Click here to switch to the map view.

The map label for this gene is pgk

Identifier: 193213710

GI number: 193213710

Start: 2279386

End: 2280579

Strand: Direct

Name: pgk

Synonym: Cpar_2077

Alternate gene names: 193213710

Gene position: 2279386-2280579 (Clockwise)

Preceding gene: 193213709

Following gene: 193213711

Centisome position: 99.57

GC content: 59.72

Gene sequence:

>1194_bases
ATGCAGAAAAAGACGTTGTCTGACATATCGTTACAGGGAAAACGGGTCTTGATGCGTGTTGATTTTAACGTTCCGCTCGA
TCAGGACAGGAACATCACCGACGACAAAAGAATTGTCGGGGCGCTGCCTTCGATCCGCAAGGTTATCGAAGAGGGCGGAC
GGCTGATCCTGATGTCGCACCTCGGCAGACCCAAAGGCAAAGTCAATCCCGCATTCTCCCTGGCACCGGCGGCAAAGCGT
CTTTCGGAGCTGCTCGGTATGCCGGTGACGATGGCAAATGACTGCATCGGCACTGAAGTGATGCAGGAGGTGCTCGCCCT
GCAGGATGGCGAAGTGATGATGCTTGAAAACCTCCGGTTCCATCCCGAAGAGGAGGCAAACGATCCGGATTTCGCCCGCG
AGCTGGCATCGATGGGCGAAATCTACGTGAACGATGCGTTCGGAACGGCCCACCGCGCCCACGCTTCGACCGAAGGCATC
ACCCACTACGTGCCGACCGCCGTGGCCGGCTACCTTATCGAAAAGGAGCTGCGCTACCTCGGCACGGCACTCAACGATGC
AAAACGACCGTTCGTGGCCATTCTCGGCGGCGCCAAGATTTCCGGCAAGATCGACGTGCTCGAACACCTGTTCGACAAGG
TCGATACCGTGCTGGTAGGCGGCGCGATGGTCTTCACCTTTTTCAAGGCGCAGGGACTGCCGGTCGGCAACTCGCTGGTG
GAAGACAACAAAATCGAGCTGGCCATCTCTCTGCTTGAAAAGGCCAAAGAGAAGGGCGTTCGCCTGATCCTTCCGGAAGA
TGTGGTGGTCGCTGCCGAAATCTCGGCTGACGCCGCCTCGCGAGTCGAACCGGTTACGACGATCTCGGACGGCATGAGCG
GCCTCGACATCGGCCCGGCAACCATCGAAACCTACGCCAAAGAGATTCTCGGCGCCAAAACCGTGCTCTGGAACGGCCCG
ATGGGTGTGTTCGAAATCGACCAGTTCGCCAAAGGCACCTTCGCCGTCGCCCAGGCGCTTGCCGATGCAACCGATGCCGG
CGCCATCACCATCATCGGCGGTGGAGACTCGGCGGCGGCCATCGCCAAAGCGGGTCTGTCCGACAAGGTGACCCACGTCT
CGACCGGCGGCGGAGCCAGCCTCGAATTCCTCGAAGGCAAGGAGCTTCCCGGCATCGCGGCGCTGAACGATTAA

Upstream 100 bases:

>100_bases
AATCGGGTCGTGTAATAGGTTTTTAAAGGTGTCCTAATGTATATTCACGTTTACGAAAACTTCACCGTCCCACGAATCCA
CCAACCAACATCACAGGGAA

Downstream 100 bases:

