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The map label for this gene is gltA [H]

Identifier: 194334669

GI number: 194334669

Start: 2042235

End: 2043581

Strand: Reverse

Name: gltA [H]

Synonym: Paes_1870

Alternate gene names: 194334669

Gene position: 2043581-2042235 (Counterclockwise)

Preceding gene: 194334670

Following gene: 194334668

Centisome position: 81.32

GC content: 50.56

Gene sequence:

>1347_bases
ATGGTACACCCAAACAACGATCACTCACTGACCATCACCGATAACCGAACAGGAAAAAGCTATACGATTCCTATAGAGTG
CGGTACGGTAAGAACGATGGATCTTCGGCAGATCAAGGTTAAGGAGGATGATTTTGGCCTTCTTGGTTACGATCCCGGTT
TTCTCAATACAGCCTCCTGCAAGAGTCAGGTAACCTATATCGATGGAGAAAAGGGTATTCTCCGCTACAGGGGGTATCCT
ATCGAGCAGCTTGCTGAAAAAAGTTCATTTCTGGAAACAGCCTACCTTCTCATCAAAGGGCAGCTGCCGGATCATGACCG
GCTTGCCGCCTGGGGAAAAAATATCCAGAGCCATACGATGGTCCACACCAATCTCGCCAAGTTTATGGACGGGTTTCGCT
ACGATGGCCATCCAATGGGTATTCTTGTCGGGACTGTCGGTGCCCTTTCGACCTTCTATCCGGGAGCGAAAAACATTTTC
GACAAGGAGTCCAGAAAGCTTCAGGTTCGAAGGCTGATCGGGAAGATGCCAACCCTTGCGGCGATGAGCTTTCGTCACAG
TATGGGTTTCCCTTATGTGCTTCCGGATAATGATCTGAGCTACACTGGAAATTTTCTTTCCATGATGTTCAAGATGACCG
AGTTGAAGTATACGCCAAACCCGGTTCTGGAAAAGGCCCTGGACGTTCTTTTTATTCTTCATGCCGATCATGAGCAGAAC
TGTTCGACAAGCGCCGTGCGTTCGGTTGGGAGTTCACAGGTCGATCCCTATTCCGCCCTGGCGGCAGGGTGCGCCGCATT
GTACGGTCCTTTGCATGGCGGAGCCAACGAAGCGGTGATTCGAATGCTTGAACGCATAGGCTCTGTCGACCGTGTTCCTG
AATTCATCAGATCCGTTAAATCCGGAGAGGGCCGCCTTATGGGATTCGGCCACAGGGTGTACAAGAATTACGATCCAAGG
GCCCGCATTATCAAGAAGATTGCCTTTGAGGTTTTTGATGTTACAGGAACCAACGATCTGCTCGATATCGCTCTTGAGCT
TGAACGGATCGCACTTGAGGACGATTACTTCGTCAGCCGCAAGCTCTATCCGAACGTTGATTTCTATTCCGGTCTTATCT
ACCAGGCTATGGGATTTCCGCTTGACATGTTTCCTGTTCTTTTTGCCATCGGCAGAACGCCGGGCTGGCTTGCCCAGTGG
ACTGAACATGTCAATGACAGTGAGCAGAAAATTTCCCGTCCCCGCCAGATGTATCTTGGCGAGGAACAGCGCGATTACGT
GCTGATTGACGAGCGTTTACCGCTTAATCCCGATGAGGAGCTGATGCCGGGCATGTGCAGGCTCTGA

Upstream 100 bases:

>100_bases
ATGAATTCCGAACTAAAAAGCCGGTTTTGTACTTGTAATTACTGTCTGTGCTGTAAGGAGCTGAGGCTTGACCTTTTACA
ACTTTTAAAGGCGGACTACC

Downstream 100 bases:

>100_bases
TATCATCTGCGGCAACGTTGATCCTGTTGAAGCGCTGACTGGTCTGGTAAGGTAATATGACTGAGGGCGAATGCGGGTGT
TCGCCCTTGCGTCAGGAGAG

Product: citrate synthase I

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MVHPNNDHSLTITDNRTGKSYTIPIECGTVRTMDLRQIKVKEDDFGLLGYDPGFLNTASCKSQVTYIDGEKGILRYRGYP
IEQLAEKSSFLETAYLLIKGQLPDHDRLAAWGKNIQSHTMVHTNLAKFMDGFRYDGHPMGILVGTVGALSTFYPGAKNIF
DKESRKLQVRRLIGKMPTLAAMSFRHSMGFPYVLPDNDLSYTGNFLSMMFKMTELKYTPNPVLEKALDVLFILHADHEQN
CSTSAVRSVGSSQVDPYSALAAGCAALYGPLHGGANEAVIRMLERIGSVDRVPEFIRSVKSGEGRLMGFGHRVYKNYDPR
ARIIKKIAFEVFDVTGTNDLLDIALELERIALEDDYFVSRKLYPNVDFYSGLIYQAMGFPLDMFPVLFAIGRTPGWLAQW
TEHVNDSEQKISRPRQMYLGEEQRDYVLIDERLPLNPDEELMPGMCRL

Sequences:

>Translated_448_residues
MVHPNNDHSLTITDNRTGKSYTIPIECGTVRTMDLRQIKVKEDDFGLLGYDPGFLNTASCKSQVTYIDGEKGILRYRGYP
IEQLAEKSSFLETAYLLIKGQLPDHDRLAAWGKNIQSHTMVHTNLAKFMDGFRYDGHPMGILVGTVGALSTFYPGAKNIF
DKESRKLQVRRLIGKMPTLAAMSFRHSMGFPYVLPDNDLSYTGNFLSMMFKMTELKYTPNPVLEKALDVLFILHADHEQN
CSTSAVRSVGSSQVDPYSALAAGCAALYGPLHGGANEAVIRMLERIGSVDRVPEFIRSVKSGEGRLMGFGHRVYKNYDPR
ARIIKKIAFEVFDVTGTNDLLDIALELERIALEDDYFVSRKLYPNVDFYSGLIYQAMGFPLDMFPVLFAIGRTPGWLAQW
TEHVNDSEQKISRPRQMYLGEEQRDYVLIDERLPLNPDEELMPGMCRL
>Mature_448_residues
MVHPNNDHSLTITDNRTGKSYTIPIECGTVRTMDLRQIKVKEDDFGLLGYDPGFLNTASCKSQVTYIDGEKGILRYRGYP
IEQLAEKSSFLETAYLLIKGQLPDHDRLAAWGKNIQSHTMVHTNLAKFMDGFRYDGHPMGILVGTVGALSTFYPGAKNIF
DKESRKLQVRRLIGKMPTLAAMSFRHSMGFPYVLPDNDLSYTGNFLSMMFKMTELKYTPNPVLEKALDVLFILHADHEQN
CSTSAVRSVGSSQVDPYSALAAGCAALYGPLHGGANEAVIRMLERIGSVDRVPEFIRSVKSGEGRLMGFGHRVYKNYDPR
ARIIKKIAFEVFDVTGTNDLLDIALELERIALEDDYFVSRKLYPNVDFYSGLIYQAMGFPLDMFPVLFAIGRTPGWLAQW
TEHVNDSEQKISRPRQMYLGEEQRDYVLIDERLPLNPDEELMPGMCRL

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=389, Percent_Identity=26.7352185089974, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1786939, Length=397, Percent_Identity=50.6297229219144, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1786527, Length=386, Percent_Identity=32.9015544041451, Blast_Score=191, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17555174, Length=370, Percent_Identity=28.1081081081081, Blast_Score=117, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6319850, Length=406, Percent_Identity=26.6009852216749, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324328, Length=360, Percent_Identity=25, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6325257, Length=405, Percent_Identity=25.9259259259259, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24640126, Length=379, Percent_Identity=26.6490765171504, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24640124, Length=379, Percent_Identity=26.6490765171504, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21356863, Length=421, Percent_Identity=26.8408551068884, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 50614; Mature: 50614

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVHPNNDHSLTITDNRTGKSYTIPIECGTVRTMDLRQIKVKEDDFGLLGYDPGFLNTASC
CCCCCCCCEEEEEECCCCCEEEEEEECCCEEEECCEEEEECCCCCCEEECCCCCCCCCCC
KSQVTYIDGEKGILRYRGYPIEQLAEKSSFLETAYLLIKGQLPDHDRLAAWGKNIQSHTM
CCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHCCCHHHHH
VHTNLAKFMDGFRYDGHPMGILVGTVGALSTFYPGAKNIFDKESRKLQVRRLIGKMPTLA
HHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHH
AMSFRHSMGFPYVLPDNDLSYTGNFLSMMFKMTELKYTPNPVLEKALDVLFILHADHEQN
HHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHEEEEEECCCCCC
CSTSAVRSVGSSQVDPYSALAAGCAALYGPLHGGANEAVIRMLERIGSVDRVPEFIRSVK
CCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHH
SGEGRLMGFGHRVYKNYDPRARIIKKIAFEVFDVTGTNDLLDIALELERIALEDDYFVSR
CCCCCEEECCHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEECC
KLYPNVDFYSGLIYQAMGFPLDMFPVLFAIGRTPGWLAQWTEHVNDSEQKISRPRQMYLG
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHCCCHHHHCC
EEQRDYVLIDERLPLNPDEELMPGMCRL
CCCCCEEEEECCCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MVHPNNDHSLTITDNRTGKSYTIPIECGTVRTMDLRQIKVKEDDFGLLGYDPGFLNTASC
CCCCCCCCEEEEEECCCCCEEEEEEECCCEEEECCEEEEECCCCCCEEECCCCCCCCCCC
KSQVTYIDGEKGILRYRGYPIEQLAEKSSFLETAYLLIKGQLPDHDRLAAWGKNIQSHTM
CCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHCCCHHHHH
VHTNLAKFMDGFRYDGHPMGILVGTVGALSTFYPGAKNIFDKESRKLQVRRLIGKMPTLA
HHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHH
AMSFRHSMGFPYVLPDNDLSYTGNFLSMMFKMTELKYTPNPVLEKALDVLFILHADHEQN
HHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHEEEEEECCCCCC
CSTSAVRSVGSSQVDPYSALAAGCAALYGPLHGGANEAVIRMLERIGSVDRVPEFIRSVK
CCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHH
SGEGRLMGFGHRVYKNYDPRARIIKKIAFEVFDVTGTNDLLDIALELERIALEDDYFVSR
CCCCCEEECCHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEECC
KLYPNVDFYSGLIYQAMGFPLDMFPVLFAIGRTPGWLAQWTEHVNDSEQKISRPRQMYLG
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHCCCHHHHCC
EEQRDYVLIDERLPLNPDEELMPGMCRL
CCCCCEEEEECCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]