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The map label for this gene is glmS [H]

Identifier: 193211750

GI number: 193211750

Start: 84522

End: 86366

Strand: Direct

Name: glmS [H]

Synonym: Cpar_0075

Alternate gene names: 193211750

Gene position: 84522-86366 (Clockwise)

Preceding gene: 193211749

Following gene: 193211752

Centisome position: 3.69

GC content: 59.57

Gene sequence:

>1845_bases
ATGTGTGGCATTATCGGCTATATCGGTAAGCGTGAAGCGGCTCCGCTGCTTCTGAATGGTTTGAAACGTCTTGAATACAG
AGGATATGATTCCGCCGGCATGGCGGTCATGAACGGTTCGATGCAGGTGCTCAAGCAGAAGGGCAGCGTCGGTAATCTCG
AAGAGCTGCTGAACGTTTCGGGCTCGGTCATGCTCGGGGCTACCATCGGCATCGCGCATACCCGATGGGCGACGCATGGC
GACCCGAGTGACCGGAACGCTCACCCCCACATGAACATCTCCGACGACATCGCCCTGATTCACAACGGCATCATCGAGAA
CTATACGACCCTGAAAAAAGAGCTGATCTCTCAGGGGTACGAGTTCGAGAGCGATACCGATTCCGAGGTGCTGGTGCATC
TGATCGACCGCGTCTGGAAAGCCGATCCGTCGATCGGGCTGGAGGGAGCCGTCCGCCAGGCGCTTCGGCATGTAGAAGGT
GCGTACGGCATCTGCGTGGTCTCTTCCCGGGAGCCCGACAAGATTGTGGTGGCCCGCAAGGGAAGCCCGCTGGTGATTGG
CCTGGGCGACGGCGAATATTTTATCGCCTCCGACGCAGCGCCGATCGTGGAGCACACCAACAAAGTGGTCTATCTGCTTG
ATGGCGAAATGGCTGTGGTGACCCACGAAAACTACACGGTCAAGACTATCGAGAATGTCGAGCAGGAGAAACGGGTCACC
GAACTTGATTTCAGCCTTGAAAAGATCGAGAAGGGCGGATTCGAACACTTCATGCTCAAGGAGATTTTCGAGCAGCCCGA
GGTGATGCGCGACGTCATGCGCGGCCGCATTCGCGTCGATGAGGGGCGGGTGCAGCTTGGCGGCATCGAAGATTACCTCG
ACAGGCTCAAGCAGGCCAAGCGTATCGTGATCTGCGCCTGCGGTACGAGCTGGCACGCGGGGCTGATCGGCGAGTACCTG
ATCGAGGAGTACGCCCGCATTCCGGTGGAGGTCGATTACGCGTCGGAATTCCGGTACCGCAACCCGATTGTGACCGCCGA
CGATGTGGTGATCGTCATCTCCCAGTCCGGCGAAACCGCCGATACGCTGGCCGCGCTTCGCCTTGCCAAAGAGAAGGGCG
CGCTGGTGATGGGCATCTGCAACGTGGTTGGCTCGACGATCGCCCGCGAGACCCTGTGCGGCATGTACACCCATGCAGGG
CCGGAGGTGGGCGTGGCCTCGACCAAAGCCTTCACGGCCCAGGTGATCGTGCTTTTCATGCTCGCCATGGCGCTCAGCAA
GGGGCGCACCATTTCGCAGGAGGAGATCAAGCTCAATCTGCGTGATCTGGCCGATGTGCCGGAAAAGGTTGCGCGGATTC
TGGAACAGAACGACGTTATCAAAGAGCTTGCCGCCAAACTCAAGGATGCACGCAACGCGCTCTATCTTGGCCGTGGCTAC
AACTTCCCGGTTGCGCTCGAAGGAGCGCTGAAGCTCAAAGAGATATCCTACATCCACGCGGAAGGCTATCCCGCCGCCGA
GATGAAGCACGGGCCGATTGCGCTGATTGACGAAGATATGCCGGTGATCGTCATTGCCACCCGCGACAACACCTACGCCA
AGATTCTGAGCAACATCGAGGAGGTGCGAAGCCGCAAAGGCCGCGTTATCGCCATCGCCAGCGAGGGCGACCGCGAGATC
GCCGAACTCACGCCCGACGTGATCTACATTCCCCAAGCATCCGCCGCGCTGCTGCCGCTCCTGACGGTCATTCCGTTGCA
GCTGCTCTCCTACCACGTGGCCACCATGCGCGGTTGCAACGTTGACCGCCCCCGTAACCTCGCCAAATCGGTGACGGTGG
AGTAG

Upstream 100 bases:

>100_bases
ATGTTGTGATTTTAGTGTGCAATAACATAGATATATTGGGCAAGCCTCCGGTTGATACCGGCGTCTTGTCTGCATGAAAA
CGTAATCAAGGAATTGGAAT

Downstream 100 bases:

