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The map label for this gene is hisZ [H]

Identifier: 192289751

GI number: 192289751

Start: 1413318

End: 1414466

Strand: Reverse

Name: hisZ [H]

Synonym: Rpal_1341

Alternate gene names: 192289751

Gene position: 1414466-1413318 (Counterclockwise)

Preceding gene: 192289752

Following gene: 192289750

Centisome position: 24.62

GC content: 69.89

Gene sequence:

>1149_bases
ATGACAAAGACCGCCGCCGCTCGCGCGACCGGATCCGCCGCGTGGGCGGAGGCGCTGCTGCAATCCTTCGCGGAGGCCGG
CTACGCCCAGGCCACGCCGCCGATCCTGCAGCCCGCCGAACCATTCCTCGACCTGTCGGGCGAGGACATCCGCAAGAGCC
TCTACCTGACCACCGATGCCAGCGGCGAGGAGCTGTGCCTGCGCCCCGACCTGACGATCCCGGTGGCGCGCGAATACCTC
GCCTCCAAGGCCGCCGGACAGCCGGTCGGCTTCTGCTATCTCGGCCCGGTGTTCCGCCAGCGCGGCGGCAAGCCGAGTGA
GTTCCTGCAGGCCGGGATCGAATCGTTCGGCCGCCAGGACCGCGCCGCAGCCGATGCCGAGATGCTGGCGCTGGCGCTCG
GCGCCACCACGGCGCTCAAAGCCGGCGAGGTCGAGGTCCGCACCGGCGACGTCGCGCTGTTCGCCGCATTGATCGACGCA
CTCGACCTGATGCCGGTGTGGCGGCGGCGGCTGATGAAGGATTTTCATCGCAAGGCCAGCCTGGCGCATGACCTGGAGCG
GCTGACACTCGCCCCCTCGACCAGCAACGAATACGAAGGCGTGCTTGCCGCCCTCGCCGGCTCCGACCGCAAGGCGGCGC
TGGCGCTGGTCACCGACCTGATGTCGATCGCCGGTGCCACCACGCTCGGCGGCCGTTCGGTCGCCGAGATCGCCGACCGC
TTCCTCGAGCAATCGACGCTGAAAAGCGGCGCGCTGCCGCGCGACGCGCTCGACAAGATCAAGCGCTTCCTGGCGATCGC
CGGCGCGCCGAACGACGCCCTGAAGGCGCTGCGTGCGCTCGCCGCCGACGCCAAGCTGTCGATCGACGCAGCGATCGATC
AGTTCGAAGCACGGATCGGCTTCCTGGCCGGCCGCGGCATCGATCTGTCCAAGGTGCGGTTCTCCACCGCGTTCGGCCGC
GGCGTGGATTACTACACCGGCTTCGAATTCGAGGTGCACCGCGCCGGCAACGGCGACGAGCCGCTGGTCGCCGGCGGCCG
CTACGACGGGCTGATGAGCCAGCTCGGCGCCGCCTCGCCGATCCCTGCGGTCGGCTTCTCGATCTGGATCGAGGCGATGA
AACAGACAAGCGCCGGAGGTGCCGCATGA

Upstream 100 bases:

>100_bases
CGGATGACGGTCGAATCTGTCATCCACCCGTGTTAAGGGCTGCGCCGACTAGCGTTTTCTGTTTCACCCTCCCTGCCCGG
GACCGCAGGACTGACCGATC

Downstream 100 bases:

>100_bases
GCGCGCCGTTCGTTCTCGCGGTCCCGTCCAAGGGCCGCCTGCAGGAAAACGCCGAAGCGTTCTTCGCCCGCGCCGGGCTG
ACGCTGAGCAAGCCGGGCGG

Product: ATP phosphoribosyltransferase regulatory subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MTKTAAARATGSAAWAEALLQSFAEAGYAQATPPILQPAEPFLDLSGEDIRKSLYLTTDASGEELCLRPDLTIPVAREYL
ASKAAGQPVGFCYLGPVFRQRGGKPSEFLQAGIESFGRQDRAAADAEMLALALGATTALKAGEVEVRTGDVALFAALIDA
LDLMPVWRRRLMKDFHRKASLAHDLERLTLAPSTSNEYEGVLAALAGSDRKAALALVTDLMSIAGATTLGGRSVAEIADR
FLEQSTLKSGALPRDALDKIKRFLAIAGAPNDALKALRALAADAKLSIDAAIDQFEARIGFLAGRGIDLSKVRFSTAFGR
GVDYYTGFEFEVHRAGNGDEPLVAGGRYDGLMSQLGAASPIPAVGFSIWIEAMKQTSAGGAA

Sequences:

>Translated_382_residues
MTKTAAARATGSAAWAEALLQSFAEAGYAQATPPILQPAEPFLDLSGEDIRKSLYLTTDASGEELCLRPDLTIPVAREYL
ASKAAGQPVGFCYLGPVFRQRGGKPSEFLQAGIESFGRQDRAAADAEMLALALGATTALKAGEVEVRTGDVALFAALIDA
LDLMPVWRRRLMKDFHRKASLAHDLERLTLAPSTSNEYEGVLAALAGSDRKAALALVTDLMSIAGATTLGGRSVAEIADR
FLEQSTLKSGALPRDALDKIKRFLAIAGAPNDALKALRALAADAKLSIDAAIDQFEARIGFLAGRGIDLSKVRFSTAFGR
GVDYYTGFEFEVHRAGNGDEPLVAGGRYDGLMSQLGAASPIPAVGFSIWIEAMKQTSAGGAA
>Mature_381_residues
TKTAAARATGSAAWAEALLQSFAEAGYAQATPPILQPAEPFLDLSGEDIRKSLYLTTDASGEELCLRPDLTIPVAREYLA
SKAAGQPVGFCYLGPVFRQRGGKPSEFLQAGIESFGRQDRAAADAEMLALALGATTALKAGEVEVRTGDVALFAALIDAL
DLMPVWRRRLMKDFHRKASLAHDLERLTLAPSTSNEYEGVLAALAGSDRKAALALVTDLMSIAGATTLGGRSVAEIADRF
LEQSTLKSGALPRDALDKIKRFLAIAGAPNDALKALRALAADAKLSIDAAIDQFEARIGFLAGRGIDLSKVRFSTAFGRG
VDYYTGFEFEVHRAGNGDEPLVAGGRYDGLMSQLGAASPIPAVGFSIWIEAMKQTSAGGAA

Specific function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine [H]

COG id: COG3705

COG function: function code E; ATP phosphoribosyltransferase involved in histidine biosynthesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR004516 [H]

Pfam domain/function: PF00587 tRNA-synt_2b [H]

EC number: NA

Molecular weight: Translated: 40268; Mature: 40137

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTAAARATGSAAWAEALLQSFAEAGYAQATPPILQPAEPFLDLSGEDIRKSLYLTTDA
CCCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCHHHHHEEEEEECC
SGEELCLRPDLTIPVAREYLASKAAGQPVGFCYLGPVFRQRGGKPSEFLQAGIESFGRQD
CCCCEEECCCCCCHHHHHHHHHHCCCCCCCCHHHCHHHHHCCCCHHHHHHHHHHHHCCHH
RAAADAEMLALALGATTALKAGEVEVRTGDVALFAALIDALDLMPVWRRRLMKDFHRKAS
HHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAHDLERLTLAPSTSNEYEGVLAALAGSDRKAALALVTDLMSIAGATTLGGRSVAEIADR
HHHHHHHHEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
FLEQSTLKSGALPRDALDKIKRFLAIAGAPNDALKALRALAADAKLSIDAAIDQFEARIG
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
FLAGRGIDLSKVRFSTAFGRGVDYYTGFEFEVHRAGNGDEPLVAGGRYDGLMSQLGAASP
HHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCEEECCCHHHHHHHHCCCCC
IPAVGFSIWIEAMKQTSAGGAA
CCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TKTAAARATGSAAWAEALLQSFAEAGYAQATPPILQPAEPFLDLSGEDIRKSLYLTTDA
CCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCHHHHHEEEEEECC
SGEELCLRPDLTIPVAREYLASKAAGQPVGFCYLGPVFRQRGGKPSEFLQAGIESFGRQD
CCCCEEECCCCCCHHHHHHHHHHCCCCCCCCHHHCHHHHHCCCCHHHHHHHHHHHHCCHH
RAAADAEMLALALGATTALKAGEVEVRTGDVALFAALIDALDLMPVWRRRLMKDFHRKAS
HHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAHDLERLTLAPSTSNEYEGVLAALAGSDRKAALALVTDLMSIAGATTLGGRSVAEIADR
HHHHHHHHEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
FLEQSTLKSGALPRDALDKIKRFLAIAGAPNDALKALRALAADAKLSIDAAIDQFEARIG
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
FLAGRGIDLSKVRFSTAFGRGVDYYTGFEFEVHRAGNGDEPLVAGGRYDGLMSQLGAASP
HHHCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCEEECCCHHHHHHHHCCCCC
IPAVGFSIWIEAMKQTSAGGAA
CCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]