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The map label for this gene is nadC [H]

Identifier: 193211950

GI number: 193211950

Start: 294523

End: 295416

Strand: Direct

Name: nadC [H]

Synonym: Cpar_0276

Alternate gene names: 193211950

Gene position: 294523-295416 (Clockwise)

Preceding gene: 193211947

Following gene: 193211951

Centisome position: 12.87

GC content: 58.5

Gene sequence:

>894_bases
ATGGCAGACAAAAGAACCAATCATGCTTTCAGGGAATTTTTCGAGACCTGCCGCTTAAAGGCTATGCAGCTTGCGCTCGA
TGAAGACCGTTACCAGGGCGATATCACCACCCAGGCGACCGTCGACGAGAGCCAGACCGGGATCGGCCGCATCGAAGCCA
AAGCCGAGGGCATCATCGCCGGTATCGAGGTTGTCAAGCAGGTGTTCCAGTCGACCGATCCTGAGCTTGAGTTCACGGCG
CATGTCCAGGACGGGAAGCGGGTCTATCCGGGTGAGCATATTCTCGAAGTGAGAGGGCGTATCGCTTCCATTCTGTTTGG
TGAGCGCACGGCGCTGAATTTCATGCAGCGCATGTCCGGCATCGCGACGCGCACGAACATGTATGTCGAGCGGGTCAGCC
ACACCAACGCGGCGATTCTCGACACCCGCAAAACTGCGCCGGGTCTGCGCTACTACGACAAGGACGCCGTGCGCATCGGT
GGTGGCACCAACCACCGGTTCGGGCTGTTCGACATGATTCTGATCAAGGACAACCATATCGATGCCGCCGGCAGCGTCGA
TGAGGCGATCAACCGGGCCAAAGCATACTGCAAGGAGCACGGGGTGAACGTCAAGATCGAGACCGAGGTGCGGAGCATTT
CCGAGCTGGTGAGGGCCTGCACCTGCCGACCGGATATCATTCTGCTCGACAACTTCATGGTCGATGATCTGGCGGAAGCC
GTGCGCTGGGTGAAAGCCAATGGCTATGGCGACATCCGGCTCGAAGCCTCAGGCAACATTAATCTGCACAACGTCGCGGA
GATCGCGCTGACCGGCGTCGATTACATCTCCATCGGCGAGCTGACGCACAGCGTCAAGGCGCTCGACCTCTCCATGAAAA
TCGAACGTACCTGA

Upstream 100 bases:

>100_bases
GGTGCTGAATACCAAAAAAACTGTTACCTTCTTTATCGACTCAATCCCGGTCGCCAAACAGGCGTCTTTTTTTCGCTAAC
CCCTCACTGACAGAGCAGTC

Downstream 100 bases:

>100_bases
CGATTCTGCATGGAAATCGGGGTTGACATCGTTGAAATCGCCCGCATCCGGGCCGTGTACGAACGCTCCGGCAAGGCTTT
CATGAACAAGGTGCTGACCG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MADKRTNHAFREFFETCRLKAMQLALDEDRYQGDITTQATVDESQTGIGRIEAKAEGIIAGIEVVKQVFQSTDPELEFTA
HVQDGKRVYPGEHILEVRGRIASILFGERTALNFMQRMSGIATRTNMYVERVSHTNAAILDTRKTAPGLRYYDKDAVRIG
GGTNHRFGLFDMILIKDNHIDAAGSVDEAINRAKAYCKEHGVNVKIETEVRSISELVRACTCRPDIILLDNFMVDDLAEA
VRWVKANGYGDIRLEASGNINLHNVAEIALTGVDYISIGELTHSVKALDLSMKIERT

Sequences:

>Translated_297_residues
MADKRTNHAFREFFETCRLKAMQLALDEDRYQGDITTQATVDESQTGIGRIEAKAEGIIAGIEVVKQVFQSTDPELEFTA
HVQDGKRVYPGEHILEVRGRIASILFGERTALNFMQRMSGIATRTNMYVERVSHTNAAILDTRKTAPGLRYYDKDAVRIG
GGTNHRFGLFDMILIKDNHIDAAGSVDEAINRAKAYCKEHGVNVKIETEVRSISELVRACTCRPDIILLDNFMVDDLAEA
VRWVKANGYGDIRLEASGNINLHNVAEIALTGVDYISIGELTHSVKALDLSMKIERT
>Mature_296_residues
ADKRTNHAFREFFETCRLKAMQLALDEDRYQGDITTQATVDESQTGIGRIEAKAEGIIAGIEVVKQVFQSTDPELEFTAH
VQDGKRVYPGEHILEVRGRIASILFGERTALNFMQRMSGIATRTNMYVERVSHTNAAILDTRKTAPGLRYYDKDAVRIGG
GTNHRFGLFDMILIKDNHIDAAGSVDEAINRAKAYCKEHGVNVKIETEVRSISELVRACTCRPDIILLDNFMVDDLAEAV
RWVKANGYGDIRLEASGNINLHNVAEIALTGVDYISIGELTHSVKALDLSMKIERT

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=246, Percent_Identity=33.739837398374, Blast_Score=143, Evalue=2e-34,
Organism=Escherichia coli, GI1786299, Length=305, Percent_Identity=38.6885245901639, Blast_Score=168, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6321162, Length=254, Percent_Identity=33.4645669291339, Blast_Score=140, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 33132; Mature: 33001

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKRTNHAFREFFETCRLKAMQLALDEDRYQGDITTQATVDESQTGIGRIEAKAEGIIA
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCEEEEHHHHHHHH
GIEVVKQVFQSTDPELEFTAHVQDGKRVYPGEHILEVRGRIASILFGERTALNFMQRMSG
HHHHHHHHHHCCCCCEEEEEEECCCCEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
IATRTNMYVERVSHTNAAILDTRKTAPGLRYYDKDAVRIGGGTNHRFGLFDMILIKDNHI
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCEECCCEEEECCCCCCCCEEEEEEEEECCCC
DAAGSVDEAINRAKAYCKEHGVNVKIETEVRSISELVRACTCRPDIILLDNFMVDDLAEA
CCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHH
VRWVKANGYGDIRLEASGNINLHNVAEIALTGVDYISIGELTHSVKALDLSMKIERT
HHHHHCCCCCEEEEEECCCCCHHHHHHHHEECCCEEEHHHHHHHHHEEEEEEEEECC
>Mature Secondary Structure 
ADKRTNHAFREFFETCRLKAMQLALDEDRYQGDITTQATVDESQTGIGRIEAKAEGIIA
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCEEEEHHHHHHHH
GIEVVKQVFQSTDPELEFTAHVQDGKRVYPGEHILEVRGRIASILFGERTALNFMQRMSG
HHHHHHHHHHCCCCCEEEEEEECCCCEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
IATRTNMYVERVSHTNAAILDTRKTAPGLRYYDKDAVRIGGGTNHRFGLFDMILIKDNHI
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCEECCCEEEECCCCCCCCEEEEEEEEECCCC
DAAGSVDEAINRAKAYCKEHGVNVKIETEVRSISELVRACTCRPDIILLDNFMVDDLAEA
CCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHH
VRWVKANGYGDIRLEASGNINLHNVAEIALTGVDYISIGELTHSVKALDLSMKIERT
HHHHHCCCCCEEEEEECCCCCHHHHHHHHEECCCEEEHHHHHHHHHEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]