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The map label for this gene is dnaA [H]

Identifier: 193211677

GI number: 193211677

Start: 167

End: 1648

Strand: Direct

Name: dnaA [H]

Synonym: Cpar_0001

Alternate gene names: 193211677

Gene position: 167-1648 (Clockwise)

Preceding gene: NA

Following gene: 193211678

Centisome position: 0.01

GC content: 54.12

Gene sequence:

>1482_bases
ATGCCCGAACTGATCCAGCAGGCTCCGACCGGTAACCTTCAAGCAACCCACTCCCAAAGCGGTTCATTTGCCGAAAAGGT
CTGGAACGCCTGTCTTGAACTTATTCAGGAGAACATCAACAGCCTGGCCTTCAAGACCTGGTTTCTGCCGATCCGCCCCT
TGTCGTTTTCGGGAAGCGAGCTGACCATCGAGGTACCGAGCCAGTTTTTCTATGAGTGGATCGAAGAGAACTACTCGGTG
CACGTCAAGCAGGCGTTGCGACAGGTCATCGGACCGGAAGCGAAGCTGATGTACTCGATTGTCATGGACAAGTCGCAAGG
CCAGCCCGTGACCATCGAACTGCCCCACCAGAATGCTCACGCACCGACAGAATCTGATACCAAACCCGAGCGAGCCCAAG
AGCCTGTTTCCGCGGAACGCGAGCGTTTCGAGCGGAACAGGACAAAATTCGAGAGCAATCTCAACCCGAAATACACCTTT
TCGACCCTGATCAGGGGCGATTGCAACTCCCTGGCGTTCGCTGCCGCCAAGTCCATCGCCCAGAATCCCGGCCAGAACGC
TTTCAACCCGCTGGTCATTTACGGCGGCGTAGGGTTGGGGAAAACTCACATGATGCAGGCAATCGGCAACTCCGTGCTGG
AAAACCGGATCAGCGGAGCGGTGCTGTACGTGTCGAGCGAAAAGTTCGCCATCGACTTCGTCAATGCAATCCAGAACGGC
AACATTCAGGAGTTTTCGGCTTTCTACCGGAACATCGACGTGCTGATTATCGACGATATCCAGTTCTTTGCCGGCAAAGA
GAAGACCCAGGAGGAGATCTTCCACATCTTCAACACCCTGCATCAGGCCAACAAGCAGATCATTCTGTCGGCTGACCGGC
CGATCAAGGAGATCAAGGGGATCGAAGACCGCCTCATTTCGCGCTTCAACTGGGGGCTTTCGACCGACATCCAGGCGCCC
GATTACGAAACCCGCAAGGCGATCATCCAGAGCAAGCTCAAGCAGAACGGCGTCAATCTCGATCCGGCGGTGATCGAATT
CATTGCGACCAACGTCACCAACAACGTCCGCGAGCTCGAAGGGTGCATCGTCAAGCTGCTCGCCGCCCATTCGCTCGACA
ATCAGGAGATAGACCTCCAGTTCACCAAATCGACGCTCAAGGATATCATCCGCTACAACACCAAGCAGCTTACCCTTGAA
ACCATCGAAAAAGCGGTCTGCTCCTTCTTCTCGATCACACCGAACGACCTGAAAGGCAAGTCGAAGAAAAAAGAGATCGC
CGTCGGGCGGCAGATCGCCATGTACCTCTCAAAGGATATGACCGACTCTTCGCTCAAAACGATCGGCCTGCATTTCGGCG
GACGCGACCACTCAACGGTCATTCACGCACTGAACACCATCGAGAAAAAAATCACCTCCTCGAACGAAGAGCGGAAAAAA
ATCGAAGAGCTGAAGAAGAGAATCGAAATCATGTCGATGTAA

Upstream 100 bases:

>100_bases
ATTTCGAAACTGGAATTGTTTTTTATCCACTGAAAACTGTAACTTGTGAACAGAAAATGTGGATGAACCTCCTTAAAAAC
GCCTCTCCCGCACGACTCTC

Downstream 100 bases:

>100_bases
CGAGCGGATATGTGTACAACCTGTTTATATCCTGTTGGCGGATTCTTGATGAACGCGCACTTGTCAACATCTGACTGAAT
GAGCGAAAATGCACCAACAA

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MPELIQQAPTGNLQATHSQSGSFAEKVWNACLELIQENINSLAFKTWFLPIRPLSFSGSELTIEVPSQFFYEWIEENYSV
HVKQALRQVIGPEAKLMYSIVMDKSQGQPVTIELPHQNAHAPTESDTKPERAQEPVSAERERFERNRTKFESNLNPKYTF
STLIRGDCNSLAFAAAKSIAQNPGQNAFNPLVIYGGVGLGKTHMMQAIGNSVLENRISGAVLYVSSEKFAIDFVNAIQNG
NIQEFSAFYRNIDVLIIDDIQFFAGKEKTQEEIFHIFNTLHQANKQIILSADRPIKEIKGIEDRLISRFNWGLSTDIQAP
DYETRKAIIQSKLKQNGVNLDPAVIEFIATNVTNNVRELEGCIVKLLAAHSLDNQEIDLQFTKSTLKDIIRYNTKQLTLE
TIEKAVCSFFSITPNDLKGKSKKKEIAVGRQIAMYLSKDMTDSSLKTIGLHFGGRDHSTVIHALNTIEKKITSSNEERKK
IEELKKRIEIMSM

Sequences:

>Translated_493_residues
MPELIQQAPTGNLQATHSQSGSFAEKVWNACLELIQENINSLAFKTWFLPIRPLSFSGSELTIEVPSQFFYEWIEENYSV
HVKQALRQVIGPEAKLMYSIVMDKSQGQPVTIELPHQNAHAPTESDTKPERAQEPVSAERERFERNRTKFESNLNPKYTF
STLIRGDCNSLAFAAAKSIAQNPGQNAFNPLVIYGGVGLGKTHMMQAIGNSVLENRISGAVLYVSSEKFAIDFVNAIQNG
NIQEFSAFYRNIDVLIIDDIQFFAGKEKTQEEIFHIFNTLHQANKQIILSADRPIKEIKGIEDRLISRFNWGLSTDIQAP
DYETRKAIIQSKLKQNGVNLDPAVIEFIATNVTNNVRELEGCIVKLLAAHSLDNQEIDLQFTKSTLKDIIRYNTKQLTLE
TIEKAVCSFFSITPNDLKGKSKKKEIAVGRQIAMYLSKDMTDSSLKTIGLHFGGRDHSTVIHALNTIEKKITSSNEERKK
IEELKKRIEIMSM
>Mature_492_residues
PELIQQAPTGNLQATHSQSGSFAEKVWNACLELIQENINSLAFKTWFLPIRPLSFSGSELTIEVPSQFFYEWIEENYSVH
VKQALRQVIGPEAKLMYSIVMDKSQGQPVTIELPHQNAHAPTESDTKPERAQEPVSAERERFERNRTKFESNLNPKYTFS
TLIRGDCNSLAFAAAKSIAQNPGQNAFNPLVIYGGVGLGKTHMMQAIGNSVLENRISGAVLYVSSEKFAIDFVNAIQNGN
IQEFSAFYRNIDVLIIDDIQFFAGKEKTQEEIFHIFNTLHQANKQIILSADRPIKEIKGIEDRLISRFNWGLSTDIQAPD
YETRKAIIQSKLKQNGVNLDPAVIEFIATNVTNNVRELEGCIVKLLAAHSLDNQEIDLQFTKSTLKDIIRYNTKQLTLET
IEKAVCSFFSITPNDLKGKSKKKEIAVGRQIAMYLSKDMTDSSLKTIGLHFGGRDHSTVIHALNTIEKKITSSNEERKKI
EELKKRIEIMSM

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=459, Percent_Identity=39.8692810457516, Blast_Score=346, Evalue=2e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 55616; Mature: 55485

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELIQQAPTGNLQATHSQSGSFAEKVWNACLELIQENINSLAFKTWFLPIRPLSFSGSE
CCCHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCE
LTIEVPSQFFYEWIEENYSVHVKQALRQVIGPEAKLMYSIVMDKSQGQPVTIELPHQNAH
EEEECCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCCCCCC
APTESDTKPERAQEPVSAERERFERNRTKFESNLNPKYTFSTLIRGDCNSLAFAAAKSIA
CCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHCCCHHHHHHHHHHHH
QNPGQNAFNPLVIYGGVGLGKTHMMQAIGNSVLENRISGAVLYVSSEKFAIDFVNAIQNG
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCC
NIQEFSAFYRNIDVLIIDDIQFFAGKEKTQEEIFHIFNTLHQANKQIILSADRPIKEIKG
CHHHHHHHHCCCCEEEEECHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHCC
IEDRLISRFNWGLSTDIQAPDYETRKAIIQSKLKQNGVNLDPAVIEFIATNVTNNVRELE
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GCIVKLLAAHSLDNQEIDLQFTKSTLKDIIRYNTKQLTLETIEKAVCSFFSITPNDLKGK
HHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHCCCC
SKKKEIAVGRQIAMYLSKDMTDSSLKTIGLHFGGRDHSTVIHALNTIEKKITSSNEERKK
CHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHH
IEELKKRIEIMSM
HHHHHHHHHHHCC
>Mature Secondary Structure 
PELIQQAPTGNLQATHSQSGSFAEKVWNACLELIQENINSLAFKTWFLPIRPLSFSGSE
CCHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCE
LTIEVPSQFFYEWIEENYSVHVKQALRQVIGPEAKLMYSIVMDKSQGQPVTIELPHQNAH
EEEECCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCCCCCC
APTESDTKPERAQEPVSAERERFERNRTKFESNLNPKYTFSTLIRGDCNSLAFAAAKSIA
CCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHCCCHHHHHHHHHHHH
QNPGQNAFNPLVIYGGVGLGKTHMMQAIGNSVLENRISGAVLYVSSEKFAIDFVNAIQNG
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCC
NIQEFSAFYRNIDVLIIDDIQFFAGKEKTQEEIFHIFNTLHQANKQIILSADRPIKEIKG
CHHHHHHHHCCCCEEEEECHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHCC
IEDRLISRFNWGLSTDIQAPDYETRKAIIQSKLKQNGVNLDPAVIEFIATNVTNNVRELE
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GCIVKLLAAHSLDNQEIDLQFTKSTLKDIIRYNTKQLTLETIEKAVCSFFSITPNDLKGK
HHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHCCCC
SKKKEIAVGRQIAMYLSKDMTDSSLKTIGLHFGGRDHSTVIHALNTIEKKITSSNEERKK
CHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHH
IEELKKRIEIMSM
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]