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The map label for this gene is dapA2 [H]

Identifier: 192289394

GI number: 192289394

Start: 1033778

End: 1034695

Strand: Reverse

Name: dapA2 [H]

Synonym: Rpal_0966

Alternate gene names: 192289394

Gene position: 1034695-1033778 (Counterclockwise)

Preceding gene: 192289395

Following gene: 192289393

Centisome position: 18.01

GC content: 68.3

Gene sequence:

>918_bases
ATGGAGACATCCCTGGACGCGACAGCCGAACAGCCACGCGGGCTGTGGCTGCCGCTGATCACGCCGTTTCGCGACGGCGA
GCTCGACGGCGCATCGCTGCGCCGGCTGATCGCGCACTACGCGCGAGCTCCGCTCGACGGACTGATCTTAGGGGCCACCA
CCGGCGAAGGGCTGACGCTGAATGAAGACGAGCTCGAACGCCTGGTGATGCTGAGCGCCGATGCATTGGCGGCGAGCGGC
CGCAAGCTGCCGGTGTATCTCGGGCTGTCCGGCAGCGACACGCGCAAGCTGGTGAAGACGCTGGCGCGGACCGCACACTG
GCCGATCGACGGCGTGCTGATCGCCTGCCCGTACTACACCCGCCCGTCGCAGCGGGGATTGGTGCTGCATTTCGAAGCCG
CAGCCGACGCCACCGCAAGGCCGATCCTGATCTACAACATCCCGTATCGCACCGGCGTCAATCTACACAACGAGGCGATG
CTGCGGCTCGCCGAGCGCGCCAACATCGTCGGCGTCAAGGATTGCTGCGCCGATCCTGCGCAGACAGCGGAGCTGCTGAG
GTTGCGGCCGCCGGGCTTTTCGGTGCTCACCGGCGAGGATGCGCTGGCATTCGATGCGCTGAGCCGCGGCTGCGACGGCG
CGATCCTGGCCTCGGCGCATCTGGAGACCGAGGCGTTCGCCGCGATGATGCATCGGCTGCAGGCCGGCGACCGCCTCGGT
GGGGCGACCGAATGGCAACGGCTCGCCGACCTGCCGAAGCTGCTGTTCGCCGAGCCATCCCCGGCGCCGGTGAAATATGC
GCTGTGGCGGCGCGGGTTGATCGACAGCCCAGAAGTGCGGCTGCCGATGACACCGGTGTCGCCCACGCTCGCCGCCACCC
TTGATGCGTGGATGCTGCCCGGCCTATCCGCGGCTTGA

Upstream 100 bases:

>100_bases
TAGATCAATCTCGCCTTCACGCATGCACCCAACCCCGCCGGTTTCGACGGGGTTTTTTGTTGCAGCTCCGCTTCCGGCCC
GACCTCTCAGGAGACCGAAG

Downstream 100 bases:

>100_bases
GCGGTCCGATGCGGCTCGGCCGAAGCCCTTGACGGGCGCGACCGGGACCGCCTTATGGAGCCGGCGAAAGCTGCCCGGTT
GCGGCCCGAATCCGCTAGTA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS 2 [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
METSLDATAEQPRGLWLPLITPFRDGELDGASLRRLIAHYARAPLDGLILGATTGEGLTLNEDELERLVMLSADALAASG
RKLPVYLGLSGSDTRKLVKTLARTAHWPIDGVLIACPYYTRPSQRGLVLHFEAAADATARPILIYNIPYRTGVNLHNEAM
LRLAERANIVGVKDCCADPAQTAELLRLRPPGFSVLTGEDALAFDALSRGCDGAILASAHLETEAFAAMMHRLQAGDRLG
GATEWQRLADLPKLLFAEPSPAPVKYALWRRGLIDSPEVRLPMTPVSPTLAATLDAWMLPGLSAA

Sequences:

>Translated_305_residues
METSLDATAEQPRGLWLPLITPFRDGELDGASLRRLIAHYARAPLDGLILGATTGEGLTLNEDELERLVMLSADALAASG
RKLPVYLGLSGSDTRKLVKTLARTAHWPIDGVLIACPYYTRPSQRGLVLHFEAAADATARPILIYNIPYRTGVNLHNEAM
LRLAERANIVGVKDCCADPAQTAELLRLRPPGFSVLTGEDALAFDALSRGCDGAILASAHLETEAFAAMMHRLQAGDRLG
GATEWQRLADLPKLLFAEPSPAPVKYALWRRGLIDSPEVRLPMTPVSPTLAATLDAWMLPGLSAA
>Mature_305_residues
METSLDATAEQPRGLWLPLITPFRDGELDGASLRRLIAHYARAPLDGLILGATTGEGLTLNEDELERLVMLSADALAASG
RKLPVYLGLSGSDTRKLVKTLARTAHWPIDGVLIACPYYTRPSQRGLVLHFEAAADATARPILIYNIPYRTGVNLHNEAM
LRLAERANIVGVKDCCADPAQTAELLRLRPPGFSVLTGEDALAFDALSRGCDGAILASAHLETEAFAAMMHRLQAGDRLG
GATEWQRLADLPKLLFAEPSPAPVKYALWRRGLIDSPEVRLPMTPVSPTLAATLDAWMLPGLSAA

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=253, Percent_Identity=26.0869565217391, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1788823, Length=286, Percent_Identity=34.965034965035, Blast_Score=160, Evalue=6e-41,
Organism=Escherichia coli, GI1786463, Length=279, Percent_Identity=29.0322580645161, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87082415, Length=266, Percent_Identity=28.9473684210526, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1789620, Length=299, Percent_Identity=27.7591973244147, Blast_Score=84, Evalue=8e-18,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 32890; Mature: 32890

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METSLDATAEQPRGLWLPLITPFRDGELDGASLRRLIAHYARAPLDGLILGATTGEGLTL
CCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCEE
NEDELERLVMLSADALAASGRKLPVYLGLSGSDTRKLVKTLARTAHWPIDGVLIACPYYT
CHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEECCCCC
RPSQRGLVLHFEAAADATARPILIYNIPYRTGVNLHNEAMLRLAERANIVGVKDCCADPA
CCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCEEEHHHHCCCHH
QTAELLRLRPPGFSVLTGEDALAFDALSRGCDGAILASAHLETEAFAAMMHRLQAGDRLG
HHHHHHEECCCCCEEEECCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCC
GATEWQRLADLPKLLFAEPSPAPVKYALWRRGLIDSPEVRLPMTPVSPTLAATLDAWMLP
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHHHHCC
GLSAA
CCCCC
>Mature Secondary Structure
METSLDATAEQPRGLWLPLITPFRDGELDGASLRRLIAHYARAPLDGLILGATTGEGLTL
CCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCEE
NEDELERLVMLSADALAASGRKLPVYLGLSGSDTRKLVKTLARTAHWPIDGVLIACPYYT
CHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEECCCCC
RPSQRGLVLHFEAAADATARPILIYNIPYRTGVNLHNEAMLRLAERANIVGVKDCCADPA
CCCCCCEEEEEECCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCEEEHHHHCCCHH
QTAELLRLRPPGFSVLTGEDALAFDALSRGCDGAILASAHLETEAFAAMMHRLQAGDRLG
HHHHHHEECCCCCEEEECCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCC
GATEWQRLADLPKLLFAEPSPAPVKYALWRRGLIDSPEVRLPMTPVSPTLAATLDAWMLP
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHHHHCC
GLSAA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]