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The map label for this gene is gcvPA

Identifier: 193212232

GI number: 193212232

Start: 607298

End: 608632

Strand: Direct

Name: gcvPA

Synonym: Cpar_0563

Alternate gene names: 193212232

Gene position: 607298-608632 (Clockwise)

Preceding gene: 193212231

Following gene: 193212239

Centisome position: 26.53

GC content: 60.22

Gene sequence:

>1335_bases
ATGCCTTTCATTGTCAATACCGATGCTGAGCGGGCCGAGATGCTTCGCGAAATCGGCGTCGAGAATTTCGAGGCGCTGAT
CGCTGATATTCCCGAAGAGGTTCGTCTCAAAAAGGCGCTCGATCTGCTGCCCGCAATGGGCGAGCCGGAGGTGAAAAGTC
TGCTCGAAAAGATGGCGTCGAGCAACGCCGCCACTTGCGACCACGTGAGTTTCCTCGGTGCGGGCGCTTATGACCACTTC
ATTCCTGCCGCTGTCAAGACCATCGCTTCAAGGAGCGAATTCTACACGGCTTACACGCCGTACCAGGCCGAGGTATCGCA
GGGCACGTTGCAGGCGATTTACGAATACCAGAGCGTGATGTGCCGCCTGTACGGCATGGACGTGGCCAACGCTTCGATGT
ACGACGGCGCGAGCGCGCTGGCCGAAGCGGCTCTGATCGCCCTGAACGTCACCGGGCGCAACGGCATCGTGGTGGCTGGC
AAGCTGCATCCCTACACCAGCCAGGTGCTCGAAACCTACCTCGAAGCCGCCGGAGACCGACCCATCGTGCAGAACAGCAT
CGAAGACGGTATTGGCAGCGTCGCGGCGCTTGAAACGCTGGTTTCTTCTGAAACCGCCGCCGTGATCGTGCAGCAGCCGA
ACTTCTACGGCTGCCTCGAAGAGGTCGAAGCGATTGGCGAGATCGCCAAGAAGCACGGCGCGCTCTTCATCGTCTCCGCC
GATCCGGTCTCCCTCGGCGTGCTCGAAGCGCCGGGCAATTACGGCGCGGACATCGCCGTCGGCGAGGGTCAGTCGGTCGG
CAACGCCCAGAGCTTTGGCGGGCCGTACCTTGGCATTCTGACGGTCAAACAGGCGCACGTGCGCAAGATTCCGGGCCGAC
TGGTCGGTATGACCAAAGACAAGGATGGCAATGACGGTTTCATCCTGACGCTCCAGACCCGCGAGCAGCACATCCGCCGC
GAAAAGGCCACCTCGAACATCTGCTCTAACCAGGCGCTCTGCGCGTTGCAGGCGGTAGTACACCTGTCGCTGCTCGGCAA
GGAGGGAATTCAGGATGTAGCCAACCGCTCGATGCAGAAGGCGCACTACCTGGCCGACCGTATCACGGAACTACCCGGCT
TTTCGCTGAAGTTCAGCGCGCCGTTCTTCCGCGAATTTGTGGTTGAGACGCCGGTTCCGGCGGCGACGATTATCGAAAAG
ATGCTCGACAAAAAGGTTTTTGCCGGCGTCGATCTCTCCGCTTGGGGCGAAGATGGCCTGCTCATCGCCGTCACCGAAAA
ACGCACGAAGGAAGAACTCGACAGCTTCGTCAGCGAACTTGCTTCACTCGGCTGA

Upstream 100 bases:

>100_bases
AAGCTCGACAACGCTGCCGAGGTCGAGTCGCTGCTCTCACCGGCGGATTACAGCGCCCTGATCGGCGAATAAGGATTATC
CAGAATTTCAATACGCAACC

Downstream 100 bases:

>100_bases
AAAGCCTCGCGCAGTGCATAAAAAAAGCCGCCCAAAGAGGCGGCTTTTTTTGTTTGAAGATCAGTCTGATCAGACTGATC
TCTTTTAAATCAGCCCGAGC

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MPFIVNTDAERAEMLREIGVENFEALIADIPEEVRLKKALDLLPAMGEPEVKSLLEKMASSNAATCDHVSFLGAGAYDHF
IPAAVKTIASRSEFYTAYTPYQAEVSQGTLQAIYEYQSVMCRLYGMDVANASMYDGASALAEAALIALNVTGRNGIVVAG
KLHPYTSQVLETYLEAAGDRPIVQNSIEDGIGSVAALETLVSSETAAVIVQQPNFYGCLEEVEAIGEIAKKHGALFIVSA
DPVSLGVLEAPGNYGADIAVGEGQSVGNAQSFGGPYLGILTVKQAHVRKIPGRLVGMTKDKDGNDGFILTLQTREQHIRR
EKATSNICSNQALCALQAVVHLSLLGKEGIQDVANRSMQKAHYLADRITELPGFSLKFSAPFFREFVVETPVPAATIIEK
MLDKKVFAGVDLSAWGEDGLLIAVTEKRTKEELDSFVSELASLG

Sequences:

>Translated_444_residues
MPFIVNTDAERAEMLREIGVENFEALIADIPEEVRLKKALDLLPAMGEPEVKSLLEKMASSNAATCDHVSFLGAGAYDHF
IPAAVKTIASRSEFYTAYTPYQAEVSQGTLQAIYEYQSVMCRLYGMDVANASMYDGASALAEAALIALNVTGRNGIVVAG
KLHPYTSQVLETYLEAAGDRPIVQNSIEDGIGSVAALETLVSSETAAVIVQQPNFYGCLEEVEAIGEIAKKHGALFIVSA
DPVSLGVLEAPGNYGADIAVGEGQSVGNAQSFGGPYLGILTVKQAHVRKIPGRLVGMTKDKDGNDGFILTLQTREQHIRR
EKATSNICSNQALCALQAVVHLSLLGKEGIQDVANRSMQKAHYLADRITELPGFSLKFSAPFFREFVVETPVPAATIIEK
MLDKKVFAGVDLSAWGEDGLLIAVTEKRTKEELDSFVSELASLG
>Mature_443_residues
PFIVNTDAERAEMLREIGVENFEALIADIPEEVRLKKALDLLPAMGEPEVKSLLEKMASSNAATCDHVSFLGAGAYDHFI
PAAVKTIASRSEFYTAYTPYQAEVSQGTLQAIYEYQSVMCRLYGMDVANASMYDGASALAEAALIALNVTGRNGIVVAGK
LHPYTSQVLETYLEAAGDRPIVQNSIEDGIGSVAALETLVSSETAAVIVQQPNFYGCLEEVEAIGEIAKKHGALFIVSAD
PVSLGVLEAPGNYGADIAVGEGQSVGNAQSFGGPYLGILTVKQAHVRKIPGRLVGMTKDKDGNDGFILTLQTREQHIRRE
KATSNICSNQALCALQAVVHLSLLGKEGIQDVANRSMQKAHYLADRITELPGFSLKFSAPFFREFVVETPVPAATIIEKM
LDKKVFAGVDLSAWGEDGLLIAVTEKRTKEELDSFVSELASLG

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=351, Percent_Identity=34.1880341880342, Blast_Score=213, Evalue=3e-55,
Organism=Escherichia coli, GI1789269, Length=390, Percent_Identity=34.6153846153846, Blast_Score=181, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17535605, Length=363, Percent_Identity=37.1900826446281, Blast_Score=212, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6323843, Length=445, Percent_Identity=32.5842696629214, Blast_Score=208, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24645648, Length=345, Percent_Identity=37.9710144927536, Blast_Score=238, Evalue=8e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_CHLP8 (B3QM32)

Other databases:

- EMBL:   CP001099
- RefSeq:   YP_001998185.1
- GeneID:   6419477
- GenomeReviews:   CP001099_GR
- KEGG:   cpc:Cpar_0563
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 47666; Mature: 47535

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFIVNTDAERAEMLREIGVENFEALIADIPEEVRLKKALDLLPAMGEPEVKSLLEKMAS
CCEEECCCHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
SNAATCDHVSFLGAGAYDHFIPAAVKTIASRSEFYTAYTPYQAEVSQGTLQAIYEYQSVM
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHHHHH
CRLYGMDVANASMYDGASALAEAALIALNVTGRNGIVVAGKLHPYTSQVLETYLEAAGDR
HHHHCCCCCCCCCCCCHHHHHHHEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHCCCC
PIVQNSIEDGIGSVAALETLVSSETAAVIVQQPNFYGCLEEVEAIGEIAKKHGALFIVSA
CHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEC
DPVSLGVLEAPGNYGADIAVGEGQSVGNAQSFGGPYLGILTVKQAHVRKIPGRLVGMTKD
CCCEEEEEECCCCCCCEEEECCCCCCCCCHHCCCCEEEEEEEHHHHHHHCCCHHEECCCC
KDGNDGFILTLQTREQHIRREKATSNICSNQALCALQAVVHLSLLGKEGIQDVANRSMQK
CCCCCCEEEEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHYLADRITELPGFSLKFSAPFFREFVVETPVPAATIIEKMLDKKVFAGVDLSAWGEDGL
HHHHHHHHHHCCCCEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCE
LIAVTEKRTKEELDSFVSELASLG
EEEEECHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PFIVNTDAERAEMLREIGVENFEALIADIPEEVRLKKALDLLPAMGEPEVKSLLEKMAS
CEEECCCHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
SNAATCDHVSFLGAGAYDHFIPAAVKTIASRSEFYTAYTPYQAEVSQGTLQAIYEYQSVM
CCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHHHHH
CRLYGMDVANASMYDGASALAEAALIALNVTGRNGIVVAGKLHPYTSQVLETYLEAAGDR
HHHHCCCCCCCCCCCCHHHHHHHEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHCCCC
PIVQNSIEDGIGSVAALETLVSSETAAVIVQQPNFYGCLEEVEAIGEIAKKHGALFIVSA
CHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEC
DPVSLGVLEAPGNYGADIAVGEGQSVGNAQSFGGPYLGILTVKQAHVRKIPGRLVGMTKD
CCCEEEEEECCCCCCCEEEECCCCCCCCCHHCCCCEEEEEEEHHHHHHHCCCHHEECCCC
KDGNDGFILTLQTREQHIRREKATSNICSNQALCALQAVVHLSLLGKEGIQDVANRSMQK
CCCCCCEEEEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHYLADRITELPGFSLKFSAPFFREFVVETPVPAATIIEKMLDKKVFAGVDLSAWGEDGL
HHHHHHHHHHCCCCEEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCE
LIAVTEKRTKEELDSFVSELASLG
EEEEECHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA