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The map label for this gene is fabG [C]

Identifier: 192290370

GI number: 192290370

Start: 2137714

End: 2138628

Strand: Reverse

Name: fabG [C]

Synonym: Rpal_1977

Alternate gene names: 192290370

Gene position: 2138628-2137714 (Counterclockwise)

Preceding gene: 192290371

Following gene: 192290363

Centisome position: 37.23

GC content: 66.56

Gene sequence:

>915_bases
ATGGCCAAGGCACTGGACGGCAAAGTCATCATCGTCACCGGCGCGGGGCGCGGCATCGGCCGCGAGATCGCGCTGCTCGC
GGCGCGCGAAGGCGCCAAGGTGGTCGTCAACGATCCGGGCGTCGCATCCGACGGCTCCGGCACCGATGCCGCCCCGGCCG
AGCAGGTCGTCGAGGAGATCAAGAAGGAAGGCGGCACCGCGGTCGCGAATTTCGAGAGCGTCGCCGAGGCGATTCCTGCC
AGCAAGATCGTCAAGCAGGCGGTCGACACCTACGGCAAGCTCGACGGCGTCGTGAACAACGCCGGCATCCTGCGCGACGC
GATCTTCCACCGCATGAGCATCGACGCGTTCGAGCAGGTGATCAAGGTGCACCTGATGGGCACGTTCTACGTGTCGCACG
CCGCCGCCCGGCTGTTCCGCGAGCAGGAGAGCGGCTCGTTCGTGCACTTCACCTCGACCTCGGGCCTGATCGGCAATTTC
GGCCAGGCCAACTATGCGGCCGCCAAGCTCGGCATTGTCGGCCTGTCGAAGTCGATCGCGCTCGACATGCAGCGCTTCAA
CGTCCGCTCCAACTGCGTGTCGCCGTTCGCCTGGAGCCGCCTGATCGGCACCATCCCGACCGAGACCGAAGCCGAGAAAG
CCCGCGTTGCGCGGATGCAGCAGATGGGCCCGGAGAAGATCGCGCCGCTGTCGGTGTATCTGCTCGGCGACGCCGCCAAG
GACGTCAGCGGCCAGATCTTCGCGGTGCGGATGAACGAGATCTTCCTGATGGGCCAGTCGCGCCCGATCCGCTCGGTGCA
TCGCGACGGCGGCTGGACCTGCGAGAGCCTCGCCGAGCACGGCATGCCGGCGCTGAAGGGCTCGTTCTACAAGCTCGACC
GCTCCGCCGACATCTTTAACTGGGATCCGGTGTAA

Upstream 100 bases:

>100_bases
AGTCTCGCTCAGCAGAACACCGCGAGATTCCGGTTTCGCGCTCCGCGCGCCCCGGAATGACTGGTAGATCACAACCAACA
ACAAACAAAAAGGACATCAC

Downstream 100 bases:

>100_bases
ACTCGGTCAGCTCCACGACGACGATCGGTTAAACACCAGCACGTCATTCCGGGGCGCGCCTAGCGCGAATCCGGAATGAC
TCGACCAAGAATCCACGCAC

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MAKALDGKVIIVTGAGRGIGREIALLAAREGAKVVVNDPGVASDGSGTDAAPAEQVVEEIKKEGGTAVANFESVAEAIPA
SKIVKQAVDTYGKLDGVVNNAGILRDAIFHRMSIDAFEQVIKVHLMGTFYVSHAAARLFREQESGSFVHFTSTSGLIGNF
GQANYAAAKLGIVGLSKSIALDMQRFNVRSNCVSPFAWSRLIGTIPTETEAEKARVARMQQMGPEKIAPLSVYLLGDAAK
DVSGQIFAVRMNEIFLMGQSRPIRSVHRDGGWTCESLAEHGMPALKGSFYKLDRSADIFNWDPV

Sequences:

>Translated_304_residues
MAKALDGKVIIVTGAGRGIGREIALLAAREGAKVVVNDPGVASDGSGTDAAPAEQVVEEIKKEGGTAVANFESVAEAIPA
SKIVKQAVDTYGKLDGVVNNAGILRDAIFHRMSIDAFEQVIKVHLMGTFYVSHAAARLFREQESGSFVHFTSTSGLIGNF
GQANYAAAKLGIVGLSKSIALDMQRFNVRSNCVSPFAWSRLIGTIPTETEAEKARVARMQQMGPEKIAPLSVYLLGDAAK
DVSGQIFAVRMNEIFLMGQSRPIRSVHRDGGWTCESLAEHGMPALKGSFYKLDRSADIFNWDPV
>Mature_303_residues
AKALDGKVIIVTGAGRGIGREIALLAAREGAKVVVNDPGVASDGSGTDAAPAEQVVEEIKKEGGTAVANFESVAEAIPAS
KIVKQAVDTYGKLDGVVNNAGILRDAIFHRMSIDAFEQVIKVHLMGTFYVSHAAARLFREQESGSFVHFTSTSGLIGNFG
QANYAAAKLGIVGLSKSIALDMQRFNVRSNCVSPFAWSRLIGTIPTETEAEKARVARMQQMGPEKIAPLSVYLLGDAAKD
VSGQIFAVRMNEIFLMGQSRPIRSVHRDGGWTCESLAEHGMPALKGSFYKLDRSADIFNWDPV

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=245, Percent_Identity=43.6734693877551, Blast_Score=193, Evalue=1e-49,
Organism=Homo sapiens, GI15277342, Length=251, Percent_Identity=32.6693227091633, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI40254992, Length=188, Percent_Identity=32.9787234042553, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI4503817, Length=229, Percent_Identity=24.8908296943231, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI19923817, Length=267, Percent_Identity=26.2172284644195, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI32483357, Length=254, Percent_Identity=25.5905511811024, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI59889578, Length=217, Percent_Identity=27.6497695852535, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI31542939, Length=210, Percent_Identity=29.0476190476191, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI66933014, Length=261, Percent_Identity=28.3524904214559, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787335, Length=257, Percent_Identity=32.6848249027237, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1787526, Length=252, Percent_Identity=29.7619047619048, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1787905, Length=248, Percent_Identity=32.258064516129, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87082100, Length=252, Percent_Identity=27.7777777777778, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=27.2, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082160, Length=256, Percent_Identity=26.171875, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI2367175, Length=254, Percent_Identity=30.3149606299213, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1788459, Length=246, Percent_Identity=27.2357723577236, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786812, Length=257, Percent_Identity=26.8482490272374, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789208, Length=198, Percent_Identity=26.7676767676768, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789057, Length=184, Percent_Identity=30.4347826086957, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17568967, Length=247, Percent_Identity=42.1052631578947, Blast_Score=185, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI25147288, Length=253, Percent_Identity=33.201581027668, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17555706, Length=253, Percent_Identity=31.2252964426877, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17564282, Length=197, Percent_Identity=29.9492385786802, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17531453, Length=199, Percent_Identity=30.1507537688442, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=204, Percent_Identity=28.921568627451, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=287, Percent_Identity=28.2229965156794, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560676, Length=252, Percent_Identity=24.6031746031746, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17567345, Length=182, Percent_Identity=26.3736263736264, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562906, Length=204, Percent_Identity=29.4117647058824, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=207, Percent_Identity=29.4685990338164, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=258, Percent_Identity=24.4186046511628, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=197, Percent_Identity=28.4263959390863, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=263, Percent_Identity=42.2053231939163, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6324126, Length=189, Percent_Identity=30.6878306878307, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI18859837, Length=237, Percent_Identity=41.7721518987342, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24639444, Length=245, Percent_Identity=32.6530612244898, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24644339, Length=196, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI23397609, Length=258, Percent_Identity=28.2945736434109, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24640492, Length=203, Percent_Identity=26.1083743842365, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17737361, Length=201, Percent_Identity=28.3582089552239, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21357673, Length=252, Percent_Identity=26.5873015873016, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281364892, Length=199, Percent_Identity=24.6231155778894, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 32528; Mature: 32396

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKALDGKVIIVTGAGRGIGREIALLAAREGAKVVVNDPGVASDGSGTDAAPAEQVVEEI
CCCCCCCCEEEEECCCCCCCHHEEEEEECCCCEEEEECCCCCCCCCCCCCCCHHHHHHHH
KKEGGTAVANFESVAEAIPASKIVKQAVDTYGKLDGVVNNAGILRDAIFHRMSIDAFEQV
HHCCCCEEECHHHHHHHCCHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHH
IKVHLMGTFYVSHAAARLFREQESGSFVHFTSTSGLIGNFGQANYAAAKLGIVGLSKSIA
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHEECCHHHH
LDMQRFNVRSNCVSPFAWSRLIGTIPTETEAEKARVARMQQMGPEKIAPLSVYLLGDAAK
HHHHHHCHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCC
DVSGQIFAVRMNEIFLMGQSRPIRSVHRDGGWTCESLAEHGMPALKGSFYKLDRSADIFN
CCCCCEEEEEEEEEEEECCCCCHHHHHCCCCCCHHHHHHCCCHHHCCCEEEECCCCCCCC
WDPV
CCCC
>Mature Secondary Structure 
AKALDGKVIIVTGAGRGIGREIALLAAREGAKVVVNDPGVASDGSGTDAAPAEQVVEEI
CCCCCCCEEEEECCCCCCCHHEEEEEECCCCEEEEECCCCCCCCCCCCCCCHHHHHHHH
KKEGGTAVANFESVAEAIPASKIVKQAVDTYGKLDGVVNNAGILRDAIFHRMSIDAFEQV
HHCCCCEEECHHHHHHHCCHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHHHHHHHH
IKVHLMGTFYVSHAAARLFREQESGSFVHFTSTSGLIGNFGQANYAAAKLGIVGLSKSIA
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHEECCHHHH
LDMQRFNVRSNCVSPFAWSRLIGTIPTETEAEKARVARMQQMGPEKIAPLSVYLLGDAAK
HHHHHHCHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCC
DVSGQIFAVRMNEIFLMGQSRPIRSVHRDGGWTCESLAEHGMPALKGSFYKLDRSADIFN
CCCCCEEEEEEEEEEEECCCCCHHHHHCCCCCCHHHHHHCCCHHHCCCEEEECCCCCCCC
WDPV
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]