>100_bases
GGCGACTGGCTGTTATTTGCTCAGGCCTGAAATAAAGCCGGCTCCGCAGATGGCGAAGCGCGGGCATCAGGCCAGTATCG
AGAGAGCAAAAAAAAAATTG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 614; Mature: 614

Protein sequence:

>614_residues
MCGIIGYIGKREAAPLLLNGLKRLEYRGYDSAGMAVMNGSMQVLKQKGSVGNLEELLNVSGSVMLGATIGIAHTRWATHG
DPSDRNAHPHMNISDDIALIHNGIIENYTTLKKELISQGYEFESDTDSEVLVHLIDRVWKADPSIGLEGAVRQALRHVEG
AYGICVVSSREPDKIVVARKGSPLVIGLGDGEYFIASDAAPIVEHTNKVVYLLDGEMAVVTHENYTVKTIENVEQEKRVT
ELDFSLEKIEKGGFEHFMLKEIFEQPEVMRDVMRGRIRVDEGRVQLGGIEDYLDRLKQAKRIVICACGTSWHAGLIGEYL
IEEYARIPVEVDYASEFRYRNPIVTADDVVIVISQSGETADTLAALRLAKEKGALVMGICNVVGSTIARETLCGMYTHAG
PEVGVASTKAFTAQVIVLFMLAMALSKGRTISQEEIKLNLRDLADVPEKVARILEQNDVIKELAAKLKDARNALYLGRGY
NFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEDMPVIVIATRDNTYAKILSNIEEVRSRKGRVIAIASEGDREI
AELTPDVIYIPQASAALLPLLTVIPLQLLSYHVATMRGCNVDRPRNLAKSVTVE

Sequences:

>Translated_614_residues
MCGIIGYIGKREAAPLLLNGLKRLEYRGYDSAGMAVMNGSMQVLKQKGSVGNLEELLNVSGSVMLGATIGIAHTRWATHG
DPSDRNAHPHMNISDDIALIHNGIIENYTTLKKELISQGYEFESDTDSEVLVHLIDRVWKADPSIGLEGAVRQALRHVEG
AYGICVVSSREPDKIVVARKGSPLVIGLGDGEYFIASDAAPIVEHTNKVVYLLDGEMAVVTHENYTVKTIENVEQEKRVT
ELDFSLEKIEKGGFEHFMLKEIFEQPEVMRDVMRGRIRVDEGRVQLGGIEDYLDRLKQAKRIVICACGTSWHAGLIGEYL
IEEYARIPVEVDYASEFRYRNPIVTADDVVIVISQSGETADTLAALRLAKEKGALVMGICNVVGSTIARETLCGMYTHAG
PEVGVASTKAFTAQVIVLFMLAMALSKGRTISQEEIKLNLRDLADVPEKVARILEQNDVIKELAAKLKDARNALYLGRGY
NFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEDMPVIVIATRDNTYAKILSNIEEVRSRKGRVIAIASEGDREI
AELTPDVIYIPQASAALLPLLTVIPLQLLSYHVATMRGCNVDRPRNLAKSVTVE
>Mature_614_residues
MCGIIGYIGKREAAPLLLNGLKRLEYRGYDSAGMAVMNGSMQVLKQKGSVGNLEELLNVSGSVMLGATIGIAHTRWATHG
DPSDRNAHPHMNISDDIALIHNGIIENYTTLKKELISQGYEFESDTDSEVLVHLIDRVWKADPSIGLEGAVRQALRHVEG
AYGICVVSSREPDKIVVARKGSPLVIGLGDGEYFIASDAAPIVEHTNKVVYLLDGEMAVVTHENYTVKTIENVEQEKRVT
ELDFSLEKIEKGGFEHFMLKEIFEQPEVMRDVMRGRIRVDEGRVQLGGIEDYLDRLKQAKRIVICACGTSWHAGLIGEYL
IEEYARIPVEVDYASEFRYRNPIVTADDVVIVISQSGETADTLAALRLAKEKGALVMGICNVVGSTIARETLCGMYTHAG
PEVGVASTKAFTAQVIVLFMLAMALSKGRTISQEEIKLNLRDLADVPEKVARILEQNDVIKELAAKLKDARNALYLGRGY
NFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEDMPVIVIATRDNTYAKILSNIEEVRSRKGRVIAIASEGDREI
AELTPDVIYIPQASAALLPLLTVIPLQLLSYHVATMRGCNVDRPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=681, Percent_Identity=40.8223201174743, Blast_Score=520, Evalue=1e-147,
Organism=Homo sapiens, GI4826742, Length=682, Percent_Identity=41.2023460410557, Blast_Score=520, Evalue=1e-147,
Organism=Escherichia coli, GI1790167, Length=618, Percent_Identity=45.7928802588997, Blast_Score=537, Evalue=1e-153,
Organism=Escherichia coli, GI1788651, Length=221, Percent_Identity=28.9592760180996, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17539970, Length=714, Percent_Identity=36.5546218487395, Blast_Score=454, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17532899, Length=432, Percent_Identity=45.6018518518519, Blast_Score=377, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17532897, Length=432, Percent_Identity=45.6018518518519, Blast_Score=377, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6322745, Length=451, Percent_Identity=43.9024390243902, Blast_Score=370, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6323731, Length=438, Percent_Identity=38.3561643835616, Blast_Score=294, Evalue=4e-80,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=38.0487804878049, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323958, Length=247, Percent_Identity=27.5303643724696, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357745, Length=684, Percent_Identity=42.5438596491228, Blast_Score=550, Evalue=1e-157,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 67489; Mature: 67489

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIIGYIGKREAAPLLLNGLKRLEYRGYDSAGMAVMNGSMQVLKQKGSVGNLEELLNVS
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHCCCCCCHHHHHCCC
GSVMLGATIGIAHTRWATHGDPSDRNAHPHMNISDDIALIHNGIIENYTTLKKELISQGY
CCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
EFESDTDSEVLVHLIDRVWKADPSIGLEGAVRQALRHVEGAYGICVVSSREPDKIVVARK
CCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEC
GSPLVIGLGDGEYFIASDAAPIVEHTNKVVYLLDGEMAVVTHENYTVKTIENVEQEKRVT
CCEEEEEECCCCEEEECCCCHHHHCCCCEEEEEECCEEEEEECCEEEEHHHHHHHHHHHH
ELDFSLEKIEKGGFEHFMLKEIFEQPEVMRDVMRGRIRVDEGRVQLGGIEDYLDRLKQAK
HHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHCCEEEECCCEEECCHHHHHHHHHHCC
RIVICACGTSWHAGLIGEYLIEEYARIPVEVDYASEFRYRNPIVTADDVVIVISQSGETA
EEEEEECCCCCCHHHHHHHHHHHHHHCCEEEECHHHCCCCCCCEECCCEEEEEECCCCHH
DTLAALRLAKEKGALVMGICNVVGSTIARETLCGMYTHAGPEVGVASTKAFTAQVIVLFM
HHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LAMALSKGRTISQEEIKLNLRDLADVPEKVARILEQNDVIKELAAKLKDARNALYLGRGY
HHHHHHCCCCCCHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCC
NFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEDMPVIVIATRDNTYAKILSNIE
CCCEEECCCEEEEHEEEEECCCCCCCCCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHH
EVRSRKGRVIAIASEGDREIAELTPDVIYIPQASAALLPLLTVIPLQLLSYHVATMRGCN
HHHHCCCCEEEEECCCCHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
VDRPRNLAKSVTVE
CCCCHHHHHHCCCC
>Mature Secondary Structure
MCGIIGYIGKREAAPLLLNGLKRLEYRGYDSAGMAVMNGSMQVLKQKGSVGNLEELLNVS
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHCCCCCCHHHHHCCC
GSVMLGATIGIAHTRWATHGDPSDRNAHPHMNISDDIALIHNGIIENYTTLKKELISQGY
CCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
EFESDTDSEVLVHLIDRVWKADPSIGLEGAVRQALRHVEGAYGICVVSSREPDKIVVARK
CCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEC
GSPLVIGLGDGEYFIASDAAPIVEHTNKVVYLLDGEMAVVTHENYTVKTIENVEQEKRVT
CCEEEEEECCCCEEEECCCCHHHHCCCCEEEEEECCEEEEEECCEEEEHHHHHHHHHHHH
ELDFSLEKIEKGGFEHFMLKEIFEQPEVMRDVMRGRIRVDEGRVQLGGIEDYLDRLKQAK
HHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHCCEEEECCCEEECCHHHHHHHHHHCC
RIVICACGTSWHAGLIGEYLIEEYARIPVEVDYASEFRYRNPIVTADDVVIVISQSGETA
EEEEEECCCCCCHHHHHHHHHHHHHHCCEEEECHHHCCCCCCCEECCCEEEEEECCCCHH
DTLAALRLAKEKGALVMGICNVVGSTIARETLCGMYTHAGPEVGVASTKAFTAQVIVLFM
HHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
LAMALSKGRTISQEEIKLNLRDLADVPEKVARILEQNDVIKELAAKLKDARNALYLGRGY
HHHHHHCCCCCCHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCC
NFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDEDMPVIVIATRDNTYAKILSNIE
CCCEEECCCEEEEHEEEEECCCCCCCCCCCCCEEEEECCCCEEEEEECCCHHHHHHHHHH
EVRSRKGRVIAIASEGDREIAELTPDVIYIPQASAALLPLLTVIPLQLLSYHVATMRGCN
HHHHCCCCEEEEECCCCHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
VDRPRNLAKSVTVE
CCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]