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The map label for this gene is cobC [H]

Identifier: 193213828

GI number: 193213828

Start: 127191

End: 127781

Strand: Direct

Name: cobC [H]

Synonym: Ctha_0109

Alternate gene names: 193213828

Gene position: 127191-127781 (Clockwise)

Preceding gene: 193213827

Following gene: 193213829

Centisome position: 3.86

GC content: 46.87

Gene sequence:

>591_bases
ATGGAAGTCTTTTTAGTTCGTCATCTCGAAATTCCATCTTATGAAAAGGGCGTCTGCGTCGGCCAATCCGACGTTGCATT
AACCGAAACGGGTTTGGCAAACATTCAGCCACTTGCCGAAACACTCGCCGACCTTGAGCCCGAAGTGATTATCACGAGCG
ATCTTCAACGCTGCAAAAAACTCGCTGAAGCCATCGGCAGCTGCTTGAATTTGCAGATTGAAGTCAATCCAGAATGGCGT
GAAATCAATTTCGGCGAATGGGAAAATCGTGAATGGGAAGAACTTAGGGAAAATGATCCCGAAAATGTCAAAAAATGGAT
TGACGATTACGTGCATGTCACGCCACCGGAAGGGGAATCGTTTTTCCAACTTTTTGAGCGTGTGGGCAATCAACTTATGG
ATCTAACTCGACGCGAAAAAAAGCGCATCATAATTGTAACGCACTCGGGCGCCATTCGCTCGGCGCTTTGCTTCGCACTT
GGCATTCCGCTCGATCGCTCATTCTCTTTGGAAATCAGCTACGGCGCGATTGCTGGCTTGCATTATTTAAACGACCGATG
GTCGCTGTTTCGATTAACTAACCAACTATAA

Upstream 100 bases:

>100_bases
TTACTGGCGACACGCTCGGTGCAGCCAGCCAATTCGTTGAACTTTCCGTTTATTTAGGCATCTTAATTCAATCAAATTTT
CTTACCACTATTTCTCTTCT

Downstream 100 bases:

>100_bases
TTCCCCCAACTACTTATATGGAAACTTTTTATCATAACGGCGTAGAAAAGAGCGTGACAATTAAAGAAGCTCAATTATTT
CAACGCTCTATGAGTTTATT

Product: phosphoglycerate mutase

Products: NA

Alternate protein names: Alpha-ribazole-5'-phosphate phosphatase [H]

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MEVFLVRHLEIPSYEKGVCVGQSDVALTETGLANIQPLAETLADLEPEVIITSDLQRCKKLAEAIGSCLNLQIEVNPEWR
EINFGEWENREWEELRENDPENVKKWIDDYVHVTPPEGESFFQLFERVGNQLMDLTRREKKRIIIVTHSGAIRSALCFAL
GIPLDRSFSLEISYGAIAGLHYLNDRWSLFRLTNQL

Sequences:

>Translated_196_residues
MEVFLVRHLEIPSYEKGVCVGQSDVALTETGLANIQPLAETLADLEPEVIITSDLQRCKKLAEAIGSCLNLQIEVNPEWR
EINFGEWENREWEELRENDPENVKKWIDDYVHVTPPEGESFFQLFERVGNQLMDLTRREKKRIIIVTHSGAIRSALCFAL
GIPLDRSFSLEISYGAIAGLHYLNDRWSLFRLTNQL
>Mature_196_residues
MEVFLVRHLEIPSYEKGVCVGQSDVALTETGLANIQPLAETLADLEPEVIITSDLQRCKKLAEAIGSCLNLQIEVNPEWR
EINFGEWENREWEELRENDPENVKKWIDDYVHVTPPEGESFFQLFERVGNQLMDLTRREKKRIIIVTHSGAIRSALCFAL
GIPLDRSFSLEISYGAIAGLHYLNDRWSLFRLTNQL

Specific function: Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin [H]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family [H]

Homologues:

Organism=Escherichia coli, GI1786857, Length=195, Percent_Identity=26.1538461538462, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1790856, Length=189, Percent_Identity=29.1005291005291, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR017578 [H]

Pfam domain/function: PF00300 PGAM [H]

EC number: =3.1.3.73 [H]

Molecular weight: Translated: 22530; Mature: 22530

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVFLVRHLEIPSYEKGVCVGQSDVALTETGLANIQPLAETLADLEPEVIITSDLQRCKK
CCEEEEEECCCCCCCCCEEECCCCCEEECCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHH
LAEAIGSCLNLQIEVNPEWREINFGEWENREWEELRENDPENVKKWIDDYVHVTPPEGES
HHHHHHHHEEEEEEECCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHCCEEECCCCCHH
FFQLFERVGNQLMDLTRREKKRIIIVTHSGAIRSALCFALGIPLDRSFSLEISYGAIAGL
HHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCCCEEEEECCHHHHHH
HYLNDRWSLFRLTNQL
HHHCCCHHHHHHHCCC
>Mature Secondary Structure
MEVFLVRHLEIPSYEKGVCVGQSDVALTETGLANIQPLAETLADLEPEVIITSDLQRCKK
CCEEEEEECCCCCCCCCEEECCCCCEEECCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHH
LAEAIGSCLNLQIEVNPEWREINFGEWENREWEELRENDPENVKKWIDDYVHVTPPEGES
HHHHHHHHEEEEEEECCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHCCEEECCCCCHH
FFQLFERVGNQLMDLTRREKKRIIIVTHSGAIRSALCFALGIPLDRSFSLEISYGAIAGL
HHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCCCEEEEECCHHHHHH
HYLNDRWSLFRLTNQL
HHHCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]