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The map label for this gene is yqeC [H]

Identifier: 194334706

GI number: 194334706

Start: 2085378

End: 2086265

Strand: Reverse

Name: yqeC [H]

Synonym: Paes_1907

Alternate gene names: 194334706

Gene position: 2086265-2085378 (Counterclockwise)

Preceding gene: 194334707

Following gene: 194334705

Centisome position: 83.02

GC content: 52.14

Gene sequence:

>888_bases
ATGAAAACAGGTTTTGTCGGGCTTGGAAAAATGGGTTTGAATATGGTCGAAAACCTTCTCGATCATGGCCATGATGTCGT
TGTCTATGACCTTTCTTCGGCTCAGGTCTTGCAGGCTGTGCAAAAAGGGGCTGTTGGTGCTTCATCGCTCAAGGATCTTG
CCGATACCGGTCTTATCTGGATGATGGTCCCTGCCGGTGCGCCTGTCGATGCTACCATTGACGAACTGCTTCCGATTCTC
AAGGCCGGTGATATCATTATCGATGGCGGAAACTCGAATTATCATGATACGGTGAGACGGGCCCTGCGGGTTCAGGGTGC
TGGTATGCATTATCTCGATGTCGGGACCAGCGGAGGGCTGGAAGGTGCGCGCAATGGTGCCTGTATGATGATCGGGGGCA
GCAGCGAGATTGTCGACCGGCTCGACGAGCTCTTCAGGGATATGTGTGTTCCCGGAGGGTATGGCTATGTCGGGCCCAAT
GGAGCAGGTCATTTTGCCAAGATGGTGCATAACGGTGTAGAATACGGTATGATGCAGGCAATCGGCGAGGGATTCGATAT
TCTCGAGTCAGCTCCTTTTACATTTGATCATCATGCTGTTGCCGGGATATGGTCTAACGGATCGGTAATCAGAGGCTGGC
TCATGGATCTTGTTGCCGCTGCATTTGAAAAAGACGGCGCGCTCGACTATCTCTCAGGTGAAATCGCTGATTCCGGTGAA
GGTCGCTGGACCATCGATGCGGCTCTTGATCAGGGTGTTTCCATACCGGTGATCGCTAATGCGCTGTTCAGACGCTACCG
TTCGCGCTCTCACGATAATTTTTCCGATAAGGTCGTTGCAGCTCTTCGTCATGAGTTCGGTGGCCACGGTTTTACTCCTA
AATCCTGA

Upstream 100 bases:

>100_bases
ATGAGCTGGAGGAGGAGTTCAGGACGCTTCACAATGAGATGCAGCAGTCATCTCTGCTGAAAACGTAATCAAAAGACGGA
GAAACAACAGGATACATACT

Downstream 100 bases:

>100_bases
CTGTATGGCTCCTGCTGAGAGAGAAATTTCAAATTTTACGCTTGTCCTGTTCGGGGCAAACGGTGACCTTGCGTTAAGGA
AGCTGTTCCCTTCAATGTAT

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MKTGFVGLGKMGLNMVENLLDHGHDVVVYDLSSAQVLQAVQKGAVGASSLKDLADTGLIWMMVPAGAPVDATIDELLPIL
KAGDIIIDGGNSNYHDTVRRALRVQGAGMHYLDVGTSGGLEGARNGACMMIGGSSEIVDRLDELFRDMCVPGGYGYVGPN
GAGHFAKMVHNGVEYGMMQAIGEGFDILESAPFTFDHHAVAGIWSNGSVIRGWLMDLVAAAFEKDGALDYLSGEIADSGE
GRWTIDAALDQGVSIPVIANALFRRYRSRSHDNFSDKVVAALRHEFGGHGFTPKS

Sequences:

>Translated_295_residues
MKTGFVGLGKMGLNMVENLLDHGHDVVVYDLSSAQVLQAVQKGAVGASSLKDLADTGLIWMMVPAGAPVDATIDELLPIL
KAGDIIIDGGNSNYHDTVRRALRVQGAGMHYLDVGTSGGLEGARNGACMMIGGSSEIVDRLDELFRDMCVPGGYGYVGPN
GAGHFAKMVHNGVEYGMMQAIGEGFDILESAPFTFDHHAVAGIWSNGSVIRGWLMDLVAAAFEKDGALDYLSGEIADSGE
GRWTIDAALDQGVSIPVIANALFRRYRSRSHDNFSDKVVAALRHEFGGHGFTPKS
>Mature_295_residues
MKTGFVGLGKMGLNMVENLLDHGHDVVVYDLSSAQVLQAVQKGAVGASSLKDLADTGLIWMMVPAGAPVDATIDELLPIL
KAGDIIIDGGNSNYHDTVRRALRVQGAGMHYLDVGTSGGLEGARNGACMMIGGSSEIVDRLDELFRDMCVPGGYGYVGPN
GAGHFAKMVHNGVEYGMMQAIGEGFDILESAPFTFDHHAVAGIWSNGSVIRGWLMDLVAAAFEKDGALDYLSGEIADSGE
GRWTIDAALDQGVSIPVIANALFRRYRSRSHDNFSDKVVAALRHEFGGHGFTPKS

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=308, Percent_Identity=36.3636363636364, Blast_Score=146, Evalue=3e-35,
Organism=Escherichia coli, GI1788341, Length=304, Percent_Identity=33.8815789473684, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI145693186, Length=217, Percent_Identity=27.6497695852535, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786719, Length=190, Percent_Identity=30, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17542558, Length=288, Percent_Identity=35.7638888888889, Blast_Score=157, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6321695, Length=290, Percent_Identity=36.2068965517241, Blast_Score=163, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6321977, Length=285, Percent_Identity=36.140350877193, Blast_Score=152, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24639279, Length=288, Percent_Identity=36.1111111111111, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24655230, Length=194, Percent_Identity=29.3814432989691, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19922568, Length=194, Percent_Identity=29.3814432989691, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 31313; Mature: 31313

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00895 3_HYDROXYISOBUT_DH ; PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTGFVGLGKMGLNMVENLLDHGHDVVVYDLSSAQVLQAVQKGAVGASSLKDLADTGLIW
CCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHCCEEE
MMVPAGAPVDATIDELLPILKAGDIIIDGGNSNYHDTVRRALRVQGAGMHYLDVGTSGGL
EEECCCCCCCCCHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCC
EGARNGACMMIGGSSEIVDRLDELFRDMCVPGGYGYVGPNGAGHFAKMVHNGVEYGMMQA
CCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
IGEGFDILESAPFTFDHHAVAGIWSNGSVIRGWLMDLVAAAFEKDGALDYLSGEIADSGE
HCCCHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCC
GRWTIDAALDQGVSIPVIANALFRRYRSRSHDNFSDKVVAALRHEFGGHGFTPKS
CCEEEEHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKTGFVGLGKMGLNMVENLLDHGHDVVVYDLSSAQVLQAVQKGAVGASSLKDLADTGLIW
CCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCCHHHHHHHHHCCEEE
MMVPAGAPVDATIDELLPILKAGDIIIDGGNSNYHDTVRRALRVQGAGMHYLDVGTSGGL
EEECCCCCCCCCHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCC
EGARNGACMMIGGSSEIVDRLDELFRDMCVPGGYGYVGPNGAGHFAKMVHNGVEYGMMQA
CCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
IGEGFDILESAPFTFDHHAVAGIWSNGSVIRGWLMDLVAAAFEKDGALDYLSGEIADSGE
HCCCHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCC
GRWTIDAALDQGVSIPVIANALFRRYRSRSHDNFSDKVVAALRHEFGGHGFTPKS
CCEEEEHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]