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The map label for this gene is pgsA [H]

Identifier: 194334493

GI number: 194334493

Start: 1841288

End: 1841878

Strand: Reverse

Name: pgsA [H]

Synonym: Paes_1688

Alternate gene names: 194334493

Gene position: 1841878-1841288 (Counterclockwise)

Preceding gene: 194334494

Following gene: 194334492

Centisome position: 73.3

GC content: 46.19

Gene sequence:

>591_bases
ATGACACTGCCGAACCAGTTGACCATATTACGCATTGTGCTTGTACCTGTTTTTGTGTATCTGCTGATGCTTTCTTCACC
TCTTATGAAGCTTTTCGGGGTGGTCGTTTTCATCATTGCTTCGGTGACTGATGCCTATGATGGCTATCATGCCAGGAAAT
ACGGGGAGACGACCCGACTTGGAGCGTTCCTTGATCCCCTTGCCGACAAGTTTCTCATTACGGCCGCTTTTCTTGTCTAT
GTGTGGTACGGCTATCTTGATTTGTGGATGGTTGTTCTTGTGGCTTTGCGTGATATCGTGGTTACCGTTCTGAGAGTCTA
TGCTGAATGGAAGGACCGCCCTGTCGTTACAAGCAGTGAAGCGAAATACAAGACGCTTTCACAGAACATTTTTGCCTATG
TGATTATGCTGTTTATGCTTCTTGCAGAGCCAACCTTTACGGGCGCAGCTGTTGCTTCACGTATGAGAGAGGTTCTCTTT
GCAGACTACCTTGATTATATCATGCTTGCGATTACGCTCTTTACGGTTTATACAGGGGTGTCGTATCTTTTGCAGAACAG
GAAGCATCTAATGGAGAAGACGACGTCATGA

Upstream 100 bases:

>100_bases
GATTGAGAAAACGCTCTCTTTGGGTTATCTTGTGCGCAGACAGGTGTTTTTTTGTTTTTTGAACCTGCTATGATTTTTTA
TAAGATTTGCCTTTCATGCT

Downstream 100 bases:

>100_bases
GTGCTCAGCGTTCACCATTCGCCATGAAACTCTTCATGGCCCGTTTTTTCGGAAGTTGTGGCGGTCTGGGTTTTTTTCCG
GTTGCACCTGGAACCGTGAC

Product: CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MTLPNQLTILRIVLVPVFVYLLMLSSPLMKLFGVVVFIIASVTDAYDGYHARKYGETTRLGAFLDPLADKFLITAAFLVY
VWYGYLDLWMVVLVALRDIVVTVLRVYAEWKDRPVVTSSEAKYKTLSQNIFAYVIMLFMLLAEPTFTGAAVASRMREVLF
ADYLDYIMLAITLFTVYTGVSYLLQNRKHLMEKTTS

Sequences:

>Translated_196_residues
MTLPNQLTILRIVLVPVFVYLLMLSSPLMKLFGVVVFIIASVTDAYDGYHARKYGETTRLGAFLDPLADKFLITAAFLVY
VWYGYLDLWMVVLVALRDIVVTVLRVYAEWKDRPVVTSSEAKYKTLSQNIFAYVIMLFMLLAEPTFTGAAVASRMREVLF
ADYLDYIMLAITLFTVYTGVSYLLQNRKHLMEKTTS
>Mature_195_residues
TLPNQLTILRIVLVPVFVYLLMLSSPLMKLFGVVVFIIASVTDAYDGYHARKYGETTRLGAFLDPLADKFLITAAFLVYV
WYGYLDLWMVVLVALRDIVVTVLRVYAEWKDRPVVTSSEAKYKTLSQNIFAYVIMLFMLLAEPTFTGAAVASRMREVLFA
DYLDYIMLAITLFTVYTGVSYLLQNRKHLMEKTTS

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1788220, Length=137, Percent_Identity=35.7664233576642, Blast_Score=81, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24650130, Length=100, Percent_Identity=34, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24650126, Length=100, Percent_Identity=34, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24650128, Length=100, Percent_Identity=34, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 22401; Mature: 22270

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPNQLTILRIVLVPVFVYLLMLSSPLMKLFGVVVFIIASVTDAYDGYHARKYGETTRL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHH
GAFLDPLADKFLITAAFLVYVWYGYLDLWMVVLVALRDIVVTVLRVYAEWKDRPVVTSSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
AKYKTLSQNIFAYVIMLFMLLAEPTFTGAAVASRMREVLFADYLDYIMLAITLFTVYTGV
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SYLLQNRKHLMEKTTS
HHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLPNQLTILRIVLVPVFVYLLMLSSPLMKLFGVVVFIIASVTDAYDGYHARKYGETTRL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHH
GAFLDPLADKFLITAAFLVYVWYGYLDLWMVVLVALRDIVVTVLRVYAEWKDRPVVTSSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
AKYKTLSQNIFAYVIMLFMLLAEPTFTGAAVASRMREVLFADYLDYIMLAITLFTVYTGV
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SYLLQNRKHLMEKTTS
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7750561; 9384377 [H]