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The map label for this gene is umuD [H]

Identifier: 193214005

GI number: 193214005

Start: 325041

End: 325853

Strand: Direct

Name: umuD [H]

Synonym: Ctha_0286

Alternate gene names: 193214005

Gene position: 325041-325853 (Clockwise)

Preceding gene: 193213995

Following gene: 193214012

Centisome position: 9.87

GC content: 54.61

Gene sequence:

>813_bases
ATGGAAGAGATGATTGGAGATCGTTTCAAAGCGGTCAGAAAAGCGCTGATGCTCAATCAGGATGCGTTTTCAAAGGATAT
TGGCATTTCGCAAAGCTCGCTTTCGGAAATCGAGAACGGAAAATTTTCGCCGGGCAGCGACATTATTTTATCGCTTTGCC
GATATTTCAATATCGACAGCAACTGGCTGCTGACGGGAACAGGCAAGATGTTTCTGGAAAAAAAGCCCGAATCGGAAAAT
ATTTCGGAGGCGGGCGACGAGCCGAGCGCGGCGGACTGGCAGCTTCAGGCCGAGCAAGCCGCAAAAACGGCAGCAAGCCG
CAGCGAAAGCGAGGCGCTGGCCGGCGATGTGGCGGCGCTGAAAAAGCAGGTCAATGAGCTTTTCGGGCTGGTGCGCGGCA
GGATGGATGTGCTGGAAGACGCGATGGTTGAAATTCCGGTGTTTATGCACCGTGTGTCGGCGGGACCGGCGGTGGCGTCC
TCATCGGAAATTGAGGAATATATTAAGTTACCGACCGTGCTGCTGAAGCATCCGAAGCGCAGCTACGCGGTGCGGGCGAG
CGGCAACAGCATGGTCGGCGCGGGCATCCATTCCGGTGACCTTTTGATTGTGGATCAGGAAGCGGCCATCAAGCACAAGT
GCATCGTGATTGCGAGCATCAACGGCGAGCAGACGGTCAAGCGCCTGCTGATCGAAGACGGCGAGCTGGTGCTTGCGCCG
GAAAACAGCCACTACCAATCAACGCCCATCACCAAAGAGATGAATTTCAGCATTTTGGGCGTGGTAATGCACATCATTCG
CACGGTTTACTAA

Upstream 100 bases:

>100_bases
TTTGCCCATGATTTATTCTTTTATTAGATTACCGATATATTATGCTCACAATATATCGCTTAAGCGATAAATAGCAAAAT
AAAAATATCATTTTTCTGAT

Downstream 100 bases:

>100_bases
GCCGTCGCCGGCACATCGCGCCGCGATTTTCCGCCACATTTTTTTGCAAGCCAAAAGTGTGGCGAGGGGACGGTGTTTCT
CAAAATTCATAAAAACAAAC

Product: XRE family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MEEMIGDRFKAVRKALMLNQDAFSKDIGISQSSLSEIENGKFSPGSDIILSLCRYFNIDSNWLLTGTGKMFLEKKPESEN
ISEAGDEPSAADWQLQAEQAAKTAASRSESEALAGDVAALKKQVNELFGLVRGRMDVLEDAMVEIPVFMHRVSAGPAVAS
SSEIEEYIKLPTVLLKHPKRSYAVRASGNSMVGAGIHSGDLLIVDQEAAIKHKCIVIASINGEQTVKRLLIEDGELVLAP
ENSHYQSTPITKEMNFSILGVVMHIIRTVY

Sequences:

>Translated_270_residues
MEEMIGDRFKAVRKALMLNQDAFSKDIGISQSSLSEIENGKFSPGSDIILSLCRYFNIDSNWLLTGTGKMFLEKKPESEN
ISEAGDEPSAADWQLQAEQAAKTAASRSESEALAGDVAALKKQVNELFGLVRGRMDVLEDAMVEIPVFMHRVSAGPAVAS
SSEIEEYIKLPTVLLKHPKRSYAVRASGNSMVGAGIHSGDLLIVDQEAAIKHKCIVIASINGEQTVKRLLIEDGELVLAP
ENSHYQSTPITKEMNFSILGVVMHIIRTVY
>Mature_270_residues
MEEMIGDRFKAVRKALMLNQDAFSKDIGISQSSLSEIENGKFSPGSDIILSLCRYFNIDSNWLLTGTGKMFLEKKPESEN
ISEAGDEPSAADWQLQAEQAAKTAASRSESEALAGDVAALKKQVNELFGLVRGRMDVLEDAMVEIPVFMHRVSAGPAVAS
SSEIEEYIKLPTVLLKHPKRSYAVRASGNSMVGAGIHSGDLLIVDQEAAIKHKCIVIASINGEQTVKRLLIEDGELVLAP
ENSHYQSTPITKEMNFSILGVVMHIIRTVY

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1787431, Length=126, Percent_Identity=38.8888888888889, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790476, Length=192, Percent_Identity=30.2083333333333, Blast_Score=68, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 29509; Mature: 29509

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50943 HTH_CROC1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEMIGDRFKAVRKALMLNQDAFSKDIGISQSSLSEIENGKFSPGSDIILSLCRYFNIDS
CCHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
NWLLTGTGKMFLEKKPESENISEAGDEPSAADWQLQAEQAAKTAASRSESEALAGDVAAL
CEEEEECCCEEEECCCCCCCHHHCCCCCCCCCCEEHHHHHHHHHHHCCHHHHHHHHHHHH
KKQVNELFGLVRGRMDVLEDAMVEIPVFMHRVSAGPAVASSSEIEEYIKLPTVLLKHPKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCC
SYAVRASGNSMVGAGIHSGDLLIVDQEAAIKHKCIVIASINGEQTVKRLLIEDGELVLAP
CEEEEECCCCEEECCCCCCCEEEEECHHHCCEEEEEEEECCHHHHHHHHHHCCCCEEECC
ENSHYQSTPITKEMNFSILGVVMHIIRTVY
CCCCCCCCCCCHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEEMIGDRFKAVRKALMLNQDAFSKDIGISQSSLSEIENGKFSPGSDIILSLCRYFNIDS
CCHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
NWLLTGTGKMFLEKKPESENISEAGDEPSAADWQLQAEQAAKTAASRSESEALAGDVAAL
CEEEEECCCEEEECCCCCCCHHHCCCCCCCCCCEEHHHHHHHHHHHCCHHHHHHHHHHHH
KKQVNELFGLVRGRMDVLEDAMVEIPVFMHRVSAGPAVASSSEIEEYIKLPTVLLKHPKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCC
SYAVRASGNSMVGAGIHSGDLLIVDQEAAIKHKCIVIASINGEQTVKRLLIEDGELVLAP
CEEEEECCCCEEECCCCCCCEEEEECHHHCCEEEEEEEECCHHHHHHHHHHCCCCEEECC
ENSHYQSTPITKEMNFSILGVVMHIIRTVY
CCCCCCCCCCCHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2144275; 2203737; 11677609; 1910151 [H]