAELRTKESDRISAVVSNLQR
CCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHCCCHHHHHHHHHHHHH
LGFLCEEFPDGFAVKGRQRVPSGKVILESYDDHRIAMSFAIADKALESELEISDREIIGV
HHHHHHHCCCCCEECCCCCCCCCCEEEECCCCCEEEEEHHHHHHHHHHHCCCCCCEEEEE
SFPNFFDIIESLRQ
CCCHHHHHHHHHCC
>Mature Secondary Structure 
TAYKGEVFNLPPDKSISHRAALIGALADGTTEISNFSGGFDNQSTLGVLQACGIRLSQD
CCCCCCEECCCCCCCCHHHHHHHHHHCCCCHHHCCCCCCCCCCHHHHHHHHHCCHHHHH
IVQGADGRQTRHVVLHSSGLWSFSAPDAPLMCNNSGSTMRMFAGILAGQPFDSTLVGDNS
HHCCCCCCCEEEEEEECCCCEECCCCCCCEEECCCCCHHHHHHHHHCCCCCCCEEECCHH
LMKRPMKRIADPLRRMGAGISLSPDGTAPVGINGTRDLKPITYELPMPSAQVKSLVAFAA
HHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHH
LHADGESRVIETLPSRNHTELMLDLKTEALSDGRRAVIIPGGKSLEARPFHIPADPSAAC
HHCCCCHHHHHHCCCCCCCEEEEEEEHHHHCCCCEEEEECCCCCCCCCCEECCCCCCHHH
FMIALGLLVPGSEILLRDVCLNPTRAGYIELLIGAGADIGFENRRVIGGETIGDIVVRYS
HHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCEEECCCCCEEEEEEEC
GSVEPLRIDEPSIVANIIDEIPMLAVFSACATAEFELHHAAELRTKESDRISAVVSNLQR
CCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHCCCHHHHHHHHHHHHH
LGFLCEEFPDGFAVKGRQRVPSGKVILESYDDHRIAMSFAIADKALESELEISDREIIGV
HHHHHHHCCCCCEECCCCCCCCCCEEEECCCCCEEEEEHHHHHHHHHHHCCCCCCEEEEE
SFPNFFDIIESLRQ
CCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA