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The map label for this gene is moaA [H]

Identifier: 192290582

GI number: 192290582

Start: 2374542

End: 2375576

Strand: Reverse

Name: moaA [H]

Synonym: Rpal_2191

Alternate gene names: 192290582

Gene position: 2375576-2374542 (Counterclockwise)

Preceding gene: 192290583

Following gene: 192290581

Centisome position: 41.36

GC content: 66.76

Gene sequence:

>1035_bases
ATGACCAGCGCCGCGATCACTCCGCCAACCACCGTGGATCGGCCGATGACCGATCCGTTCGGGCGGACCATCGACTACCT
GCGCGTCTCCATCACCGACCGTTGTGACTTCCGCTGTGTGTACTGCATGGCGGAGGACATGACCTTCCTGCCCCGCGCCG
ATCTGCTGACGCTGGAAGAGCTTGACCGGCTGTGCTCGGCCTTCATCGCCAAGGGCGTGCGCAAGCTGCGCCTCACCGGC
GGAGAGCCGCTGGTCCGCCGCAACATGATGTCCCTGGTGCGGTCGCTGTCCCGACACCTGAAGACAGGCGCGCTCGACGA
ACTCACCCTCACCACCAACGGCTCGCAGCTCGCCCGCTTCGCCGCGGAGCTGGCCGACTGCGGCGTCCGCCGCGTCAACG
TCTCGCTCGACACGCTCGACCCGGACGAGTTCCGCCGGATCACCCGCTGGGGCGATCTCGACCGGGTACTAGCGGGCATC
AATGCCGCCCGCGCCGCGGGCCTTGCGGTGAAGATCAACAGCGTGGTGCTGAAGGGTTCCAACGAGGACGAGATCCCGTC
GCTGATGCGCTGGGCGCATGGCCTCGGCATGGGGCTGACGCTGATCGAAGTTATGCCGCTCGGCGAAATTGGCGAAGGCC
GGATCGATCAGTATGTACCGCTGTCGCTGATCCGCGCCCGGCTCTCCGCCAACTACACGCTGACCGACCTGCCCGACTCC
ACCGGCGGGCCGGCCCGCTACGTCCGTGTCGAGGAGACCGGCGGCCGGCTCGGCTTCATTACTCCACTCACGCACAATTT
CTGCGAATCCTGCAATCGGGTGCGGATTACCTGCACCGGCACGATTCACACCTGCCTCGGCCATGAGGACGCCTCCGACC
TGCGACGCCCGCTGCGCGCCTCCGCAGACGATGCCCTGCTCAGCGCCGCGATCGATCAGGCGATCGGCTCAAAACCCAAG
GGCCACGACTTCATCATCGACCGCCGCCATAACCGGCCGAGCGTCAGCCGGCACATGAGCGTCACCGGCGGCTAA

Upstream 100 bases:

>100_bases
GCAGCGCATCACGGCGCGTGATTGTGCGCGCCGCTGATCGTGCCTAGATAGTGCGGAGACATTAGCCGCGACTGGCGGCG
ACCGCGACAGGGCACGCCGC

Downstream 100 bases:

>100_bases
GCGCTCCCACCTGCGACTAATCATTCCGCTGAACAGCGCTCCTGATTGCCATTTTCCAATTGACGGAACGGTGACGCGCT
GGTTTGGTGCGCACGCTTCG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MTSAAITPPTTVDRPMTDPFGRTIDYLRVSITDRCDFRCVYCMAEDMTFLPRADLLTLEELDRLCSAFIAKGVRKLRLTG
GEPLVRRNMMSLVRSLSRHLKTGALDELTLTTNGSQLARFAAELADCGVRRVNVSLDTLDPDEFRRITRWGDLDRVLAGI
NAARAAGLAVKINSVVLKGSNEDEIPSLMRWAHGLGMGLTLIEVMPLGEIGEGRIDQYVPLSLIRARLSANYTLTDLPDS
TGGPARYVRVEETGGRLGFITPLTHNFCESCNRVRITCTGTIHTCLGHEDASDLRRPLRASADDALLSAAIDQAIGSKPK
GHDFIIDRRHNRPSVSRHMSVTGG

Sequences:

>Translated_344_residues
MTSAAITPPTTVDRPMTDPFGRTIDYLRVSITDRCDFRCVYCMAEDMTFLPRADLLTLEELDRLCSAFIAKGVRKLRLTG
GEPLVRRNMMSLVRSLSRHLKTGALDELTLTTNGSQLARFAAELADCGVRRVNVSLDTLDPDEFRRITRWGDLDRVLAGI
NAARAAGLAVKINSVVLKGSNEDEIPSLMRWAHGLGMGLTLIEVMPLGEIGEGRIDQYVPLSLIRARLSANYTLTDLPDS
TGGPARYVRVEETGGRLGFITPLTHNFCESCNRVRITCTGTIHTCLGHEDASDLRRPLRASADDALLSAAIDQAIGSKPK
GHDFIIDRRHNRPSVSRHMSVTGG
>Mature_343_residues
TSAAITPPTTVDRPMTDPFGRTIDYLRVSITDRCDFRCVYCMAEDMTFLPRADLLTLEELDRLCSAFIAKGVRKLRLTGG
EPLVRRNMMSLVRSLSRHLKTGALDELTLTTNGSQLARFAAELADCGVRRVNVSLDTLDPDEFRRITRWGDLDRVLAGIN
AARAAGLAVKINSVVLKGSNEDEIPSLMRWAHGLGMGLTLIEVMPLGEIGEGRIDQYVPLSLIRARLSANYTLTDLPDST
GGPARYVRVEETGGRLGFITPLTHNFCESCNRVRITCTGTIHTCLGHEDASDLRRPLRASADDALLSAAIDQAIGSKPKG
HDFIIDRRHNRPSVSRHMSVTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=325, Percent_Identity=36, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI22027536, Length=325, Percent_Identity=36, Blast_Score=202, Evalue=4e-52,
Organism=Escherichia coli, GI1786999, Length=333, Percent_Identity=32.7327327327327, Blast_Score=190, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17561210, Length=336, Percent_Identity=37.202380952381, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI32566331, Length=332, Percent_Identity=34.6385542168675, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI32566329, Length=333, Percent_Identity=35.1351351351351, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI28574488, Length=330, Percent_Identity=37.2727272727273, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI28574490, Length=324, Percent_Identity=37.6543209876543, Blast_Score=194, Evalue=9e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37789; Mature: 37658

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAAITPPTTVDRPMTDPFGRTIDYLRVSITDRCDFRCVYCMAEDMTFLPRADLLTLEE
CCCCCCCCCCCCCCCCCCHHHCCEEHEEEEECCCCCCEEEEEEECCCCCCCCCCCCCHHH
LDRLCSAFIAKGVRKLRLTGGEPLVRRNMMSLVRSLSRHLKTGALDELTLTTNGSQLARF
HHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHH
AAELADCGVRRVNVSLDTLDPDEFRRITRWGDLDRVLAGINAARAAGLAVKINSVVLKGS
HHHHHHCCCEEEEEEEECCCHHHHHHHHHCCCHHHHHHCCHHHHHCCEEEEEEEEEEECC
NEDEIPSLMRWAHGLGMGLTLIEVMPLGEIGEGRIDQYVPLSLIRARLSANYTLTDLPDS
CCCHHHHHHHHHHHCCCCCHHHHEECCCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCC
TGGPARYVRVEETGGRLGFITPLTHNFCESCNRVRITCTGTIHTCLGHEDASDLRRPLRA
CCCCEEEEEEECCCCEEEEECHHHHHHHHCCCCEEEEEECEEHHHCCCCCHHHHHHHHHC
SADDALLSAAIDQAIGSKPKGHDFIIDRRHNRPSVSRHMSVTGG
CCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHEEECCCC
>Mature Secondary Structure 
TSAAITPPTTVDRPMTDPFGRTIDYLRVSITDRCDFRCVYCMAEDMTFLPRADLLTLEE
CCCCCCCCCCCCCCCCCHHHCCEEHEEEEECCCCCCEEEEEEECCCCCCCCCCCCCHHH
LDRLCSAFIAKGVRKLRLTGGEPLVRRNMMSLVRSLSRHLKTGALDELTLTTNGSQLARF
HHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHH
AAELADCGVRRVNVSLDTLDPDEFRRITRWGDLDRVLAGINAARAAGLAVKINSVVLKGS
HHHHHHCCCEEEEEEEECCCHHHHHHHHHCCCHHHHHHCCHHHHHCCEEEEEEEEEEECC
NEDEIPSLMRWAHGLGMGLTLIEVMPLGEIGEGRIDQYVPLSLIRARLSANYTLTDLPDS
CCCHHHHHHHHHHHCCCCCHHHHEECCCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCC
TGGPARYVRVEETGGRLGFITPLTHNFCESCNRVRITCTGTIHTCLGHEDASDLRRPLRA
CCCCEEEEEEECCCCEEEEECHHHHHHHHCCCCEEEEEECEEHHHCCCCCHHHHHHHHHC
SADDALLSAAIDQAIGSKPKGHDFIIDRRHNRPSVSRHMSVTGG
CCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA