Click here to switch to the map view.

The map label for this gene is xseA [H]

Identifier: 192289762

GI number: 192289762

Start: 1423340

End: 1424953

Strand: Reverse

Name: xseA [H]

Synonym: Rpal_1352

Alternate gene names: 192289762

Gene position: 1424953-1423340 (Counterclockwise)

Preceding gene: 192289765

Following gene: 192289761

Centisome position: 24.81

GC content: 70.07

Gene sequence:

>1614_bases
ATGGCCCGACTGCAAACGCCCCAAGCCCTCGCCAATGTCGGCGAATTCACCGTCTCCGAGCTGTCGCAGGCGCTGAAGCG
GACGGTCGAGGACACCTATGGGCATGTCCGGGTGCGCGGCGAGATTACCGGATTCCGCGGGCCGCATTCGTCCGGTCACT
GCTATTTTGCGCTCAAGGACGAGGGCGCCAAGATCGAGGCGGTGATCTGGAAGGGCGTCGCCGGCCGGATGCGGTTCAAG
CCGCAGGAAGGCCTGGAAGTCATCGCCACCGGCAAGCTGACCACCTACCCCGGCTCGTCGAAATATCAGATCGTGATCGA
GGCGCTCGAACCGGCCGGCGTCGGCGCGCTGATGGCGCTGATGGAAGAGCGCAAGAAGAAGCTCGCCGCCGAGGGCCTGT
TCGACGAGGCGCGCAAACAGCTGCTGCCATGGCTGCCGGAGGTGATCGGCGTCGTCACATCCCCCACCGGGGCGGTGATC
CGCGACATCCTGCACCGGCTGGAAGACCGCTTCCCGCGCCGCGTGCTGGTGTGGCCGGTGCGGGTGCAGGGCGAAGGCTC
GGCCGAGCAGATTGCCGCCGCGATCCACGGTTTCAACGCGCTGCCCGAAGACGGCCCGATCCCGCGTCCCGACCTGCTGA
TCGTCGCGCGCGGCGGCGGCTCCCTCGAAGATCTGTGGTCGTTCAACGAAGAGATCGTGGTCCGTGCCGCGGCTGACAGC
ATGATCCCGCTGATCTCGGCGGTCGGCCATGAGACCGACGTTACCCTGATCGATTTCGCATCCGACAAGCGGGCTCCGAC
CCCGACGGCGGCGGCCGAAATGGCGGTGCCGGTGCGGGCCGAACTGTTCGTCGAAGTCGGCGGGCTGGCGCGGCGGATAC
TGTCGAGCTGGCAGCGCGGCCAGGATTTTCGCCGCAACGAGCTGCGCGCCGCCGCCCGCGCCCTGCCGGGCGCGTCCGAT
CTGCTCGCGATTCCACGACAACGGCTCGACGGCGCGTCCGCCGCCCTGCCCCGCGCCCTGCGCGCCAGTACGAACGCCCA
TCACCGCCGTTTCGCTGCGGCAGCGGCGGGCATGACGCTCAAGGTGCTGCGGGCGCAGGTGGCGCACAGCGCCCACCGGC
TCGACAGCGCGGGCACGCAATTGCAACGCTGCGCCCGCGCCACGCTGCGGCATCGCCGGGAGCGGTTCGATGGGCTGGCG
GTGCGGCTGCAGGCCTCGAAACTGGCCAATCAGCAGGCGCAGCGGATGCGGATCGCCCGCGAACAGGAGCGGCTGCAGCG
CCTCGGCGAGCGGGCGCGGCGGGCGCTGATCACCCTGCTGGAACGCCGGCAGGCGCGAGTCGACGCCACCGGCAAGCTCC
TCACCGCATTATCATACCGAGGCGTGCTGGCGCGCGGGTTCGCGCTGGTGCGGGACGCCGATGGCCGCTCGGTGCACGCC
GCCGCGTCCGTCGCCGCAGGCGCCCGACTCAGTGTCGAATTTGCCGACGGCCGGGTTGCTGTTACCGCCGACGGCGGCAG
CGGATCGCCGGTCGAGGCTGCCAAACCGGCGCCAACACCGGCAAAGCCGGCCAAGCGGCCGACAAGTCCCGCCGACCAGG
GGTCACTATTCTAG

Upstream 100 bases:

>100_bases
TCCGGCCGCACCGGCGTGGCAGACTGGACGTCCCCGCGGGTTGGCGTCCGCGGCGAAAGCCCCTACCTTCCGCCGCATCC
TGAAACCTCGATCGAATCGC

Downstream 100 bases:

>100_bases
AACCGAACGACCGCTGGCCGCGGGGAAAACGAAGCCGCCATGACAGGACGGCGGTTTGCAATGCGGCGCTTCCGTTCTAT
CTGTCAGGTGTATCGACCTG

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit [H]

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MARLQTPQALANVGEFTVSELSQALKRTVEDTYGHVRVRGEITGFRGPHSSGHCYFALKDEGAKIEAVIWKGVAGRMRFK
PQEGLEVIATGKLTTYPGSSKYQIVIEALEPAGVGALMALMEERKKKLAAEGLFDEARKQLLPWLPEVIGVVTSPTGAVI
RDILHRLEDRFPRRVLVWPVRVQGEGSAEQIAAAIHGFNALPEDGPIPRPDLLIVARGGGSLEDLWSFNEEIVVRAAADS
MIPLISAVGHETDVTLIDFASDKRAPTPTAAAEMAVPVRAELFVEVGGLARRILSSWQRGQDFRRNELRAAARALPGASD
LLAIPRQRLDGASAALPRALRASTNAHHRRFAAAAAGMTLKVLRAQVAHSAHRLDSAGTQLQRCARATLRHRRERFDGLA
VRLQASKLANQQAQRMRIAREQERLQRLGERARRALITLLERRQARVDATGKLLTALSYRGVLARGFALVRDADGRSVHA
AASVAAGARLSVEFADGRVAVTADGGSGSPVEAAKPAPTPAKPAKRPTSPADQGSLF

Sequences:

>Translated_537_residues
MARLQTPQALANVGEFTVSELSQALKRTVEDTYGHVRVRGEITGFRGPHSSGHCYFALKDEGAKIEAVIWKGVAGRMRFK
PQEGLEVIATGKLTTYPGSSKYQIVIEALEPAGVGALMALMEERKKKLAAEGLFDEARKQLLPWLPEVIGVVTSPTGAVI
RDILHRLEDRFPRRVLVWPVRVQGEGSAEQIAAAIHGFNALPEDGPIPRPDLLIVARGGGSLEDLWSFNEEIVVRAAADS
MIPLISAVGHETDVTLIDFASDKRAPTPTAAAEMAVPVRAELFVEVGGLARRILSSWQRGQDFRRNELRAAARALPGASD
LLAIPRQRLDGASAALPRALRASTNAHHRRFAAAAAGMTLKVLRAQVAHSAHRLDSAGTQLQRCARATLRHRRERFDGLA
VRLQASKLANQQAQRMRIAREQERLQRLGERARRALITLLERRQARVDATGKLLTALSYRGVLARGFALVRDADGRSVHA
AASVAAGARLSVEFADGRVAVTADGGSGSPVEAAKPAPTPAKPAKRPTSPADQGSLF
>Mature_536_residues
ARLQTPQALANVGEFTVSELSQALKRTVEDTYGHVRVRGEITGFRGPHSSGHCYFALKDEGAKIEAVIWKGVAGRMRFKP
QEGLEVIATGKLTTYPGSSKYQIVIEALEPAGVGALMALMEERKKKLAAEGLFDEARKQLLPWLPEVIGVVTSPTGAVIR
DILHRLEDRFPRRVLVWPVRVQGEGSAEQIAAAIHGFNALPEDGPIPRPDLLIVARGGGSLEDLWSFNEEIVVRAAADSM
IPLISAVGHETDVTLIDFASDKRAPTPTAAAEMAVPVRAELFVEVGGLARRILSSWQRGQDFRRNELRAAARALPGASDL
LAIPRQRLDGASAALPRALRASTNAHHRRFAAAAAGMTLKVLRAQVAHSAHRLDSAGTQLQRCARATLRHRRERFDGLAV
RLQASKLANQQAQRMRIAREQERLQRLGERARRALITLLERRQARVDATGKLLTALSYRGVLARGFALVRDADGRSVHAA
ASVAAGARLSVEFADGRVAVTADGGSGSPVEAAKPAPTPAKPAKRPTSPADQGSLF

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides [H]

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family [H]

Homologues:

Organism=Escherichia coli, GI1788856, Length=487, Percent_Identity=35.9342915811088, Blast_Score=253, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365 [H]

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti [H]

EC number: =3.1.11.6 [H]

Molecular weight: Translated: 58001; Mature: 57870

Theoretical pI: Translated: 11.05; Mature: 11.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARLQTPQALANVGEFTVSELSQALKRTVEDTYGHVRVRGEITGFRGPHSSGHCYFALKD
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCEEEEEECC
EGAKIEAVIWKGVAGRMRFKPQEGLEVIATGKLTTYPGSSKYQIVIEALEPAGVGALMAL
CCCEEEEEEECCCCCCCCCCCCCCCEEEEECCEEECCCCCCEEEEEEECCCCCHHHHHHH
MEERKKKLAAEGLFDEARKQLLPWLPEVIGVVTSPTGAVIRDILHRLEDRFPRRVLVWPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEE
RVQGEGSAEQIAAAIHGFNALPEDGPIPRPDLLIVARGGGSLEDLWSFNEEIVVRAAADS
EECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCHHEEEEEHHHH
MIPLISAVGHETDVTLIDFASDKRAPTPTAAAEMAVPVRAELFVEVGGLARRILSSWQRG
HHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
QDFRRNELRAAARALPGASDLLAIPRQRLDGASAALPRALRASTNAHHRRFAAAAAGMTL
CHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHH
KVLRAQVAHSAHRLDSAGTQLQRCARATLRHRRERFDGLAVRLQASKLANQQAQRMRIAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHH
EQERLQRLGERARRALITLLERRQARVDATGKLLTALSYRGVLARGFALVRDADGRSVHA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCEEEEECCCCCEEHH
AASVAAGARLSVEFADGRVAVTADGGSGSPVEAAKPAPTPAKPAKRPTSPADQGSLF
HHHHHCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ARLQTPQALANVGEFTVSELSQALKRTVEDTYGHVRVRGEITGFRGPHSSGHCYFALKD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCEEEEEECC
EGAKIEAVIWKGVAGRMRFKPQEGLEVIATGKLTTYPGSSKYQIVIEALEPAGVGALMAL
CCCEEEEEEECCCCCCCCCCCCCCCEEEEECCEEECCCCCCEEEEEEECCCCCHHHHHHH
MEERKKKLAAEGLFDEARKQLLPWLPEVIGVVTSPTGAVIRDILHRLEDRFPRRVLVWPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEE
RVQGEGSAEQIAAAIHGFNALPEDGPIPRPDLLIVARGGGSLEDLWSFNEEIVVRAAADS
EECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCHHEEEEEHHHH
MIPLISAVGHETDVTLIDFASDKRAPTPTAAAEMAVPVRAELFVEVGGLARRILSSWQRG
HHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCC
QDFRRNELRAAARALPGASDLLAIPRQRLDGASAALPRALRASTNAHHRRFAAAAAGMTL
CHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHCCHHH
KVLRAQVAHSAHRLDSAGTQLQRCARATLRHRRERFDGLAVRLQASKLANQQAQRMRIAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHH
EQERLQRLGERARRALITLLERRQARVDATGKLLTALSYRGVLARGFALVRDADGRSVHA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCEEEEECCCCCEEHH
AASVAAGARLSVEFADGRVAVTADGGSGSPVEAAKPAPTPAKPAKRPTSPADQGSLF
HHHHHCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]