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The map label for this gene is hemA [H]

Identifier: 192289350

GI number: 192289350

Start: 980273

End: 981502

Strand: Reverse

Name: hemA [H]

Synonym: Rpal_0922

Alternate gene names: 192289350

Gene position: 981502-980273 (Counterclockwise)

Preceding gene: 192289351

Following gene: 192289349

Centisome position: 17.09

GC content: 63.66

Gene sequence:

>1230_bases
ATGCAGTACAATCAATTCTTTCAAGACGCTCTCACCCGCCTCCACGACGAGCGTCGTTACCGGGTGTTCGCTGATCTCGA
GCGGATGGCCGGTAGGTTTCCGCATGCCACGTGGCACTCGAACTCCGGACCTCGCGATGTTGTGATCTGGTGCTCGAACG
ACTATCTCGGCATGGGCCAGCACCCGAAGGTGGTCGGCGCAATGGTCGAGACCGCAACGCGGATCGGCACCGGTGCCGGT
GGTACCCGCAATATCGCCGGTACGCATCACCCGCTGGTGCAGCTCGAGCAGGAAATCGCCTCGCTGCACGGCAAGGAAGC
GGCGCTGCTGTTCACCTCGGGCTATGTCTCCAACCAGACCGGCCTGTCGACGCTCGGCAAGTTGATCCCGAACTGCCTGA
TCCTGTCGGACGCGCTCAATCACAATTCGATGATTGAAGGCATCCGCCAGTCGGGCTGCGAGCGCGTGGTGTGGCGCCAC
AACGATACCGCGCACCTCGAAGAGCTGCTGATCGCCGCCGGTCCCGACCGACCGAAGCTGATCGCATTCGAGAGTCTGTA
CTCGATGGACGGTGACACCGCGCCGCTGGCGAAGATCTGCGATCTCGCCGAGAAGTACAACGCGATGACCTACTGCGACG
AAGTGCATGCGGTCGGCATGTACGGCGCCCACGGTGCCGGCGTCGCCGAGCGTGACGGCGTGATGGATCGCATCGACATC
ATCGAAGCGACCCTGGCCAAGGCGTTCGGCTGCCTCGGCGGCTACATCACAGGCAAGAACGAAGTTATCGACGCCGTACG
CTCCTACGCGCCGGGCTTCATCTTCACCACGTCGCTGCCGCCGCCGATCTGCGCCGCCGCGACTGCCGCGATCAAGCATC
TGCGCAGCTCGACCTGGGAGCGTGAACGCCATCAGGACCGCGCTGCCCGCGTCAAAGCGGTGCTGAACAACGCCGGCATT
CCGGTGATGCCGACCGACACCCACATCGTGCCGGTGTTCGTCGGCGACGCCGAGAAGTGCAAGAAGGCGTCCGATCTGCT
GCTCGAACAGCACAACATCTACATTCAGCCGATCAATTACCCGACCGTCGCCCGCGGCCTCGAACGGCTCCGCATCACGC
CGTCGCCGTATCACGACGACAAGCTGATCGATGCACTCGCCGAAGCCCTGGTGCAGGTCTGGAACGAGCTCGGCCTGCCG
CTCGGCGCCAAGGCGATCGCTGCGGAGTGA

Upstream 100 bases:

>100_bases
GTCGAATTGCGCCTCGACTTCGGTGATGGAAGAGTTCTAATAGTTTCGCCGGCTCTACGGCGTTCCGTCGTTCGATCCGC
CTCCCCAACAGGTCATCGCG

Downstream 100 bases:

>100_bases
TCCGCATCGCTCGCACGACGCGGTAATGATTTTCGGCGGGGGCGCCCGCGGCTGGGAAAATCCCTGTCGCAGGCGCCCCT
TCTGTTTTGGTAGACTTGCG

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MQYNQFFQDALTRLHDERRYRVFADLERMAGRFPHATWHSNSGPRDVVIWCSNDYLGMGQHPKVVGAMVETATRIGTGAG
GTRNIAGTHHPLVQLEQEIASLHGKEAALLFTSGYVSNQTGLSTLGKLIPNCLILSDALNHNSMIEGIRQSGCERVVWRH
NDTAHLEELLIAAGPDRPKLIAFESLYSMDGDTAPLAKICDLAEKYNAMTYCDEVHAVGMYGAHGAGVAERDGVMDRIDI
IEATLAKAFGCLGGYITGKNEVIDAVRSYAPGFIFTTSLPPPICAAATAAIKHLRSSTWERERHQDRAARVKAVLNNAGI
PVMPTDTHIVPVFVGDAEKCKKASDLLLEQHNIYIQPINYPTVARGLERLRITPSPYHDDKLIDALAEALVQVWNELGLP
LGAKAIAAE

Sequences:

>Translated_409_residues
MQYNQFFQDALTRLHDERRYRVFADLERMAGRFPHATWHSNSGPRDVVIWCSNDYLGMGQHPKVVGAMVETATRIGTGAG
GTRNIAGTHHPLVQLEQEIASLHGKEAALLFTSGYVSNQTGLSTLGKLIPNCLILSDALNHNSMIEGIRQSGCERVVWRH
NDTAHLEELLIAAGPDRPKLIAFESLYSMDGDTAPLAKICDLAEKYNAMTYCDEVHAVGMYGAHGAGVAERDGVMDRIDI
IEATLAKAFGCLGGYITGKNEVIDAVRSYAPGFIFTTSLPPPICAAATAAIKHLRSSTWERERHQDRAARVKAVLNNAGI
PVMPTDTHIVPVFVGDAEKCKKASDLLLEQHNIYIQPINYPTVARGLERLRITPSPYHDDKLIDALAEALVQVWNELGLP
LGAKAIAAE
>Mature_409_residues
MQYNQFFQDALTRLHDERRYRVFADLERMAGRFPHATWHSNSGPRDVVIWCSNDYLGMGQHPKVVGAMVETATRIGTGAG
GTRNIAGTHHPLVQLEQEIASLHGKEAALLFTSGYVSNQTGLSTLGKLIPNCLILSDALNHNSMIEGIRQSGCERVVWRH
NDTAHLEELLIAAGPDRPKLIAFESLYSMDGDTAPLAKICDLAEKYNAMTYCDEVHAVGMYGAHGAGVAERDGVMDRIDI
IEATLAKAFGCLGGYITGKNEVIDAVRSYAPGFIFTTSLPPPICAAATAAIKHLRSSTWERERHQDRAARVKAVLNNAGI
PVMPTDTHIVPVFVGDAEKCKKASDLLLEQHNIYIQPINYPTVARGLERLRITPSPYHDDKLIDALAEALVQVWNELGLP
LGAKAIAAE

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=412, Percent_Identity=49.0291262135922, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI83977440, Length=412, Percent_Identity=49.0291262135922, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI83977444, Length=412, Percent_Identity=49.0291262135922, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI4502025, Length=405, Percent_Identity=49.1358024691358, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI40316939, Length=405, Percent_Identity=49.1358024691358, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI7657118, Length=361, Percent_Identity=36.2880886426593, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI284448556, Length=364, Percent_Identity=35.989010989011, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI119220554, Length=397, Percent_Identity=28.9672544080605, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI4758668, Length=396, Percent_Identity=29.040404040404, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI5454084, Length=268, Percent_Identity=27.6119402985075, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1790046, Length=398, Percent_Identity=33.6683417085427, Blast_Score=208, Evalue=7e-55,
Organism=Escherichia coli, GI1786993, Length=348, Percent_Identity=30.4597701149425, Blast_Score=152, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71994529, Length=358, Percent_Identity=35.4748603351955, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI32566772, Length=389, Percent_Identity=31.1053984575836, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17560912, Length=357, Percent_Identity=29.1316526610644, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17560914, Length=357, Percent_Identity=29.1316526610644, Blast_Score=131, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI71982617, Length=251, Percent_Identity=28.2868525896414, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI71982625, Length=251, Percent_Identity=28.2868525896414, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320438, Length=422, Percent_Identity=47.6303317535545, Blast_Score=400, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6320267, Length=366, Percent_Identity=29.2349726775956, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6323954, Length=264, Percent_Identity=25.3787878787879, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17137420, Length=401, Percent_Identity=47.8802992518703, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24662918, Length=354, Percent_Identity=36.1581920903955, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI17136286, Length=353, Percent_Identity=29.1784702549575, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24653280, Length=269, Percent_Identity=28.2527881040892, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24653276, Length=269, Percent_Identity=28.2527881040892, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24653278, Length=269, Percent_Identity=28.2527881040892, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 44755; Mature: 44755

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYNQFFQDALTRLHDERRYRVFADLERMAGRFPHATWHSNSGPRDVVIWCSNDYLGMGQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
HPKVVGAMVETATRIGTGAGGTRNIAGTHHPLVQLEQEIASLHGKEAALLFTSGYVSNQT
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
GLSTLGKLIPNCLILSDALNHNSMIEGIRQSGCERVVWRHNDTAHLEELLIAAGPDRPKL
HHHHHHHHHHHHEEHHHHCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCCE
IAFESLYSMDGDTAPLAKICDLAEKYNAMTYCDEVHAVGMYGAHGAGVAERDGVMDRIDI
EEHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCHHCCCHHHHHH
IEATLAKAFGCLGGYITGKNEVIDAVRSYAPGFIFTTSLPPPICAAATAAIKHLRSSTWE
HHHHHHHHHHHHCCEECCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHH
RERHQDRAARVKAVLNNAGIPVMPTDTHIVPVFVGDAEKCKKASDLLLEQHNIYIQPINY
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEEEECCC
PTVARGLERLRITPSPYHDDKLIDALAEALVQVWNELGLPLGAKAIAAE
HHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCC
>Mature Secondary Structure
MQYNQFFQDALTRLHDERRYRVFADLERMAGRFPHATWHSNSGPRDVVIWCSNDYLGMGQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
HPKVVGAMVETATRIGTGAGGTRNIAGTHHPLVQLEQEIASLHGKEAALLFTSGYVSNQT
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
GLSTLGKLIPNCLILSDALNHNSMIEGIRQSGCERVVWRHNDTAHLEELLIAAGPDRPKL
HHHHHHHHHHHHEEHHHHCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCCCCE
IAFESLYSMDGDTAPLAKICDLAEKYNAMTYCDEVHAVGMYGAHGAGVAERDGVMDRIDI
EEHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCHHCCCHHHHHH
IEATLAKAFGCLGGYITGKNEVIDAVRSYAPGFIFTTSLPPPICAAATAAIKHLRSSTWE
HHHHHHHHHHHHCCEECCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHH
RERHQDRAARVKAVLNNAGIPVMPTDTHIVPVFVGDAEKCKKASDLLLEQHNIYIQPINY
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEEEECCC
PTVARGLERLRITPSPYHDDKLIDALAEALVQVWNELGLPLGAKAIAAE
HHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3609750; 12597275 [H]