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The map label for this gene is dfrA [H]

Identifier: 193212625

GI number: 193212625

Start: 1072445

End: 1073440

Strand: Direct

Name: dfrA [H]

Synonym: Cpar_0970

Alternate gene names: 193212625

Gene position: 1072445-1073440 (Clockwise)

Preceding gene: 193212624

Following gene: 193212626

Centisome position: 46.85

GC content: 54.42

Gene sequence:

>996_bases
GTGGGGAAAAAAATCGTCGTTACCGGAGGCACCGGCTTTATCGGCTCCCGCCTTGTGCACAAACTCGCTGAATCGGGGCA
CGAGGTCAATGCGCTTGTTCGTACGAGCTCCGACCTCACGTCGCTCAAGGGCTGCCTCGACAAGATCAATCTGGTGTATG
GCGATGTCACCAATGCGTCGTCTCTGAAAGGTGTGTTCGATGGCGTCGATGAGGTCTATCATTGCGCCGGCATCACCTAC
ATGGGGGGCAAGAAGAATCCGCTGCTTCAGAAAATCAACGTTGACGGTACCCGCCATGTGCTTGAAGCTTCGCGCTTGGC
CGGTGTCAGGCGGGTTGTGCATGTCAGCTCGATTACTGCGGTCGGCATAAGCGGCCCGAACCGGAAATTCGACGAGGAGA
GTCCCTGGAATTTCGATACGATCGATCTCGAATACGCTCGCACCAAGTATGTCGCCGAGCAGATCGTGGCCGAAGAGGTT
CGCAAGGGGCTCGATTGCGTGATCGTGGTGCCGGCCTTTGTGTTCGGTGCCGGCGATATCAACTTCAATGCCGGTCGCAT
TATCAAGGATGTCTATAACCGCAAGATGCCGTTTTATCCCCTCGGAGGCATCTGCGTGGTCGATGTCGAGATTGTGGCCG
AGACCCTGATAGCCGCGATGAACCAGGGGCGCAAAGGTGAACGCTACATCGTCGGCGGCGACAACGTTTCCTTCAAGGAG
CTGGCGCAGACCATCATGAAGGTGACTGGTGTACATCAGCTTTCACTTCCGCTTCCAATATGGGCTGCGCATTTCATCAC
GTATCTTCTTAAATTCAGTAAGGAGAGGAACAGAATATCCAAGCTGTTCAACATGAGCATGTTCACCGTGGCTTCGAAGT
TTCTTTATTTCGACTCATCGAAAGCGGAGCGTGAGCTGGGAATGCGCTACGAGCCCTACGAAAAGAGCATCAAGCGCACG
TTCGAGTGGTATCGTGAACACCGCATGCTGGTCTGA

Upstream 100 bases:

>100_bases
ACATCTCCGTTACGGAGTAAAACAATAGCGCCCGAAAGGGCTTTCAGCGCGGCAGGAGCTTATTGCGCGCATTTATTACC
AACAGTTCTTGAGATCATCC

Downstream 100 bases:

>100_bases
CTTTCTGTCCCATTCCTGTCACATCGTTCCGGTGCGGCCATAGATAAGAGGATGAACCCGCCAATCTTCGGGAGTCTCAG
GCATGAACAACGCTACTCCG

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: DFR; Dihydrokaempferol 4-reductase [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MGKKIVVTGGTGFIGSRLVHKLAESGHEVNALVRTSSDLTSLKGCLDKINLVYGDVTNASSLKGVFDGVDEVYHCAGITY
MGGKKNPLLQKINVDGTRHVLEASRLAGVRRVVHVSSITAVGISGPNRKFDEESPWNFDTIDLEYARTKYVAEQIVAEEV
RKGLDCVIVVPAFVFGAGDINFNAGRIIKDVYNRKMPFYPLGGICVVDVEIVAETLIAAMNQGRKGERYIVGGDNVSFKE
LAQTIMKVTGVHQLSLPLPIWAAHFITYLLKFSKERNRISKLFNMSMFTVASKFLYFDSSKAERELGMRYEPYEKSIKRT
FEWYREHRMLV

Sequences:

>Translated_331_residues
MGKKIVVTGGTGFIGSRLVHKLAESGHEVNALVRTSSDLTSLKGCLDKINLVYGDVTNASSLKGVFDGVDEVYHCAGITY
MGGKKNPLLQKINVDGTRHVLEASRLAGVRRVVHVSSITAVGISGPNRKFDEESPWNFDTIDLEYARTKYVAEQIVAEEV
RKGLDCVIVVPAFVFGAGDINFNAGRIIKDVYNRKMPFYPLGGICVVDVEIVAETLIAAMNQGRKGERYIVGGDNVSFKE
LAQTIMKVTGVHQLSLPLPIWAAHFITYLLKFSKERNRISKLFNMSMFTVASKFLYFDSSKAERELGMRYEPYEKSIKRT
FEWYREHRMLV
>Mature_330_residues
GKKIVVTGGTGFIGSRLVHKLAESGHEVNALVRTSSDLTSLKGCLDKINLVYGDVTNASSLKGVFDGVDEVYHCAGITYM
GGKKNPLLQKINVDGTRHVLEASRLAGVRRVVHVSSITAVGISGPNRKFDEESPWNFDTIDLEYARTKYVAEQIVAEEVR
KGLDCVIVVPAFVFGAGDINFNAGRIIKDVYNRKMPFYPLGGICVVDVEIVAETLIAAMNQGRKGERYIVGGDNVSFKEL
AQTIMKVTGVHQLSLPLPIWAAHFITYLLKFSKERNRISKLFNMSMFTVASKFLYFDSSKAERELGMRYEPYEKSIKRTF
EWYREHRMLV

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroflavonol-4-reductase family [H]

Homologues:

Organism=Homo sapiens, GI116268111, Length=356, Percent_Identity=24.438202247191, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI193211614, Length=347, Percent_Identity=23.9193083573487, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI8393516, Length=347, Percent_Identity=23.9193083573487, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI19923621, Length=363, Percent_Identity=26.4462809917355, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI87081792, Length=348, Percent_Identity=24.4252873563218, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1786974, Length=209, Percent_Identity=26.3157894736842, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71987463, Length=323, Percent_Identity=27.5541795665635, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321437, Length=351, Percent_Identity=23.0769230769231, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR017829
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =1.1.1.219 [H]

Molecular weight: Translated: 36988; Mature: 36857

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKKIVVTGGTGFIGSRLVHKLAESGHEVNALVRTSSDLTSLKGCLDKINLVYGDVTNAS
CCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHEECCCCCCH
SLKGVFDGVDEVYHCAGITYMGGKKNPLLQKINVDGTRHVLEASRLAGVRRVVHVSSITA
HHHHHHHHHHHHHHHHCCEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHEEE
VGISGPNRKFDEESPWNFDTIDLEYARTKYVAEQIVAEEVRKGLDCVIVVPAFVFGAGDI
EECCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCC
NFNAGRIIKDVYNRKMPFYPLGGICVVDVEIVAETLIAAMNQGRKGERYIVGGDNVSFKE
CCCHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHH
LAQTIMKVTGVHQLSLPLPIWAAHFITYLLKFSKERNRISKLFNMSMFTVASKFLYFDSS
HHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
KAERELGMRYEPYEKSIKRTFEWYREHRMLV
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GKKIVVTGGTGFIGSRLVHKLAESGHEVNALVRTSSDLTSLKGCLDKINLVYGDVTNAS
CCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHEECCCCCCH
SLKGVFDGVDEVYHCAGITYMGGKKNPLLQKINVDGTRHVLEASRLAGVRRVVHVSSITA
HHHHHHHHHHHHHHHHCCEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHEEE
VGISGPNRKFDEESPWNFDTIDLEYARTKYVAEQIVAEEVRKGLDCVIVVPAFVFGAGDI
EECCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCC
NFNAGRIIKDVYNRKMPFYPLGGICVVDVEIVAETLIAAMNQGRKGERYIVGGDNVSFKE
CCCHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHH
LAQTIMKVTGVHQLSLPLPIWAAHFITYLLKFSKERNRISKLFNMSMFTVASKFLYFDSS
HHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCC
KAERELGMRYEPYEKSIKRTFEWYREHRMLV
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]