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The map label for this gene is livM [H]

Identifier: 192290332

GI number: 192290332

Start: 2091719

End: 2092642

Strand: Reverse

Name: livM [H]

Synonym: Rpal_1939

Alternate gene names: 192290332

Gene position: 2092642-2091719 (Counterclockwise)

Preceding gene: 192290333

Following gene: 192290331

Centisome position: 36.43

GC content: 65.15

Gene sequence:

>924_bases
ATGGGGTTCTTCACGTCACGATTGTTCTGGATCGCCCTGCTGGTGGTCGCTGTCGCGGCGACGCTGCCGCTCTACGTCTC
CGGCTACATCCTCGGGCTGCTGACGGTGGCTTTCTACTTCGGCGTTTTCGCGATGTCCTGGGATCTGCTGTTCGGCTTTG
CCGGCGAGGTGAATTTCGGCCCGACCTTCCTGATCGGCACCGGCGCCTACACCGCAGGCATCGTCAACAATCTCTACGGC
GTGTCGCCGTACTTCTGCATTTTCATCGGCGCGATGGCCGCGGTGGTCGCGGGCTTCGTCCTGGCGCTTCCGGCGCTGCG
GGTGCGCGGGCCGTATTTCGGCCTGACCACGCTGGTCGCAGTGCTGATGCTGCAGAACTTCATCGTCGTGTTCGCCGACC
TCACCGGCGGCGAGATCGGGTTGACCATTCCGGACGTCATTACCATCAACGCCGGTGCCAATTACTGGATCGCGCTCGGC
TTCATGACGGTGAGCGGCGCGATACTGTACGGGCTATCGCAGTCGCCGATCGGCCTGGTGCTGCAGGCCTCGGGCCAGGA
TCCGGTGCAGGCCGGCGCGCTCGGCTTCAACATCGTCAAGCACAAGCTGTTCGCCTTCGTGGTTAGCGCCTTCTTCTCCG
GCCTATCGGGCGCGCTTTTGGTGTTCTACTTCGGCACCGCCTCGGTCGGCACCGTGGTCGATGTCGCGGTCGGCGTGAAC
GTGATCGTGGCAGCCGTGCTCGGCGGGCGGCGAACCGTGATCGGCGCGGCGCTGGGCGCGGTGTTCCTGATCGTCGCCGG
CGAATTCCTGCGCCCGACCGGCGAACTCGCCACCTTCATCGTCTCGGCGATCGCTCTGCTCGTCGTGCTGTTCTTCCCCG
GCGGCTTCCTCGGAGCCGCCATGTCGCGTGAGGCCCGGACTTGA

Upstream 100 bases:

>100_bases
GCTTACATGATCTCGCCGGCCTATCGATCGATCCCGGCGCTGCTACTGTTGGTCACGGTGATGTATCTGCGGCCTCAGGG
CCTGCTCGGGAGGCGCTGAG

Downstream 100 bases:

>100_bases
TGGACGCAGTCTCCAGCAACTTCGCTCCCACACTCGAAGTCCGCGGCCTCACCAAGCGGTTCGGCGGACTCACTGCGGTG
AAGAACCTATCGTTCGACCT

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MGFFTSRLFWIALLVVAVAATLPLYVSGYILGLLTVAFYFGVFAMSWDLLFGFAGEVNFGPTFLIGTGAYTAGIVNNLYG
VSPYFCIFIGAMAAVVAGFVLALPALRVRGPYFGLTTLVAVLMLQNFIVVFADLTGGEIGLTIPDVITINAGANYWIALG
FMTVSGAILYGLSQSPIGLVLQASGQDPVQAGALGFNIVKHKLFAFVVSAFFSGLSGALLVFYFGTASVGTVVDVAVGVN
VIVAAVLGGRRTVIGAALGAVFLIVAGEFLRPTGELATFIVSAIALLVVLFFPGGFLGAAMSREART

Sequences:

>Translated_307_residues
MGFFTSRLFWIALLVVAVAATLPLYVSGYILGLLTVAFYFGVFAMSWDLLFGFAGEVNFGPTFLIGTGAYTAGIVNNLYG
VSPYFCIFIGAMAAVVAGFVLALPALRVRGPYFGLTTLVAVLMLQNFIVVFADLTGGEIGLTIPDVITINAGANYWIALG
FMTVSGAILYGLSQSPIGLVLQASGQDPVQAGALGFNIVKHKLFAFVVSAFFSGLSGALLVFYFGTASVGTVVDVAVGVN
VIVAAVLGGRRTVIGAALGAVFLIVAGEFLRPTGELATFIVSAIALLVVLFFPGGFLGAAMSREART
>Mature_306_residues
GFFTSRLFWIALLVVAVAATLPLYVSGYILGLLTVAFYFGVFAMSWDLLFGFAGEVNFGPTFLIGTGAYTAGIVNNLYGV
SPYFCIFIGAMAAVVAGFVLALPALRVRGPYFGLTTLVAVLMLQNFIVVFADLTGGEIGLTIPDVITINAGANYWIALGF
MTVSGAILYGLSQSPIGLVLQASGQDPVQAGALGFNIVKHKLFAFVVSAFFSGLSGALLVFYFGTASVGTVVDVAVGVNV
IVAAVLGGRRTVIGAALGAVFLIVAGEFLRPTGELATFIVSAIALLVVLFFPGGFLGAAMSREART

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=315, Percent_Identity=25.7142857142857, Blast_Score=78, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 31893; Mature: 31762

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFFTSRLFWIALLVVAVAATLPLYVSGYILGLLTVAFYFGVFAMSWDLLFGFAGEVNFG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PTFLIGTGAYTAGIVNNLYGVSPYFCIFIGAMAAVVAGFVLALPALRVRGPYFGLTTLVA
CEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
VLMLQNFIVVFADLTGGEIGLTIPDVITINAGANYWIALGFMTVSGAILYGLSQSPIGLV
HHHHHHHHHEEEECCCCEECEECCCEEEEECCCCEEEEEHHHHHHHHHHCCCCCCCCEEE
LQASGQDPVQAGALGFNIVKHKLFAFVVSAFFSGLSGALLVFYFGTASVGTVVDVAVGVN
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEECCCCHHHHHHHHHHHH
VIVAAVLGGRRTVIGAALGAVFLIVAGEFLRPTGELATFIVSAIALLVVLFFPGGFLGAA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
MSREART
HHHCCCC
>Mature Secondary Structure 
GFFTSRLFWIALLVVAVAATLPLYVSGYILGLLTVAFYFGVFAMSWDLLFGFAGEVNFG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PTFLIGTGAYTAGIVNNLYGVSPYFCIFIGAMAAVVAGFVLALPALRVRGPYFGLTTLVA
CEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
VLMLQNFIVVFADLTGGEIGLTIPDVITINAGANYWIALGFMTVSGAILYGLSQSPIGLV
HHHHHHHHHEEEECCCCEECEECCCEEEEECCCCEEEEEHHHHHHHHHHCCCCCCCCEEE
LQASGQDPVQAGALGFNIVKHKLFAFVVSAFFSGLSGALLVFYFGTASVGTVVDVAVGVN
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEECCCCHHHHHHHHHHHH
VIVAAVLGGRRTVIGAALGAVFLIVAGEFLRPTGELATFIVSAIALLVVLFFPGGFLGAA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
MSREART
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]