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The map label for this gene is zwf [H]

Identifier: 194334705

GI number: 194334705

Start: 2083940

End: 2085373

Strand: Reverse

Name: zwf [H]

Synonym: Paes_1906

Alternate gene names: 194334705

Gene position: 2085373-2083940 (Counterclockwise)

Preceding gene: 194334706

Following gene: 194334701

Centisome position: 82.99

GC content: 51.39

Gene sequence:

>1434_bases
ATGGCTCCTGCTGAGAGAGAAATTTCAAATTTTACGCTTGTCCTGTTCGGGGCAAACGGTGACCTTGCGTTAAGGAAGCT
GTTCCCTTCAATGTATGAACTTGCCCGATGGGGGCAGATGCCGGATAAATACCGGATTATCGGTGTCGGCCGTTCTGATA
TCGGTCACGATGGGTTCCGCGAGCTGGTCCGGGAGGCAATGGTCGCTCATGCACCACATATTGATACCGGTTCCGGACAT
TTCAGTGATTTTATTCAGAGTCTGTTCTACGTTCAGGTCGATCTGACAACGGTCGAGGGCTACCATCGTCTCAGGGAAGA
GATCCGGACCGGTCATGGGCGGGAGGGGACTTGCAGTAATCTGCTTTTTTACCTTTCGACTCCCCCGAGTCTGGCTCCTT
TTATTGTCCGGTTTCTCGACGAGGCTGGCCTTGGCGGCAAATCGCCATCGTGCCAGGGATGGCGGAAAATCATTATTGAG
AAGCCCTATGGTCACGATCTTCAGAGTGCGCGTGAACTCAATGTGATTGTCGGGGAAGTGTTTCACGAGGAGCAGATCTA
TCGCATAGATCATTATCTCGGCAAGGAACCGGTTCAGAATATCCTGGTATTCCGCTTTTCTAATGGTATGTTCGAACCGC
TCTGGAATCGTCATTATATCGACAACGTCAGCATTACCATCGCCGAAGATTTCGGTATCAGGGGGCGGGGGTCGTTTTAT
GAAGAGGCCGGACTGCTTCGCGATATCATCCAGAATCACGGTCTGCAGCTTCTCGCCTCGGTGGCTATGGAGCCTCCTGT
CGATCTGAGCGCAGACGCAGTCAGAGATGAAAAAGAGAAGGTTTTTCGTTCACTTCGTCGCTTCACTGTCGAGAGTGCCA
GAGAGCATGTCGTGCTTGGTCAGTATGACGGATACCGTCAGGAAAACAATGTGGCTTCTGATTCACTGGTCGAAACCTTT
GCTTCCATACGGTTTTTTATCGATAACTGGCGCTGGAAAGGGGTTCCTTTTTATATGAAGGCCGGAAAAAATCTTGCCAG
GAGCCTGACTGAAATTGTTATCACCTTCTCATGCCCGCCTCAGAATTTTTTCGGGCCGCCTGAAAGTTGCAGTTATACCG
CCAACCAGATCGTCATTCAGATCCAGCCGGAACAAACCATTGCGATCCGTTTCGGGACAAAGCGACCCGGTGAAGCGCTG
GTTACCGACCCGGTGTTTATGAAATTCGATTACCGCGCATCATTCGAAAAGGAGGGGATGACACCCTATCACCGCCTTCT
TGTCGATGCGATGGCCGGTGATCAGATGCATTTTATCCGTCAGGACTCTGTCGAGAGCAGCTGGTCGGTGATTGACAGCA
TCAAATCGTCTTTGCAGGGAAGCGTGCCACAGCCCTACGCGGTGCATTCCTGGGGGCCTGAAACAGGTTTCTGA

Upstream 100 bases:

>100_bases
CGCTACCGTTCGCGCTCTCACGATAATTTTTCCGATAAGGTCGTTGCAGCTCTTCGTCATGAGTTCGGTGGCCACGGTTT
TACTCCTAAATCCTGACTGT

Downstream 100 bases:

>100_bases
CCGGTTGAGCCATCAGCGAGAAACCATTGGAGGTCTCCATGTTTCGGGTTTATTCTTGCGGCGGGCACCGTGTTTTGCCC
GCCGGAGATGATTTGTCGTG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MAPAEREISNFTLVLFGANGDLALRKLFPSMYELARWGQMPDKYRIIGVGRSDIGHDGFRELVREAMVAHAPHIDTGSGH
FSDFIQSLFYVQVDLTTVEGYHRLREEIRTGHGREGTCSNLLFYLSTPPSLAPFIVRFLDEAGLGGKSPSCQGWRKIIIE
KPYGHDLQSARELNVIVGEVFHEEQIYRIDHYLGKEPVQNILVFRFSNGMFEPLWNRHYIDNVSITIAEDFGIRGRGSFY
EEAGLLRDIIQNHGLQLLASVAMEPPVDLSADAVRDEKEKVFRSLRRFTVESAREHVVLGQYDGYRQENNVASDSLVETF
ASIRFFIDNWRWKGVPFYMKAGKNLARSLTEIVITFSCPPQNFFGPPESCSYTANQIVIQIQPEQTIAIRFGTKRPGEAL
VTDPVFMKFDYRASFEKEGMTPYHRLLVDAMAGDQMHFIRQDSVESSWSVIDSIKSSLQGSVPQPYAVHSWGPETGF

Sequences:

>Translated_477_residues
MAPAEREISNFTLVLFGANGDLALRKLFPSMYELARWGQMPDKYRIIGVGRSDIGHDGFRELVREAMVAHAPHIDTGSGH
FSDFIQSLFYVQVDLTTVEGYHRLREEIRTGHGREGTCSNLLFYLSTPPSLAPFIVRFLDEAGLGGKSPSCQGWRKIIIE
KPYGHDLQSARELNVIVGEVFHEEQIYRIDHYLGKEPVQNILVFRFSNGMFEPLWNRHYIDNVSITIAEDFGIRGRGSFY
EEAGLLRDIIQNHGLQLLASVAMEPPVDLSADAVRDEKEKVFRSLRRFTVESAREHVVLGQYDGYRQENNVASDSLVETF
ASIRFFIDNWRWKGVPFYMKAGKNLARSLTEIVITFSCPPQNFFGPPESCSYTANQIVIQIQPEQTIAIRFGTKRPGEAL
VTDPVFMKFDYRASFEKEGMTPYHRLLVDAMAGDQMHFIRQDSVESSWSVIDSIKSSLQGSVPQPYAVHSWGPETGF
>Mature_476_residues
APAEREISNFTLVLFGANGDLALRKLFPSMYELARWGQMPDKYRIIGVGRSDIGHDGFRELVREAMVAHAPHIDTGSGHF
SDFIQSLFYVQVDLTTVEGYHRLREEIRTGHGREGTCSNLLFYLSTPPSLAPFIVRFLDEAGLGGKSPSCQGWRKIIIEK
PYGHDLQSARELNVIVGEVFHEEQIYRIDHYLGKEPVQNILVFRFSNGMFEPLWNRHYIDNVSITIAEDFGIRGRGSFYE
EAGLLRDIIQNHGLQLLASVAMEPPVDLSADAVRDEKEKVFRSLRRFTVESAREHVVLGQYDGYRQENNVASDSLVETFA
SIRFFIDNWRWKGVPFYMKAGKNLARSLTEIVITFSCPPQNFFGPPESCSYTANQIVIQIQPEQTIAIRFGTKRPGEALV
TDPVFMKFDYRASFEKEGMTPYHRLLVDAMAGDQMHFIRQDSVESSWSVIDSIKSSLQGSVPQPYAVHSWGPETGF

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=475, Percent_Identity=34.7368421052632, Blast_Score=285, Evalue=8e-77,
Organism=Homo sapiens, GI108773793, Length=475, Percent_Identity=34.7368421052632, Blast_Score=284, Evalue=1e-76,
Organism=Homo sapiens, GI52145310, Length=491, Percent_Identity=29.7352342158859, Blast_Score=185, Evalue=9e-47,
Organism=Escherichia coli, GI1788158, Length=476, Percent_Identity=39.2857142857143, Blast_Score=340, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI17538218, Length=484, Percent_Identity=35.1239669421488, Blast_Score=298, Evalue=6e-81,
Organism=Saccharomyces cerevisiae, GI6324088, Length=482, Percent_Identity=34.0248962655602, Blast_Score=277, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24643350, Length=479, Percent_Identity=33.4029227557411, Blast_Score=268, Evalue=7e-72,
Organism=Drosophila melanogaster, GI24643352, Length=479, Percent_Identity=33.4029227557411, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI221513548, Length=488, Percent_Identity=28.2786885245902, Blast_Score=196, Evalue=3e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54166; Mature: 54035

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPAEREISNFTLVLFGANGDLALRKLFPSMYELARWGQMPDKYRIIGVGRSDIGHDGFR
CCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHH
ELVREAMVAHAPHIDTGSGHFSDFIQSLFYVQVDLTTVEGYHRLREEIRTGHGREGTCSN
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEEEEEEHHHHHHHHHHHHCCCCCCCCCCC
LLFYLSTPPSLAPFIVRFLDEAGLGGKSPSCQGWRKIIIEKPYGHDLQSARELNVIVGEV
EEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCHHEEEEECCCCCCHHHHHHHHHHHHHH
FHEEQIYRIDHYLGKEPVQNILVFRFSNGMFEPLWNRHYIDNVSITIAEDFGIRGRGSFY
HHHHHHHHHHHHHCCCHHHHEEEEEECCCCCCHHCCCEEECCEEEEEEECCCCCCCCCHH
EEAGLLRDIIQNHGLQLLASVAMEPPVDLSADAVRDEKEKVFRSLRRFTVESAREHVVLG
HHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEE
QYDGYRQENNVASDSLVETFASIRFFIDNWRWKGVPFYMKAGKNLARSLTEIVITFSCPP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEECCCCHHHHCCHHHHHHHHHEEEEEECCC
QNFFGPPESCSYTANQIVIQIQPEQTIAIRFGTKRPGEALVTDPVFMKFDYRASFEKEGM
CCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCEEECCEEEEEECCCCCCCCCC
TPYHRLLVDAMAGDQMHFIRQDSVESSWSVIDSIKSSLQGSVPQPYAVHSWGPETGF
CHHHHHHHHHHCCCCEEHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCC
>Mature Secondary Structure 
APAEREISNFTLVLFGANGDLALRKLFPSMYELARWGQMPDKYRIIGVGRSDIGHDGFR
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHH
ELVREAMVAHAPHIDTGSGHFSDFIQSLFYVQVDLTTVEGYHRLREEIRTGHGREGTCSN
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEEEEEEHHHHHHHHHHHHCCCCCCCCCCC
LLFYLSTPPSLAPFIVRFLDEAGLGGKSPSCQGWRKIIIEKPYGHDLQSARELNVIVGEV
EEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCHHEEEEECCCCCCHHHHHHHHHHHHHH
FHEEQIYRIDHYLGKEPVQNILVFRFSNGMFEPLWNRHYIDNVSITIAEDFGIRGRGSFY
HHHHHHHHHHHHHCCCHHHHEEEEEECCCCCCHHCCCEEECCEEEEEEECCCCCCCCCHH
EEAGLLRDIIQNHGLQLLASVAMEPPVDLSADAVRDEKEKVFRSLRRFTVESAREHVVLG
HHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEE
QYDGYRQENNVASDSLVETFASIRFFIDNWRWKGVPFYMKAGKNLARSLTEIVITFSCPP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEECCCCHHHHCCHHHHHHHHHEEEEEECCC
QNFFGPPESCSYTANQIVIQIQPEQTIAIRFGTKRPGEALVTDPVFMKFDYRASFEKEGM
CCCCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCEEECCEEEEEECCCCCCCCCC
TPYHRLLVDAMAGDQMHFIRQDSVESSWSVIDSIKSSLQGSVPQPYAVHSWGPETGF
CHHHHHHHHHHCCCCEEHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]