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The map label for this gene is mmlH [H]

Identifier: 193212168

GI number: 193212168

Start: 534325

End: 535566

Strand: Direct

Name: mmlH [H]

Synonym: Cpar_0499

Alternate gene names: 193212168

Gene position: 534325-535566 (Clockwise)

Preceding gene: 193212166

Following gene: 193212169

Centisome position: 23.34

GC content: 57.97

Gene sequence:

>1242_bases
ATGCAGGACTCATCTCACGCGAGCATTCGCGACGTTTTCAGTCTTCCGGTTATTGTGGCCGCTCTCGGTTATTTCGTGGA
TATTTATGACCTCGTGCTGTTCAGCATCGTGCGCGTGCCGAGCCTCAAAGCGTTCGGTTTGCAAGGGCAGGAGTTGATCG
ATTACGGCGTCTATCTGCTCAACATGCAGATGATCGGAATGCTGGTTGGCGGTGTGCTGTGGGGTTGGCTGGGTGACGTG
AAGGGGCGCCTGAAGATCATGTTCGGTTCGATCCTGATCTACTCGCTGGCCAATATCGCCAACGGTTTTGCTGGATCGCT
GGAGGCCTATGCCGTGCTGCGCTTCATCGCGGGAGTGGGTCTTGCCGGAGAACTGGGGGCAGGTATCACGCTGGTTTCGG
AGATTCTGCACACGAAAATCCGCGGCTACGGCACGATGCTGGTGGCCTCGATCGGCGTGACTGGCGCGATTCTGGCCAAT
GCGGTGGCGACCCACTACGACTGGCGTACAGCTTTCTTTATCGGCGGTGCGCTTGGACTGGTGCTGCTGGTGGCTCGGTT
CAAGGTTTCCGAGTCGGGCATGTTCCAGAAGATCGAGTCCAAAGCGGCAGTCAGCAAAGGCAATCTGCTGGCGCTCTTCA
CCAGCCGCGAGCGCTTTTTCCGCTACCTGAACTCGATCCTCATCGGCGTGCCGATCTGGTTCGTGGTGGGCGTGCTCATC
ACCTTTTCGCCCGAATTCGCCACGGCGCTCGGCATCAAGGGTACGATCTCTGCAGGTAACGCTGTGATGTTCTGCTACCT
CGGCCTGGTGTTCGGCGACCTGTCGAGTGGCCTGTTGAGCCAGGTACTGCAGAGCCGCAAAAAGGCGGTGCTGGTGTTCC
TTGTGCTGAACATCATCTCCATTGCGGTCTATTTCATGCAGCGTGGAGCGACGCCGACCGCTTTCTACTGGGTTTCGTTC
GCGCTCGGATTTTCGGGCGGATACTGGGCCATTTTTGTGACGGTGGCCGCCGAACAGTTCGGTACCAATCTGCGAGCAAC
GGTAGCCACTACCGTGCCGAACCTCGTGCGCGGCATGGTGGTGCCGATCACGATGCTTTTCCAGTTCACTCGCGGCCAGT
TCGGTCTCGAAGGCGGCGCGATTATCGTGGGGGTAATCTGCATGGTCGCGGCGTTTGTTTCACTCGCCGCGCTGGAGGAG
ACCTTCCACAAAGACCTCGATTATTTCGAGGAGTTTATGTGA

Upstream 100 bases:

>100_bases
TGTGGTTGACAATCCGGTGGGCTTTGGCCGCGGTTATATCCCGGAAAAAAATTGTATTATCCTTGTCGTTTGATTGTTAA
TTGTTTATCCATTTTACCCC

Downstream 100 bases:

>100_bases
CGCCGGGATTGGGTCGTATTAGCCCAATTGTGCTTATTGGTCTAATGGGTCAAACAAGTCTTATGGGTTCCATAGGACTT
GTCTGACCCATACGTCTCAT

Product: major facilitator superfamily protein

Products: Proton [Cytoplasm]; N-acetylneuraminate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MQDSSHASIRDVFSLPVIVAALGYFVDIYDLVLFSIVRVPSLKAFGLQGQELIDYGVYLLNMQMIGMLVGGVLWGWLGDV
KGRLKIMFGSILIYSLANIANGFAGSLEAYAVLRFIAGVGLAGELGAGITLVSEILHTKIRGYGTMLVASIGVTGAILAN
AVATHYDWRTAFFIGGALGLVLLVARFKVSESGMFQKIESKAAVSKGNLLALFTSRERFFRYLNSILIGVPIWFVVGVLI
TFSPEFATALGIKGTISAGNAVMFCYLGLVFGDLSSGLLSQVLQSRKKAVLVFLVLNIISIAVYFMQRGATPTAFYWVSF
ALGFSGGYWAIFVTVAAEQFGTNLRATVATTVPNLVRGMVVPITMLFQFTRGQFGLEGGAIIVGVICMVAAFVSLAALEE
TFHKDLDYFEEFM

Sequences:

>Translated_413_residues
MQDSSHASIRDVFSLPVIVAALGYFVDIYDLVLFSIVRVPSLKAFGLQGQELIDYGVYLLNMQMIGMLVGGVLWGWLGDV
KGRLKIMFGSILIYSLANIANGFAGSLEAYAVLRFIAGVGLAGELGAGITLVSEILHTKIRGYGTMLVASIGVTGAILAN
AVATHYDWRTAFFIGGALGLVLLVARFKVSESGMFQKIESKAAVSKGNLLALFTSRERFFRYLNSILIGVPIWFVVGVLI
TFSPEFATALGIKGTISAGNAVMFCYLGLVFGDLSSGLLSQVLQSRKKAVLVFLVLNIISIAVYFMQRGATPTAFYWVSF
ALGFSGGYWAIFVTVAAEQFGTNLRATVATTVPNLVRGMVVPITMLFQFTRGQFGLEGGAIIVGVICMVAAFVSLAALEE
TFHKDLDYFEEFM
>Mature_413_residues
MQDSSHASIRDVFSLPVIVAALGYFVDIYDLVLFSIVRVPSLKAFGLQGQELIDYGVYLLNMQMIGMLVGGVLWGWLGDV
KGRLKIMFGSILIYSLANIANGFAGSLEAYAVLRFIAGVGLAGELGAGITLVSEILHTKIRGYGTMLVASIGVTGAILAN
AVATHYDWRTAFFIGGALGLVLLVARFKVSESGMFQKIESKAAVSKGNLLALFTSRERFFRYLNSILIGVPIWFVVGVLI
TFSPEFATALGIKGTISAGNAVMFCYLGLVFGDLSSGLLSQVLQSRKKAVLVFLVLNIISIAVYFMQRGATPTAFYWVSF
ALGFSGGYWAIFVTVAAEQFGTNLRATVATTVPNLVRGMVVPITMLFQFTRGQFGLEGGAIIVGVICMVAAFVSLAALEE
TFHKDLDYFEEFM

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082231, Length=220, Percent_Identity=26.8181818181818, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87082404, Length=209, Percent_Identity=30.1435406698565, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44544; Mature: 44544

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDSSHASIRDVFSLPVIVAALGYFVDIYDLVLFSIVRVPSLKAFGLQGQELIDYGVYLL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHH
NMQMIGMLVGGVLWGWLGDVKGRLKIMFGSILIYSLANIANGFAGSLEAYAVLRFIAGVG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
LAGELGAGITLVSEILHTKIRGYGTMLVASIGVTGAILANAVATHYDWRTAFFIGGALGL
CCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
VLLVARFKVSESGMFQKIESKAAVSKGNLLALFTSRERFFRYLNSILIGVPIWFVVGVLI
HHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
TFSPEFATALGIKGTISAGNAVMFCYLGLVFGDLSSGLLSQVLQSRKKAVLVFLVLNIIS
HCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAVYFMQRGATPTAFYWVSFALGFSGGYWAIFVTVAAEQFGTNLRATVATTVPNLVRGMV
HHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VPITMLFQFTRGQFGLEGGAIIVGVICMVAAFVSLAALEETFHKDLDYFEEFM
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQDSSHASIRDVFSLPVIVAALGYFVDIYDLVLFSIVRVPSLKAFGLQGQELIDYGVYLL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHH
NMQMIGMLVGGVLWGWLGDVKGRLKIMFGSILIYSLANIANGFAGSLEAYAVLRFIAGVG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
LAGELGAGITLVSEILHTKIRGYGTMLVASIGVTGAILANAVATHYDWRTAFFIGGALGL
CCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
VLLVARFKVSESGMFQKIESKAAVSKGNLLALFTSRERFFRYLNSILIGVPIWFVVGVLI
HHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
TFSPEFATALGIKGTISAGNAVMFCYLGLVFGDLSSGLLSQVLQSRKKAVLVFLVLNIIS
HCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAVYFMQRGATPTAFYWVSFALGFSGGYWAIFVTVAAEQFGTNLRATVATTVPNLVRGMV
HHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VPITMLFQFTRGQFGLEGGAIIVGVICMVAAFVSLAALEETFHKDLDYFEEFM
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; N-acetylneuraminate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + N-acetylneuraminate [Periplasm] = Proton [Cytoplasm] + N-acetylneuraminate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]