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The map label for this gene is clpB [H]

Identifier: 193214019

GI number: 193214019

Start: 341351

End: 343906

Strand: Direct

Name: clpB [H]

Synonym: Ctha_0300

Alternate gene names: 193214019

Gene position: 341351-343906 (Clockwise)

Preceding gene: 193214018

Following gene: 193214020

Centisome position: 10.36

GC content: 47.93

Gene sequence:

>2556_bases
ATGGAAGGCAATTTTTCAAACAGGGTACAGGATGTCATTCGTTACAGCCGCGAGGAAGCATTAAGGCTGGGGCATGACTA
CATTGGTACGGAGCATTTGCTATTAGGCATCATTCGTGAAGGCGAAGGCATTGCTGTGCGAATCCTGAAAAACCTCGGTT
GTGATCTTTACAAACTCAAACGCGCCATTGAAGACTCCGTTCGCTCAACCGGCGGCACACTCACGCTGGGCAATGTGCCG
CTCACGAAGCAAGCAGAAAAAGTGCTAAAAATCACTTACTTAGAAGCCAAAATTTGTAAGTCGGACATTATTGGCACGGA
GCATCTTTTGTTATCGCTTTTAAAAGATGAAGAAAATATCGCTTCGCAAATTTTATCACAGTTTGGAGTGCGTTACGAAA
CCGTTCGCGAAGAACTTGAAAACATTATGAGCGGCAAGTCCAGCAGCGGCGAGATTTCTGCAATGTCTCCAGGCCAGCAA
AGTGGTAGCGGGCAATATCAACAACAATATGAATCTCGAAAGATGGAAAAGACAAAAACACCCGTCTTAGACAATTTTGG
TCGTGATTTAACCAAGTTAGCGCTTGAGGACAAACTCGATCCGATTATCGGTCGCGAGAAAGAAATCGAGCGTGTGGCTC
AGGTTTTAAGTCGTAGAAAAAAGAACAATCCGGTTCTCATCGGCGAGCCTGGCGTGGGAAAAACCGCCATTGCGGAAGGC
CTTGCACTGAGAATTGTCCAACGCAAAGTTTCCAGAGTGCTTTACGACAAGCGAGTTGTTGCGCTTGACCTTGCTGCGCT
TGTCGCTGGCACGAAATATCGTGGCCAGTTCGAAGAGCGAATGAAAGCCGTGATGAACGAACTTGAAAAATCGAAAGATG
TGATTTTGTTCATCGATGAGCTGCACACCATTGTGGGCGCTGGCGGCGCTTCGGGGTCGCTTGATGCGAGCAACATTTTC
AAGCCGGCGCTTGCTCGCGGCGACTTGCAGTGCATCGGCGCAACCACGCTCGACGAATATCGCCAATACATCGAAAAAGA
TGGTGCGCTCGACCGTCGTTTCCAGAAAATCATGATTGAACCGACTTCAGTCGAAGAAACGGTTAGCATTTTAAACAATA
TTAAGGAAAAGTACGAGACGCACCACAATGTGCGCTACATGCCGGAGGCTATTGACTCAGCCGTCAAACTCTCCGACCGT
TATATCACCGATAGGCATTTGCCTGACAAAGCCATCGATGTCTTGGATGAAGCGGGCGCTCGTGTGCACTTGTCCAATAT
TCATGTTCCAAAAGAAATCTTAGACCTTGAGGCCAAAATTGAGGACATCAAGGTTGAGAAGAATCAGGTCGTCAAATCGC
AGAATTTTGAAGAAGCGGCGCGGCTACGCGACCAAGAAAAGAAGTTGCTCGAGACACTCGATAAAGCCAAGCAGGATTGG
GAAAAGACCACTGCCGAAATGGTTTATGATGTCAATGAAAGTGATGTGGCTGCGGTGGTTGCCATGATGACCGGCATTCC
TGTGCTGAAAGTTGCTCAGTCGGAATCTGAAAGATTACTTAAAATGGGCGAGATGCTCAAAGGTGAAGTCATCGGACAAA
ACGAAGCCATTGAAAAAGTCACGAAAGCCATCCAAAGAACCCGTGCTGGCTTGAAAGATCCAAACCGCCCGATCGGCTCG
TTTATTTTCCTTGGTCCAACAGGCGTTGGAAAAACCGAGCTGGCCAAAGCCTTGACACGCTATCTCTTCGACACGGAAGA
AGCACTGATTCGCATCGACATGAGCGAATACATGGAGAAATTCTCCGTCAGCCGATTGGTGGGAGCGCCTCCCGGATATG
TTGGCTACGAAGAAGGCGGGCAGCTCACTGAGAAAGTTCGTCGCAAGCCGTACTCGGTTGTGTTGCTTGACGAGATCGAA
AAAGCGCATCCTGATGTATTCAACATTCTCCTGCAAGTGCTCGATGATGGAATCTTGACCGATGGACTGGGTCGTCGTGT
AGACTTCCGAAACACCGTTATTATTATGACATCAAACATCGGCGCGCGCGATATCAAGAGCATGGGAATGGGCATGGGCT
TTGGCGGTGCACCTGACCACAAGTCAAAATACGATAGCATGAAGTCCACGATTGAAGATGCTTTGAAGCGTGTCTTTAAT
CCTGAGTTCCTAAACCGAATCGACGATGTCATCGTCTTTCATCAGCTTGAGAAAGCCGACATCTTCAAGATTATCGACAT
CTCGGCAGGCCGTCTCTTTAAGCGCATTCGTGACATGGGCATCAGCATTGAAATTACCGATCGCGCCAAGCAATTTCTTG
TCGACAAAGGCTACGATCAGCAATTTGGCGCCAGACCGCTTCGCAGAGCCTTGCAGCGCTACATTGAAGAACCGCTTGCA
GAAGAAATGCTTAAGGGCAATTTTGCAGAAGGAAGCACCATCAGAATCAAGTATGATGAAAGCAATGACGCATTGCAATT
TGTAGATGCAGCCAAAGATGATTCTTCAAGTGAAGAGTCTGGCCAAACGGTTGAAGGCAAGCAACAAGATGCCTAA

Upstream 100 bases:

>100_bases
CGGCGAGATCGATATTTGCAACGAAGCACCGTTCAAAAAATGCAATTAAGAAAAAGCCCTACGAGGTAATCATTCAAGGA
ATTCTCTACGATAAAAAATT

Downstream 100 bases:

>100_bases
AATCCAAACTGCTACATAACATTTAGAAGACCTGCTAAATTAGCAGGTCTTTTTTTTACCCAATACGACGCGTTTCATCC
GTCATAGCGAAGATTTTTAG

Product: AAA ATPase-2 domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 851; Mature: 851

Protein sequence:

>851_residues
MEGNFSNRVQDVIRYSREEALRLGHDYIGTEHLLLGIIREGEGIAVRILKNLGCDLYKLKRAIEDSVRSTGGTLTLGNVP
LTKQAEKVLKITYLEAKICKSDIIGTEHLLLSLLKDEENIASQILSQFGVRYETVREELENIMSGKSSSGEISAMSPGQQ
SGSGQYQQQYESRKMEKTKTPVLDNFGRDLTKLALEDKLDPIIGREKEIERVAQVLSRRKKNNPVLIGEPGVGKTAIAEG
LALRIVQRKVSRVLYDKRVVALDLAALVAGTKYRGQFEERMKAVMNELEKSKDVILFIDELHTIVGAGGASGSLDASNIF
KPALARGDLQCIGATTLDEYRQYIEKDGALDRRFQKIMIEPTSVEETVSILNNIKEKYETHHNVRYMPEAIDSAVKLSDR
YITDRHLPDKAIDVLDEAGARVHLSNIHVPKEILDLEAKIEDIKVEKNQVVKSQNFEEAARLRDQEKKLLETLDKAKQDW
EKTTAEMVYDVNESDVAAVVAMMTGIPVLKVAQSESERLLKMGEMLKGEVIGQNEAIEKVTKAIQRTRAGLKDPNRPIGS
FIFLGPTGVGKTELAKALTRYLFDTEEALIRIDMSEYMEKFSVSRLVGAPPGYVGYEEGGQLTEKVRRKPYSVVLLDEIE
KAHPDVFNILLQVLDDGILTDGLGRRVDFRNTVIIMTSNIGARDIKSMGMGMGFGGAPDHKSKYDSMKSTIEDALKRVFN
PEFLNRIDDVIVFHQLEKADIFKIIDISAGRLFKRIRDMGISIEITDRAKQFLVDKGYDQQFGARPLRRALQRYIEEPLA
EEMLKGNFAEGSTIRIKYDESNDALQFVDAAKDDSSSEESGQTVEGKQQDA

Sequences:

>Translated_851_residues
MEGNFSNRVQDVIRYSREEALRLGHDYIGTEHLLLGIIREGEGIAVRILKNLGCDLYKLKRAIEDSVRSTGGTLTLGNVP
LTKQAEKVLKITYLEAKICKSDIIGTEHLLLSLLKDEENIASQILSQFGVRYETVREELENIMSGKSSSGEISAMSPGQQ
SGSGQYQQQYESRKMEKTKTPVLDNFGRDLTKLALEDKLDPIIGREKEIERVAQVLSRRKKNNPVLIGEPGVGKTAIAEG
LALRIVQRKVSRVLYDKRVVALDLAALVAGTKYRGQFEERMKAVMNELEKSKDVILFIDELHTIVGAGGASGSLDASNIF
KPALARGDLQCIGATTLDEYRQYIEKDGALDRRFQKIMIEPTSVEETVSILNNIKEKYETHHNVRYMPEAIDSAVKLSDR
YITDRHLPDKAIDVLDEAGARVHLSNIHVPKEILDLEAKIEDIKVEKNQVVKSQNFEEAARLRDQEKKLLETLDKAKQDW
EKTTAEMVYDVNESDVAAVVAMMTGIPVLKVAQSESERLLKMGEMLKGEVIGQNEAIEKVTKAIQRTRAGLKDPNRPIGS
FIFLGPTGVGKTELAKALTRYLFDTEEALIRIDMSEYMEKFSVSRLVGAPPGYVGYEEGGQLTEKVRRKPYSVVLLDEIE
KAHPDVFNILLQVLDDGILTDGLGRRVDFRNTVIIMTSNIGARDIKSMGMGMGFGGAPDHKSKYDSMKSTIEDALKRVFN
PEFLNRIDDVIVFHQLEKADIFKIIDISAGRLFKRIRDMGISIEITDRAKQFLVDKGYDQQFGARPLRRALQRYIEEPLA
EEMLKGNFAEGSTIRIKYDESNDALQFVDAAKDDSSSEESGQTVEGKQQDA
>Mature_851_residues
MEGNFSNRVQDVIRYSREEALRLGHDYIGTEHLLLGIIREGEGIAVRILKNLGCDLYKLKRAIEDSVRSTGGTLTLGNVP
LTKQAEKVLKITYLEAKICKSDIIGTEHLLLSLLKDEENIASQILSQFGVRYETVREELENIMSGKSSSGEISAMSPGQQ
SGSGQYQQQYESRKMEKTKTPVLDNFGRDLTKLALEDKLDPIIGREKEIERVAQVLSRRKKNNPVLIGEPGVGKTAIAEG
LALRIVQRKVSRVLYDKRVVALDLAALVAGTKYRGQFEERMKAVMNELEKSKDVILFIDELHTIVGAGGASGSLDASNIF
KPALARGDLQCIGATTLDEYRQYIEKDGALDRRFQKIMIEPTSVEETVSILNNIKEKYETHHNVRYMPEAIDSAVKLSDR
YITDRHLPDKAIDVLDEAGARVHLSNIHVPKEILDLEAKIEDIKVEKNQVVKSQNFEEAARLRDQEKKLLETLDKAKQDW
EKTTAEMVYDVNESDVAAVVAMMTGIPVLKVAQSESERLLKMGEMLKGEVIGQNEAIEKVTKAIQRTRAGLKDPNRPIGS
FIFLGPTGVGKTELAKALTRYLFDTEEALIRIDMSEYMEKFSVSRLVGAPPGYVGYEEGGQLTEKVRRKPYSVVLLDEIE
KAHPDVFNILLQVLDDGILTDGLGRRVDFRNTVIIMTSNIGARDIKSMGMGMGFGGAPDHKSKYDSMKSTIEDALKRVFN
PEFLNRIDDVIVFHQLEKADIFKIIDISAGRLFKRIRDMGISIEITDRAKQFLVDKGYDQQFGARPLRRALQRYIEEPLA
EEMLKGNFAEGSTIRIKYDESNDALQFVDAAKDDSSSEESGQTVEGKQQDA

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=321, Percent_Identity=34.5794392523364, Blast_Score=194, Evalue=3e-49,
Organism=Escherichia coli, GI1788943, Length=867, Percent_Identity=45.5594002306805, Blast_Score=695, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=809, Percent_Identity=40.2966625463535, Blast_Score=572, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6320464, Length=758, Percent_Identity=45.3825857519789, Blast_Score=615, Evalue=1e-177,
Organism=Saccharomyces cerevisiae, GI6323002, Length=356, Percent_Identity=41.8539325842697, Blast_Score=274, Evalue=4e-74,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 95341; Mature: 95341

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS50151 UVR ; PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGNFSNRVQDVIRYSREEALRLGHDYIGTEHLLLGIIREGEGIAVRILKNLGCDLYKLK
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHH
RAIEDSVRSTGGTLTLGNVPLTKQAEKVLKITYLEAKICKSDIIGTEHLLLSLLKDEENI
HHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHH
ASQILSQFGVRYETVREELENIMSGKSSSGEISAMSPGQQSGSGQYQQQYESRKMEKTKT
HHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCC
PVLDNFGRDLTKLALEDKLDPIIGREKEIERVAQVLSRRKKNNPVLIGEPGVGKTAIAEG
CHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHH
LALRIVQRKVSRVLYDKRVVALDLAALVAGTKYRGQFEERMKAVMNELEKSKDVILFIDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEHHH
LHTIVGAGGASGSLDASNIFKPALARGDLQCIGATTLDEYRQYIEKDGALDRRFQKIMIE
HHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHCC
PTSVEETVSILNNIKEKYETHHNVRYMPEAIDSAVKLSDRYITDRHLPDKAIDVLDEAGA
CCCHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
RVHLSNIHVPKEILDLEAKIEDIKVEKNQVVKSQNFEEAARLRDQEKKLLETLDKAKQDW
EEEECCCCCCHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EKTTAEMVYDVNESDVAAVVAMMTGIPVLKVAQSESERLLKMGEMLKGEVIGQNEAIEKV
HHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
TKAIQRTRAGLKDPNRPIGSFIFLGPTGVGKTELAKALTRYLFDTEEALIRIDMSEYMEK
HHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCHHHEEECHHHHHHH
FSVSRLVGAPPGYVGYEEGGQLTEKVRRKPYSVVLLDEIEKAHPDVFNILLQVLDDGILT
HHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEHHHHHHHCCHHHHHHHHHHHCCHHC
DGLGRRVDFRNTVIIMTSNIGARDIKSMGMGMGFGGAPDHKSKYDSMKSTIEDALKRVFN
CCCCCCEECCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
PEFLNRIDDVIVFHQLEKADIFKIIDISAGRLFKRIRDMGISIEITDRAKQFLVDKGYDQ
HHHHHHHHHHHHHHHHCHHHHHHEEECCHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCH
QFGARPLRRALQRYIEEPLAEEMLKGNFAEGSTIRIKYDESNDALQFVDAAKDDSSSEES
HCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCC
GQTVEGKQQDA
CCCCCCCCCCC
>Mature Secondary Structure
MEGNFSNRVQDVIRYSREEALRLGHDYIGTEHLLLGIIREGEGIAVRILKNLGCDLYKLK
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHH
RAIEDSVRSTGGTLTLGNVPLTKQAEKVLKITYLEAKICKSDIIGTEHLLLSLLKDEENI
HHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHH
ASQILSQFGVRYETVREELENIMSGKSSSGEISAMSPGQQSGSGQYQQQYESRKMEKTKT
HHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCC
PVLDNFGRDLTKLALEDKLDPIIGREKEIERVAQVLSRRKKNNPVLIGEPGVGKTAIAEG
CHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHH
LALRIVQRKVSRVLYDKRVVALDLAALVAGTKYRGQFEERMKAVMNELEKSKDVILFIDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEHHH
LHTIVGAGGASGSLDASNIFKPALARGDLQCIGATTLDEYRQYIEKDGALDRRFQKIMIE
HHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHCC
PTSVEETVSILNNIKEKYETHHNVRYMPEAIDSAVKLSDRYITDRHLPDKAIDVLDEAGA
CCCHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
RVHLSNIHVPKEILDLEAKIEDIKVEKNQVVKSQNFEEAARLRDQEKKLLETLDKAKQDW
EEEECCCCCCHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EKTTAEMVYDVNESDVAAVVAMMTGIPVLKVAQSESERLLKMGEMLKGEVIGQNEAIEKV
HHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
TKAIQRTRAGLKDPNRPIGSFIFLGPTGVGKTELAKALTRYLFDTEEALIRIDMSEYMEK
HHHHHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCHHHEEECHHHHHHH
FSVSRLVGAPPGYVGYEEGGQLTEKVRRKPYSVVLLDEIEKAHPDVFNILLQVLDDGILT
HHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCEEEEHHHHHHHCCHHHHHHHHHHHCCHHC
DGLGRRVDFRNTVIIMTSNIGARDIKSMGMGMGFGGAPDHKSKYDSMKSTIEDALKRVFN
CCCCCCEECCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
PEFLNRIDDVIVFHQLEKADIFKIIDISAGRLFKRIRDMGISIEITDRAKQFLVDKGYDQ
HHHHHHHHHHHHHHHHCHHHHHHEEECCHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCH
QFGARPLRRALQRYIEEPLAEEMLKGNFAEGSTIRIKYDESNDALQFVDAAKDDSSSEES
HCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCC
GQTVEGKQQDA
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]