>100_bases
CCCCTGACGCGCATTGTTGGTGACGGAAGCAAATTCCGAACCGTACGAACAATCTTGGGCGCTTCTGAAAAACAGCTTGA
TGCAGAGCAACAGGTTTTCA

Product: phosphoglycerate kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MQKKTLSDISLQGKRVLMRVDFNVPLDQDRNITDDKRIVGALPSIRKVIEEGGRLILMSHLGRPKGKVNPAFSLAPAAKR
LSELLGMPVTMANDCIGTEVMQEVLALQDGEVMMLENLRFHPEEEANDPDFARELASMGEIYVNDAFGTAHRAHASTEGI
THYVPTAVAGYLIEKELRYLGTALNDAKRPFVAILGGAKISGKIDVLEHLFDKVDTVLVGGAMVFTFFKAQGLPVGNSLV
EDNKIELAISLLEKAKEKGVRLILPEDVVVAAEISADAASRVEPVTTISDGMSGLDIGPATIETYAKEILGAKTVLWNGP
MGVFEIDQFAKGTFAVAQALADATDAGAITIIGGGDSAAAIAKAGLSDKVTHVSTGGGASLEFLEGKELPGIAALND

Sequences:

>Translated_397_residues
MQKKTLSDISLQGKRVLMRVDFNVPLDQDRNITDDKRIVGALPSIRKVIEEGGRLILMSHLGRPKGKVNPAFSLAPAAKR
LSELLGMPVTMANDCIGTEVMQEVLALQDGEVMMLENLRFHPEEEANDPDFARELASMGEIYVNDAFGTAHRAHASTEGI
THYVPTAVAGYLIEKELRYLGTALNDAKRPFVAILGGAKISGKIDVLEHLFDKVDTVLVGGAMVFTFFKAQGLPVGNSLV
EDNKIELAISLLEKAKEKGVRLILPEDVVVAAEISADAASRVEPVTTISDGMSGLDIGPATIETYAKEILGAKTVLWNGP
MGVFEIDQFAKGTFAVAQALADATDAGAITIIGGGDSAAAIAKAGLSDKVTHVSTGGGASLEFLEGKELPGIAALND
>Mature_397_residues
MQKKTLSDISLQGKRVLMRVDFNVPLDQDRNITDDKRIVGALPSIRKVIEEGGRLILMSHLGRPKGKVNPAFSLAPAAKR
LSELLGMPVTMANDCIGTEVMQEVLALQDGEVMMLENLRFHPEEEANDPDFARELASMGEIYVNDAFGTAHRAHASTEGI
THYVPTAVAGYLIEKELRYLGTALNDAKRPFVAILGGAKISGKIDVLEHLFDKVDTVLVGGAMVFTFFKAQGLPVGNSLV
EDNKIELAISLLEKAKEKGVRLILPEDVVVAAEISADAASRVEPVTTISDGMSGLDIGPATIETYAKEILGAKTVLWNGP
MGVFEIDQFAKGTFAVAQALADATDAGAITIIGGGDSAAAIAKAGLSDKVTHVSTGGGASLEFLEGKELPGIAALND

Specific function: Second phase of glycolysis; second step. [C]

COG id: COG0126

COG function: function code G; 3-phosphoglycerate kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate kinase family

Homologues:

Organism=Homo sapiens, GI4505763, Length=415, Percent_Identity=44.8192771084337, Blast_Score=348, Evalue=4e-96,
Organism=Homo sapiens, GI31543397, Length=415, Percent_Identity=44.0963855421687, Blast_Score=348, Evalue=4e-96,
Organism=Escherichia coli, GI1789294, Length=394, Percent_Identity=42.6395939086294, Blast_Score=294, Evalue=6e-81,
Organism=Caenorhabditis elegans, GI17508823, Length=414, Percent_Identity=46.8599033816425, Blast_Score=365, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6319857, Length=412, Percent_Identity=48.5436893203884, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24581203, Length=416, Percent_Identity=46.3942307692308, Blast_Score=359, Evalue=2e-99,
Organism=Drosophila melanogaster, GI17136394, Length=413, Percent_Identity=45.5205811138014, Blast_Score=336, Evalue=2e-92,

Paralogues:

None

Copy number: 2990 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1460 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). [C]

Swissprot (AC and ID): PGK_CHLP8 (B3QLX7)

Other databases:

- EMBL:   CP001099
- RefSeq:   YP_001999663.1
- GeneID:   6421030
- GenomeReviews:   CP001099_GR
- KEGG:   cpc:Cpar_2077
- HOGENOM:   HBG453500
- OMA:   LSYFSKA
- ProtClustDB:   PRK00073
- GO:   GO:0005737
- GO:   GO:0006096
- HAMAP:   MF_00145
- InterPro:   IPR001576
- InterPro:   IPR015901
- InterPro:   IPR015911
- InterPro:   IPR015824
- Gene3D:   G3DSA:3.40.50.1270
- Gene3D:   G3DSA:3.40.50.1260
- PANTHER:   PTHR11406
- PIRSF:   PIRSF000724
- PRINTS:   PR00477

Pfam domain/function: PF00162 PGK; SSF53748 PGK

EC number: =2.7.2.3

Molecular weight: Translated: 42104; Mature: 42104

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00111 PGLYCERATE_KINASE

Important sites: BINDING 37-37 BINDING 119-119 BINDING 152-152 BINDING 203-203 BINDING 294-294 BINDING 325-325

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKKTLSDISLQGKRVLMRVDFNVPLDQDRNITDDKRIVGALPSIRKVIEEGGRLILMSH
CCCCCCCHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHCCHHHHHHHHHCCCEEEEEC
LGRPKGKVNPAFSLAPAAKRLSELLGMPVTMANDCIGTEVMQEVLALQDGEVMMLENLRF
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
HPEEEANDPDFARELASMGEIYVNDAFGTAHRAHASTEGITHYVPTAVAGYLIEKELRYL
CCCCCCCCHHHHHHHHHCCCEEEECCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
GTALNDAKRPFVAILGGAKISGKIDVLEHLFDKVDTVLVGGAMVFTFFKAQGLPVGNSLV
HHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
EDNKIELAISLLEKAKEKGVRLILPEDVVVAAEISADAASRVEPVTTISDGMSGLDIGPA
CCCHHHHHHHHHHHHHHCCCEEECCCCEEEEEECCCCHHHHCCCCHHHHCCCCCCCCCHH
TIETYAKEILGAKTVLWNGPMGVFEIDQFAKGTFAVAQALADATDAGAITIIGGGDSAAA
HHHHHHHHHHCCCEEEECCCCCCEEHHHHHCHHHHHHHHHHCCCCCCEEEEEECCCCHHH
IAKAGLSDKVTHVSTGGGASLEFLEGKELPGIAALND
HHHCCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MQKKTLSDISLQGKRVLMRVDFNVPLDQDRNITDDKRIVGALPSIRKVIEEGGRLILMSH
CCCCCCCHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHCCHHHHHHHHHCCCEEEEEC
LGRPKGKVNPAFSLAPAAKRLSELLGMPVTMANDCIGTEVMQEVLALQDGEVMMLENLRF
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
HPEEEANDPDFARELASMGEIYVNDAFGTAHRAHASTEGITHYVPTAVAGYLIEKELRYL
CCCCCCCCHHHHHHHHHCCCEEEECCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
GTALNDAKRPFVAILGGAKISGKIDVLEHLFDKVDTVLVGGAMVFTFFKAQGLPVGNSLV
HHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
EDNKIELAISLLEKAKEKGVRLILPEDVVVAAEISADAASRVEPVTTISDGMSGLDIGPA
CCCHHHHHHHHHHHHHHCCCEEECCCCEEEEEECCCCHHHHCCCCHHHHCCCCCCCCCHH
TIETYAKEILGAKTVLWNGPMGVFEIDQFAKGTFAVAQALADATDAGAITIIGGGDSAAA
HHHHHHHHHHCCCEEEECCCCCCEEHHHHHCHHHHHHHHHHCCCCCCEEEEEECCCCHHH
IAKAGLSDKVTHVSTGGGASLEFLEGKELPGIAALND
HHHCCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA