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The map label for this gene is clpP [H]

Identifier: 193212075

GI number: 193212075

Start: 433247

End: 433924

Strand: Direct

Name: clpP [H]

Synonym: Cpar_0405

Alternate gene names: 193212075

Gene position: 433247-433924 (Clockwise)

Preceding gene: 193212073

Following gene: 193212076

Centisome position: 18.93

GC content: 59.0

Gene sequence:

>678_bases
ATGGCTAACATCAATTTCGGTTTCAATCATCACGCCAAGAAGCTCTACTCCGGAGCGATTGAAAACAGCATCAACAACCA
GCTCGTGCCGATGGTTATCGAGACCTCGGGACGCGGCGAGCGTGCGTTCGACATCTTTTCCCGCCTTCTGCGTGAGCGCA
TCATCTTCCTCGGTTCTCCCATTGACGAGCACGTTGCGGGGCTGATCATGGCGCAGCTCATCTTCCTCGAATCGGAAGAC
CCGGAGCGCGACATCTACATCTACGTCAACTCGCCCGGCGGAAGCGTATCGGCAGGTCTCGGCATCTACGACACGATGCA
GTACATCCGTCCCGACATCTCGACGGTTTGCGTCGGCATGGCGGCCAGTATGGGCGCATTCCTGCTTGCCAGTGGAACGG
CAGGCAAGCGCGCTTCGCTTCCGCACTCGCGCATCATGATTCACCAGCCTTCGGGCGGCGCGCAGGGTCAGGAGACCGAC
ATTCTCATTCAGGCCCGCGAGATCGAGAAGATCCGCCACCTGCTCGAAGATCTGCTCGCCAAGCACACCGGCCAGAATGT
CAAGACCATTCGCGAGGATTCCGAGCGCGACCGCTGGATGAACGCCACCGAGGCCAAGGAGTACGGACTGATCGACCAGA
TTTTCGAAAAACGTCCGGCTCCGGAAAACGCCGGCTGA

Upstream 100 bases:

>100_bases
GATCTTTTGCAGGGCTTCGTTACGATCTGGCAAGGATTTCTGCGAAGCTGTAACACACGGGGGCCTTATCGCCGGTTTCC
GCAAAAAAAGTTTGAAGCAT

Downstream 100 bases:

>100_bases
ACGGTTTTCTGATCAACATTTCGGGCGTCATCCTTTATCGAAGAGGGGTGGCGCCCGTCACCTTTAAATTCGCTTTGCAC
GATACTCATGAGTGACCATT

Product: ATP-dependent Clp protease, proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MANINFGFNHHAKKLYSGAIENSINNQLVPMVIETSGRGERAFDIFSRLLRERIIFLGSPIDEHVAGLIMAQLIFLESED
PERDIYIYVNSPGGSVSAGLGIYDTMQYIRPDISTVCVGMAASMGAFLLASGTAGKRASLPHSRIMIHQPSGGAQGQETD
ILIQAREIEKIRHLLEDLLAKHTGQNVKTIREDSERDRWMNATEAKEYGLIDQIFEKRPAPENAG

Sequences:

>Translated_225_residues
MANINFGFNHHAKKLYSGAIENSINNQLVPMVIETSGRGERAFDIFSRLLRERIIFLGSPIDEHVAGLIMAQLIFLESED
PERDIYIYVNSPGGSVSAGLGIYDTMQYIRPDISTVCVGMAASMGAFLLASGTAGKRASLPHSRIMIHQPSGGAQGQETD
ILIQAREIEKIRHLLEDLLAKHTGQNVKTIREDSERDRWMNATEAKEYGLIDQIFEKRPAPENAG
>Mature_224_residues
ANINFGFNHHAKKLYSGAIENSINNQLVPMVIETSGRGERAFDIFSRLLRERIIFLGSPIDEHVAGLIMAQLIFLESEDP
ERDIYIYVNSPGGSVSAGLGIYDTMQYIRPDISTVCVGMAASMGAFLLASGTAGKRASLPHSRIMIHQPSGGAQGQETDI
LIQAREIEKIRHLLEDLLAKHTGQNVKTIREDSERDRWMNATEAKEYGLIDQIFEKRPAPENAG

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=192, Percent_Identity=58.8541666666667, Blast_Score=241, Evalue=3e-64,
Organism=Escherichia coli, GI1786641, Length=204, Percent_Identity=59.3137254901961, Blast_Score=265, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=51.0752688172043, Blast_Score=211, Evalue=3e-55,
Organism=Drosophila melanogaster, GI20129427, Length=204, Percent_Identity=54.4117647058823, Blast_Score=229, Evalue=9e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 24911; Mature: 24780

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANINFGFNHHAKKLYSGAIENSINNQLVPMVIETSGRGERAFDIFSRLLRERIIFLGSP
CCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
IDEHVAGLIMAQLIFLESEDPERDIYIYVNSPGGSVSAGLGIYDTMQYIRPDISTVCVGM
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHCCCHHHHHHHH
AASMGAFLLASGTAGKRASLPHSRIMIHQPSGGAQGQETDILIQAREIEKIRHLLEDLLA
HHHHHHHEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHH
KHTGQNVKTIREDSERDRWMNATEAKEYGLIDQIFEKRPAPENAG
HHCCCCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ANINFGFNHHAKKLYSGAIENSINNQLVPMVIETSGRGERAFDIFSRLLRERIIFLGSP
CCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCC
IDEHVAGLIMAQLIFLESEDPERDIYIYVNSPGGSVSAGLGIYDTMQYIRPDISTVCVGM
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHCCCHHHHHHHH
AASMGAFLLASGTAGKRASLPHSRIMIHQPSGGAQGQETDILIQAREIEKIRHLLEDLLA
HHHHHHHEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHH
KHTGQNVKTIREDSERDRWMNATEAKEYGLIDQIFEKRPAPENAG
HHCCCCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]