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The map label for this gene is tetA [H]

Identifier: 193212871

GI number: 193212871

Start: 1331795

End: 1333060

Strand: Direct

Name: tetA [H]

Synonym: Cpar_1219

Alternate gene names: 193212871

Gene position: 1331795-1333060 (Clockwise)

Preceding gene: 193212863

Following gene: 193212872

Centisome position: 58.18

GC content: 58.14

Gene sequence:

>1266_bases
ATGAAGAAATCACCGCTGGTCATTCTGTTCCTGACAGTTCTGCTCGACCTGATCGGCTTCGGTATCGTGCTTCCGCTGCT
GCCGACCTATGCCAAGGAGCTTGGAGCGTCGCCCTTCATGATCGGCCTGATCGCGGCGATCTACTCGACGATGCAGTTCA
TCTTTTCGCCGATCTGGGGCAAGCTGAGCGACAAGATCGGACGACGTCCGGTAATGCTGTCGAGCATCTTTCTGGCCTCA
GTCTCCTACGTCTTCTTCTCACAGGCGGTGACGATTCCTCTCCTGATTCTGGCGCGTTCGCTGTCGGGAATCGGCTCGGC
CAACATCGCGGCGGCGCAGGCAGCCATTACCGACGTGACCGACTCGAAAAGCCGCTCGGGCGCAATGGGCATGCTTGGCG
CAGCGTTCGGTATCGGCTTCATCATCGGCCCGCTGATCGGCGGTGTGCTGATGACCAACTTCGGCATTTCGATGGTCGGT
CTGTTCGCAGCCGGACTGAACTTCACCAACTTCACCCTGGCGCTCTTCCTGCTAAGCGAAACCAATCCTCACGCCGAGGG
CTTCCTGTCGCTCTTCAGAAAGAGCGGAGAAGCAGCTCATGCCGACACCTCGCTCCTGGCCTCGCTCGCCCGCAAGAGCA
GCGCGTATGCGGAACGAGTCCACGAAGCGTTCAGCTCACGTCCGGTGGCGCTGCTGATGATTATCAACTTCATCTACTCG
CTGGCAATCGTGAACATGCAGGTGGCGGCGATTCTGCTTTGGGGCGACAGGTTCCACACTACCGAGCAGCAGGTAGGCTA
CCTGTTCGCTTACGTCGGGTTCATTTCGGTGATCGTGCAGGGCGGAATGCTGCCGAAAATGACCCGCAAGCTCGGCGAGC
ACAAGCTCATGGTTTTCGGCCACATTGCTTCGTTTATCGGTGTCTTTTTCATCCCGTTCATTCCGGTAAACGCACTCTTC
ACGATCGGCCTCGGCATCCTGCTCTTTTTCGCCATCGGCACGAGTCTGGTCAACCCGCTGAACATTTCGATGATCTCGCT
CTACAGCTACAAGCAGAAGCAGGGGCAGATTATGGGCTTCGCGCAGTCGGTCAACGCCCTGGCCCGCATCCTCGGCCCCA
TCACCGGCAGTGTGCTTTACGGGATGGACTACCGGTTCCCCTACTACACGGCGGGAGCGCTGACCATCATCGGGACGATC
ATATCCATGAGCCTGTTCAAATACGACATCGAGGCGCTGGAGCCATCGGCAAGCGTAGCAGACTAA

Upstream 100 bases:

>100_bases
TTTCCCCCATCCACCCCACAAACTTGACATGCCGTTTCAACATGGCGGGCGATTTTTGTATTTTGGGCATTTTCAGCTCC
ATCTAACGGCTCGCCCCTTC

Downstream 100 bases:

>100_bases
CCAACCGACTGCAAACGAAAAGGAGACAACCATGCGCATAGGCGTTGCAGGCGTCGGCAAGCTCGGCGAATTCCATACGA
ACCTACTCAAACAGATCGCC

Product: major facilitator superfamily protein

Products: NA

Alternate protein names: TetA(A) [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MKKSPLVILFLTVLLDLIGFGIVLPLLPTYAKELGASPFMIGLIAAIYSTMQFIFSPIWGKLSDKIGRRPVMLSSIFLAS
VSYVFFSQAVTIPLLILARSLSGIGSANIAAAQAAITDVTDSKSRSGAMGMLGAAFGIGFIIGPLIGGVLMTNFGISMVG
LFAAGLNFTNFTLALFLLSETNPHAEGFLSLFRKSGEAAHADTSLLASLARKSSAYAERVHEAFSSRPVALLMIINFIYS
LAIVNMQVAAILLWGDRFHTTEQQVGYLFAYVGFISVIVQGGMLPKMTRKLGEHKLMVFGHIASFIGVFFIPFIPVNALF
TIGLGILLFFAIGTSLVNPLNISMISLYSYKQKQGQIMGFAQSVNALARILGPITGSVLYGMDYRFPYYTAGALTIIGTI
ISMSLFKYDIEALEPSASVAD

Sequences:

>Translated_421_residues
MKKSPLVILFLTVLLDLIGFGIVLPLLPTYAKELGASPFMIGLIAAIYSTMQFIFSPIWGKLSDKIGRRPVMLSSIFLAS
VSYVFFSQAVTIPLLILARSLSGIGSANIAAAQAAITDVTDSKSRSGAMGMLGAAFGIGFIIGPLIGGVLMTNFGISMVG
LFAAGLNFTNFTLALFLLSETNPHAEGFLSLFRKSGEAAHADTSLLASLARKSSAYAERVHEAFSSRPVALLMIINFIYS
LAIVNMQVAAILLWGDRFHTTEQQVGYLFAYVGFISVIVQGGMLPKMTRKLGEHKLMVFGHIASFIGVFFIPFIPVNALF
TIGLGILLFFAIGTSLVNPLNISMISLYSYKQKQGQIMGFAQSVNALARILGPITGSVLYGMDYRFPYYTAGALTIIGTI
ISMSLFKYDIEALEPSASVAD
>Mature_421_residues
MKKSPLVILFLTVLLDLIGFGIVLPLLPTYAKELGASPFMIGLIAAIYSTMQFIFSPIWGKLSDKIGRRPVMLSSIFLAS
VSYVFFSQAVTIPLLILARSLSGIGSANIAAAQAAITDVTDSKSRSGAMGMLGAAFGIGFIIGPLIGGVLMTNFGISMVG
LFAAGLNFTNFTLALFLLSETNPHAEGFLSLFRKSGEAAHADTSLLASLARKSSAYAERVHEAFSSRPVALLMIINFIYS
LAIVNMQVAAILLWGDRFHTTEQQVGYLFAYVGFISVIVQGGMLPKMTRKLGEHKLMVFGHIASFIGVFFIPFIPVNALF
TIGLGILLFFAIGTSLVNPLNISMISLYSYKQKQGQIMGFAQSVNALARILGPITGSVLYGMDYRFPYYTAGALTIIGTI
ISMSLFKYDIEALEPSASVAD

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI217416366, Length=428, Percent_Identity=26.6355140186916, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI225703104, Length=345, Percent_Identity=26.0869565217391, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI225703102, Length=345, Percent_Identity=26.0869565217391, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI166064062, Length=361, Percent_Identity=25.4847645429363, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI166064060, Length=361, Percent_Identity=25.4847645429363, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI87081738, Length=195, Percent_Identity=31.7948717948718, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17551570, Length=418, Percent_Identity=24.4019138755981, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71996331, Length=410, Percent_Identity=21.4634146341463, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17738085, Length=373, Percent_Identity=27.0777479892761, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45235; Mature: 45235

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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C
>Mature Secondary Structure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C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312499; 6310527 [H]