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The map label for this gene is sdhA [H]

Identifier: 192288647

GI number: 192288647

Start: 234650

End: 236473

Strand: Reverse

Name: sdhA [H]

Synonym: Rpal_0216

Alternate gene names: 192288647

Gene position: 236473-234650 (Counterclockwise)

Preceding gene: 192288648

Following gene: 192288646

Centisome position: 4.12

GC content: 66.5

Gene sequence:

>1824_bases
ATGGCGGCGAACGTCAACGGCGCCCCGGCGGCGGGCGGCTACGCCTATCCGATCGAGGACCACACCTACGACGTCGTGGT
GGTCGGCGCCGGCGGCGCGGGGTTGCGCGCAGTGGTCGGCTGCAGCGAAGCGGGCCTGCGCACCGCCTGCATCACCAAGG
TGTTCCCGACCCGCTCGCACACCGTGGCTGCCCAGGGCGGCATCTCGGCCTCGCTCGGCAACATGCATAAGGATGACTGG
CGCTGGCACATGTACGACACCGTGAAGGGGTCGGACTGGCTCGGCGATCAGGACTCGATCGAGTACATGGTCCGCAACGC
GCCGGAAGCCGTGTACGAACTCGAGCATTGGGGTGTGCCGTTCTCGCGCACCGAAGACGGTAAGATCTATCAGCGGCCGT
TCGGCGGCATGACGATGGATTTCGGCAAGGGCCAGGCGCAGCGCACCTGCGCGGCCGCCGACCGCACCGGCCACGCCATG
CTGCACACGATGTACGGTCAGGCGCTGCGCCACTCGGCTGAGTTCTACATCGAGTTCTTCGCCATCGACCTGATCATGGA
CGATCAGGGCTGCTGCCGCGGCGTCGTGGCGCTGAAGCTCGACGACGGCACCATCCATCGTTTCAAGGCGCAGACCACCA
TTCTGGCGACCGGCGGCTACGGCCGTGCCTACGCCTCCTGCACGTCGGCGCACACCTGCACCGGCGACGGCGGCGCGATG
GCGTTGCGCGCCGGCCTGCCGCTGCAGGACATGGAGTTCGTTCAGTTCCACCCGACCGGCATCTACGGCTCGGGCTGTCT
GGTGACCGAAGGCGCCCGCGGCGAGGGTGGCTATCTGGTCAACTCCGAGGGCGAGCGCTTCATGGAGCGCTATGCGCCGT
CGGCCAAGGACCTCGCCTCGCGCGATGTCGTTTCGCGCGCAATGACCATCGAAATGCGCGAAGGTCGCGGCGTCGGCAAG
AAGAAGGACCACATCTTCCTGCACCTCGACCATCTGGCGCCGGAAGTGCTGCACGAGCGGCTGCCGGGCATCTCGGAATC
GGCACGGATCTTCGCCGGCGTCGACGTCACCCGCGAGCCGATCCCGATCCTGCCGACCGTGCACTACAACATGGGCGGCA
TCCCGACGAACTTCCACGGCGAAGTCGTGACCAAGAAGGACGGCGACGACAACGCAGTGGTGCCGGGCCTGATGGCGATT
GGCGAAGCGGCCTGCGTGTCGGTGCACGGCGCCAACCGCCTCGGTTCCAACTCGCTGATCGACCTCGTGGTGTTCGGCCG
CGCCGCAGCGCTGCGCTGCGCCGAGAAGCTGGTGCCGAACGGCAAGCAGCCTGAACTGCCGGCCAGCTCCGCCGACATGT
CGCTGTCGCGGCTCGACAAGTATCGTTACGCCAAGGGCGGCACCCCGACCGCCAAGCTGCGCGAGCGGATGCAGCACGTG
ATGCAGAACAACTGCGCGGTGTTCCGCACCGGCGAAGTGCTCGCCGAGGGCAAGGAACTGATCGCCAACGTCCATGGCAG
CGTCGGCGACGTCGGCGTGTCGGATCGCACGCTGGTGTGGAATTCCGATCTCGTCGAGACACTGGAATTCGACAATCTGA
TCGTCCAGGCGGTGGTGACGATGAACTCCGCCGCCAACCGCACCGAGAGCCGCGGCGCCCACGCCCGCGAAGACTTCCCG
GATCGCGATGACGCCAACTGGATGAAGCACACGCTGGCCTGGATCGGTGACAAGGGCGACGTGACCATCGATTATCGGCC
GGTGCACGACTACACGATGACCAACGACGTCCAGTACATTCCGCCGAAGCCGCGGGTGTATTGA

Upstream 100 bases:

>100_bases
GCTCAAGTTGGTCACCATCATGGCCAACAACTTCTTCTCGATCGCCGTGGCGCTGGCCGCGATCTTTGCGATCTTCAAAA
TGGCATCCGGAGTTTAAGGC

Downstream 100 bases:

>100_bases
TTCAAAATCGTCATGCGCGGACTTGATCCGCGCATCCATCTTCTTCCCAACGAGATGGATCGCCGGGTCGAGCCCGGCAA
TGACCAGGAGAGACCAGAGG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 607; Mature: 606

Protein sequence:

>607_residues
MAANVNGAPAAGGYAYPIEDHTYDVVVVGAGGAGLRAVVGCSEAGLRTACITKVFPTRSHTVAAQGGISASLGNMHKDDW
RWHMYDTVKGSDWLGDQDSIEYMVRNAPEAVYELEHWGVPFSRTEDGKIYQRPFGGMTMDFGKGQAQRTCAAADRTGHAM
LHTMYGQALRHSAEFYIEFFAIDLIMDDQGCCRGVVALKLDDGTIHRFKAQTTILATGGYGRAYASCTSAHTCTGDGGAM
ALRAGLPLQDMEFVQFHPTGIYGSGCLVTEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRAMTIEMREGRGVGK
KKDHIFLHLDHLAPEVLHERLPGISESARIFAGVDVTREPIPILPTVHYNMGGIPTNFHGEVVTKKDGDDNAVVPGLMAI
GEAACVSVHGANRLGSNSLIDLVVFGRAAALRCAEKLVPNGKQPELPASSADMSLSRLDKYRYAKGGTPTAKLRERMQHV
MQNNCAVFRTGEVLAEGKELIANVHGSVGDVGVSDRTLVWNSDLVETLEFDNLIVQAVVTMNSAANRTESRGAHAREDFP
DRDDANWMKHTLAWIGDKGDVTIDYRPVHDYTMTNDVQYIPPKPRVY

Sequences:

>Translated_607_residues
MAANVNGAPAAGGYAYPIEDHTYDVVVVGAGGAGLRAVVGCSEAGLRTACITKVFPTRSHTVAAQGGISASLGNMHKDDW
RWHMYDTVKGSDWLGDQDSIEYMVRNAPEAVYELEHWGVPFSRTEDGKIYQRPFGGMTMDFGKGQAQRTCAAADRTGHAM
LHTMYGQALRHSAEFYIEFFAIDLIMDDQGCCRGVVALKLDDGTIHRFKAQTTILATGGYGRAYASCTSAHTCTGDGGAM
ALRAGLPLQDMEFVQFHPTGIYGSGCLVTEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRAMTIEMREGRGVGK
KKDHIFLHLDHLAPEVLHERLPGISESARIFAGVDVTREPIPILPTVHYNMGGIPTNFHGEVVTKKDGDDNAVVPGLMAI
GEAACVSVHGANRLGSNSLIDLVVFGRAAALRCAEKLVPNGKQPELPASSADMSLSRLDKYRYAKGGTPTAKLRERMQHV
MQNNCAVFRTGEVLAEGKELIANVHGSVGDVGVSDRTLVWNSDLVETLEFDNLIVQAVVTMNSAANRTESRGAHAREDFP
DRDDANWMKHTLAWIGDKGDVTIDYRPVHDYTMTNDVQYIPPKPRVY
>Mature_606_residues
AANVNGAPAAGGYAYPIEDHTYDVVVVGAGGAGLRAVVGCSEAGLRTACITKVFPTRSHTVAAQGGISASLGNMHKDDWR
WHMYDTVKGSDWLGDQDSIEYMVRNAPEAVYELEHWGVPFSRTEDGKIYQRPFGGMTMDFGKGQAQRTCAAADRTGHAML
HTMYGQALRHSAEFYIEFFAIDLIMDDQGCCRGVVALKLDDGTIHRFKAQTTILATGGYGRAYASCTSAHTCTGDGGAMA
LRAGLPLQDMEFVQFHPTGIYGSGCLVTEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRAMTIEMREGRGVGKK
KDHIFLHLDHLAPEVLHERLPGISESARIFAGVDVTREPIPILPTVHYNMGGIPTNFHGEVVTKKDGDDNAVVPGLMAIG
EAACVSVHGANRLGSNSLIDLVVFGRAAALRCAEKLVPNGKQPELPASSADMSLSRLDKYRYAKGGTPTAKLRERMQHVM
QNNCAVFRTGEVLAEGKELIANVHGSVGDVGVSDRTLVWNSDLVETLEFDNLIVQAVVTMNSAANRTESRGAHAREDFPD
RDDANWMKHTLAWIGDKGDVTIDYRPVHDYTMTNDVQYIPPKPRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=612, Percent_Identity=61.6013071895425, Blast_Score=747, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=551, Percent_Identity=55.8983666061706, Blast_Score=585, Evalue=1e-168,
Organism=Escherichia coli, GI1790597, Length=578, Percent_Identity=41.3494809688581, Blast_Score=408, Evalue=1e-115,
Organism=Escherichia coli, GI1788928, Length=564, Percent_Identity=30.1418439716312, Blast_Score=199, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17550100, Length=628, Percent_Identity=59.8726114649682, Blast_Score=744, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=613, Percent_Identity=59.0538336052202, Blast_Score=715, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=610, Percent_Identity=66.2295081967213, Blast_Score=802, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=597, Percent_Identity=65.4941373534338, Blast_Score=776, Evalue=0.0,
Organism=Drosophila melanogaster, GI17137288, Length=612, Percent_Identity=62.9084967320261, Blast_Score=779, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=612, Percent_Identity=62.9084967320261, Blast_Score=779, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=612, Percent_Identity=62.9084967320261, Blast_Score=779, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=613, Percent_Identity=55.7911908646003, Blast_Score=687, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65945; Mature: 65814

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAANVNGAPAAGGYAYPIEDHTYDVVVVGAGGAGLRAVVGCSEAGLRTACITKVFPTRSH
CCCCCCCCCCCCCEEECCCCCCEEEEEEECCCCCCEEEEECCCCCCHHHHHHHCCCCCCC
TVAAQGGISASLGNMHKDDWRWHMYDTVKGSDWLGDQDSIEYMVRNAPEAVYELEHWGVP
EEEECCCCCHHHCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCC
FSRTEDGKIYQRPFGGMTMDFGKGQAQRTCAAADRTGHAMLHTMYGQALRHSAEFYIEFF
CCCCCCCEEEECCCCCEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEEEEE
AIDLIMDDQGCCRGVVALKLDDGTIHRFKAQTTILATGGYGRAYASCTSAHTCTGDGGAM
EEEEEECCCCCCCEEEEEEECCCCEEEEEEEEEEEEECCCCCHHHHCCCCCEECCCCCEE
ALRAGLPLQDMEFVQFHPTGIYGSGCLVTEGARGEGGYLVNSEGERFMERYAPSAKDLAS
EEECCCCCCCCCEEEEECCCEECCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHH
RDVVSRAMTIEMREGRGVGKKKDHIFLHLDHLAPEVLHERLPGISESARIFAGVDVTREP
HHHHHHEEEEEEECCCCCCCCCCEEEEEEHHCCHHHHHHHCCCCCCCCEEEEECCCCCCC
IPILPTVHYNMGGIPTNFHGEVVTKKDGDDNAVVPGLMAIGEAACVSVHGANRLGSNSLI
CCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHCCEEEEEEECCCCCCCCCEE
DLVVFGRAAALRCAEKLVPNGKQPELPASSADMSLSRLDKYRYAKGGTPTAKLRERMQHV
EEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
MQNNCAVFRTGEVLAEGKELIANVHGSVGDVGVSDRTLVWNSDLVETLEFDNLIVQAVVT
HHCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHH
MNSAANRTESRGAHAREDFPDRDDANWMKHTLAWIGDKGDVTIDYRPVHDYTMTNDVQYI
HCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCEECCCCEEC
PPKPRVY
CCCCCCC
>Mature Secondary Structure 
AANVNGAPAAGGYAYPIEDHTYDVVVVGAGGAGLRAVVGCSEAGLRTACITKVFPTRSH
CCCCCCCCCCCCEEECCCCCCEEEEEEECCCCCCEEEEECCCCCCHHHHHHHCCCCCCC
TVAAQGGISASLGNMHKDDWRWHMYDTVKGSDWLGDQDSIEYMVRNAPEAVYELEHWGVP
EEEECCCCCHHHCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCC
FSRTEDGKIYQRPFGGMTMDFGKGQAQRTCAAADRTGHAMLHTMYGQALRHSAEFYIEFF
CCCCCCCEEEECCCCCEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEEEEE
AIDLIMDDQGCCRGVVALKLDDGTIHRFKAQTTILATGGYGRAYASCTSAHTCTGDGGAM
EEEEEECCCCCCCEEEEEEECCCCEEEEEEEEEEEEECCCCCHHHHCCCCCEECCCCCEE
ALRAGLPLQDMEFVQFHPTGIYGSGCLVTEGARGEGGYLVNSEGERFMERYAPSAKDLAS
EEECCCCCCCCCEEEEECCCEECCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHH
RDVVSRAMTIEMREGRGVGKKKDHIFLHLDHLAPEVLHERLPGISESARIFAGVDVTREP
HHHHHHEEEEEEECCCCCCCCCCEEEEEEHHCCHHHHHHHCCCCCCCCEEEEECCCCCCC
IPILPTVHYNMGGIPTNFHGEVVTKKDGDDNAVVPGLMAIGEAACVSVHGANRLGSNSLI
CCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHCCEEEEEEECCCCCCCCCEE
DLVVFGRAAALRCAEKLVPNGKQPELPASSADMSLSRLDKYRYAKGGTPTAKLRERMQHV
EEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHH
MQNNCAVFRTGEVLAEGKELIANVHGSVGDVGVSDRTLVWNSDLVETLEFDNLIVQAVVT
HHCCCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHH
MNSAANRTESRGAHAREDFPDRDDANWMKHTLAWIGDKGDVTIDYRPVHDYTMTNDVQYI
HCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCEECCCCEEC
PPKPRVY
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA