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The map label for this gene is gyrA [H]

Identifier: 193211771

GI number: 193211771

Start: 108004

End: 110484

Strand: Direct

Name: gyrA [H]

Synonym: Cpar_0096

Alternate gene names: 193211771

Gene position: 108004-110484 (Clockwise)

Preceding gene: 193211770

Following gene: 193211772

Centisome position: 4.72

GC content: 58.52

Gene sequence:

>2481_bases
ATGCAGCGCGAAAAGATATTGCCGATCAGCATTGAAGAGGAAATGCGGGATGCCTATCTCGATTATTCAATGTCGGTCAT
CGTCAGTCGAGCGCTGCCTGATGTGCGCGACGGCCTGAAGCCGGTGCATCGCCGTGTGCTGTACGGTATGCACGAGCTTG
GTCTCCAGTCAAACAAGCCTCACAAGAAATCGGCTCGCGTGGTCGGTGAGGTGCTCGGTAAGTATCATCCGCATGGTGAC
TCGGCTGTTTACGACAGCCTTGTTCGCATGGTGCAGGACTTCTCGCTGCGCTATCCTCTGATCGACGGCCAGGGTAACTT
CGGTTCGGTCGATGGCGACTCTCCGGCGGCGATGCGTTACACCGAGGTGCGCATGAAGGCGATCGCAGGCGAAATGCTCA
AGGATCTCGACAAGGAGACGGTCGATTTCGCGCTGAACTTCGACGATTCGCTCGAAGAGCCGACGGTGCTTCCCTCGGCG
ATTCCGAATCTGCTGGTGAACGGTGCTTCGGGTATCGCGGTCGGCATGGCAACCAATATTCCGCCGCATAACATGCGCGA
GGTGGTCAGCGGACTGATCGCCATGATCGACGATCCGGAGATCGAGATCACCGATCTCATGAAATATGTGACTGCGCCCG
ACTTCCCGACCGGAGGCATCATCTACGGCTACGAAGGTGTTCGTCAGGCCTACCTGACCGGTCGCGGCAAGGTGGTTATC
CGGGCCAGGGCCGTCGTCGAGGTGACGCAGAAGAATGGTCGCGAGTCGATCATCGTTACCGAACTTCCCTATCAGGTCAA
CAAGGTCAGGCTTATCGAGAAGATTGTCGAGCTGGTGCACGACAAGAAGATCGAGGGCATCGCCGACATCCGCGACGAGT
CCGACCGTGAAGGTATGCGTCTGGTGATCGAGCTGAAGCGCGACGCCGTGCCGAAGGTGGTGCTGAATCACCTCTACAAG
CACACTCCGATGCAGGATACCTTCGGCGTTATCATGCTGGCTCTGGTCGATGGTGTGCCGAGAGTGCTCAATCTCAAGGA
GATGATGCAGTACTACATCCGGCATCGCAACGAAATCGTGCTGCGCCGTACGCAATACGATCTCAACGCAGCCGAAAAGC
GTGCGCACATCCTCGAAGGTCTCAAGATCTGCCTCGACAATCTCGACGAGGTGATCACCACCATTCGCCAGTCTCCCGAT
ACTCCTACTGCGCAGAGCCGCCTGATCGACCGTTTCGGCTTGACCGAAGTGCAGGCCAAGGCGATTCTCGAAATGCGCTT
GCAGCGCCTGACCGGCATGGAGCGCCAGAAAATCGACGACGAGTACAAGCAGACGATGGCGCTTATCGAAGAGCTGAAAT
CGATTCTCGCGAGCCCGGCCAAGCAGATGGAAATTATCAAGGAGGAGCTGCTCAAGGTCAGCGAGGTTTACGGCGACGAA
CGCCGCACCGAGATGCGTCCTCAGGAGGGCGACTTCTCGATCGAGGACATGATCGCCCAGGAGGATGTGGTCATTACCAT
CACCCACGACGGCTTCATCAAGCGCTTCCCGGTTTCGGGCTATCGCCGTCAGCATCGCGGTGGACGCGGCGTTGCCGGAG
CGCAGGCGAAGAACGAGGATTTCATCGAGCACATGTTCATCGCTTCGACGCACAACTATATCCTCTTCTTCACCACGGCT
GGTCGTTGCTACTGGCTCAAGGTGTACGAAATTCCGGAGGCGGGACGTTCGGCGCGTGGCCGTTCGCTGGCCAACATCAT
GGAGCTGCCGCCCGGCGAGAAGATCCGCACCTACATCAACATCCGGAACTTCGACGATCCGCACTTCATCATCATGGCTA
CGGCCAACGGCATCGTCAAGAAGACCGATCTCAAGCAGTACTCCAATCCGCGACGTACCGGCATCAACGCCATTACGATC
GAGGAGGGCGATGAACTGATCGAGGCGCGCTTGACCGACGGCGACCATCAGGTTATTCTGGCCAAGAGCTCGGGCTATGC
CGTCCGGTTCCCGGAATCGGAGGTTCGCTCGATGGGCCGCACCGCGATGGGCGTCAAGGGCATCACCCTTGACGAGGCCG
AACGCTGCATCTCGATGGTCACCACCAAGCGCAACGACACCTCGTTGCTCGCCGTTACGGACAACGGCTACGGCAAGCGC
AGCAAGGTCGAGGATTACCGCATGACCAAGCGCGGCGCGCGCGGCGTCATCACGATCAAGGCGCACGAGAAAATCGGCAA
CTTGGTCGGGCTGCTCGACGTCAACGACGAGGACGACCTGATCATCATCACGACCAACGGCATCGTCATCCGCCAGCACG
TTTCGGACATCCGGGTGCTTGGTCGGAACACCTCAGGAGTCAGGCTCATCAGGCTTGATGCCGGCGACAGGATTTCTGCC
ACGGCGCGCGTGCCCAAGAGCGACGACGAGCCGACGAGCGAGCCTCTTGGTGAAGATGGGCAGATTGATATGGGATTTTA
G

Upstream 100 bases:

>100_bases
AGCGATCGCTTGCCGGAGGGAAAGAGCTTTATGTTTTTACGAGCTATTTCATACATTAAGCCGTTGTTTGTCACGGTAAA
TCAAAGTCAGGGTATCGATT

Downstream 100 bases:

>100_bases
CGAGACCTGCTGCGAGTTGGTGGCTGGCCCCGCGAACGAATGAAATGCGGTGAGCGTGCAGCTTTCCGCAGAAAGAGGTG
ACTGTTATTACTTAATTATC

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 826; Mature: 826

Protein sequence:

>826_residues
MQREKILPISIEEEMRDAYLDYSMSVIVSRALPDVRDGLKPVHRRVLYGMHELGLQSNKPHKKSARVVGEVLGKYHPHGD
SAVYDSLVRMVQDFSLRYPLIDGQGNFGSVDGDSPAAMRYTEVRMKAIAGEMLKDLDKETVDFALNFDDSLEEPTVLPSA
IPNLLVNGASGIAVGMATNIPPHNMREVVSGLIAMIDDPEIEITDLMKYVTAPDFPTGGIIYGYEGVRQAYLTGRGKVVI
RARAVVEVTQKNGRESIIVTELPYQVNKVRLIEKIVELVHDKKIEGIADIRDESDREGMRLVIELKRDAVPKVVLNHLYK
HTPMQDTFGVIMLALVDGVPRVLNLKEMMQYYIRHRNEIVLRRTQYDLNAAEKRAHILEGLKICLDNLDEVITTIRQSPD
TPTAQSRLIDRFGLTEVQAKAILEMRLQRLTGMERQKIDDEYKQTMALIEELKSILASPAKQMEIIKEELLKVSEVYGDE
RRTEMRPQEGDFSIEDMIAQEDVVITITHDGFIKRFPVSGYRRQHRGGRGVAGAQAKNEDFIEHMFIASTHNYILFFTTA
GRCYWLKVYEIPEAGRSARGRSLANIMELPPGEKIRTYINIRNFDDPHFIIMATANGIVKKTDLKQYSNPRRTGINAITI
EEGDELIEARLTDGDHQVILAKSSGYAVRFPESEVRSMGRTAMGVKGITLDEAERCISMVTTKRNDTSLLAVTDNGYGKR
SKVEDYRMTKRGARGVITIKAHEKIGNLVGLLDVNDEDDLIIITTNGIVIRQHVSDIRVLGRNTSGVRLIRLDAGDRISA
TARVPKSDDEPTSEPLGEDGQIDMGF

Sequences:

>Translated_826_residues
MQREKILPISIEEEMRDAYLDYSMSVIVSRALPDVRDGLKPVHRRVLYGMHELGLQSNKPHKKSARVVGEVLGKYHPHGD
SAVYDSLVRMVQDFSLRYPLIDGQGNFGSVDGDSPAAMRYTEVRMKAIAGEMLKDLDKETVDFALNFDDSLEEPTVLPSA
IPNLLVNGASGIAVGMATNIPPHNMREVVSGLIAMIDDPEIEITDLMKYVTAPDFPTGGIIYGYEGVRQAYLTGRGKVVI
RARAVVEVTQKNGRESIIVTELPYQVNKVRLIEKIVELVHDKKIEGIADIRDESDREGMRLVIELKRDAVPKVVLNHLYK
HTPMQDTFGVIMLALVDGVPRVLNLKEMMQYYIRHRNEIVLRRTQYDLNAAEKRAHILEGLKICLDNLDEVITTIRQSPD
TPTAQSRLIDRFGLTEVQAKAILEMRLQRLTGMERQKIDDEYKQTMALIEELKSILASPAKQMEIIKEELLKVSEVYGDE
RRTEMRPQEGDFSIEDMIAQEDVVITITHDGFIKRFPVSGYRRQHRGGRGVAGAQAKNEDFIEHMFIASTHNYILFFTTA
GRCYWLKVYEIPEAGRSARGRSLANIMELPPGEKIRTYINIRNFDDPHFIIMATANGIVKKTDLKQYSNPRRTGINAITI
EEGDELIEARLTDGDHQVILAKSSGYAVRFPESEVRSMGRTAMGVKGITLDEAERCISMVTTKRNDTSLLAVTDNGYGKR
SKVEDYRMTKRGARGVITIKAHEKIGNLVGLLDVNDEDDLIIITTNGIVIRQHVSDIRVLGRNTSGVRLIRLDAGDRISA
TARVPKSDDEPTSEPLGEDGQIDMGF
>Mature_826_residues
MQREKILPISIEEEMRDAYLDYSMSVIVSRALPDVRDGLKPVHRRVLYGMHELGLQSNKPHKKSARVVGEVLGKYHPHGD
SAVYDSLVRMVQDFSLRYPLIDGQGNFGSVDGDSPAAMRYTEVRMKAIAGEMLKDLDKETVDFALNFDDSLEEPTVLPSA
IPNLLVNGASGIAVGMATNIPPHNMREVVSGLIAMIDDPEIEITDLMKYVTAPDFPTGGIIYGYEGVRQAYLTGRGKVVI
RARAVVEVTQKNGRESIIVTELPYQVNKVRLIEKIVELVHDKKIEGIADIRDESDREGMRLVIELKRDAVPKVVLNHLYK
HTPMQDTFGVIMLALVDGVPRVLNLKEMMQYYIRHRNEIVLRRTQYDLNAAEKRAHILEGLKICLDNLDEVITTIRQSPD
TPTAQSRLIDRFGLTEVQAKAILEMRLQRLTGMERQKIDDEYKQTMALIEELKSILASPAKQMEIIKEELLKVSEVYGDE
RRTEMRPQEGDFSIEDMIAQEDVVITITHDGFIKRFPVSGYRRQHRGGRGVAGAQAKNEDFIEHMFIASTHNYILFFTTA
GRCYWLKVYEIPEAGRSARGRSLANIMELPPGEKIRTYINIRNFDDPHFIIMATANGIVKKTDLKQYSNPRRTGINAITI
EEGDELIEARLTDGDHQVILAKSSGYAVRFPESEVRSMGRTAMGVKGITLDEAERCISMVTTKRNDTSLLAVTDNGYGKR
SKVEDYRMTKRGARGVITIKAHEKIGNLVGLLDVNDEDDLIIITTNGIVIRQHVSDIRVLGRNTSGVRLIRLDAGDRISA
TARVPKSDDEPTSEPLGEDGQIDMGF

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=320, Percent_Identity=25.3125, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI19913406, Length=177, Percent_Identity=29.9435028248588, Blast_Score=77, Evalue=8e-14,
Organism=Escherichia coli, GI1788562, Length=840, Percent_Identity=51.6666666666667, Blast_Score=859, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=698, Percent_Identity=37.5358166189112, Blast_Score=422, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17535065, Length=369, Percent_Identity=24.1192411924119, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=368, Percent_Identity=23.9130434782609, Blast_Score=77, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI212645845, Length=200, Percent_Identity=27, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=177, Percent_Identity=31.0734463276836, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17136538, Length=177, Percent_Identity=31.0734463276836, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 92870; Mature: 92870

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQREKILPISIEEEMRDAYLDYSMSVIVSRALPDVRDGLKPVHRRVLYGMHELGLQSNKP
CCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
HKKSARVVGEVLGKYHPHGDSAVYDSLVRMVQDFSLRYPLIDGQGNFGSVDGDSPAAMRY
CHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCHHHH
TEVRMKAIAGEMLKDLDKETVDFALNFDDSLEEPTVLPSAIPNLLVNGASGIAVGMATNI
HHHHHHHHHHHHHHHCCHHHEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCC
PPHNMREVVSGLIAMIDDPEIEITDLMKYVTAPDFPTGGIIYGYEGVRQAYLTGRGKVVI
CCCHHHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCCCCCEEECCHHHHHHHHCCCCEEEE
RARAVVEVTQKNGRESIIVTELPYQVNKVRLIEKIVELVHDKKIEGIADIRDESDREGMR
EEEEEHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCE
LVIELKRDAVPKVVLNHLYKHTPMQDTFGVIMLALVDGVPRVLNLKEMMQYYIRHRNEIV
EEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHCCCEEE
LRRTQYDLNAAEKRAHILEGLKICLDNLDEVITTIRQSPDTPTAQSRLIDRFGLTEVQAK
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHH
AILEMRLQRLTGMERQKIDDEYKQTMALIEELKSILASPAKQMEIIKEELLKVSEVYGDE
HHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCH
RRTEMRPQEGDFSIEDMIAQEDVVITITHDGFIKRFPVSGYRRQHRGGRGVAGAQAKNED
HHHCCCCCCCCCCHHHHHCCCCEEEEEECCCCEEECCCCCHHHHCCCCCCCCCCCCCCHH
FIEHMFIASTHNYILFFTTAGRCYWLKVYEIPEAGRSARGRSLANIMELPPGEKIRTYIN
HHHHHHHEECCCEEEEEEECCCEEEEEEEECCCCCCCCCCCHHHHHHHCCCCCCEEEEEE
IRNFDDPHFIIMATANGIVKKTDLKQYSNPRRTGINAITIEEGDELIEARLTDGDHQVIL
EECCCCCCEEEEEECCCCEECCHHHHCCCCCCCCCCEEEECCCCHHHHHHCCCCCCEEEE
AKSSGYAVRFPESEVRSMGRTAMGVKGITLDEAERCISMVTTKRNDTSLLAVTDNGYGKR
EECCCCEEECCHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCC
SKVEDYRMTKRGARGVITIKAHEKIGNLVGLLDVNDEDDLIIITTNGIVIRQHVSDIRVL
CCCHHHHHHHCCCCEEEEEEEHHHHCCEEEEEECCCCCCEEEEEECCEEEEEHHHHHHEE
GRNTSGVRLIRLDAGDRISATARVPKSDDEPTSEPLGEDGQIDMGF
CCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCEECCC
>Mature Secondary Structure
MQREKILPISIEEEMRDAYLDYSMSVIVSRALPDVRDGLKPVHRRVLYGMHELGLQSNKP
CCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
HKKSARVVGEVLGKYHPHGDSAVYDSLVRMVQDFSLRYPLIDGQGNFGSVDGDSPAAMRY
CHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCHHHH
TEVRMKAIAGEMLKDLDKETVDFALNFDDSLEEPTVLPSAIPNLLVNGASGIAVGMATNI
HHHHHHHHHHHHHHHCCHHHEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEECCC
PPHNMREVVSGLIAMIDDPEIEITDLMKYVTAPDFPTGGIIYGYEGVRQAYLTGRGKVVI
CCCHHHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCCCCCEEECCHHHHHHHHCCCCEEEE
RARAVVEVTQKNGRESIIVTELPYQVNKVRLIEKIVELVHDKKIEGIADIRDESDREGMR
EEEEEHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCE
LVIELKRDAVPKVVLNHLYKHTPMQDTFGVIMLALVDGVPRVLNLKEMMQYYIRHRNEIV
EEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHCCCEEE
LRRTQYDLNAAEKRAHILEGLKICLDNLDEVITTIRQSPDTPTAQSRLIDRFGLTEVQAK
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHH
AILEMRLQRLTGMERQKIDDEYKQTMALIEELKSILASPAKQMEIIKEELLKVSEVYGDE
HHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCH
RRTEMRPQEGDFSIEDMIAQEDVVITITHDGFIKRFPVSGYRRQHRGGRGVAGAQAKNED
HHHCCCCCCCCCCHHHHHCCCCEEEEEECCCCEEECCCCCHHHHCCCCCCCCCCCCCCHH
FIEHMFIASTHNYILFFTTAGRCYWLKVYEIPEAGRSARGRSLANIMELPPGEKIRTYIN
HHHHHHHEECCCEEEEEEECCCEEEEEEEECCCCCCCCCCCHHHHHHHCCCCCCEEEEEE
IRNFDDPHFIIMATANGIVKKTDLKQYSNPRRTGINAITIEEGDELIEARLTDGDHQVIL
EECCCCCCEEEEEECCCCEECCHHHHCCCCCCCCCCEEEECCCCHHHHHHCCCCCCEEEE
AKSSGYAVRFPESEVRSMGRTAMGVKGITLDEAERCISMVTTKRNDTSLLAVTDNGYGKR
EECCCCEEECCHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCC
SKVEDYRMTKRGARGVITIKAHEKIGNLVGLLDVNDEDDLIIITTNGIVIRQHVSDIRVL
CCCHHHHHHHCCCCEEEEEEEHHHHCCEEEEEECCCCCCEEEEEECCEEEEEHHHHHHEE
GRNTSGVRLIRLDAGDRISATARVPKSDDEPTSEPLGEDGQIDMGF
CCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]