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The map label for this gene is pyrG

Identifier: 193211772

GI number: 193211772

Start: 110595

End: 112292

Strand: Direct

Name: pyrG

Synonym: Cpar_0097

Alternate gene names: 193211772

Gene position: 110595-112292 (Clockwise)

Preceding gene: 193211771

Following gene: 193211773

Centisome position: 4.83

GC content: 56.48

Gene sequence:

>1698_bases
ATGGCTCGACCGAAAAACGTAAAGCATATTTTTGTCACCGGCGGTGTGATCTCTTCCCTCGGTAAAGGCATCCTTTCCGC
CTCGCTGGGTATGCTGCTCAAATCCCGCGGATTGCGCGTGGCGATCCAGAAATATGATCCCTACATCAACGTCGATCCCG
GTACGATGTCGCCGTATCAGCACGGCGAAGTCTATGTGACCGACGACGGCGCGGAGACCGACCTCGACCTCGGCCACTAC
GAGCGATTCCTCGACGAGCCGACTTCGCAGGCCTCCAACCTGACGATGGGGCGCGTGTACAAATCGGTGATCGACAAAGA
GCGCCGCGGCGAGTACCTCGGCGGTACGGTGCAGGTGGTGCCGCACGTGATCGACGAGATCAAGGAGAAGATGAATGATC
TGGCCAAGAACGGCAGCCTCGACGTGCTCATTACTGAAATCGGTGGCACCATCGGTGACATCGAGTCGCTACCCTTCCTC
GAAGCGATGCGCCAGCTCAAGCTCGAGCTTGGTGACCGCAACGTGCTGAACATCCATCTCACCTTCGTGCCGTACATCAA
GGCCGCCAGCGAGCTGAAGACCAAGCCCACGCAGCACAGCGTCAAGATGCTGCTCGAAACCGGCATCCAGCCGGACATTC
TGGTTTGCCGGAGCGAAAAGCCGCTGTCGCGTGAAATCAAGAACAAAGTCGGACACTTCTGCAACGTGCACGAGCAGGAT
GTAATCGGCCTGAACGACTGCGAAACGATCTACGCCGTGCCGCTCATGCTGCTCCGCGAGCAGCTCGATCTGCGCGTCAT
GAAAAAGCTCGGTCTGAAGAAATTCCGTGAACCCAACCTTGAGCATTGGAAACGCTTCTGCGAAAAGGTTACCAACCCCA
AGGATGGCGAAATCACCATCGGTGTTTGCGGCAAGTACACCGAGTATCCCGACGCCTACAAGTCGATTATTGAAGCCTTC
ATTCATGCCGGAGCAAGCAACGACGTAAAGGTTTCGGTCAAGATGCTCAGGGCTGAGGATGCCGAAGACTCCTCGTTCAA
TATGAACAAGGCCTTCGAGGGAGTCAGCGGTCTGCTGGTCGCTCCTGGTTTTGGTGACCGCGGCATCGAAGGCAAGGTGC
AGTTTGTTCAGTACGCCCGCGAAAACAACATTCCGTTTTTCGGTATTTGCCTCGGTATGCAGTGCGCGAGCATCGAGTTC
GCCCGCAACGTCTGCGACCTCCCCGACGCTAACTCGACCGAGTTCAACAAGCGGGCGCGCTTCCCGGTGATCGACCTCAT
GGAGCAGCAGAAAAAGGTCAAGGAGAAGGGAGGCACCATGCGCCTCGGCAGCTATCCCTGCATTCTCAAGGAGGGTTCGA
AAGTCCACGAGGTCTATGGCAAATTCCTGATCAACGAGCGGCATCGCCATCGCTACGAATTCAACAACCAGTTCCGTAAG
CTCTTCGAGGAAAAGGGGATGATTTTCTCCGGCACCTCCCCGAATGGTGAGCTGGTCGAAATTATCGAGCTGAAAGAGCA
TCGCTGGTTCGTCGCCGTACAGTTTCACCCGGAACTCAAATCGAGAGTGCAGAAGGTGCATCCGCTTTTCGACGGGTTTG
TGCAGGCCGCCAAAGAGTTCGCCATGGGAAAGCGTCAGCTCACCCTGGAGGATGAACTGCCGCGTTTGAGCAGTGAGGAG
ATGGAGGGGGCTGGCTGA

Upstream 100 bases:

>100_bases
TGCGAGTTGGTGGCTGGCCCCGCGAACGAATGAAATGCGGTGAGCGTGCAGCTTTCCGCAGAAAGAGGTGACTGTTATTA
CTTAATTATCTATAGAAGGT

Downstream 100 bases:

>100_bases
GAGGAGCACTTAAGGCTTTTCTTGCAGATAGAGTGGGTTGAATGGGCGAGGACTACTCGTGCGTTCAGCCCATGTTCTTT
TTTATAACGGTCTATGCAAA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MARPKNVKHIFVTGGVISSLGKGILSASLGMLLKSRGLRVAIQKYDPYINVDPGTMSPYQHGEVYVTDDGAETDLDLGHY
ERFLDEPTSQASNLTMGRVYKSVIDKERRGEYLGGTVQVVPHVIDEIKEKMNDLAKNGSLDVLITEIGGTIGDIESLPFL
EAMRQLKLELGDRNVLNIHLTFVPYIKAASELKTKPTQHSVKMLLETGIQPDILVCRSEKPLSREIKNKVGHFCNVHEQD
VIGLNDCETIYAVPLMLLREQLDLRVMKKLGLKKFREPNLEHWKRFCEKVTNPKDGEITIGVCGKYTEYPDAYKSIIEAF
IHAGASNDVKVSVKMLRAEDAEDSSFNMNKAFEGVSGLLVAPGFGDRGIEGKVQFVQYARENNIPFFGICLGMQCASIEF
ARNVCDLPDANSTEFNKRARFPVIDLMEQQKKVKEKGGTMRLGSYPCILKEGSKVHEVYGKFLINERHRHRYEFNNQFRK
LFEEKGMIFSGTSPNGELVEIIELKEHRWFVAVQFHPELKSRVQKVHPLFDGFVQAAKEFAMGKRQLTLEDELPRLSSEE
MEGAG

Sequences:

>Translated_565_residues
MARPKNVKHIFVTGGVISSLGKGILSASLGMLLKSRGLRVAIQKYDPYINVDPGTMSPYQHGEVYVTDDGAETDLDLGHY
ERFLDEPTSQASNLTMGRVYKSVIDKERRGEYLGGTVQVVPHVIDEIKEKMNDLAKNGSLDVLITEIGGTIGDIESLPFL
EAMRQLKLELGDRNVLNIHLTFVPYIKAASELKTKPTQHSVKMLLETGIQPDILVCRSEKPLSREIKNKVGHFCNVHEQD
VIGLNDCETIYAVPLMLLREQLDLRVMKKLGLKKFREPNLEHWKRFCEKVTNPKDGEITIGVCGKYTEYPDAYKSIIEAF
IHAGASNDVKVSVKMLRAEDAEDSSFNMNKAFEGVSGLLVAPGFGDRGIEGKVQFVQYARENNIPFFGICLGMQCASIEF
ARNVCDLPDANSTEFNKRARFPVIDLMEQQKKVKEKGGTMRLGSYPCILKEGSKVHEVYGKFLINERHRHRYEFNNQFRK
LFEEKGMIFSGTSPNGELVEIIELKEHRWFVAVQFHPELKSRVQKVHPLFDGFVQAAKEFAMGKRQLTLEDELPRLSSEE
MEGAG
>Mature_564_residues
ARPKNVKHIFVTGGVISSLGKGILSASLGMLLKSRGLRVAIQKYDPYINVDPGTMSPYQHGEVYVTDDGAETDLDLGHYE
RFLDEPTSQASNLTMGRVYKSVIDKERRGEYLGGTVQVVPHVIDEIKEKMNDLAKNGSLDVLITEIGGTIGDIESLPFLE
AMRQLKLELGDRNVLNIHLTFVPYIKAASELKTKPTQHSVKMLLETGIQPDILVCRSEKPLSREIKNKVGHFCNVHEQDV
IGLNDCETIYAVPLMLLREQLDLRVMKKLGLKKFREPNLEHWKRFCEKVTNPKDGEITIGVCGKYTEYPDAYKSIIEAFI
HAGASNDVKVSVKMLRAEDAEDSSFNMNKAFEGVSGLLVAPGFGDRGIEGKVQFVQYARENNIPFFGICLGMQCASIEFA
RNVCDLPDANSTEFNKRARFPVIDLMEQQKKVKEKGGTMRLGSYPCILKEGSKVHEVYGKFLINERHRHRYEFNNQFRKL
FEEKGMIFSGTSPNGELVEIIELKEHRWFVAVQFHPELKSRVQKVHPLFDGFVQAAKEFAMGKRQLTLEDELPRLSSEEM
EGAG

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=549, Percent_Identity=43.3515482695811, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI28559085, Length=556, Percent_Identity=43.3453237410072, Blast_Score=439, Evalue=1e-123,
Organism=Homo sapiens, GI28559083, Length=556, Percent_Identity=43.3453237410072, Blast_Score=439, Evalue=1e-123,
Organism=Homo sapiens, GI221316689, Length=556, Percent_Identity=43.3453237410072, Blast_Score=439, Evalue=1e-123,
Organism=Escherichia coli, GI1789142, Length=551, Percent_Identity=51.5426497277677, Blast_Score=547, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI25148299, Length=608, Percent_Identity=37.0065789473684, Blast_Score=394, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6322563, Length=562, Percent_Identity=40.5693950177936, Blast_Score=415, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6319432, Length=564, Percent_Identity=40.4255319148936, Blast_Score=409, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24664469, Length=551, Percent_Identity=45.5535390199637, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI21357815, Length=495, Percent_Identity=43.6363636363636, Blast_Score=384, Evalue=1e-106,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_CHLP8 (B3QRL0)

Other databases:

- EMBL:   CP001099
- RefSeq:   YP_001997725.1
- ProteinModelPortal:   B3QRL0
- GeneID:   6418998
- GenomeReviews:   CP001099_GR
- KEGG:   cpc:Cpar_0097
- HOGENOM:   HBG597806
- OMA:   NIKIDPY
- ProtClustDB:   PRK05380
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 63736; Mature: 63605

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 390-390 ACT_SITE 516-516 ACT_SITE 518-518

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARPKNVKHIFVTGGVISSLGKGILSASLGMLLKSRGLRVAIQKYDPYINVDPGTMSPYQ
CCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCC
HGEVYVTDDGAETDLDLGHYERFLDEPTSQASNLTMGRVYKSVIDKERRGEYLGGTVQVV
CCEEEEECCCCCCCCCHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHH
PHVIDEIKEKMNDLAKNGSLDVLITEIGGTIGDIESLPFLEAMRQLKLELGDRNVLNIHL
HHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEE
TFVPYIKAASELKTKPTQHSVKMLLETGIQPDILVCRSEKPLSREIKNKVGHFCNVHEQD
EEHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCC
VIGLNDCETIYAVPLMLLREQLDLRVMKKLGLKKFREPNLEHWKRFCEKVTNPKDGEITI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHCCCCCCEEEE
GVCGKYTEYPDAYKSIIEAFIHAGASNDVKVSVKMLRAEDAEDSSFNMNKAFEGVSGLLV
EECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCHHHHHCCCCCEEE
APGFGDRGIEGKVQFVQYARENNIPFFGICLGMQCASIEFARNVCDLPDANSTEFNKRAR
ECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
FPVIDLMEQQKKVKEKGGTMRLGSYPCILKEGSKVHEVYGKFLINERHRHRYEFNNQFRK
CCHHHHHHHHHHHHHCCCCEEECCCCEEECCCCHHHHHHHHHHHCHHHHHHHHHHHHHHH
LFEEKGMIFSGTSPNGELVEIIELKEHRWFVAVQFHPELKSRVQKVHPLFDGFVQAAKEF
HHHHCCCEEECCCCCCCEEEEEEECCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
AMGKRQLTLEDELPRLSSEEMEGAG
HCCCCEEEEHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
ARPKNVKHIFVTGGVISSLGKGILSASLGMLLKSRGLRVAIQKYDPYINVDPGTMSPYQ
CCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCCCCC
HGEVYVTDDGAETDLDLGHYERFLDEPTSQASNLTMGRVYKSVIDKERRGEYLGGTVQVV
CCEEEEECCCCCCCCCHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHH
PHVIDEIKEKMNDLAKNGSLDVLITEIGGTIGDIESLPFLEAMRQLKLELGDRNVLNIHL
HHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEE
TFVPYIKAASELKTKPTQHSVKMLLETGIQPDILVCRSEKPLSREIKNKVGHFCNVHEQD
EEHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCC
VIGLNDCETIYAVPLMLLREQLDLRVMKKLGLKKFREPNLEHWKRFCEKVTNPKDGEITI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHCCCCCCEEEE
GVCGKYTEYPDAYKSIIEAFIHAGASNDVKVSVKMLRAEDAEDSSFNMNKAFEGVSGLLV
EECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCHHHHHCCCCCEEE
APGFGDRGIEGKVQFVQYARENNIPFFGICLGMQCASIEFARNVCDLPDANSTEFNKRAR
ECCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
FPVIDLMEQQKKVKEKGGTMRLGSYPCILKEGSKVHEVYGKFLINERHRHRYEFNNQFRK
CCHHHHHHHHHHHHHCCCCEEECCCCEEECCCCHHHHHHHHHHHCHHHHHHHHHHHHHHH
LFEEKGMIFSGTSPNGELVEIIELKEHRWFVAVQFHPELKSRVQKVHPLFDGFVQAAKEF
HHHHCCCEEECCCCCCCEEEEEEECCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
AMGKRQLTLEDELPRLSSEEMEGAG
HCCCCEEEEHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA