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The map label for this gene is copA [H]

Identifier: 192289467

GI number: 192289467

Start: 1105025

End: 1106854

Strand: Reverse

Name: copA [H]

Synonym: Rpal_1040

Alternate gene names: 192289467

Gene position: 1106854-1105025 (Counterclockwise)

Preceding gene: 192289470

Following gene: 192289466

Centisome position: 19.27

GC content: 57.76

Gene sequence:

>1830_bases
GTGATCGCCCTTCCCTATGATTATTTTCTGCTTGGCTGGTTTGCCATAGCGCTAATTTCGACGGTTTACGTCGGCTACGA
TCAGTTTGCGGGGAATCCCGAGCCCACAGTGATGAAATGGGCGTTTATCTTGATAACGCTCTATATGGGGCCGTTCGGAC
TCTTGCTCTACGTGCTTGCAGACAAGGAGCCTCGCCCCGGAGAACACGAACGGTTCACTTCGCCGCTTTGGAAGCAAGGT
GTCGGCAGCACCATTCATTGCGTCGCCGGAGACGCGACCGGCATCATTTTGGCCGCGGTAACGACCGCGTTGCTCGGATT
GCCGATGTGGATCGACTTGATCGTTGAGTATCTGGCCGGATTCTCATTCGGGCTCTTCATCTTCCAGTCTCTGTTCATGA
AGCGAATGATGGGCGGCTCGTACTGGCAGAACGTAAAGATGAGCTTCATGCCCGAATTCATCAGCATGAACGCGATGATG
GCCGGAATGGCCCCGACGATGAGCTTCCTGATGATGGGGCGTGATATGCGCGCCATGGACCCGCTCGAACTGACGTTCTG
GGGCGTAATGTCGCTCGGTGTGATCGTGGGATTCACGACAGCCTATCCCTTCAACGTTTGGATGGTGCGCGCCGGCATCA
AGCACGGCCTCATGACTGAAAGATCCAGCGAACACGACGAAGGCGATAACCGGCAAGGAGATCATGGCGGCGGAAAGGGA
ATGAAGAGCGAGGCGACCGGGCCGCAACTTGCAGCCTTGGCAGGGGTCACTGGATTGCTACTCATAACCGGAATGGTATG
GCCCGGCTTTTTCGTGAATCTGAACCTGAGCGCTCGCGACGTGGACGGCGCGATAATGCCGCCCGGCATGATCAATACGT
TCGAACTGCCGGCCGCCGCCATGCGCGAAATGGCGGCGGTGAAGCCTCGGCAGGTGAGATACGAGGCGCCGAAGACGGCC
CGCGGCGACCAGGTGCTGCAGCCGCGGCTGGAGAACGGCGTCAAGGTGTTCGATATCGAGGCTTCCGTGATCCGCTGGAA
CATCCTGCCCGACGTCGCGGTGCAGGCTTATGCCTACAACCGCCAGATACCCGGGCCTCGGCTGGAGCTCACGGAGGGCG
ACCACGTGAGGATCAACTTCCGCAACGAGCTGCCGGAGAGTACGACAGTGCATTGGCATGGATTGATCGTGCCGAATGAG
ATGGATGGCCCGGCGAAGATCACGCAACCTCCGGTGCCACGGGGCGGATCATATAGCTACGAGTTCACCGTAGGGCAGCA
CGGGACGTATTTCTATCATAGTCATGACCACCCCGATCGGCAGCAGGCCCTCGGATTATATGGCGCGCTTATCGTTCATC
CGAAAGATCCGTCGTCGGAGGTCAAAGCGGACCTTGAGTATACGATCCAACTTCAGGAGTGGCTGAAACGGGAATGGCTC
ACTTATCCAGCGATGCTGATGGAAGGAGAGCTACCCAACTACTTCACGATCAACGGTAAGGCTTTCCCGGCGACCGACAC
GGTGCAGATGAAGGTTGGGCAGACGATAAAGTTGCGCTTCATCGGGACCAACAACAACTTCGTTCATCCGATGCACGTAC
ACGGTGGCCCCTTCGAAGTCGTGGCAGTGGATGGGGTTACTCTTACCGAAGGCGCCCGCTACCAGGCCGACACTGTCAAC
GTCGGTCCGGGGCAAAGATACGACGTGGTTTGGACCGCCCGCAGGAGCGGGAAGTGGTTGGTGCATTGTCATATTCCCCA
TCACACCTCGAACAACAATGTCGAGCAAGAAGGGGGCGGCGGGTTGATGCTGGTCTTGAACGTTCAGTGA

Upstream 100 bases:

>100_bases
ACAGCGATTGCCAACATTTTTCTCACGTCGGGACCGCGTTGGGAAATGGAACGAAGAACTTAAGCGGCGGTTGCGTGACG
GACAATGCATCGGAGGAGCC

Downstream 100 bases:

>100_bases
TCGTCAACGACGATCGGATGAGTGCGGCCGTTGTGTCGACAGGGGCCCATGGGATGCCGGCGTGCGCCTAGTCCAACTCG
AGCATGGTGTTGATTTGCCC

Product: multicopper oxidase type 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MIALPYDYFLLGWFAIALISTVYVGYDQFAGNPEPTVMKWAFILITLYMGPFGLLLYVLADKEPRPGEHERFTSPLWKQG
VGSTIHCVAGDATGIILAAVTTALLGLPMWIDLIVEYLAGFSFGLFIFQSLFMKRMMGGSYWQNVKMSFMPEFISMNAMM
AGMAPTMSFLMMGRDMRAMDPLELTFWGVMSLGVIVGFTTAYPFNVWMVRAGIKHGLMTERSSEHDEGDNRQGDHGGGKG
MKSEATGPQLAALAGVTGLLLITGMVWPGFFVNLNLSARDVDGAIMPPGMINTFELPAAAMREMAAVKPRQVRYEAPKTA
RGDQVLQPRLENGVKVFDIEASVIRWNILPDVAVQAYAYNRQIPGPRLELTEGDHVRINFRNELPESTTVHWHGLIVPNE
MDGPAKITQPPVPRGGSYSYEFTVGQHGTYFYHSHDHPDRQQALGLYGALIVHPKDPSSEVKADLEYTIQLQEWLKREWL
TYPAMLMEGELPNYFTINGKAFPATDTVQMKVGQTIKLRFIGTNNNFVHPMHVHGGPFEVVAVDGVTLTEGARYQADTVN
VGPGQRYDVVWTARRSGKWLVHCHIPHHTSNNNVEQEGGGGLMLVLNVQ

Sequences:

>Translated_609_residues
MIALPYDYFLLGWFAIALISTVYVGYDQFAGNPEPTVMKWAFILITLYMGPFGLLLYVLADKEPRPGEHERFTSPLWKQG
VGSTIHCVAGDATGIILAAVTTALLGLPMWIDLIVEYLAGFSFGLFIFQSLFMKRMMGGSYWQNVKMSFMPEFISMNAMM
AGMAPTMSFLMMGRDMRAMDPLELTFWGVMSLGVIVGFTTAYPFNVWMVRAGIKHGLMTERSSEHDEGDNRQGDHGGGKG
MKSEATGPQLAALAGVTGLLLITGMVWPGFFVNLNLSARDVDGAIMPPGMINTFELPAAAMREMAAVKPRQVRYEAPKTA
RGDQVLQPRLENGVKVFDIEASVIRWNILPDVAVQAYAYNRQIPGPRLELTEGDHVRINFRNELPESTTVHWHGLIVPNE
MDGPAKITQPPVPRGGSYSYEFTVGQHGTYFYHSHDHPDRQQALGLYGALIVHPKDPSSEVKADLEYTIQLQEWLKREWL
TYPAMLMEGELPNYFTINGKAFPATDTVQMKVGQTIKLRFIGTNNNFVHPMHVHGGPFEVVAVDGVTLTEGARYQADTVN
VGPGQRYDVVWTARRSGKWLVHCHIPHHTSNNNVEQEGGGGLMLVLNVQ
>Mature_609_residues
MIALPYDYFLLGWFAIALISTVYVGYDQFAGNPEPTVMKWAFILITLYMGPFGLLLYVLADKEPRPGEHERFTSPLWKQG
VGSTIHCVAGDATGIILAAVTTALLGLPMWIDLIVEYLAGFSFGLFIFQSLFMKRMMGGSYWQNVKMSFMPEFISMNAMM
AGMAPTMSFLMMGRDMRAMDPLELTFWGVMSLGVIVGFTTAYPFNVWMVRAGIKHGLMTERSSEHDEGDNRQGDHGGGKG
MKSEATGPQLAALAGVTGLLLITGMVWPGFFVNLNLSARDVDGAIMPPGMINTFELPAAAMREMAAVKPRQVRYEAPKTA
RGDQVLQPRLENGVKVFDIEASVIRWNILPDVAVQAYAYNRQIPGPRLELTEGDHVRINFRNELPESTTVHWHGLIVPNE
MDGPAKITQPPVPRGGSYSYEFTVGQHGTYFYHSHDHPDRQQALGLYGALIVHPKDPSSEVKADLEYTIQLQEWLKREWL
TYPAMLMEGELPNYFTINGKAFPATDTVQMKVGQTIKLRFIGTNNNFVHPMHVHGGPFEVVAVDGVTLTEGARYQADTVN
VGPGQRYDVVWTARRSGKWLVHCHIPHHTSNNNVEQEGGGGLMLVLNVQ

Specific function: Mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein CopC. May have oxidase activity [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=227, Percent_Identity=27.7533039647577, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321067, Length=233, Percent_Identity=27.0386266094421, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323703, Length=222, Percent_Identity=27.9279279279279, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28574104, Length=153, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24585842, Length=240, Percent_Identity=31.6666666666667, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24650186, Length=140, Percent_Identity=38.5714285714286, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221330000, Length=240, Percent_Identity=31.6666666666667, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281360167, Length=240, Percent_Identity=31.6666666666667, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221329998, Length=240, Percent_Identity=31.6666666666667, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI18859919, Length=124, Percent_Identity=37.9032258064516, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 67709; Mature: 67709

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIALPYDYFLLGWFAIALISTVYVGYDQFAGNPEPTVMKWAFILITLYMGPFGLLLYVLA
CEECCHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHEEEEE
DKEPRPGEHERFTSPLWKQGVGSTIHCVAGDATGIILAAVTTALLGLPMWIDLIVEYLAG
CCCCCCCCHHHHCCHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
FSFGLFIFQSLFMKRMMGGSYWQNVKMSFMPEFISMNAMMAGMAPTMSFLMMGRDMRAMD
CHHHHHHHHHHHHHHHHCCCHHHCCHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PLELTFWGVMSLGVIVGFTTAYPFNVWMVRAGIKHGLMTERSSEHDEGDNRQGDHGGGKG
CHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHCCCCCCCCCCCCCCCCCCCCCCCCC
MKSEATGPQLAALAGVTGLLLITGMVWPGFFVNLNLSARDVDGAIMPPGMINTFELPAAA
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCHHH
MREMAAVKPRQVRYEAPKTARGDQVLQPRLENGVKVFDIEASVIRWNILPDVAVQAYAYN
HHHHHHCCCCCEEECCCCCCCCCHHHHHHHHCCCEEEEEEEEEEEEECCCHHHHHHHHCC
RQIPGPRLELTEGDHVRINFRNELPESTTVHWHGLIVPNEMDGPAKITQPPVPRGGSYSY
CCCCCCEEEECCCCEEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCEEE
EFTVGQHGTYFYHSHDHPDRQQALGLYGALIVHPKDPSSEVKADLEYTIQLQEWLKREWL
EEEECCCCEEEEECCCCCCHHHHHCEEEEEEEECCCCHHHHCCCCEEEEEHHHHHHHHHH
TYPAMLMEGELPNYFTINGKAFPATDTVQMKVGQTIKLRFIGTNNNFVHPMHVHGGPFEV
CCCHHEECCCCCCEEEECCEEECCCCEEEEECCCEEEEEEEECCCCEEEEEEECCCCEEE
VAVDGVTLTEGARYQADTVNVGPGQRYDVVWTARRSGKWLVHCHIPHHTSNNNVEQEGGG
EEECCEEECCCCCEECCEEECCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCC
GLMLVLNVQ
CEEEEEECC
>Mature Secondary Structure
MIALPYDYFLLGWFAIALISTVYVGYDQFAGNPEPTVMKWAFILITLYMGPFGLLLYVLA
CEECCHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHEEEEE
DKEPRPGEHERFTSPLWKQGVGSTIHCVAGDATGIILAAVTTALLGLPMWIDLIVEYLAG
CCCCCCCCHHHHCCHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
FSFGLFIFQSLFMKRMMGGSYWQNVKMSFMPEFISMNAMMAGMAPTMSFLMMGRDMRAMD
CHHHHHHHHHHHHHHHHCCCHHHCCHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PLELTFWGVMSLGVIVGFTTAYPFNVWMVRAGIKHGLMTERSSEHDEGDNRQGDHGGGKG
CHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHCCCCCCCCCCCCCCCCCCCCCCCCC
MKSEATGPQLAALAGVTGLLLITGMVWPGFFVNLNLSARDVDGAIMPPGMINTFELPAAA
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCHHH
MREMAAVKPRQVRYEAPKTARGDQVLQPRLENGVKVFDIEASVIRWNILPDVAVQAYAYN
HHHHHHCCCCCEEECCCCCCCCCHHHHHHHHCCCEEEEEEEEEEEEECCCHHHHHHHHCC
RQIPGPRLELTEGDHVRINFRNELPESTTVHWHGLIVPNEMDGPAKITQPPVPRGGSYSY
CCCCCCEEEECCCCEEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCEEE
EFTVGQHGTYFYHSHDHPDRQQALGLYGALIVHPKDPSSEVKADLEYTIQLQEWLKREWL
EEEECCCCEEEEECCCCCCHHHHHCEEEEEEEECCCCHHHHCCCCEEEEEHHHHHHHHHH
TYPAMLMEGELPNYFTINGKAFPATDTVQMKVGQTIKLRFIGTNNNFVHPMHVHGGPFEV
CCCHHEECCCCCCEEEECCEEECCCCEEEEECCCEEEEEEEECCCCEEEEEEECCCCEEE
VAVDGVTLTEGARYQADTVNVGPGQRYDVVWTARRSGKWLVHCHIPHHTSNNNVEQEGGG
EEECCEEECCCCCEECCEEECCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCCCCCC
GLMLVLNVQ
CEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3372485; 1924351 [H]