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The map label for this gene is nadC [H]

Identifier: 192289655

GI number: 192289655

Start: 1321153

End: 1322028

Strand: Reverse

Name: nadC [H]

Synonym: Rpal_1245

Alternate gene names: 192289655

Gene position: 1322028-1321153 (Counterclockwise)

Preceding gene: 192289656

Following gene: 192289651

Centisome position: 23.02

GC content: 67.69

Gene sequence:

>876_bases
ATGTTGCCGTCTGCCCTGCTGCATCCCGATGCATTCCTGTCGCCATTGGCGATCACCGACGCTGTGCGGCGCGCGCTCGA
CGAGGATCTCGGCCGTGCCGGCGACGTCACCTCGGTCGCAACGATTCCGGAAGCAACCCAAGCGCACGCGATCCTGGTGG
CGCGCCAGGCCGGCGTGATCGCAGGATTGCCGCTGGCGATCGAGACGTTTCGCCAGCTCTCGACGGACGTCGCCATCACC
GCGCATGCGCGCGACGGCGACACTGTGGCGGCGGGCATTCAGGTGCTGACGATCTCGGGCCCGGCCCGCGCCGTGCTCAC
CGGCGAGCGTACCGCGCTGAACTTCGTCGGCCGGCTGTCGGGCATTGCGACGCTGACCGCGGACTACGTCCGCCACACCG
CAGGCACCAAGATGCGGATCTGCTGCACCCGCAAGACCACGCCGGGGCTGCGCGCGCTGGAGAAATACGCGGTGCGCTGC
GGCGGCGGCTTCAACCACCGCTTCGGCCTCGACGACGCCATCCTGATCAAGGACAACCACATCGCGGTGGCCGGCGGCAT
CCGACCGGTGCTGGAAGCGGCGCGCGCCAAGATCGGCCATCTGGTCAAGATCGAGATCGAGGTCGACACGCTCGATCAGC
TGCGCGAGGTGCTCGACACCAATCTTGCCGACGTCGTGCTGCTCGACAACATGGATCTCGACACGCTGAAGAAAGCGGTG
GCGATGAGCGCCGGCCGCGTCGTGCTCGAAGCTTCCGGCGGCGTCACCCGCGAGTCGATCAGCAGCATCGCCGCAACCGG
CGTCGACTACGCCTCCTCCGGCGCGCTCACACACTCGGCGCCGAATTTCGACGTCGCGCTGGATATCGATGCGTAG

Upstream 100 bases:

>100_bases
GCTCAGGCCCGCGAGCGCGCCGCCGCGCTCGGCGGCGGTGCCCCGCGCTCCCCTCGCCTCTCTGCGCAATCCGCGCTCGC
CTGATTCAGGACCATCTTTC

Downstream 100 bases:

>100_bases
TCTGGCACCGACGCCCCCGAAACGTCGATGGTTAGTTCTCAGCGGCGACCGCTGGTCCATGTCGATTTTGGCAGCAATGC
AGGATCGCGACGAATAAGCG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MLPSALLHPDAFLSPLAITDAVRRALDEDLGRAGDVTSVATIPEATQAHAILVARQAGVIAGLPLAIETFRQLSTDVAIT
AHARDGDTVAAGIQVLTISGPARAVLTGERTALNFVGRLSGIATLTADYVRHTAGTKMRICCTRKTTPGLRALEKYAVRC
GGGFNHRFGLDDAILIKDNHIAVAGGIRPVLEAARAKIGHLVKIEIEVDTLDQLREVLDTNLADVVLLDNMDLDTLKKAV
AMSAGRVVLEASGGVTRESISSIAATGVDYASSGALTHSAPNFDVALDIDA

Sequences:

>Translated_291_residues
MLPSALLHPDAFLSPLAITDAVRRALDEDLGRAGDVTSVATIPEATQAHAILVARQAGVIAGLPLAIETFRQLSTDVAIT
AHARDGDTVAAGIQVLTISGPARAVLTGERTALNFVGRLSGIATLTADYVRHTAGTKMRICCTRKTTPGLRALEKYAVRC
GGGFNHRFGLDDAILIKDNHIAVAGGIRPVLEAARAKIGHLVKIEIEVDTLDQLREVLDTNLADVVLLDNMDLDTLKKAV
AMSAGRVVLEASGGVTRESISSIAATGVDYASSGALTHSAPNFDVALDIDA
>Mature_291_residues
MLPSALLHPDAFLSPLAITDAVRRALDEDLGRAGDVTSVATIPEATQAHAILVARQAGVIAGLPLAIETFRQLSTDVAIT
AHARDGDTVAAGIQVLTISGPARAVLTGERTALNFVGRLSGIATLTADYVRHTAGTKMRICCTRKTTPGLRALEKYAVRC
GGGFNHRFGLDDAILIKDNHIAVAGGIRPVLEAARAKIGHLVKIEIEVDTLDQLREVLDTNLADVVLLDNMDLDTLKKAV
AMSAGRVVLEASGGVTRESISSIAATGVDYASSGALTHSAPNFDVALDIDA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=292, Percent_Identity=32.8767123287671, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI1786299, Length=276, Percent_Identity=43.1159420289855, Blast_Score=195, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6321162, Length=255, Percent_Identity=34.9019607843137, Blast_Score=142, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30427; Mature: 30427

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPSALLHPDAFLSPLAITDAVRRALDEDLGRAGDVTSVATIPEATQAHAILVARQAGVI
CCCCHHCCCHHHHCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEEEECCCCE
AGLPLAIETFRQLSTDVAITAHARDGDTVAAGIQVLTISGPARAVLTGERTALNFVGRLS
ECCHHHHHHHHHHCCCEEEEEECCCCCEEEECEEEEEECCCCEEEEECCHHHHHHHHHHH
GIATLTADYVRHTAGTKMRICCTRKTTPGLRALEKYAVRCGGGFNHRFGLDDAILIKDNH
HHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCC
IAVAGGIRPVLEAARAKIGHLVKIEIEVDTLDQLREVLDTNLADVVLLDNMDLDTLKKAV
EEEECCHHHHHHHHHHHHCCEEEEEEEECCHHHHHHHHCCCCCEEEEECCCCHHHHHHHH
AMSAGRVVLEASGGVTRESISSIAATGVDYASSGALTHSAPNFDVALDIDA
HHCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCEECCCCCCEEEEEECC
>Mature Secondary Structure
MLPSALLHPDAFLSPLAITDAVRRALDEDLGRAGDVTSVATIPEATQAHAILVARQAGVI
CCCCHHCCCHHHHCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEEEECCCCE
AGLPLAIETFRQLSTDVAITAHARDGDTVAAGIQVLTISGPARAVLTGERTALNFVGRLS
ECCHHHHHHHHHHCCCEEEEEECCCCCEEEECEEEEEECCCCEEEEECCHHHHHHHHHHH
GIATLTADYVRHTAGTKMRICCTRKTTPGLRALEKYAVRCGGGFNHRFGLDDAILIKDNH
HHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCC
IAVAGGIRPVLEAARAKIGHLVKIEIEVDTLDQLREVLDTNLADVVLLDNMDLDTLKKAV
EEEECCHHHHHHHHHHHHCCEEEEEEEECCHHHHHHHHCCCCCEEEEECCCCHHHHHHHH
AMSAGRVVLEASGGVTRESISSIAATGVDYASSGALTHSAPNFDVALDIDA
HHCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCEECCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]