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The map label for this gene is glmS [H]

Identifier: 194334544

GI number: 194334544

Start: 1900313

End: 1902199

Strand: Reverse

Name: glmS [H]

Synonym: Paes_1739

Alternate gene names: 194334544

Gene position: 1902199-1900313 (Counterclockwise)

Preceding gene: 194334545

Following gene: 194334543

Centisome position: 75.7

GC content: 59.78

Gene sequence:

>1887_bases
ATGTGTGGAATAGTAGGATATATCGGGCAGCAGGAAGCTGCCCCTTTGCTTTTAAAGGGGTTGCAGCGGCTGGAATACCG
TGGGTATGATTCTGCGGGGATCGCGGTGTTGGATGGTGTTAGGTGTGATGTGTTAGGTGGGGGGATGAACGATGATGCTG
GGGTTCGGGTGGTGAAGCGGAAGGGGAATGTGGCTTCGCTTGGTGAGGCTTTGGCTGGGAGCAATGGGGCGGTGTCTGGT
GCTACTATGGGCATTGGGCATACGCGGTGGGCGACGCATGGGGATCCGAGTGACCGGAATGCGCATCCGCATGTGAGTGC
TGATGGCCAGATTGCGTTGATCCATAACGGGATTATCGAGAACCATGCGGCGCTGCGGGTTGAGCTGAGGAAGCACGGGT
ATGAGTTTGTGAGTGATACGGATTCGGAGGTGCTGGTGCACCTGATCGATCACTTGTGGAAGAGTATTCCCTTCATGAAT
TTCGAGGGGGCAGTGCGCGAGGCGCTCTCGATTGTGGACGGGGCGTACGGGATCTGCGTGATTTCGTCGCGTGAGCCGGA
CAAGCTGCTGGTTGCGCGTAACGGTAGCCCGCTGGTGATCGGGGTTGGCGAGGGAGAGTACTTCGTTGCGTCGGATGCGG
CGCCGATTGTGGAGCATACGCGGCGGGTGGTGTACCTGTCGGACGGTGAGATGGGCGTGATTACGCGGGACGGGTATACG
GTGAAGAGTATCGGTAATATTGTGTGCGAGAAGGGGCTGACGGAGCTGGATTTCGACCTGGAGGAGATCGAGAAGGCGGG
GTTCGAGCACTTTATGCTGAAGGAGATTTTCGAGCAGCCGGAGGTGATGCAGGATGTGATGCGCGGCAGGGTGCGGCTCG
ACGAGGGGCGGATCCAGTTGGGCGGGATTGCCGATCAGCTGGAGCAGCTGCGCGAGGCGAAGCGGATTGTGATCTGTGCG
TGCGGGACGAGCTGGCATGCGGGGTTGATTGGGGAGTACCTGATCGAGGAGTTTGCGCGCATTCCGGTGGAGGTGGATTA
TGCGTCGGAGTTCCGCTACCGGAGCCCGATTGTGGGGCCGGGGGATGTGATGATCGTGATTTCGCAGTCGGGCGAGACGG
CTGATACGCTGGCGGCCTTGCGGCTGGCGAAGGAGAAGGGGGCGATGGTTGTGGGGATCTGCAACGTGGTGGGGTCCACG
ATTGCGCGTGAGACCGATTGCGGGATGTACACGCACGCCGGGCCGGAGATCGGGGTGGCGTCGACGAAGGCGTTCACCGC
GCAGGTGATTGTGTTGACCATGCTGGCGCTGGCGCTTTCGAAGGACCGGACGATGACGGACGGCGAGGTGATGGATGCGC
TGCGTTGCTTGAATGAGCTGCCGGAACGGGTGAAGAGGATCCTGGACTACAACGGGGAGATCCAGAGCATTGCGGAGGAG
TACAAGAATGCGCGCAACTTCCTCTATCTGGGGCGCGGGTACAACTTCCCGGTGGCGCTGGAAGGGGCGCTGAAGCTGAA
GGAGATTTCCTACATCCACGCCGAGGGGTACCCGGCAGCGGAGATGAAGCATGGCCCGATTGCGCTGATCGACGAGGAGA
TGCCGGTGGTGGTGATTGCGCCGAAGGATGATACGTACCAAAAGGTGCTGAGTAACATCCAGGAAGTCAAGGCCCGAGGT
GGCCGTGTGATTGCCATTGCCACGGAGGGCGACGAAGAGATCAGGGAACTGGCCGACCACGTGATGTACGTTCCGGAAGG
CAAGGCGTTCATAATGCCCCTTCTGACGGTTATCCCGCTGCAGCTGCTGTCGTATTATATCGCGACCCTGCGGGGGTGTG
ATGTTGACCGGCCGAGGAATCTGGCGAAGTCGGTAACGGTTGAATAG

Upstream 100 bases:

>100_bases
AAGGGGATGAAGCGATTGCTCATGGGCAGTACAGCCGAAAATGTGATTCGTGATGCCGAGTGCCCTGTGGTAGTGGTGAA
AGGAAAAAAATAGAGAGAAT

Downstream 100 bases:

>100_bases
CGCGCCGCTGGCGCGCGGTGACGAGTGACAAGTGACGCGTGACGAGAGCACGCTTTCGCGTGCGGGAGGCTGGAGACCGG
ATGCGCTTCGCGCGGGGAAA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 628; Mature: 628

Protein sequence:

>628_residues
MCGIVGYIGQQEAAPLLLKGLQRLEYRGYDSAGIAVLDGVRCDVLGGGMNDDAGVRVVKRKGNVASLGEALAGSNGAVSG
ATMGIGHTRWATHGDPSDRNAHPHVSADGQIALIHNGIIENHAALRVELRKHGYEFVSDTDSEVLVHLIDHLWKSIPFMN
FEGAVREALSIVDGAYGICVISSREPDKLLVARNGSPLVIGVGEGEYFVASDAAPIVEHTRRVVYLSDGEMGVITRDGYT
VKSIGNIVCEKGLTELDFDLEEIEKAGFEHFMLKEIFEQPEVMQDVMRGRVRLDEGRIQLGGIADQLEQLREAKRIVICA
CGTSWHAGLIGEYLIEEFARIPVEVDYASEFRYRSPIVGPGDVMIVISQSGETADTLAALRLAKEKGAMVVGICNVVGST
IARETDCGMYTHAGPEIGVASTKAFTAQVIVLTMLALALSKDRTMTDGEVMDALRCLNELPERVKRILDYNGEIQSIAEE
YKNARNFLYLGRGYNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEEMPVVVIAPKDDTYQKVLSNIQEVKARG
GRVIAIATEGDEEIRELADHVMYVPEGKAFIMPLLTVIPLQLLSYYIATLRGCDVDRPRNLAKSVTVE

Sequences:

>Translated_628_residues
MCGIVGYIGQQEAAPLLLKGLQRLEYRGYDSAGIAVLDGVRCDVLGGGMNDDAGVRVVKRKGNVASLGEALAGSNGAVSG
ATMGIGHTRWATHGDPSDRNAHPHVSADGQIALIHNGIIENHAALRVELRKHGYEFVSDTDSEVLVHLIDHLWKSIPFMN
FEGAVREALSIVDGAYGICVISSREPDKLLVARNGSPLVIGVGEGEYFVASDAAPIVEHTRRVVYLSDGEMGVITRDGYT
VKSIGNIVCEKGLTELDFDLEEIEKAGFEHFMLKEIFEQPEVMQDVMRGRVRLDEGRIQLGGIADQLEQLREAKRIVICA
CGTSWHAGLIGEYLIEEFARIPVEVDYASEFRYRSPIVGPGDVMIVISQSGETADTLAALRLAKEKGAMVVGICNVVGST
IARETDCGMYTHAGPEIGVASTKAFTAQVIVLTMLALALSKDRTMTDGEVMDALRCLNELPERVKRILDYNGEIQSIAEE
YKNARNFLYLGRGYNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEEMPVVVIAPKDDTYQKVLSNIQEVKARG
GRVIAIATEGDEEIRELADHVMYVPEGKAFIMPLLTVIPLQLLSYYIATLRGCDVDRPRNLAKSVTVE
>Mature_628_residues
MCGIVGYIGQQEAAPLLLKGLQRLEYRGYDSAGIAVLDGVRCDVLGGGMNDDAGVRVVKRKGNVASLGEALAGSNGAVSG
ATMGIGHTRWATHGDPSDRNAHPHVSADGQIALIHNGIIENHAALRVELRKHGYEFVSDTDSEVLVHLIDHLWKSIPFMN
FEGAVREALSIVDGAYGICVISSREPDKLLVARNGSPLVIGVGEGEYFVASDAAPIVEHTRRVVYLSDGEMGVITRDGYT
VKSIGNIVCEKGLTELDFDLEEIEKAGFEHFMLKEIFEQPEVMQDVMRGRVRLDEGRIQLGGIADQLEQLREAKRIVICA
CGTSWHAGLIGEYLIEEFARIPVEVDYASEFRYRSPIVGPGDVMIVISQSGETADTLAALRLAKEKGAMVVGICNVVGST
IARETDCGMYTHAGPEIGVASTKAFTAQVIVLTMLALALSKDRTMTDGEVMDALRCLNELPERVKRILDYNGEIQSIAEE
YKNARNFLYLGRGYNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEEMPVVVIAPKDDTYQKVLSNIQEVKARG
GRVIAIATEGDEEIRELADHVMYVPEGKAFIMPLLTVIPLQLLSYYIATLRGCDVDRPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=690, Percent_Identity=41.1594202898551, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI205277386, Length=690, Percent_Identity=39.1304347826087, Blast_Score=496, Evalue=1e-140,
Organism=Homo sapiens, GI29570798, Length=159, Percent_Identity=30.188679245283, Blast_Score=67, Evalue=7e-11,
Organism=Escherichia coli, GI1790167, Length=632, Percent_Identity=46.0443037974684, Blast_Score=548, Evalue=1e-157,
Organism=Escherichia coli, GI1788651, Length=281, Percent_Identity=29.1814946619217, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17539970, Length=717, Percent_Identity=35.7043235704324, Blast_Score=431, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17532899, Length=435, Percent_Identity=45.2873563218391, Blast_Score=374, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17532897, Length=435, Percent_Identity=45.2873563218391, Blast_Score=374, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6322745, Length=451, Percent_Identity=43.0155210643016, Blast_Score=364, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323731, Length=428, Percent_Identity=36.6822429906542, Blast_Score=272, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6323730, Length=216, Percent_Identity=37.037037037037, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI21357745, Length=691, Percent_Identity=41.534008683068, Blast_Score=544, Evalue=1e-155,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 68439; Mature: 68439

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYIGQQEAAPLLLKGLQRLEYRGYDSAGIAVLDGVRCDVLGGGMNDDAGVRVVKR
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCCCCCCEEEEEC
KGNVASLGEALAGSNGAVSGATMGIGHTRWATHGDPSDRNAHPHVSADGQIALIHNGIIE
CCCHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCC
NHAALRVELRKHGYEFVSDTDSEVLVHLIDHLWKSIPFMNFEGAVREALSIVDGAYGICV
CCHHEEEEEHHCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEE
ISSREPDKLLVARNGSPLVIGVGEGEYFVASDAAPIVEHTRRVVYLSDGEMGVITRDGYT
ECCCCCCEEEEEECCCEEEEEECCCCEEEECCCCHHHHCCCEEEEEECCCEEEEEECCEE
VKSIGNIVCEKGLTELDFDLEEIEKAGFEHFMLKEIFEQPEVMQDVMRGRVRLDEGRIQL
HHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHCCHHHHHHHHHCCEEECCCCEEE
GGIADQLEQLREAKRIVICACGTSWHAGLIGEYLIEEFARIPVEVDYASEFRYRSPIVGP
CCHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEECHHHCCCCCCCCCC
GDVMIVISQSGETADTLAALRLAKEKGAMVVGICNVVGSTIARETDCGMYTHAGPEIGVA
CCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCCCEECCCCCCCCC
STKAFTAQVIVLTMLALALSKDRTMTDGEVMDALRCLNELPERVKRILDYNGEIQSIAEE
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
YKNARNFLYLGRGYNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEEMPVVVIA
HHCCCCEEEEECCCCCCEEECCCEEEEHEEEEECCCCCCCCCCCCCEEEEECCCCEEEEE
PKDDTYQKVLSNIQEVKARGGRVIAIATEGDEEIRELADHVMYVPEGKAFIMPLLTVIPL
CCCCHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHEEECCCCCHHHHHHHHHHHH
QLLSYYIATLRGCDVDRPRNLAKSVTVE
HHHHHHHHHHCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MCGIVGYIGQQEAAPLLLKGLQRLEYRGYDSAGIAVLDGVRCDVLGGGMNDDAGVRVVKR
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEECCCCCCCCCEEEEEC
KGNVASLGEALAGSNGAVSGATMGIGHTRWATHGDPSDRNAHPHVSADGQIALIHNGIIE
CCCHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCC
NHAALRVELRKHGYEFVSDTDSEVLVHLIDHLWKSIPFMNFEGAVREALSIVDGAYGICV
CCHHEEEEEHHCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEE
ISSREPDKLLVARNGSPLVIGVGEGEYFVASDAAPIVEHTRRVVYLSDGEMGVITRDGYT
ECCCCCCEEEEEECCCEEEEEECCCCEEEECCCCHHHHCCCEEEEEECCCEEEEEECCEE
VKSIGNIVCEKGLTELDFDLEEIEKAGFEHFMLKEIFEQPEVMQDVMRGRVRLDEGRIQL
HHHHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHHHCCHHHHHHHHHCCEEECCCCEEE
GGIADQLEQLREAKRIVICACGTSWHAGLIGEYLIEEFARIPVEVDYASEFRYRSPIVGP
CCHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEECHHHCCCCCCCCCC
GDVMIVISQSGETADTLAALRLAKEKGAMVVGICNVVGSTIARETDCGMYTHAGPEIGVA
CCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCCCEECCCCCCCCC
STKAFTAQVIVLTMLALALSKDRTMTDGEVMDALRCLNELPERVKRILDYNGEIQSIAEE
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
YKNARNFLYLGRGYNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEEMPVVVIA
HHCCCCEEEEECCCCCCEEECCCEEEEHEEEEECCCCCCCCCCCCCEEEEECCCCEEEEE
PKDDTYQKVLSNIQEVKARGGRVIAIATEGDEEIRELADHVMYVPEGKAFIMPLLTVIPL
CCCCHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHEEECCCCCHHHHHHHHHHHH
QLLSYYIATLRGCDVDRPRNLAKSVTVE
HHHHHHHHHHCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]