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The map label for this gene is panC

Identifier: 193213753

GI number: 193213753

Start: 45156

End: 46010

Strand: Direct

Name: panC

Synonym: Ctha_0033

Alternate gene names: 193213753

Gene position: 45156-46010 (Clockwise)

Preceding gene: 193213752

Following gene: 193213754

Centisome position: 1.37

GC content: 49.12

Gene sequence:

>855_bases
ATGAAAATTATTGAGACGGTTTCTGAAATGCAGCACTTTTCCGAGTCGCTTCGGATTGCAGAAAAACGGCTTGGCGTGGT
GCCAACCATGGGCGCTTTGCACGACGGTCATTTAAGTTTGGTAAAACTTGCTCTTAAGCACGCCGACGTGGCGATTATGA
CTATTTTCGTCAATCCGCTGCAATTTGGCCCAAGCGAAGATTTTGCAAAATACCCACGCACATTTGAACGCGATGCCATG
CTTGCCGAAAAAGCAGGCGTTTCGTGCATTTTCGCGCCAACCCCCGAGACGCTTTATCCGAGTGGGTTTCAAACACACGT
CACGGTCGATGAGATTACCCAAGGATTTGAAGGCGAGCTCCGACCAGGACATTTTCGCGGCGTCACTACGGTGGTTGCAA
AACTTTTCAACATCACCAAACCGCACGTGGCCGTTTTTGGCGAAAAGGACGCACAGCAACTGGCTGCGATTCGAAAAATG
CAAAAGGATTTGAATTTTGATGTCGAAATTGTTCCCGCGCCGATTGTTCGCGAAACCGATGGCTTAGCCAAAAGCTCACG
AAACATTTACCTCAACCCGGCGGAACGCAAGCAAGCTGTGGTTCTCAACGAATCGCTTGAAATTGCCAAAAGTGCCATAC
AACATGGCGAGCGCAATGTAAAAACGCTGCTCGAGGTGCTAAATCGCCACATTCAAAGCGCGCCGCTTGCTGAGCCGGAT
TACATCGCGATTGTTGATGCCGAAAGCTTTCAGCCTGTACAAGAAGAACTTCTGGCAGAGGAAACCTATCTTGTTTTGCT
TACGGTTCGTTTCGGGTCAACGCGTTTGCTCGATAACTGCCGAATTGAGCTTTAG

Upstream 100 bases:

>100_bases
GCGAAAGCAAATTTGCAGGAAAGGAAAATTCAAGGCGAGTTTGTCGTGATTGTTGAAGGAAAAAACGCGAAATCCAAAAA
CGAGACGTACGAAAACCAAG

Downstream 100 bases:

>100_bases
CCAAAATGCTTCGGCGAACGGATTTTCAAGCCTGGACTTTTTTCCGATGCGATGAAAAATCAGATTCGAAGATTTTGAAA
AGTACGCAAATTGATTTACT

Product: pantoate/beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MKIIETVSEMQHFSESLRIAEKRLGVVPTMGALHDGHLSLVKLALKHADVAIMTIFVNPLQFGPSEDFAKYPRTFERDAM
LAEKAGVSCIFAPTPETLYPSGFQTHVTVDEITQGFEGELRPGHFRGVTTVVAKLFNITKPHVAVFGEKDAQQLAAIRKM
QKDLNFDVEIVPAPIVRETDGLAKSSRNIYLNPAERKQAVVLNESLEIAKSAIQHGERNVKTLLEVLNRHIQSAPLAEPD
YIAIVDAESFQPVQEELLAEETYLVLLTVRFGSTRLLDNCRIEL

Sequences:

>Translated_284_residues
MKIIETVSEMQHFSESLRIAEKRLGVVPTMGALHDGHLSLVKLALKHADVAIMTIFVNPLQFGPSEDFAKYPRTFERDAM
LAEKAGVSCIFAPTPETLYPSGFQTHVTVDEITQGFEGELRPGHFRGVTTVVAKLFNITKPHVAVFGEKDAQQLAAIRKM
QKDLNFDVEIVPAPIVRETDGLAKSSRNIYLNPAERKQAVVLNESLEIAKSAIQHGERNVKTLLEVLNRHIQSAPLAEPD
YIAIVDAESFQPVQEELLAEETYLVLLTVRFGSTRLLDNCRIEL
>Mature_284_residues
MKIIETVSEMQHFSESLRIAEKRLGVVPTMGALHDGHLSLVKLALKHADVAIMTIFVNPLQFGPSEDFAKYPRTFERDAM
LAEKAGVSCIFAPTPETLYPSGFQTHVTVDEITQGFEGELRPGHFRGVTTVVAKLFNITKPHVAVFGEKDAQQLAAIRKM
QKDLNFDVEIVPAPIVRETDGLAKSSRNIYLNPAERKQAVVLNESLEIAKSAIQHGERNVKTLLEVLNRHIQSAPLAEPD
YIAIVDAESFQPVQEELLAEETYLVLLTVRFGSTRLLDNCRIEL

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=286, Percent_Identity=44.0559440559441, Blast_Score=237, Evalue=7e-64,
Organism=Saccharomyces cerevisiae, GI6322046, Length=274, Percent_Identity=37.2262773722628, Blast_Score=166, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_CHLT3 (B3QSB4)

Other databases:

- EMBL:   CP001100
- RefSeq:   YP_001994952.1
- GeneID:   6421205
- GenomeReviews:   CP001100_GR
- KEGG:   cts:Ctha_0033
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31642; Mature: 31642

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 153-153 BINDING 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIETVSEMQHFSESLRIAEKRLGVVPTMGALHDGHLSLVKLALKHADVAIMTIFVNPL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEEECCC
QFGPSEDFAKYPRTFERDAMLAEKAGVSCIFAPTPETLYPSGFQTHVTVDEITQGFEGEL
CCCCCHHHHHCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEHHHHHCCCCCCC
RPGHFRGVTTVVAKLFNITKPHVAVFGEKDAQQLAAIRKMQKDLNFDVEIVPAPIVRETD
CCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCCEECCC
GLAKSSRNIYLNPAERKQAVVLNESLEIAKSAIQHGERNVKTLLEVLNRHIQSAPLAEPD
CHHHCCCCEEECCCCCCEEEEECHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCC
YIAIVDAESFQPVQEELLAEETYLVLLTVRFGSTRLLDNCRIEL
EEEEEECCCCCHHHHHHHHCCEEEEEEEEECCCEEECCCCEECC
>Mature Secondary Structure
MKIIETVSEMQHFSESLRIAEKRLGVVPTMGALHDGHLSLVKLALKHADVAIMTIFVNPL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEEECCC
QFGPSEDFAKYPRTFERDAMLAEKAGVSCIFAPTPETLYPSGFQTHVTVDEITQGFEGEL
CCCCCHHHHHCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEHHHHHCCCCCCC
RPGHFRGVTTVVAKLFNITKPHVAVFGEKDAQQLAAIRKMQKDLNFDVEIVPAPIVRETD
CCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCCEECCC
GLAKSSRNIYLNPAERKQAVVLNESLEIAKSAIQHGERNVKTLLEVLNRHIQSAPLAEPD
CHHHCCCCEEECCCCCCEEEEECHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCC
YIAIVDAESFQPVQEELLAEETYLVLLTVRFGSTRLLDNCRIEL
EEEEEECCCCCHHHHHHHHCCEEEEEEEEECCCEEECCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA