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The map label for this gene is cobM [H]

Identifier: 192290758

GI number: 192290758

Start: 2559219

End: 2559998

Strand: Reverse

Name: cobM [H]

Synonym: Rpal_2374

Alternate gene names: 192290758

Gene position: 2559998-2559219 (Counterclockwise)

Preceding gene: 192290759

Following gene: 192290757

Centisome position: 44.57

GC content: 70.38

Gene sequence:

>780_bases
ATGACCGTCCACTTCATCGGCGCCGGCCCCGGCGCGCCCGACCTGATCACCGTGCGCGGCCGCGATCTGGTAATGCGCTG
TCCGGTGTGCCTCTATGCCGGTTCGTTAGTCCCACGCGAGATCGTGGCGCTGTGCCCGAAGGACGCGCGCGTGGTTGACA
CTGCGCCGCTCGACCTCGACGCCATCACCGCGGAGTTCGTCGCCGCCGCGGAGGCCGGCCACGACGTCGCGCGGCTACAT
TCCGGCGATTTGTCGGTGTGGAGCGCGATGGGCGAACAAATCCGCCGCCTGGAGCAGCACGGCATCTCCTACACCGTCAC
GCCCGGCGTGCCGTCGTTCGCGGCGGCCGCCGCCGTGCTCGGTCGCGAACTGACCTTGCCGGAAGTCGCGCAGACCGTGG
TGCTGACCCGGACCTCGGGCCGCGCATCGGCGATGCCGCCGCGCGAGACGCTGGAAGCCTTCGCCGCCACCGGCGCGACG
CTGGCGATCCATCTGTCGATCCACGTAATCGCCGACGTCGTCGAACGGCTGCGCCCGCACTATGGCGACGACGGTGCGGT
CGCGGTGGTGGTACGCGCCAGCTGGCCGGAGCAGCAGGTGATCCGCGGCACACTCAGCTCGATCGCCGCGCAGGTCGCCG
CCGAAGGCATCGACCGCACCGCGTTGATCCTGGTCGGCCCGTCACTCGCCGCCACCGACTTCCGCGAGAGCTCGCTCTAC
GCACCCGACTACGATCGCCGTTATCGCCGCTCGGCGGAGGACGGCCGTGATCGTGACTGA

Upstream 100 bases:

>100_bases
CGCTGGCTGCCGCCGGACCGACCGCGCGGCTGATCGTATCCCGTTTGATCTCACAGGATCGCCTCGCGACGGCCGCGGTG
GCGATCGAGGAGCCGCTGCC

Downstream 100 bases:

>100_bases
TCACATCCTCCCAACAGCGCCGAACGGCCGACCGCCTGGGCTGATCATCGCGGCGCCATCGACCAATAGCGGCAAGACCA
CGGTGACGCTGGCGCTGCAC

Product: precorrin-4 C11-methyltransferase

Products: NA

Alternate protein names: Precorrin-3 methylase [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MTVHFIGAGPGAPDLITVRGRDLVMRCPVCLYAGSLVPREIVALCPKDARVVDTAPLDLDAITAEFVAAAEAGHDVARLH
SGDLSVWSAMGEQIRRLEQHGISYTVTPGVPSFAAAAAVLGRELTLPEVAQTVVLTRTSGRASAMPPRETLEAFAATGAT
LAIHLSIHVIADVVERLRPHYGDDGAVAVVVRASWPEQQVIRGTLSSIAAQVAAEGIDRTALILVGPSLAATDFRESSLY
APDYDRRYRRSAEDGRDRD

Sequences:

>Translated_259_residues
MTVHFIGAGPGAPDLITVRGRDLVMRCPVCLYAGSLVPREIVALCPKDARVVDTAPLDLDAITAEFVAAAEAGHDVARLH
SGDLSVWSAMGEQIRRLEQHGISYTVTPGVPSFAAAAAVLGRELTLPEVAQTVVLTRTSGRASAMPPRETLEAFAATGAT
LAIHLSIHVIADVVERLRPHYGDDGAVAVVVRASWPEQQVIRGTLSSIAAQVAAEGIDRTALILVGPSLAATDFRESSLY
APDYDRRYRRSAEDGRDRD
>Mature_258_residues
TVHFIGAGPGAPDLITVRGRDLVMRCPVCLYAGSLVPREIVALCPKDARVVDTAPLDLDAITAEFVAAAEAGHDVARLHS
GDLSVWSAMGEQIRRLEQHGISYTVTPGVPSFAAAAAVLGRELTLPEVAQTVVLTRTSGRASAMPPRETLEAFAATGATL
AIHLSIHVIADVVERLRPHYGDDGAVAVVVRASWPEQQVIRGTLSSIAAQVAAEGIDRTALILVGPSLAATDFRESSLYA
PDYDRRYRRSAEDGRDRD

Specific function: Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5 [H]

COG id: COG2875

COG function: function code H; Precorrin-4 methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=232, Percent_Identity=28.448275862069, Blast_Score=72, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322922, Length=254, Percent_Identity=25.5905511811024, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006362
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.133 [H]

Molecular weight: Translated: 27570; Mature: 27438

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVHFIGAGPGAPDLITVRGRDLVMRCPVCLYAGSLVPREIVALCPKDARVVDTAPLDLD
CEEEEEECCCCCCCEEEECCCCEEEECCHHHHHCCCCHHHHHHHCCCCCEEEECCCCCHH
AITAEFVAAAEAGHDVARLHSGDLSVWSAMGEQIRRLEQHGISYTVTPGVPSFAAAAAVL
HHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHH
GRELTLPEVAQTVVLTRTSGRASAMPPRETLEAFAATGATLAIHLSIHVIADVVERLRPH
CCCCCHHHHHHEEEEEECCCCCCCCCCHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCC
YGDDGAVAVVVRASWPEQQVIRGTLSSIAAQVAAEGIDRTALILVGPSLAATDFRESSLY
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHCCCCCCCCC
APDYDRRYRRSAEDGRDRD
CCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TVHFIGAGPGAPDLITVRGRDLVMRCPVCLYAGSLVPREIVALCPKDARVVDTAPLDLD
EEEEEECCCCCCCEEEECCCCEEEECCHHHHHCCCCHHHHHHHCCCCCEEEECCCCCHH
AITAEFVAAAEAGHDVARLHSGDLSVWSAMGEQIRRLEQHGISYTVTPGVPSFAAAAAVL
HHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHH
GRELTLPEVAQTVVLTRTSGRASAMPPRETLEAFAATGATLAIHLSIHVIADVVERLRPH
CCCCCHHHHHHEEEEEECCCCCCCCCCHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCC
YGDDGAVAVVVRASWPEQQVIRGTLSSIAAQVAAEGIDRTALILVGPSLAATDFRESSLY
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHCCCCCCCCC
APDYDRRYRRSAEDGRDRD
CCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211521; 8226690 [H]