Click here to switch to the map view.

The map label for this gene is hisG [H]

Identifier: 192289750

GI number: 192289750

Start: 1412344

End: 1413321

Strand: Reverse

Name: hisG [H]

Synonym: Rpal_1340

Alternate gene names: 192289750

Gene position: 1413321-1412344 (Counterclockwise)

Preceding gene: 192289751

Following gene: 192289749

Centisome position: 24.6

GC content: 68.4

Gene sequence:

>978_bases
ATGAGCGCGCCGTTCGTTCTCGCGGTCCCGTCCAAGGGCCGCCTGCAGGAAAACGCCGAAGCGTTCTTCGCCCGCGCCGG
GCTGACGCTGAGCAAGCCGGGCGGCGCGCGCGATTATCGCGGCACGATCGCCGGCCTCGACAATGTCGAGGTCGCCTATC
TGTCGGCCAGCGAGATCGCCGCCAACCTCGCCCGCGGCTCGGTGCATTTCGGCGTCACCGGCGAGGATCTGGTGCGCGAG
AGCATCACCGATGCCGACAAGCGCGTGCTGCTGATCGACGGCCTCGGCTTCGGCTACGCCAACGTCGTGGTCGCGGTGCC
GCAGGCGTGGATCGACGTCCGCACCATGGCCGACCTCGACGACGTCACCACCGGCTTCCGCGCCCAGCACAACCGGCGGA
TGCGGGTCGCGACCAAGTACATCAACCTGACCCGCGGCTTCTTCGCCCAGCATAACGTCGTCGACTACCGCATTGTCGAG
AGCGCCGGCGCGACCGAGGGCGCGCCCGCGGTCGGCACCGCCGAGATGATCGTCGACATCACCACCACCGGCGCGACGCT
GGCCGCCAACGGCCTCAAGGTGCTCGACGACGGCGTAATGCTGCGCAGCCAGGCCAATCTCGTCGCCTCGCGCGAAGCCG
ACTGGTCGGACACCGCGCGCGAAACCGCGCGCGTGATCCTCGATCACATTGCCTCGCGCGCTCGCGCCGGCAAGTACAAG
GAAGTCCGCACCCGGTTCAAAGGCTGCAACGACGCGCTGCTCGCCGAAGCCCACAGCCGGTTCGGCGTGGTGTCGCCGTT
CGGCGGGCCGACCTCGTCGGGCATGCTGACGCTGCACTGTCCGCCGGCGCAGATCTACGCGCTCGGCAGTTTCCTGCGGC
AGCATGGCGCAGACACCGTGTCGGTGGCCGCGCTCGACTACGTGTTCGACAAGGAAAACCCGCTGTTCAGCAAGCTTGCG
GCGTTCCTGCCGCAATAA

Upstream 100 bases:

>100_bases
ACGGGCTGATGAGCCAGCTCGGCGCCGCCTCGCCGATCCCTGCGGTCGGCTTCTCGATCTGGATCGAGGCGATGAAACAG
ACAAGCGCCGGAGGTGCCGC

Downstream 100 bases:

>100_bases
TGCCGAGGCAACCCGGCGCCGGTGGCGCCGGCGGGTGGAACCACCATATAGTCACGAGACAAACAAGGCCGTGTGCAAGC
CGGAAGTCGATCGATGATGC

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MSAPFVLAVPSKGRLQENAEAFFARAGLTLSKPGGARDYRGTIAGLDNVEVAYLSASEIAANLARGSVHFGVTGEDLVRE
SITDADKRVLLIDGLGFGYANVVVAVPQAWIDVRTMADLDDVTTGFRAQHNRRMRVATKYINLTRGFFAQHNVVDYRIVE
SAGATEGAPAVGTAEMIVDITTTGATLAANGLKVLDDGVMLRSQANLVASREADWSDTARETARVILDHIASRARAGKYK
EVRTRFKGCNDALLAEAHSRFGVVSPFGGPTSSGMLTLHCPPAQIYALGSFLRQHGADTVSVAALDYVFDKENPLFSKLA
AFLPQ

Sequences:

>Translated_325_residues
MSAPFVLAVPSKGRLQENAEAFFARAGLTLSKPGGARDYRGTIAGLDNVEVAYLSASEIAANLARGSVHFGVTGEDLVRE
SITDADKRVLLIDGLGFGYANVVVAVPQAWIDVRTMADLDDVTTGFRAQHNRRMRVATKYINLTRGFFAQHNVVDYRIVE
SAGATEGAPAVGTAEMIVDITTTGATLAANGLKVLDDGVMLRSQANLVASREADWSDTARETARVILDHIASRARAGKYK
EVRTRFKGCNDALLAEAHSRFGVVSPFGGPTSSGMLTLHCPPAQIYALGSFLRQHGADTVSVAALDYVFDKENPLFSKLA
AFLPQ
>Mature_324_residues
SAPFVLAVPSKGRLQENAEAFFARAGLTLSKPGGARDYRGTIAGLDNVEVAYLSASEIAANLARGSVHFGVTGEDLVRES
ITDADKRVLLIDGLGFGYANVVVAVPQAWIDVRTMADLDDVTTGFRAQHNRRMRVATKYINLTRGFFAQHNVVDYRIVES
AGATEGAPAVGTAEMIVDITTTGATLAANGLKVLDDGVMLRSQANLVASREADWSDTARETARVILDHIASRARAGKYKE
VRTRFKGCNDALLAEAHSRFGVVSPFGGPTSSGMLTLHCPPAQIYALGSFLRQHGADTVSVAALDYVFDKENPLFSKLAA
FLPQ

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=242, Percent_Identity=25.6198347107438, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 34790; Mature: 34659

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPFVLAVPSKGRLQENAEAFFARAGLTLSKPGGARDYRGTIAGLDNVEVAYLSASEIA
CCCCEEEECCCCCCCHHHHHHHHHHCCCEEECCCCCCCCCCEECCCCCCEEEEEEHHHHH
ANLARGSVHFGVTGEDLVRESITDADKRVLLIDGLGFGYANVVVAVPQAWIDVRTMADLD
HHHHCCCEEECCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHEEECCHHHHHHHHHHCHH
DVTTGFRAQHNRRMRVATKYINLTRGFFAQHNVVDYRIVESAGATEGAPAVGTAEMIVDI
HHHHHHHHHCCCHHEEHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEEEE
TTTGATLAANGLKVLDDGVMLRSQANLVASREADWSDTARETARVILDHIASRARAGKYK
ECCCCEECCCCCEEECCCEEEECCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHH
EVRTRFKGCNDALLAEAHSRFGVVSPFGGPTSSGMLTLHCPPAQIYALGSFLRQHGADTV
HHHHHHCCCCHHHHHHHHHHCCEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEE
SVAALDYVFDKENPLFSKLAAFLPQ
EEEEEEEEECCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SAPFVLAVPSKGRLQENAEAFFARAGLTLSKPGGARDYRGTIAGLDNVEVAYLSASEIA
CCCEEEECCCCCCCHHHHHHHHHHCCCEEECCCCCCCCCCEECCCCCCEEEEEEHHHHH
ANLARGSVHFGVTGEDLVRESITDADKRVLLIDGLGFGYANVVVAVPQAWIDVRTMADLD
HHHHCCCEEECCCHHHHHHHHHCCCCCEEEEEECCCCCHHHHEEECCHHHHHHHHHHCHH
DVTTGFRAQHNRRMRVATKYINLTRGFFAQHNVVDYRIVESAGATEGAPAVGTAEMIVDI
HHHHHHHHHCCCHHEEHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEEEE
TTTGATLAANGLKVLDDGVMLRSQANLVASREADWSDTARETARVILDHIASRARAGKYK
ECCCCEECCCCCEEECCCEEEECCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHH
EVRTRFKGCNDALLAEAHSRFGVVSPFGGPTSSGMLTLHCPPAQIYALGSFLRQHGADTV
HHHHHHCCCCHHHHHHHHHHCCEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCEE
SVAALDYVFDKENPLFSKLAAFLPQ
EEEEEEEEECCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA