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The map label for this gene is cobH [H]

Identifier: 192290764

GI number: 192290764

Start: 2563838

End: 2564467

Strand: Reverse

Name: cobH [H]

Synonym: Rpal_2380

Alternate gene names: 192290764

Gene position: 2564467-2563838 (Counterclockwise)

Preceding gene: 192290765

Following gene: 192290763

Centisome position: 44.65

GC content: 68.57

Gene sequence:

>630_bases
ATGACCTACGCTTACGAAAAAGACGGCGACGCGATCTATCGTCAGTCGTTCTCCATTATCCGCGCCGAAGCCGCACTCGA
TCGGTTCACGCGTGACGAGGAGAAGATCGCGGTGCGGATCATCCACGCCAGCGGCATGGTCGAAGTCGCAGCCGACATCG
CGTTCACGCCCGGCTTTGTATCGGCGGGCCGCGCGGCGCTGCGGGCCGGCGCACCGATCCTGTGCGACGCGCAGATGGTC
GCCAACGGCGTCACCCGCAAGCGGCTGCCGGCCGACAACGAAGTGATCTGCACGCTGAACCATCCCGATGTCCCGGCCCT
CGCCGCAAAGCTCGGCACTACCCGGTCGGCCGCCGCGGTCGATCTGTGGCGCGACCGGATGCAGGGCGCGGTGGTGGCGA
TCGGCAATGCGCCGACTGCGCTGTTCCGCCTGCTCGAAATCCTTGTCGAGCCCGGCGCACCGCGCCCCGCTGCGATTATC
GGCATCCCGGTCGGTTTCGTCGGCGCGGCCGAGTCCAAGGAGGCGCTGTTGGCGGACGCGCCCTCGCCTTGCGTGATCGT
GCGCGGCCGTCGCGGCGGCAGCGCGATGACCGCGGCAGCGATCAACGCGCTGGCGAGCGAACGCGAATGA

Upstream 100 bases:

>100_bases
GCCTCAGCATCACCGCGATGGATGCGCAGAGCGATAACGCGACCGCCGATGCAGACCCGCACCCCTCCATTCTCCCCGAG
CTGATCGAGGACGCCGCCCG

Downstream 100 bases:

>100_bases
ACACACCGACGATCTATGGCGTCGGCGTCGGCCCCGGCGCGCCCGATCTGATGAGCGTCCGCGCCGCGCGACTGATCGGT
GCCGCCAAGGTGGTGGCGTA

Product: precorrin-8X methylmutase

Products: NA

Alternate protein names: HBA synthase; Precorrin isomerase [H]

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MTYAYEKDGDAIYRQSFSIIRAEAALDRFTRDEEKIAVRIIHASGMVEVAADIAFTPGFVSAGRAALRAGAPILCDAQMV
ANGVTRKRLPADNEVICTLNHPDVPALAAKLGTTRSAAAVDLWRDRMQGAVVAIGNAPTALFRLLEILVEPGAPRPAAII
GIPVGFVGAAESKEALLADAPSPCVIVRGRRGGSAMTAAAINALASERE

Sequences:

>Translated_209_residues
MTYAYEKDGDAIYRQSFSIIRAEAALDRFTRDEEKIAVRIIHASGMVEVAADIAFTPGFVSAGRAALRAGAPILCDAQMV
ANGVTRKRLPADNEVICTLNHPDVPALAAKLGTTRSAAAVDLWRDRMQGAVVAIGNAPTALFRLLEILVEPGAPRPAAII
GIPVGFVGAAESKEALLADAPSPCVIVRGRRGGSAMTAAAINALASERE
>Mature_208_residues
TYAYEKDGDAIYRQSFSIIRAEAALDRFTRDEEKIAVRIIHASGMVEVAADIAFTPGFVSAGRAALRAGAPILCDAQMVA
NGVTRKRLPADNEVICTLNHPDVPALAAKLGTTRSAAAVDLWRDRMQGAVVAIGNAPTALFRLLEILVEPGAPRPAAIIG
IPVGFVGAAESKEALLADAPSPCVIVRGRRGGSAMTAAAINALASERE

Specific function: Catalyzes the conversion of precorrin-8X to hydrogenobyrinic acid; a methyl migration reaction during the transformation of precorrin-3 to form cobyrinic acid [H]

COG id: COG2082

COG function: function code H; Precorrin isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003722 [H]

Pfam domain/function: PF02570 CbiC [H]

EC number: =5.4.1.2 [H]

Molecular weight: Translated: 21890; Mature: 21759

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYAYEKDGDAIYRQSFSIIRAEAALDRFTRDEEKIAVRIIHASGMVEVAADIAFTPGFV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEHHHHEECCCHH
SAGRAALRAGAPILCDAQMVANGVTRKRLPADNEVICTLNHPDVPALAAKLGTTRSAAAV
HHCHHHHHCCCCEEECHHHHHCCCHHHCCCCCCCEEEEECCCCCHHHHHHHCCCCCHHHH
DLWRDRMQGAVVAIGNAPTALFRLLEILVEPGAPRPAAIIGIPVGFVGAAESKEALLADA
HHHHHHHCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCEEECC
PSPCVIVRGRRGGSAMTAAAINALASERE
CCCEEEEECCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TYAYEKDGDAIYRQSFSIIRAEAALDRFTRDEEKIAVRIIHASGMVEVAADIAFTPGFV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEHHHHEECCCHH
SAGRAALRAGAPILCDAQMVANGVTRKRLPADNEVICTLNHPDVPALAAKLGTTRSAAAV
HHCHHHHHCCCCEEECHHHHHCCCHHHCCCCCCCEEEEECCCCCHHHHHHHCCCCCHHHH
DLWRDRMQGAVVAIGNAPTALFRLLEILVEPGAPRPAAIIGIPVGFVGAAESKEALLADA
HHHHHHHCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCEEECC
PSPCVIVRGRRGGSAMTAAAINALASERE
CCCEEEEECCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211521; 1732194 [H]