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The map label for this gene is mutS2 [H]

Identifier: 194334494

GI number: 194334494

Start: 1842019

End: 1844400

Strand: Reverse

Name: mutS2 [H]

Synonym: Paes_1689

Alternate gene names: 194334494

Gene position: 1844400-1842019 (Counterclockwise)

Preceding gene: 194334503

Following gene: 194334493

Centisome position: 73.4

GC content: 52.52

Gene sequence:

>2382_bases
ATGGATGGTTTTACGAAAAAGAGACTTGAGTTTGATAGAATAGTAGACTGCGTTTCGCAGTTGTGTTTGTCGGATATGGG
GCGCGATGAACTTTCCGCTGCTTCGCCGCTCCTTTGCAGAGAGGCTCTTGTCAGAGAGCTCGAACGAGTGATGGAGCTGA
AAAACTTTCTTCTCGAAGGTCAGCCGCTGCCCTTTGCTGCGCTTCCTGATACCAGATCGCTTGTGCGGAAGCTGGAAACG
CTTGATACCTATCTCGAACCGGAGGAGTTACTTGATATCCATGATCTTCTGCAGGCGTCGGTTTCTCTCAGAACGTTCAT
GTACCGCAATCGAACGCTCTATCCGGCGGTCAATGAGTTTACGGTGCAGCTCTGGATGGAAAAGTCTCTTCAGTTCGAGA
TCAAAGGGATTGTTGATGAAGAGGCCAGGGTGCGTGATACTGCCAGCGACGGCTTGCTTATGATCCGGCGTGAGCTGCGG
GAGGGTCGTCAAACTTTGCGACGGAAGATGGAGCGTCTTCTGCGTCGTTGTCAGGAGAACAACTGGCTGATGGAGGATAC
CGTGGCTATGAAGAACGGTCGTCTGGTCCTCGGGCTCAGGGTGGAGTATAAGTATAAGCTTCCGGGCTATATCCAGGACT
ATTCGCAAAGCGGCCAGACGGTGTTTGTTGAACCGGCTGAAACGCTTGAGCTGAACAATCGTCTGCAGGATCTTGAGCTT
GATGAGCGGCGTGAGGTTGAGCGGATTCTCAGGGAAATGTCATCAAGGATCCGGGAGGAGCTGGATAATGTGCAGCATAA
CCAGTCGGTGATGGCTGTATTTGATTCGATCTACGCAAGGGCGCGTTTTGCTGTTGATACGGCCGGAGTCATGCCGGCGC
TTGATGACGGGCGGCGATTGAAGATTGTTCGTGGTTTTCATCCATGGCTTCTGGTGACGCACCGGGCTCGCGGTGAAGAG
GTGTTTCCTCTCGATATGGAGCTGGATGGTGATGAGCAGGTTCTCGTGATTTCCGGGCCGAATGCAGGAGGAAAGTCGGT
GGGGATGAAAACGGTTGGTCTGCTCTGTTGTATGCTGCATCACGGCTATCTTGTTCCCTGTAGCGAGAGTTCTGTGTTTC
CTCTTTTCGATGATATTTTTATAGGGATCGGTGACGAACAGTCGATTGAAAACGATCTTTCAACCTTCAGTTCGCATCTT
GAGCAAATTCGTCTGATTCTCGCTTCGGCATCGGCAAGAAGTCTTGTGCTCATCGATGAACTCTGCTCGGGTACCGATGT
CGAGGAGGGGAGCGCAATTGCCCGGGCGGTGATCGAGGAGCTGCTTCTTAAGGAGTGCAAGGCGGTGATTACGACCCATC
TTGGCGAATTGAAGGTCTATGCTCATGAGCGGAAGGGCGCCGTTAACGGCGCTATGGAGTTTGATCGTGCGACGTTGAGT
CCGTCGTTTCGTTTTCTCAAGGGTCTTCCCGGTAACAGCTTTGCTTTTGCTATGATGCAGCGCCTTGGGTTTGACCGGGG
GGTTATCGACCGGGCTAACGGTTTTCTTTGCCGCAAAAGCGCCGGGTTTGAACTGATGCTTGATGATCTGAAAACGGTTC
TGGAGGAGAATCGTTTGCTTCGTGAGCGTCTTGGTGAGGAGCGCAGGCAGCTTGAGTGTCGGGAGCAGCAGATCGCTCTT
TCTGAAGCTGCGTTGCTGCGCCGTCAGAAAGAGATGAAAGCGACTGTTTCGCGGGAGGTGCAGAAGGAGGTTGAGCATGC
TCGTAAAATGATTCGCGATATTGTCCGGGAAGCTAAAGCCTCACCTGATGCGCACGCTGTCGAATCTGCAAGGCAAAAAC
TTCATGCGCGCAAGAAACAGGCCGAGGCTGAGGAGGTGAAGGCTGTTGCATCATTGGAGGAGCATGTTGATGAAGATCGT
ACGATCAGGCCGGGTGATATGGTTCGTGTGATGACGACCAACACGACAGGTGAGGTGGTATCGGTTGACCGCGACGATGT
GGTGGTGCAGTGCGGAACGTTCAGGCTGTCGACGTCGCTGAAACATGTAGAGAAGACCTCGAAAACCCAGGCGAAAAAAC
TTGAGCGAGAGGTTCGGGGTTCAAAAGCGAAAGGGTGGAGTTCCCGTTCATCGGTTCTTGAATCGACGCGTCTTGATCTT
CGAGGCCTCAATGGCGATGAGGCGATTGTGGAAATTGACCGGTTTATCGATAAACTTCGTCTGAACAGGGTGTCGAGCGC
TGTGATCATTCATGGTAAAGGAACCGGCGCCCTGCGGATGCGTATCGCGGATTTTCTGAAAACCCACAATCATGTGGAGC
ATTTTCGTCTTGGGGAGTTGTCTGAAGGGGGAAGCGGCGTGACGGTCATCGATGTCTTGTAA

Upstream 100 bases:

>100_bases
TGAATGTTTTGAAGTGTCTGGTTGTTTGAGTTAATTAGCGCATTGTTGACGCGCATTGTTCGCGTTGTTGGCCCAATGAT
TATGAATACCGGTATCAGGC

Downstream 100 bases:

>100_bases
CACTCTGCTCGTCCATGCGGCAAAAAAGCTTATGAGGGTGGATTGAGAAAACGCTCTCTTTGGGTTATCTTGTGCGCAGA
CAGGTGTTTTTTTGTTTTTT

Product: Smr protein/MutS2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 793; Mature: 793

Protein sequence:

>793_residues
MDGFTKKRLEFDRIVDCVSQLCLSDMGRDELSAASPLLCREALVRELERVMELKNFLLEGQPLPFAALPDTRSLVRKLET
LDTYLEPEELLDIHDLLQASVSLRTFMYRNRTLYPAVNEFTVQLWMEKSLQFEIKGIVDEEARVRDTASDGLLMIRRELR
EGRQTLRRKMERLLRRCQENNWLMEDTVAMKNGRLVLGLRVEYKYKLPGYIQDYSQSGQTVFVEPAETLELNNRLQDLEL
DERREVERILREMSSRIREELDNVQHNQSVMAVFDSIYARARFAVDTAGVMPALDDGRRLKIVRGFHPWLLVTHRARGEE
VFPLDMELDGDEQVLVISGPNAGGKSVGMKTVGLLCCMLHHGYLVPCSESSVFPLFDDIFIGIGDEQSIENDLSTFSSHL
EQIRLILASASARSLVLIDELCSGTDVEEGSAIARAVIEELLLKECKAVITTHLGELKVYAHERKGAVNGAMEFDRATLS
PSFRFLKGLPGNSFAFAMMQRLGFDRGVIDRANGFLCRKSAGFELMLDDLKTVLEENRLLRERLGEERRQLECREQQIAL
SEAALLRRQKEMKATVSREVQKEVEHARKMIRDIVREAKASPDAHAVESARQKLHARKKQAEAEEVKAVASLEEHVDEDR
TIRPGDMVRVMTTNTTGEVVSVDRDDVVVQCGTFRLSTSLKHVEKTSKTQAKKLEREVRGSKAKGWSSRSSVLESTRLDL
RGLNGDEAIVEIDRFIDKLRLNRVSSAVIIHGKGTGALRMRIADFLKTHNHVEHFRLGELSEGGSGVTVIDVL

Sequences:

>Translated_793_residues
MDGFTKKRLEFDRIVDCVSQLCLSDMGRDELSAASPLLCREALVRELERVMELKNFLLEGQPLPFAALPDTRSLVRKLET
LDTYLEPEELLDIHDLLQASVSLRTFMYRNRTLYPAVNEFTVQLWMEKSLQFEIKGIVDEEARVRDTASDGLLMIRRELR
EGRQTLRRKMERLLRRCQENNWLMEDTVAMKNGRLVLGLRVEYKYKLPGYIQDYSQSGQTVFVEPAETLELNNRLQDLEL
DERREVERILREMSSRIREELDNVQHNQSVMAVFDSIYARARFAVDTAGVMPALDDGRRLKIVRGFHPWLLVTHRARGEE
VFPLDMELDGDEQVLVISGPNAGGKSVGMKTVGLLCCMLHHGYLVPCSESSVFPLFDDIFIGIGDEQSIENDLSTFSSHL
EQIRLILASASARSLVLIDELCSGTDVEEGSAIARAVIEELLLKECKAVITTHLGELKVYAHERKGAVNGAMEFDRATLS
PSFRFLKGLPGNSFAFAMMQRLGFDRGVIDRANGFLCRKSAGFELMLDDLKTVLEENRLLRERLGEERRQLECREQQIAL
SEAALLRRQKEMKATVSREVQKEVEHARKMIRDIVREAKASPDAHAVESARQKLHARKKQAEAEEVKAVASLEEHVDEDR
TIRPGDMVRVMTTNTTGEVVSVDRDDVVVQCGTFRLSTSLKHVEKTSKTQAKKLEREVRGSKAKGWSSRSSVLESTRLDL
RGLNGDEAIVEIDRFIDKLRLNRVSSAVIIHGKGTGALRMRIADFLKTHNHVEHFRLGELSEGGSGVTVIDVL
>Mature_793_residues
MDGFTKKRLEFDRIVDCVSQLCLSDMGRDELSAASPLLCREALVRELERVMELKNFLLEGQPLPFAALPDTRSLVRKLET
LDTYLEPEELLDIHDLLQASVSLRTFMYRNRTLYPAVNEFTVQLWMEKSLQFEIKGIVDEEARVRDTASDGLLMIRRELR
EGRQTLRRKMERLLRRCQENNWLMEDTVAMKNGRLVLGLRVEYKYKLPGYIQDYSQSGQTVFVEPAETLELNNRLQDLEL
DERREVERILREMSSRIREELDNVQHNQSVMAVFDSIYARARFAVDTAGVMPALDDGRRLKIVRGFHPWLLVTHRARGEE
VFPLDMELDGDEQVLVISGPNAGGKSVGMKTVGLLCCMLHHGYLVPCSESSVFPLFDDIFIGIGDEQSIENDLSTFSSHL
EQIRLILASASARSLVLIDELCSGTDVEEGSAIARAVIEELLLKECKAVITTHLGELKVYAHERKGAVNGAMEFDRATLS
PSFRFLKGLPGNSFAFAMMQRLGFDRGVIDRANGFLCRKSAGFELMLDDLKTVLEENRLLRERLGEERRQLECREQQIAL
SEAALLRRQKEMKATVSREVQKEVEHARKMIRDIVREAKASPDAHAVESARQKLHARKKQAEAEEVKAVASLEEHVDEDR
TIRPGDMVRVMTTNTTGEVVSVDRDDVVVQCGTFRLSTSLKHVEKTSKTQAKKLEREVRGSKAKGWSSRSSVLESTRLDL
RGLNGDEAIVEIDRFIDKLRLNRVSSAVIIHGKGTGALRMRIADFLKTHNHVEHFRLGELSEGGSGVTVIDVL

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI4504191, Length=413, Percent_Identity=26.1501210653753, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI36949366, Length=252, Percent_Identity=29.3650793650794, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI284813531, Length=240, Percent_Identity=30.8333333333333, Blast_Score=96, Evalue=2e-19,
Organism=Homo sapiens, GI26638666, Length=169, Percent_Identity=36.094674556213, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI4505253, Length=169, Percent_Identity=36.094674556213, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI4557761, Length=207, Percent_Identity=29.4685990338164, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI26638664, Length=170, Percent_Identity=35.8823529411765, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI262231786, Length=170, Percent_Identity=35.8823529411765, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1789089, Length=271, Percent_Identity=26.9372693726937, Blast_Score=93, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17508445, Length=309, Percent_Identity=26.537216828479, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17534743, Length=256, Percent_Identity=25, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17508447, Length=304, Percent_Identity=26.6447368421053, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539736, Length=281, Percent_Identity=26.6903914590747, Blast_Score=76, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6321912, Length=242, Percent_Identity=28.099173553719, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319935, Length=391, Percent_Identity=25.8312020460358, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324482, Length=618, Percent_Identity=23.462783171521, Blast_Score=87, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6320302, Length=202, Percent_Identity=30.1980198019802, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321109, Length=122, Percent_Identity=30.327868852459, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24664545, Length=324, Percent_Identity=28.3950617283951, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24584320, Length=183, Percent_Identity=30.6010928961749, Blast_Score=85, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 89937; Mature: 89937

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGFTKKRLEFDRIVDCVSQLCLSDMGRDELSAASPLLCREALVRELERVMELKNFLLEG
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
QPLPFAALPDTRSLVRKLETLDTYLEPEELLDIHDLLQASVSLRTFMYRNRTLYPAVNEF
CCCCEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHH
TVQLWMEKSLQFEIKGIVDEEARVRDTASDGLLMIRRELREGRQTLRRKMERLLRRCQEN
HHHHHHHCCCCEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NWLMEDTVAMKNGRLVLGLRVEYKYKLPGYIQDYSQSGQTVFVEPAETLELNNRLQDLEL
CCEEHHHHHCCCCCEEEEEEEEEEECCCCHHHHHCCCCCEEEECCHHHHHHHCCHHCCCC
DERREVERILREMSSRIREELDNVQHNQSVMAVFDSIYARARFAVDTAGVMPALDDGRRL
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCEE
KIVRGFHPWLLVTHRARGEEVFPLDMELDGDEQVLVISGPNAGGKSVGMKTVGLLCCMLH
EEEECCCCEEEEEECCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHH
HGYLVPCSESSVFPLFDDIFIGIGDEQSIENDLSTFSSHLEQIRLILASASARSLVLIDE
CCEEEECCCCCCCCCHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHH
LCSGTDVEEGSAIARAVIEELLLKECKAVITTHLGELKVYAHERKGAVNGAMEFDRATLS
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHCC
PSFRFLKGLPGNSFAFAMMQRLGFDRGVIDRANGFLCRKSAGFELMLDDLKTVLEENRLL
CCHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHH
RERLGEERRQLECREQQIALSEAALLRRQKEMKATVSREVQKEVEHARKMIRDIVREAKA
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SPDAHAVESARQKLHARKKQAEAEEVKAVASLEEHVDEDRTIRPGDMVRVMTTNTTGEVV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEE
SVDRDDVVVQCGTFRLSTSLKHVEKTSKTQAKKLEREVRGSKAKGWSSRSSVLESTRLDL
EECCCCEEEEECCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
RGLNGDEAIVEIDRFIDKLRLNRVSSAVIIHGKGTGALRMRIADFLKTHNHVEHFRLGEL
CCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCHHHHCCCCC
SEGGSGVTVIDVL
CCCCCCEEEEEEC
>Mature Secondary Structure
MDGFTKKRLEFDRIVDCVSQLCLSDMGRDELSAASPLLCREALVRELERVMELKNFLLEG
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
QPLPFAALPDTRSLVRKLETLDTYLEPEELLDIHDLLQASVSLRTFMYRNRTLYPAVNEF
CCCCEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCEECCCHHHH
TVQLWMEKSLQFEIKGIVDEEARVRDTASDGLLMIRRELREGRQTLRRKMERLLRRCQEN
HHHHHHHCCCCEEEEECCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NWLMEDTVAMKNGRLVLGLRVEYKYKLPGYIQDYSQSGQTVFVEPAETLELNNRLQDLEL
CCEEHHHHHCCCCCEEEEEEEEEEECCCCHHHHHCCCCCEEEECCHHHHHHHCCHHCCCC
DERREVERILREMSSRIREELDNVQHNQSVMAVFDSIYARARFAVDTAGVMPALDDGRRL
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCEE
KIVRGFHPWLLVTHRARGEEVFPLDMELDGDEQVLVISGPNAGGKSVGMKTVGLLCCMLH
EEEECCCCEEEEEECCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHH
HGYLVPCSESSVFPLFDDIFIGIGDEQSIENDLSTFSSHLEQIRLILASASARSLVLIDE
CCEEEECCCCCCCCCHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHH
LCSGTDVEEGSAIARAVIEELLLKECKAVITTHLGELKVYAHERKGAVNGAMEFDRATLS
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHCC
PSFRFLKGLPGNSFAFAMMQRLGFDRGVIDRANGFLCRKSAGFELMLDDLKTVLEENRLL
CCHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHH
RERLGEERRQLECREQQIALSEAALLRRQKEMKATVSREVQKEVEHARKMIRDIVREAKA
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SPDAHAVESARQKLHARKKQAEAEEVKAVASLEEHVDEDRTIRPGDMVRVMTTNTTGEVV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEE
SVDRDDVVVQCGTFRLSTSLKHVEKTSKTQAKKLEREVRGSKAKGWSSRSSVLESTRLDL
EECCCCEEEEECCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
RGLNGDEAIVEIDRFIDKLRLNRVSSAVIIHGKGTGALRMRIADFLKTHNHVEHFRLGEL
CCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCHHHHCCCCC
SEGGSGVTVIDVL
CCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA