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The map label for this gene is rsbU [H]

Identifier: 193213942

GI number: 193213942

Start: 262432

End: 264687

Strand: Direct

Name: rsbU [H]

Synonym: Ctha_0223

Alternate gene names: 193213942

Gene position: 262432-264687 (Clockwise)

Preceding gene: 193213939

Following gene: 193213943

Centisome position: 7.97

GC content: 44.64

Gene sequence:

>2256_bases
ATGTCCAGCAAAAAACGAATCACATACCTTTTTGCATTCGTTATTGTTCTATGCGAAATGTTCCTGCTCGGGCTTGATGT
CAGCATTTTTTATGCGATCAAAGCTAAAACTTATCTTCTCCCCAGTGGCTTCATTTATCTGAAAGACATCTTGGCCTCGT
TGGTGTTTATTGCCCTTTATGCGCTGATTCGAAAAGGGATTCGCTTGAATCGAAACGACCAAACCAATCCGATTTGGATC
GAACCCTCACGCGGCGCGTGGGATGCGATGGTTACATTAGTGCTTATTATTGGCGCCATTTTTGTCTATGACCAGACTTT
TCCTGAAGCTGTGTACAGGCGAATCAGCAACTTTGGGTTGGATTTCTACGCGCCCGAAAGCCTTTACACCATTTTTAAAT
CGCATTTCATTACACTTTTGCTTGGAAGCGCGCTATTGGCCGGCCTGATTACCATTGAGCGCCTTATTCTGTATAAACGC
ACCAAAAATACAGCGATTAATTTCGCGCTTTTTATTATCGCCCTATTTGGGTTTTCCTTCTCAATGGCGGGCACTGTGCC
AGGAGCTCAATTTAGCCCAATTTCTCTTGGTTTGGGCATTACTGCATTGATTTTGATGTTCATCAACGCATTTCGGGTTT
CCTGGATATTGCCCATGAGTCGCCAAGATAAATGGCAAATCATGGGGCTGACCGTTATTATCGGGATTTGTGGCCTCATT
TTGCTCAATGGATTTCACTTCCCGCCTTACTTATTATGGTATAGTAGTTTTGTTGGGCATTTTTTACTTAGCTTAACGGC
GTTTGTCACGCTCTATTTTTGCGTGTCGTTTTTGGGCATTTTGATTTATTTACCGTCTTCACGCGACTTTGAGCGAAAGT
CTGAAGAGGTTCGCAAGCTCTATAAAATGAGCAAGTTCATCACCGATGTGTTTGATGAGGACAAAATCTACACATCGCTC
ATCCGCTTTGTTTGCGAGTCCATCGGGGAAAATTCGCTGGGCTGGTTTGATTTGTATGTGCCCAATTCGGTCAGCGAAAA
GGCGGCTGGAACATTTCACACGGTTCACTACACCGATGTGAGTGGAACAAAGCAAGTTGCTCATTTTCGGACGGTCGCAA
CCAACAATGTGTCTTCGAACATTATTGCAGAAATGCAGCGCTCTGCGGGATTTATCTGGCAGCAAGTTTTGGAAAAAAAA
GACATCGTTCAAGTCGATGATATGGTGACTGATAAACGGTTAAATGCAAAAATCCCGCCGATTCATGCGGTGCTAAAACG
GTTAAATATTCGGAAACGGCATCCAAAACCGCTGTTTCCAATTGGGTCAATTGTTTCTGTGCCGCTGACCATGCGCTCGG
AACTGATTGGGATTATTCACGTTGCCAAAGATGTTGAGTTTAGCTTTATCCGAGAAGATTTGGAACTCATCACCATATTT
GCAGATCAAGCGGCCATTGCAATCGACAACTCGCGCTTGATCAAGCAGCTTATTGGCAAAGAACGCTTGGAACAACAACT
TGAAATTGCGCGGGAAATTCAGTCGCGCCTTTTGCCGCAAGAGCCACTTCAGGTTCCAGGCTTCGACATGGCGGGCATTT
CCGAACCGGCGTATGAAGTAGGCGGCGACTATTACGACTTTTTTCAACTGGACGACGGCGATGAAATCTCACGGTTTGGC
ATTGTCATCGCGGACGTTTCGGGAAAAGGGACTTCAGCCGCGTTCTACATGGCGGAATTAAAGGGCATCATTCAATCGCT
TTGCAAAGTTTATCCCGATGCACCCAGAGATTTGCTTAAAAAAGCCAACGAAACGCTGAGCCAAAGTCTCGGAAAAAATG
CGTATATCAGCTTGCTTTATGGCGTAGTTGATGTTAAAGAAAATACGCTCTCGCTTGTCAATGCGGGGCATTGCCCGGCT
GCCGCTGTGATGAATAAAAATCCCAGCTATTTGAAACTTCAAGGCCTGGCACTTGGTTTGGATACAGGCAAAATTTTTAA
CCAGGTCGTATCCAAAAACATTTATCCGCTTGCGGATGGCGATGTGATTGTTTTTTATACCGACGGCGTTGTCGAAGCGA
TTAATCATGAGGGAAAACAGTTCGGCTACGATCGGCTTTTGAAGATTGTAAATCAGTCTCGCGAAAAGAATGCAAAGGAC
ATTACAAACGACATTTTTACTGCAGTGAATGATTTTACCAAAACGGGAGGCGCTGTTAGGGACGACTTAACGTTAGTTGT
GGTCAAAAAACTGTAA

Upstream 100 bases:

>100_bases
CTTTGGCCAACATCTTAAGAATTTTGCCTATCTTCAGCCTGTTTCAACGGGCTTCTTTTTATCTTGCTAAGAATCGATTT
AGTGAAAATAAAAACACCAA

Downstream 100 bases:

>100_bases
CTCTTGGATTTGAAGCTTGCCTTACTTTGATTTTAGAGATTTCGTCAGTATCCTTGAAAGTCAAATCTCGTAACATTTTG
CTGGTGCATTCGCATAAAAT

Product: protein serine/threonine phosphatase

Products: NA

Alternate protein names: Sigma factor sigB regulation protein rsbU [H]

Number of amino acids: Translated: 751; Mature: 750

Protein sequence:

>751_residues
MSSKKRITYLFAFVIVLCEMFLLGLDVSIFYAIKAKTYLLPSGFIYLKDILASLVFIALYALIRKGIRLNRNDQTNPIWI
EPSRGAWDAMVTLVLIIGAIFVYDQTFPEAVYRRISNFGLDFYAPESLYTIFKSHFITLLLGSALLAGLITIERLILYKR
TKNTAINFALFIIALFGFSFSMAGTVPGAQFSPISLGLGITALILMFINAFRVSWILPMSRQDKWQIMGLTVIIGICGLI
LLNGFHFPPYLLWYSSFVGHFLLSLTAFVTLYFCVSFLGILIYLPSSRDFERKSEEVRKLYKMSKFITDVFDEDKIYTSL
IRFVCESIGENSLGWFDLYVPNSVSEKAAGTFHTVHYTDVSGTKQVAHFRTVATNNVSSNIIAEMQRSAGFIWQQVLEKK
DIVQVDDMVTDKRLNAKIPPIHAVLKRLNIRKRHPKPLFPIGSIVSVPLTMRSELIGIIHVAKDVEFSFIREDLELITIF
ADQAAIAIDNSRLIKQLIGKERLEQQLEIAREIQSRLLPQEPLQVPGFDMAGISEPAYEVGGDYYDFFQLDDGDEISRFG
IVIADVSGKGTSAAFYMAELKGIIQSLCKVYPDAPRDLLKKANETLSQSLGKNAYISLLYGVVDVKENTLSLVNAGHCPA
AAVMNKNPSYLKLQGLALGLDTGKIFNQVVSKNIYPLADGDVIVFYTDGVVEAINHEGKQFGYDRLLKIVNQSREKNAKD
ITNDIFTAVNDFTKTGGAVRDDLTLVVVKKL

Sequences:

>Translated_751_residues
MSSKKRITYLFAFVIVLCEMFLLGLDVSIFYAIKAKTYLLPSGFIYLKDILASLVFIALYALIRKGIRLNRNDQTNPIWI
EPSRGAWDAMVTLVLIIGAIFVYDQTFPEAVYRRISNFGLDFYAPESLYTIFKSHFITLLLGSALLAGLITIERLILYKR
TKNTAINFALFIIALFGFSFSMAGTVPGAQFSPISLGLGITALILMFINAFRVSWILPMSRQDKWQIMGLTVIIGICGLI
LLNGFHFPPYLLWYSSFVGHFLLSLTAFVTLYFCVSFLGILIYLPSSRDFERKSEEVRKLYKMSKFITDVFDEDKIYTSL
IRFVCESIGENSLGWFDLYVPNSVSEKAAGTFHTVHYTDVSGTKQVAHFRTVATNNVSSNIIAEMQRSAGFIWQQVLEKK
DIVQVDDMVTDKRLNAKIPPIHAVLKRLNIRKRHPKPLFPIGSIVSVPLTMRSELIGIIHVAKDVEFSFIREDLELITIF
ADQAAIAIDNSRLIKQLIGKERLEQQLEIAREIQSRLLPQEPLQVPGFDMAGISEPAYEVGGDYYDFFQLDDGDEISRFG
IVIADVSGKGTSAAFYMAELKGIIQSLCKVYPDAPRDLLKKANETLSQSLGKNAYISLLYGVVDVKENTLSLVNAGHCPA
AAVMNKNPSYLKLQGLALGLDTGKIFNQVVSKNIYPLADGDVIVFYTDGVVEAINHEGKQFGYDRLLKIVNQSREKNAKD
ITNDIFTAVNDFTKTGGAVRDDLTLVVVKKL
>Mature_750_residues
SSKKRITYLFAFVIVLCEMFLLGLDVSIFYAIKAKTYLLPSGFIYLKDILASLVFIALYALIRKGIRLNRNDQTNPIWIE
PSRGAWDAMVTLVLIIGAIFVYDQTFPEAVYRRISNFGLDFYAPESLYTIFKSHFITLLLGSALLAGLITIERLILYKRT
KNTAINFALFIIALFGFSFSMAGTVPGAQFSPISLGLGITALILMFINAFRVSWILPMSRQDKWQIMGLTVIIGICGLIL
LNGFHFPPYLLWYSSFVGHFLLSLTAFVTLYFCVSFLGILIYLPSSRDFERKSEEVRKLYKMSKFITDVFDEDKIYTSLI
RFVCESIGENSLGWFDLYVPNSVSEKAAGTFHTVHYTDVSGTKQVAHFRTVATNNVSSNIIAEMQRSAGFIWQQVLEKKD
IVQVDDMVTDKRLNAKIPPIHAVLKRLNIRKRHPKPLFPIGSIVSVPLTMRSELIGIIHVAKDVEFSFIREDLELITIFA
DQAAIAIDNSRLIKQLIGKERLEQQLEIAREIQSRLLPQEPLQVPGFDMAGISEPAYEVGGDYYDFFQLDDGDEISRFGI
VIADVSGKGTSAAFYMAELKGIIQSLCKVYPDAPRDLLKKANETLSQSLGKNAYISLLYGVVDVKENTLSLVNAGHCPAA
AVMNKNPSYLKLQGLALGLDTGKIFNQVVSKNIYPLADGDVIVFYTDGVVEAINHEGKQFGYDRLLKIVNQSREKNAKDI
TNDIFTAVNDFTKTGGAVRDDLTLVVVKKL

Specific function: Positive regulator of sigma-B activity. Dephosphorylates rsbV in response to environmental stress conveyed from the rsbXST module [H]

COG id: COG2208

COG function: function code TK; Serine phosphatase RsbU, regulator of sigma subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PP2C-like domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017944
- InterPro:   IPR001932
- InterPro:   IPR014787
- InterPro:   IPR010822
- ProDom:   PD685490 [H]

Pfam domain/function: PF08673 RsbU_N; PF07228 SpoIIE [H]

EC number: =3.1.3.3 [H]

