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The map label for this gene is thiD [H]

Identifier: 193212773

GI number: 193212773

Start: 1236430

End: 1237260

Strand: Direct

Name: thiD [H]

Synonym: Cpar_1119

Alternate gene names: 193212773

Gene position: 1236430-1237260 (Clockwise)

Preceding gene: 193212772

Following gene: 193212778

Centisome position: 54.01

GC content: 58.6

Gene sequence:

>831_bases
ATGAACGCGACACGCGACTACACAACAGTACTGACCATCGCCGGTTCGGACGGCAGTGGCGGTGCAGGTATCCAGGCAGA
CCTGAAAACCATCGCCGCGCATAGCTGCTACGGCCTGAGCGTCATCACCGCCGTGACTGCGCAAAGCACGATGGGGGTAG
CTGACGTTCACCCGATTCCATCCTCATTTATCGCCAAGCAGTTCGAGACAATTGTATCGGATATCCGCATCGATGCGATC
AAGATCGGCATGCTGGGCCCTGCTGGGAACGCTGAGACGATTGCAGGGCTGATTGCAGGACTCGACGGCGTGCCGATCGT
GCTCGACACCGTGCTGCGCTCTTCGAGCGGTGCCGCGCTGTTTTCGGCGAACGATACGGCGGCAATGAAACGTCTATTTC
CGCTGGTAAGCCTCATCACCCCGAACCTGCCCGAAGCAACCATGCTGACAGGCCGTAACGCCCCGCCATCAGGCGGCAAA
GAGGAGATCGAACAGATCGCGCTGGAGTTACAAATGCAGGGAGCACCGTCGGTGCTGGTCAAAGGCGGGCACTGGGAGGG
CAAGGTTTGTCACGACTGCCTGCTGCACGAAGAGAGGTTTTACTGGTTTTCGAATCCGAAAATCAACACCGTCAACACGC
ACGGCACCGGCTGCACGCTCTCATCAGCCATCGCAGCGGGGTTTGCAATGAAATTGGGGATGTCCGAAGCCGTAGCCAGA
GGAATCGATTATACCCGCAAAGCATTGCAGGCCGGCGCAGGCTGGAGACTTGGTCACGGACACGGCCCGCTCTACCACTT
TCCCGACAAGACTGAAAGTCGGGCTGACTGA

Upstream 100 bases:

>100_bases
TCATCAAGGCCGGAGCATCAGGCGTTGCGGTCATCTCGGCAGTCTCAGGTAGTGCCGACCCGGTTGCAGCGACCCGCGAA
CTGGTCAAACGCATCCGTCA

Downstream 100 bases:

>100_bases
CCGGAAAGAGTCACGGTTATCGTCACTCAAAGCCAACCAACAAACTGCGTTCAGCTCATAACCACTCTATCCATTGCGCT
ACCCCCTCTTTGGTGCCATA

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MNATRDYTTVLTIAGSDGSGGAGIQADLKTIAAHSCYGLSVITAVTAQSTMGVADVHPIPSSFIAKQFETIVSDIRIDAI
KIGMLGPAGNAETIAGLIAGLDGVPIVLDTVLRSSSGAALFSANDTAAMKRLFPLVSLITPNLPEATMLTGRNAPPSGGK
EEIEQIALELQMQGAPSVLVKGGHWEGKVCHDCLLHEERFYWFSNPKINTVNTHGTGCTLSSAIAAGFAMKLGMSEAVAR
GIDYTRKALQAGAGWRLGHGHGPLYHFPDKTESRAD

Sequences:

>Translated_276_residues
MNATRDYTTVLTIAGSDGSGGAGIQADLKTIAAHSCYGLSVITAVTAQSTMGVADVHPIPSSFIAKQFETIVSDIRIDAI
KIGMLGPAGNAETIAGLIAGLDGVPIVLDTVLRSSSGAALFSANDTAAMKRLFPLVSLITPNLPEATMLTGRNAPPSGGK
EEIEQIALELQMQGAPSVLVKGGHWEGKVCHDCLLHEERFYWFSNPKINTVNTHGTGCTLSSAIAAGFAMKLGMSEAVAR
GIDYTRKALQAGAGWRLGHGHGPLYHFPDKTESRAD
>Mature_276_residues
MNATRDYTTVLTIAGSDGSGGAGIQADLKTIAAHSCYGLSVITAVTAQSTMGVADVHPIPSSFIAKQFETIVSDIRIDAI
KIGMLGPAGNAETIAGLIAGLDGVPIVLDTVLRSSSGAALFSANDTAAMKRLFPLVSLITPNLPEATMLTGRNAPPSGGK
EEIEQIALELQMQGAPSVLVKGGHWEGKVCHDCLLHEERFYWFSNPKINTVNTHGTGCTLSSAIAAGFAMKLGMSEAVAR
GIDYTRKALQAGAGWRLGHGHGPLYHFPDKTESRAD

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=258, Percent_Identity=44.1860465116279, Blast_Score=194, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6325378, Length=256, Percent_Identity=35.546875, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6324997, Length=271, Percent_Identity=36.5313653136531, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324517, Length=256, Percent_Identity=37.109375, Blast_Score=130, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28872; Mature: 28872

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNATRDYTTVLTIAGSDGSGGAGIQADLKTIAAHSCYGLSVITAVTAQSTMGVADVHPIP
CCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCC
SSFIAKQFETIVSDIRIDAIKIGMLGPAGNAETIAGLIAGLDGVPIVLDTVLRSSSGAAL
HHHHHHHHHHHHHHHEEEEEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCEE
FSANDTAAMKRLFPLVSLITPNLPEATMLTGRNAPPSGGKEEIEQIALELQMQGAPSVLV
EECCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEE
KGGHWEGKVCHDCLLHEERFYWFSNPKINTVNTHGTGCTLSSAIAAGFAMKLGMSEAVAR
ECCCCCCHHHHHHHHHHCCEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHCHHHHHHH
GIDYTRKALQAGAGWRLGHGHGPLYHFPDKTESRAD
HHHHHHHHHHCCCCEEECCCCCCCEECCCCCCCCCC
>Mature Secondary Structure
MNATRDYTTVLTIAGSDGSGGAGIQADLKTIAAHSCYGLSVITAVTAQSTMGVADVHPIP
CCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCC
SSFIAKQFETIVSDIRIDAIKIGMLGPAGNAETIAGLIAGLDGVPIVLDTVLRSSSGAAL
HHHHHHHHHHHHHHHEEEEEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCEE
FSANDTAAMKRLFPLVSLITPNLPEATMLTGRNAPPSGGKEEIEQIALELQMQGAPSVLV
EECCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEEE
KGGHWEGKVCHDCLLHEERFYWFSNPKINTVNTHGTGCTLSSAIAAGFAMKLGMSEAVAR
ECCCCCCHHHHHHHHHHCCEEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHCHHHHHHH
GIDYTRKALQAGAGWRLGHGHGPLYHFPDKTESRAD
HHHHHHHHHHCCCCEEECCCCCCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10075431; 9097040; 9278503 [H]