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The map label for this gene is phoR [H]

Identifier: 194334238

GI number: 194334238

Start: 1554702

End: 1556915

Strand: Reverse

Name: phoR [H]

Synonym: Paes_1430

Alternate gene names: 194334238

Gene position: 1556915-1554702 (Counterclockwise)

Preceding gene: 194334239

Following gene: 194334237

Centisome position: 61.96

GC content: 43.77

Gene sequence:

>2214_bases
ATGTCCCTTTCCAATCAGAAAACCACCGTTCTCATAGCCGACGACAGCGCAACGATGAGAACGTTGATCTCACATGTCGT
TCATAAGCTTGGTTATGACACATTAACCGCTTCGGACGGCAATGAGGCAATCGACAGGCTATCGAACCGTCCTTGTGATG
CGCTTCTGCTTGATCTCAACATGCCTGTCAAAAGCGGTATGGACGTCCTGGATTTTGTCGTCAGAAATAATTACCAGTTA
CCGGTTATTATTGTGTCGGGTTCAAGTGATATCGAGCAAGCTGTTGAATGTATCAAGCTCGGTGCGTATGAATATCTGAC
AAAGCCGATAGACAATAATCGTCTCGAGATCACCCTGAACAATGCGCTTTCAGAATTTTCCTTGAAGCAGCAAGTCAGGC
TTCTGAACGAAGCGATGGACCAGAGCCCGGTTTCCATTGTCATTACTGATTTTAATGGTTTGATAGAGTATGTGAATCCT
TTTTTCTGCAGGGTCACCGGTTACTCCTCTGAAGACGTTCTGCATCAAAAAGTAAGCATACTTAAATCCGGAGAGCATAG
CCAGGATTTCTATCGGATTTTGTGGGAAACAATATCAGGAGGTAAGGTCTGGCAGGGTGAAATTTGCAATAAAAAGAAAG
ACGGGGAACTGTTCTGGGAGAATATCATAATCAGCCCTGTCAGAAACAACGTGCATTCTATTTCTCATTTTCTTGCCATC
AAAGAAGATGTTACTGAAAAAATACGAGATAAAGAGGCTCTTGCAACAAGTGAGCGGCGCTTCAGGGAGCTTTCGGATCT
GCTTCCTCAACCGGTGTTTGAAACAGATGGGTCAAATACTGTAACCTATTTTAACCGGGCAGGATATACTGTTTTTGGCT
ATAAAGGGAAAGATCTCGACCGTGGCCTGAATGTTTTTCAGCTTTTCAGTCCGCAGGAAAGAGGGACGATTGAAGAGAAT
ATCAGGAAAAGAATTAAAGGCGAAAAGAGTGCCGATTATGAATACAGGGCGTTGAAAAAAGATGGGTCATCTTTTCCTGT
GCTGGTATACTGTGCCCCTATAATGACCCAGGCGGGTTTTCAGGGCATACGGGGGATCGTGCTCGATATAACGCACCGTA
AGCAGTATGAAAGAAAAATAAAAGAAAACGAGGCGAATTACCGGAATCTCTTTCAGGTGATACCTGATCCGATTATCGTT
GCTGATTTCAAGAGTGGAAACATCGTACACTGGAATAGAAAGGCGTTGTCTTTTTTCGGTTATAGCAAAAAGGAGCTTGC
TGCGCTCTCGGTAGAAATGCTGTTCTCCAGAACAGTCGATGACAAGAGAGAGATGACGGGTTTTGCAGGAACGATGAGCA
CCGCATCAGTGGAGGCACAAATACGGACAAAAGACGGCTTTACAATCGAGGTTCTTGTCAGTTCAGTACTGTTTGATTTC
TCTAAGCATAAACGGCTTCTTGTGGTGTTTCGTGATATAACGGAACAGAAGAAATCAGAGCGTCTCATAAAGGAAAATAT
CCGGTTGAAAAATGATTTTATCGCCAACGTTTCCCATGAGTTAAGGAGCCCTCTTTTTTCCATCCTTGGTTTTTCTTCCA
CTCTCCTGAAAGAGCGAAAAGAACTTGATTTTGAAACAACAGGTGAATTCCTGGGAATAATTCATGACGAAAGCAAGAGA
CTTTCATCACTTATTGAGGATGTCCTCAATGTTTCGAGAATCGATTCCGGCAAAGTAGCATACAAGAAGAAAATTATCGA
TCCGGCACCCGTTGTTATCGGAGCATGCGAATCCCTGAAAATGATGGCCAGTGAGAAGAGCGTAGAGTTTTCGATACATG
TTGAGCCGGAAACAATGCAGGTCAATGCCGATCCCGATGCCTTGAAACAGGTTGTCATTAATCTTGCTGTCAACGCGATC
AAATTCACTCCTCGAGATGGTTGTGTGCGTGTATCTCTTTCAAATGATGCGCATTGGATGGTGTTGACAGTCAAGGATAG
CGGGGTAGGAATTCCCGAGAGTGATTACGATAAAATTTTTGAAAAATTTTATCGGGTTGAGAGGCCGGGCGAGGAAATAG
AGGGGACAGGTCTTGGTTTGCCTATTGTCAAGGAGATTATAGCGGCACATAAAGGAAGCATCGAAGTGAACAGTAAAAAG
GATTTCGGGTCAACGTTTTTTGTGCGTCTTCCGTTATCGACATCCGGAAATTGA

Upstream 100 bases:

>100_bases
CCCTGAAACTTCGTCATATAGCCAACACATTTATTGACAGGGACTACAGGGTCTTGTTTTGTGACTGACAATTCCTCAAT
GGGTAACAGAAGGTCAAACT

Downstream 100 bases:

>100_bases
GCTATGTGTTTTTCTTTACGCCAGAGCCTGAAAACATCATCGAAACTGTAAAGCATTATCTACAATGAAACAGTCACGTA
TTCTCATCATTGATGACTCT

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 737; Mature: 736

Protein sequence:

>737_residues
MSLSNQKTTVLIADDSATMRTLISHVVHKLGYDTLTASDGNEAIDRLSNRPCDALLLDLNMPVKSGMDVLDFVVRNNYQL
PVIIVSGSSDIEQAVECIKLGAYEYLTKPIDNNRLEITLNNALSEFSLKQQVRLLNEAMDQSPVSIVITDFNGLIEYVNP
FFCRVTGYSSEDVLHQKVSILKSGEHSQDFYRILWETISGGKVWQGEICNKKKDGELFWENIIISPVRNNVHSISHFLAI
KEDVTEKIRDKEALATSERRFRELSDLLPQPVFETDGSNTVTYFNRAGYTVFGYKGKDLDRGLNVFQLFSPQERGTIEEN
IRKRIKGEKSADYEYRALKKDGSSFPVLVYCAPIMTQAGFQGIRGIVLDITHRKQYERKIKENEANYRNLFQVIPDPIIV
ADFKSGNIVHWNRKALSFFGYSKKELAALSVEMLFSRTVDDKREMTGFAGTMSTASVEAQIRTKDGFTIEVLVSSVLFDF
SKHKRLLVVFRDITEQKKSERLIKENIRLKNDFIANVSHELRSPLFSILGFSSTLLKERKELDFETTGEFLGIIHDESKR
LSSLIEDVLNVSRIDSGKVAYKKKIIDPAPVVIGACESLKMMASEKSVEFSIHVEPETMQVNADPDALKQVVINLAVNAI
KFTPRDGCVRVSLSNDAHWMVLTVKDSGVGIPESDYDKIFEKFYRVERPGEEIEGTGLGLPIVKEIIAAHKGSIEVNSKK
DFGSTFFVRLPLSTSGN

Sequences:

>Translated_737_residues
MSLSNQKTTVLIADDSATMRTLISHVVHKLGYDTLTASDGNEAIDRLSNRPCDALLLDLNMPVKSGMDVLDFVVRNNYQL
PVIIVSGSSDIEQAVECIKLGAYEYLTKPIDNNRLEITLNNALSEFSLKQQVRLLNEAMDQSPVSIVITDFNGLIEYVNP
FFCRVTGYSSEDVLHQKVSILKSGEHSQDFYRILWETISGGKVWQGEICNKKKDGELFWENIIISPVRNNVHSISHFLAI
KEDVTEKIRDKEALATSERRFRELSDLLPQPVFETDGSNTVTYFNRAGYTVFGYKGKDLDRGLNVFQLFSPQERGTIEEN
IRKRIKGEKSADYEYRALKKDGSSFPVLVYCAPIMTQAGFQGIRGIVLDITHRKQYERKIKENEANYRNLFQVIPDPIIV
ADFKSGNIVHWNRKALSFFGYSKKELAALSVEMLFSRTVDDKREMTGFAGTMSTASVEAQIRTKDGFTIEVLVSSVLFDF
SKHKRLLVVFRDITEQKKSERLIKENIRLKNDFIANVSHELRSPLFSILGFSSTLLKERKELDFETTGEFLGIIHDESKR
LSSLIEDVLNVSRIDSGKVAYKKKIIDPAPVVIGACESLKMMASEKSVEFSIHVEPETMQVNADPDALKQVVINLAVNAI
KFTPRDGCVRVSLSNDAHWMVLTVKDSGVGIPESDYDKIFEKFYRVERPGEEIEGTGLGLPIVKEIIAAHKGSIEVNSKK
DFGSTFFVRLPLSTSGN
>Mature_736_residues
SLSNQKTTVLIADDSATMRTLISHVVHKLGYDTLTASDGNEAIDRLSNRPCDALLLDLNMPVKSGMDVLDFVVRNNYQLP
VIIVSGSSDIEQAVECIKLGAYEYLTKPIDNNRLEITLNNALSEFSLKQQVRLLNEAMDQSPVSIVITDFNGLIEYVNPF
FCRVTGYSSEDVLHQKVSILKSGEHSQDFYRILWETISGGKVWQGEICNKKKDGELFWENIIISPVRNNVHSISHFLAIK
EDVTEKIRDKEALATSERRFRELSDLLPQPVFETDGSNTVTYFNRAGYTVFGYKGKDLDRGLNVFQLFSPQERGTIEENI
RKRIKGEKSADYEYRALKKDGSSFPVLVYCAPIMTQAGFQGIRGIVLDITHRKQYERKIKENEANYRNLFQVIPDPIIVA
DFKSGNIVHWNRKALSFFGYSKKELAALSVEMLFSRTVDDKREMTGFAGTMSTASVEAQIRTKDGFTIEVLVSSVLFDFS
KHKRLLVVFRDITEQKKSERLIKENIRLKNDFIANVSHELRSPLFSILGFSSTLLKERKELDFETTGEFLGIIHDESKRL
SSLIEDVLNVSRIDSGKVAYKKKIIDPAPVVIGACESLKMMASEKSVEFSIHVEPETMQVNADPDALKQVVINLAVNAIK
FTPRDGCVRVSLSNDAHWMVLTVKDSGVGIPESDYDKIFEKFYRVERPGEEIEGTGLGLPIVKEIIAAHKGSIEVNSKKD
FGSTFFVRLPLSTSGN

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=376, Percent_Identity=27.9255319148936, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI145693157, Length=255, Percent_Identity=31.7647058823529, Blast_Score=125, Evalue=9e-30,
Organism=Escherichia coli, GI48994928, Length=252, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1788549, Length=347, Percent_Identity=26.8011527377522, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1789149, Length=248, Percent_Identity=32.258064516129, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI1786600, Length=250, Percent_Identity=27.2, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1788393, Length=233, Percent_Identity=30.0429184549356, Blast_Score=107, Evalue=4e-24,
Organism=Escherichia coli, GI1790861, Length=241, Percent_Identity=29.045643153527, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1790436, Length=267, Percent_Identity=28.0898876404494, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI87081816, Length=243, Percent_Identity=28.3950617283951, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1786783, Length=229, Percent_Identity=28.3842794759825, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1786912, Length=247, Percent_Identity=27.9352226720648, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1790346, Length=236, Percent_Identity=29.2372881355932, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1788550, Length=133, Percent_Identity=30.0751879699248, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790299, Length=128, Percent_Identity=30.46875, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788279, Length=219, Percent_Identity=28.7671232876712, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1790437, Length=122, Percent_Identity=30.327868852459, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1789808, Length=223, Percent_Identity=25.5605381165919, Blast_Score=73, Evalue=7e-14,
Organism=Escherichia coli, GI1789403, Length=211, Percent_Identity=26.0663507109005, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=25.8771929824561, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790551, Length=220, Percent_Identity=25.9090909090909, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1787894, Length=254, Percent_Identity=25.1968503937008, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI1790300, Length=261, Percent_Identity=23.7547892720307, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 83089; Mature: 82958

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSNQKTTVLIADDSATMRTLISHVVHKLGYDTLTASDGNEAIDRLSNRPCDALLLDLN
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHCCCCCCEEEEECC
MPVKSGMDVLDFVVRNNYQLPVIIVSGSSDIEQAVECIKLGAYEYLTKPIDNNRLEITLN
CCHHCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHCCCCCCCEEEEEEC
NALSEFSLKQQVRLLNEAMDQSPVSIVITDFNGLIEYVNPFFCRVTGYSSEDVLHQKVSI
CHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHCCCEEEEEECCCCHHHHHHHHHH
LKSGEHSQDFYRILWETISGGKVWQGEICNKKKDGELFWENIIISPVRNNVHSISHFLAI
HHCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCCEEEHHEEECHHHHHHHHHHHHHHH
KEDVTEKIRDKEALATSERRFRELSDLLPQPVFETDGSNTVTYFNRAGYTVFGYKGKDLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEECCCCHH
RGLNVFQLFSPQERGTIEENIRKRIKGEKSADYEYRALKKDGSSFPVLVYCAPIMTQAGF
CCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCEEEEEHHHHHHHHH
QGIRGIVLDITHRKQYERKIKENEANYRNLFQVIPDPIIVADFKSGNIVHWNRKALSFFG
HCCCEEEEEEHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEECCCCCEEEECHHHHHHCC
YSKKELAALSVEMLFSRTVDDKREMTGFAGTMSTASVEAQIRTKDGFTIEVLVSSVLFDF
CCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHH
SKHKRLLVVFRDITEQKKSERLIKENIRLKNDFIANVSHELRSPLFSILGFSSTLLKERK
HCCCEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ELDFETTGEFLGIIHDESKRLSSLIEDVLNVSRIDSGKVAYKKKIIDPAPVVIGACESLK
HCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHCCHHHHH
MMASEKSVEFSIHVEPETMQVNADPDALKQVVINLAVNAIKFTPRDGCVRVSLSNDAHWM
HHHCCCCEEEEEEECCCEEEECCCHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCEEE
VLTVKDSGVGIPESDYDKIFEKFYRVERPGEEIEGTGLGLPIVKEIIAAHKGSIEVNSKK
EEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCC
DFGSTFFVRLPLSTSGN
CCCCEEEEEEECCCCCC
>Mature Secondary Structure 
SLSNQKTTVLIADDSATMRTLISHVVHKLGYDTLTASDGNEAIDRLSNRPCDALLLDLN
CCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHCCCCCCEEEEECC
MPVKSGMDVLDFVVRNNYQLPVIIVSGSSDIEQAVECIKLGAYEYLTKPIDNNRLEITLN
CCHHCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCHHHHCCCCCCCEEEEEEC
NALSEFSLKQQVRLLNEAMDQSPVSIVITDFNGLIEYVNPFFCRVTGYSSEDVLHQKVSI
CHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHCCCEEEEEECCCCHHHHHHHHHH
LKSGEHSQDFYRILWETISGGKVWQGEICNKKKDGELFWENIIISPVRNNVHSISHFLAI
HHCCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCCEEEHHEEECHHHHHHHHHHHHHHH
KEDVTEKIRDKEALATSERRFRELSDLLPQPVFETDGSNTVTYFNRAGYTVFGYKGKDLD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEEECCCCHH
RGLNVFQLFSPQERGTIEENIRKRIKGEKSADYEYRALKKDGSSFPVLVYCAPIMTQAGF
CCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCEEEEEHHHHHHHHH
QGIRGIVLDITHRKQYERKIKENEANYRNLFQVIPDPIIVADFKSGNIVHWNRKALSFFG
HCCCEEEEEEHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEECCCCCEEEECHHHHHHCC
YSKKELAALSVEMLFSRTVDDKREMTGFAGTMSTASVEAQIRTKDGFTIEVLVSSVLFDF
CCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHH
SKHKRLLVVFRDITEQKKSERLIKENIRLKNDFIANVSHELRSPLFSILGFSSTLLKERK
HCCCEEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ELDFETTGEFLGIIHDESKRLSSLIEDVLNVSRIDSGKVAYKKKIIDPAPVVIGACESLK
HCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHCCHHHHH
MMASEKSVEFSIHVEPETMQVNADPDALKQVVINLAVNAIKFTPRDGCVRVSLSNDAHWM
HHHCCCCEEEEEEECCCEEEECCCHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCEEE
VLTVKDSGVGIPESDYDKIFEKFYRVERPGEEIEGTGLGLPIVKEIIAAHKGSIEVNSKK
EEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCC
DFGSTFFVRLPLSTSGN
CCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]