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The map label for this gene is dsbD [H]

Identifier: 193213952

GI number: 193213952

Start: 278096

End: 280258

Strand: Direct

Name: dsbD [H]

Synonym: Ctha_0233

Alternate gene names: 193213952

Gene position: 278096-280258 (Clockwise)

Preceding gene: 193213949

Following gene: 193213953

Centisome position: 8.44

GC content: 53.63

Gene sequence:

>2163_bases
ATGTTAAAAAGACCCTTCAAAAACGCGTTTTGGTTTACTGCGTTTTTTTCTGTTCTCAGCCTATTTTTTGCAAAAAACGC
CGCCGCGCAGTTTCCCGATTTCGGCGACGGAAAGAAACTCGTGCAGCCAAGTTTGGTAGTCGGCACGGAGAATTTTCGCG
AGCCGTTTATCATTGGCATTCGCTTTAAGCTTGAGCCGGAATGGCATATTTATTGGAAAAATGCGGGCGACGCTGGTACG
CCAGTTGAAGTCGAGTGGAACTTGCCCGACGGCTTCCGCGTGAGCGAGCTGGACTATCCCGTGCCGATAAAGTTTGTGCT
GAGCGGCGTTGTCGGCTACGGCTACACCGACGAGGTCGTGCTTTTGGCAAAAGTTGAGCCGCCGAAAAATTATTCCCCGA
AAAAAGCGCCGGAAATTTCCGCCAAGCTGAGCTGGCTCGTTTGCCGCGAATCGTGCATTCCTGGCGAAGGCGAAGTTTCC
TTAAACCTTGAAACACTTTCCCAAAAAGACGTCGCCGAAGGCAAAAAGCTGATTGAAAAATTTGAGGCGAAATTGCCCGG
CCAATCCGGCAATTTGGACATCAAGCTTGAGCAGGCCGTAGCCAAAGGGTCAGGGAAAAATGTGACCGCTGAGCTTCGCT
TTTCGGGAAAGCAGGCTTCCGAAATTACTGACTTTTTCCCCGACATTTTGGAAAATGCGTTCATCGGCTACAACGATATT
CAGGTGGCAAACAACACGATTTCCTTCCCGATGCAGCTTTCAGCGCCGGACGCCGAACTGCCGGAAATTCGCGGGCTGCT
CGTCACCGAAACGCACGGCTATGAATTTTCCGCGACGCTCAAGGCTGCAACTGAAAGCTTGCTTGATGATTCGTTTCAAG
TCGCAGGCGAGCGACCGGACGAGTCGCCGCTTTGGATGATTTTGCTGTTGGCGTTCGTGGGCGGGCTGTTGCTGAACATC
ATGCCGTGCGTGTTGCCGGTGCTCTCGCTCAAGGTGCTGAGCTTTGTCGAACATTCATCGATGGAAAAATCGCATACGCG
ATATTTGAGCTTCATTTTTGCGCTCGGCGTGTTGGTGTCGTTTTGGGTCTTGGCGCTCGGCGTGGGCGTTTTGCAAAACG
CAGGCGAGCAAATCGGTTGGGGTTTTCAATTTCAATCGCCTTGGTTTGTCGTTGGCATGTCGGTGGTGGTGTTCATTTTT
GGGATGAACCTCGTGGGCGTGTTTGAATTCGCCTCGCCGAATGTCACGGGCGATGTCAGCAAAACGCTGAGCCGCCACGA
TGCGCTGGGCGCGTTTATGAACGGCGTGCTGGCCACCACGCTGGCCACGCCTTGCACCGCGCCGTTTCTCGGCACGGCGC
TCGGCTTCGCGTTTTCGCAACCGTTCTATATGATTTTCTTGATTTTCAGCCTTGTGGCGCTCGGGCTGGCCGCGCCGTAT
GTGATTTTATCGCTCAATCCCGCGTGGCTGAAATTCATCCCGAAGCCGGGCGTTTGGATGGAGCGATTCAAGCAAGCGAT
GGGCTTTTTGCTTTTCGCCACGCTGGTTTGGTTGCTCTCGGTGCTTGGCAGCCAGACGGGCGCAACGGGCATCTTGGCCG
CGCTGACCTTGCTGCTGGGCGTCTCCGTCGGGCTGTGGCTCATCGGCGCGTTCATCGATTACGGCACACCGGCCACGAAA
AAATTCATGATTTGGGGAATCGCCCTCTTGCTTGCGGGAGCGAGTTATTATTTAGGATTTGAAAAATGGTTTCCGATTCG
TGAGACGGCGCAAACGCAAACGGAGGCCGCAAAACCGCACGATGGACTCATCGACTGGAAGCCGTTTTCCATTGCGACGG
TTGAAAAGGAGGTTTCGGCGGGAAAACCGGTGTTTATCGATTTCACCGCCGATTGGTGCTTTACTTGCAAAGTGACCGAA
CAAACCGTGCTGCACACCGACGCCGTGAGCGGGAAAATCAAGGAACTCGGCATCGTCCCGATTCGCGCGGATTGGACGAA
TCGCAACGACGAAATCACCGGCCTGCTCAAAAAATTCGGGCGTTCCGGCGTGCCGCTTTATGTCGTGTTTCCGGCGGGAA
AATTGTCCGAACCGATTGTCCTTCCCGAAGTCGTGACGCCAGAGCTTTTAATCGAAGCATTTGAAAAGGCCGTTTCGAAA
TAA

Upstream 100 bases:

>100_bases
GTTTATGTCGTACCCTAAAAAAGGTAACGTAACCCCCGCGAAGTTCGTTGTATGCTAAGAAAATTAGAAACATAAAAACC
GCTTAAAACAAAAATCAACA

Downstream 100 bases:

>100_bases
ATAAAAATCGTAACAGGTATTATTCTTAATCGTTATAAACCGAGAAAGAATAATACCTGAAATTTTTAACGAGTTATTTT
ATGAGCTATCAAAAATTGAA

Product: cytochrome c biogenesis protein transmembrane region

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 720; Mature: 720

Protein sequence:

>720_residues
MLKRPFKNAFWFTAFFSVLSLFFAKNAAAQFPDFGDGKKLVQPSLVVGTENFREPFIIGIRFKLEPEWHIYWKNAGDAGT
PVEVEWNLPDGFRVSELDYPVPIKFVLSGVVGYGYTDEVVLLAKVEPPKNYSPKKAPEISAKLSWLVCRESCIPGEGEVS
LNLETLSQKDVAEGKKLIEKFEAKLPGQSGNLDIKLEQAVAKGSGKNVTAELRFSGKQASEITDFFPDILENAFIGYNDI
QVANNTISFPMQLSAPDAELPEIRGLLVTETHGYEFSATLKAATESLLDDSFQVAGERPDESPLWMILLLAFVGGLLLNI
MPCVLPVLSLKVLSFVEHSSMEKSHTRYLSFIFALGVLVSFWVLALGVGVLQNAGEQIGWGFQFQSPWFVVGMSVVVFIF
GMNLVGVFEFASPNVTGDVSKTLSRHDALGAFMNGVLATTLATPCTAPFLGTALGFAFSQPFYMIFLIFSLVALGLAAPY
VILSLNPAWLKFIPKPGVWMERFKQAMGFLLFATLVWLLSVLGSQTGATGILAALTLLLGVSVGLWLIGAFIDYGTPATK
KFMIWGIALLLAGASYYLGFEKWFPIRETAQTQTEAAKPHDGLIDWKPFSIATVEKEVSAGKPVFIDFTADWCFTCKVTE
QTVLHTDAVSGKIKELGIVPIRADWTNRNDEITGLLKKFGRSGVPLYVVFPAGKLSEPIVLPEVVTPELLIEAFEKAVSK

Sequences:

>Translated_720_residues
MLKRPFKNAFWFTAFFSVLSLFFAKNAAAQFPDFGDGKKLVQPSLVVGTENFREPFIIGIRFKLEPEWHIYWKNAGDAGT
PVEVEWNLPDGFRVSELDYPVPIKFVLSGVVGYGYTDEVVLLAKVEPPKNYSPKKAPEISAKLSWLVCRESCIPGEGEVS
LNLETLSQKDVAEGKKLIEKFEAKLPGQSGNLDIKLEQAVAKGSGKNVTAELRFSGKQASEITDFFPDILENAFIGYNDI
QVANNTISFPMQLSAPDAELPEIRGLLVTETHGYEFSATLKAATESLLDDSFQVAGERPDESPLWMILLLAFVGGLLLNI
MPCVLPVLSLKVLSFVEHSSMEKSHTRYLSFIFALGVLVSFWVLALGVGVLQNAGEQIGWGFQFQSPWFVVGMSVVVFIF
GMNLVGVFEFASPNVTGDVSKTLSRHDALGAFMNGVLATTLATPCTAPFLGTALGFAFSQPFYMIFLIFSLVALGLAAPY
VILSLNPAWLKFIPKPGVWMERFKQAMGFLLFATLVWLLSVLGSQTGATGILAALTLLLGVSVGLWLIGAFIDYGTPATK
KFMIWGIALLLAGASYYLGFEKWFPIRETAQTQTEAAKPHDGLIDWKPFSIATVEKEVSAGKPVFIDFTADWCFTCKVTE
QTVLHTDAVSGKIKELGIVPIRADWTNRNDEITGLLKKFGRSGVPLYVVFPAGKLSEPIVLPEVVTPELLIEAFEKAVSK
>Mature_720_residues
MLKRPFKNAFWFTAFFSVLSLFFAKNAAAQFPDFGDGKKLVQPSLVVGTENFREPFIIGIRFKLEPEWHIYWKNAGDAGT
PVEVEWNLPDGFRVSELDYPVPIKFVLSGVVGYGYTDEVVLLAKVEPPKNYSPKKAPEISAKLSWLVCRESCIPGEGEVS
LNLETLSQKDVAEGKKLIEKFEAKLPGQSGNLDIKLEQAVAKGSGKNVTAELRFSGKQASEITDFFPDILENAFIGYNDI
QVANNTISFPMQLSAPDAELPEIRGLLVTETHGYEFSATLKAATESLLDDSFQVAGERPDESPLWMILLLAFVGGLLLNI
MPCVLPVLSLKVLSFVEHSSMEKSHTRYLSFIFALGVLVSFWVLALGVGVLQNAGEQIGWGFQFQSPWFVVGMSVVVFIF
GMNLVGVFEFASPNVTGDVSKTLSRHDALGAFMNGVLATTLATPCTAPFLGTALGFAFSQPFYMIFLIFSLVALGLAAPY
VILSLNPAWLKFIPKPGVWMERFKQAMGFLLFATLVWLLSVLGSQTGATGILAALTLLLGVSVGLWLIGAFIDYGTPATK
KFMIWGIALLLAGASYYLGFEKWFPIRETAQTQTEAAKPHDGLIDWKPFSIATVEKEVSAGKPVFIDFTADWCFTCKVTE
QTVLHTDAVSGKIKELGIVPIRADWTNRNDEITGLLKKFGRSGVPLYVVFPAGKLSEPIVLPEVVTPELLIEAFEKAVSK

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=409, Percent_Identity=28.361858190709, Blast_Score=104, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 78980; Mature: 78980

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKRPFKNAFWFTAFFSVLSLFFAKNAAAQFPDFGDGKKLVQPSLVVGTENFREPFIIGI
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCHHCCCEEEECCCCCCCCEEEEE
RFKLEPEWHIYWKNAGDAGTPVEVEWNLPDGFRVSELDYPVPIKFVLSGVVGYGYTDEVV
EEEECCCEEEEEECCCCCCCCEEEEECCCCCCEECCCCCCCCHHHHHHHHHCCCCCCCEE
LLAKVEPPKNYSPKKAPEISAKLSWLVCRESCIPGEGEVSLNLETLSQKDVAEGKKLIEK
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEHHHHCHHHHHHHHHHHHH
FEAKLPGQSGNLDIKLEQAVAKGSGKNVTAELRFSGKQASEITDFFPDILENAFIGYNDI
HHHHCCCCCCCEEEEEHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCE
QVANNTISFPMQLSAPDAELPEIRGLLVTETHGYEFSATLKAATESLLDDSFQVAGERPD
EEECCEEECCEEECCCCCCCCHHCCEEEEECCCCEEEHHHHHHHHHHHCCHHHHCCCCCC
ESPLWMILLLAFVGGLLLNIMPCVLPVLSLKVLSFVEHSSMEKSHTRYLSFIFALGVLVS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
FWVLALGVGVLQNAGEQIGWGFQFQSPWFVVGMSVVVFIFGMNLVGVFEFASPNVTGDVS
HHHHHHHHHHHHCCCHHCCCCEEECCCHHHHHHHHHHHHHHCHHHEEEEECCCCCCCHHH
KTLSRHDALGAFMNGVLATTLATPCTAPFLGTALGFAFSQPFYMIFLIFSLVALGLAAPY
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCE
VILSLNPAWLKFIPKPGVWMERFKQAMGFLLFATLVWLLSVLGSQTGATGILAALTLLLG
EEEECCHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VSVGLWLIGAFIDYGTPATKKFMIWGIALLLAGASYYLGFEKWFPIRETAQTQTEAAKPH
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHCCHHHCCCCHHHHHHHHHCCCCC
DGLIDWKPFSIATVEKEVSAGKPVFIDFTADWCFTCKVTEQTVLHTDAVSGKIKELGIVP
CCCCCCCCCEEEEEHHHHCCCCCEEEEEECCEEEEEEECCCCEEEHHHCCCCHHHCCEEE
IRADWTNRNDEITGLLKKFGRSGVPLYVVFPAGKLSEPIVLPEVVTPELLIEAFEKAVSK
EEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCEECCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MLKRPFKNAFWFTAFFSVLSLFFAKNAAAQFPDFGDGKKLVQPSLVVGTENFREPFIIGI
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCHHCCCEEEECCCCCCCCEEEEE
RFKLEPEWHIYWKNAGDAGTPVEVEWNLPDGFRVSELDYPVPIKFVLSGVVGYGYTDEVV
EEEECCCEEEEEECCCCCCCCEEEEECCCCCCEECCCCCCCCHHHHHHHHHCCCCCCCEE
LLAKVEPPKNYSPKKAPEISAKLSWLVCRESCIPGEGEVSLNLETLSQKDVAEGKKLIEK
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEHHHHCHHHHHHHHHHHHH
FEAKLPGQSGNLDIKLEQAVAKGSGKNVTAELRFSGKQASEITDFFPDILENAFIGYNDI
HHHHCCCCCCCEEEEEHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCE
QVANNTISFPMQLSAPDAELPEIRGLLVTETHGYEFSATLKAATESLLDDSFQVAGERPD
EEECCEEECCEEECCCCCCCCHHCCEEEEECCCCEEEHHHHHHHHHHHCCHHHHCCCCCC
ESPLWMILLLAFVGGLLLNIMPCVLPVLSLKVLSFVEHSSMEKSHTRYLSFIFALGVLVS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
FWVLALGVGVLQNAGEQIGWGFQFQSPWFVVGMSVVVFIFGMNLVGVFEFASPNVTGDVS
HHHHHHHHHHHHCCCHHCCCCEEECCCHHHHHHHHHHHHHHCHHHEEEEECCCCCCCHHH
KTLSRHDALGAFMNGVLATTLATPCTAPFLGTALGFAFSQPFYMIFLIFSLVALGLAAPY
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCE
VILSLNPAWLKFIPKPGVWMERFKQAMGFLLFATLVWLLSVLGSQTGATGILAALTLLLG
EEEECCHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
VSVGLWLIGAFIDYGTPATKKFMIWGIALLLAGASYYLGFEKWFPIRETAQTQTEAAKPH
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHCCHHHCCCCHHHHHHHHHCCCCC
DGLIDWKPFSIATVEKEVSAGKPVFIDFTADWCFTCKVTEQTVLHTDAVSGKIKELGIVP
CCCCCCCCCEEEEEHHHHCCCCCEEEEEECCEEEEEEECCCCEEEHHHCCCCHHHCCEEE
IRADWTNRNDEITGLLKKFGRSGVPLYVVFPAGKLSEPIVLPEVVTPELLIEAFEKAVSK
EEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCEECCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]