Molecular weight: Translated: 84181; Mature: 84050

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKKRITYLFAFVIVLCEMFLLGLDVSIFYAIKAKTYLLPSGFIYLKDILASLVFIALY
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEHHEEECCCCHHHHHHHHHHHHHHHHH
ALIRKGIRLNRNDQTNPIWIEPSRGAWDAMVTLVLIIGAIFVYDQTFPEAVYRRISNFGL
HHHHCCCEECCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
DFYAPESLYTIFKSHFITLLLGSALLAGLITIERLILYKRTKNTAINFALFIIALFGFSF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
SMAGTVPGAQFSPISLGLGITALILMFINAFRVSWILPMSRQDKWQIMGLTVIIGICGLI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
LLNGFHFPPYLLWYSSFVGHFLLSLTAFVTLYFCVSFLGILIYLPSSRDFERKSEEVRKL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHH
YKMSKFITDVFDEDKIYTSLIRFVCESIGENSLGWFDLYVPNSVSEKAAGTFHTVHYTDV
HHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHCCCCEEEEEEECC
SGTKQVAHFRTVATNNVSSNIIAEMQRSAGFIWQQVLEKKDIVQVDDMVTDKRLNAKIPP
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCCCCCCH
IHAVLKRLNIRKRHPKPLFPIGSIVSVPLTMRSELIGIIHVAKDVEFSFIREDLELITIF
HHHHHHHHCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHEEEE
ADQAAIAIDNSRLIKQLIGKERLEQQLEIAREIQSRLLPQEPLQVPGFDMAGISEPAYEV
ECCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHH
GGDYYDFFQLDDGDEISRFGIVIADVSGKGTSAAFYMAELKGIIQSLCKVYPDAPRDLLK
CCCEEEEEECCCCCCCHHCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
KANETLSQSLGKNAYISLLYGVVDVKENTLSLVNAGHCPAAAVMNKNPSYLKLQGLALGL
HHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHCCCCCEEEEEEEEEEC
DTGKIFNQVVSKNIYPLADGDVIVFYTDGVVEAINHEGKQFGYDRLLKIVNQSREKNAKD
CHHHHHHHHHHCCCCEECCCCEEEEEECCHHHHHCCCCHHCCHHHHHHHHHHHHHCCHHH
ITNDIFTAVNDFTKTGGAVRDDLTLVVVKKL
HHHHHHHHHHHHHHCCCCCCCCEEEEEEECC
>Mature Secondary Structure 
SSKKRITYLFAFVIVLCEMFLLGLDVSIFYAIKAKTYLLPSGFIYLKDILASLVFIALY
CCCHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEHHEEECCCCHHHHHHHHHHHHHHHHH
ALIRKGIRLNRNDQTNPIWIEPSRGAWDAMVTLVLIIGAIFVYDQTFPEAVYRRISNFGL
HHHHCCCEECCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
DFYAPESLYTIFKSHFITLLLGSALLAGLITIERLILYKRTKNTAINFALFIIALFGFSF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
SMAGTVPGAQFSPISLGLGITALILMFINAFRVSWILPMSRQDKWQIMGLTVIIGICGLI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
LLNGFHFPPYLLWYSSFVGHFLLSLTAFVTLYFCVSFLGILIYLPSSRDFERKSEEVRKL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHH
YKMSKFITDVFDEDKIYTSLIRFVCESIGENSLGWFDLYVPNSVSEKAAGTFHTVHYTDV
HHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHCCCCEEEEEEECC
SGTKQVAHFRTVATNNVSSNIIAEMQRSAGFIWQQVLEKKDIVQVDDMVTDKRLNAKIPP
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCCCCCCH
IHAVLKRLNIRKRHPKPLFPIGSIVSVPLTMRSELIGIIHVAKDVEFSFIREDLELITIF
HHHHHHHHCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHEEEE
ADQAAIAIDNSRLIKQLIGKERLEQQLEIAREIQSRLLPQEPLQVPGFDMAGISEPAYEV
ECCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHH
GGDYYDFFQLDDGDEISRFGIVIADVSGKGTSAAFYMAELKGIIQSLCKVYPDAPRDLLK
CCCEEEEEECCCCCCCHHCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
KANETLSQSLGKNAYISLLYGVVDVKENTLSLVNAGHCPAAAVMNKNPSYLKLQGLALGL
HHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHCCCCCEEEEEEEEEEC
DTGKIFNQVVSKNIYPLADGDVIVFYTDGVVEAINHEGKQFGYDRLLKIVNQSREKNAKD
CHHHHHHHHHHCCCCEECCCCEEEEEECCHHHHHCCCCHHCCHHHHHHHHHHHHHCCHHH
ITNDIFTAVNDFTKTGGAVRDDLTLVVVKKL
HHHHHHHHHHHHHHCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8002610; 8002609; 9384377; 8824586; 9786195; 12499568 [H]