Click here to switch to the map view.

The map label for this gene is virB11c [H]

Identifier: 190895227

GI number: 190895227

Start: 990864

End: 991859

Strand: Reverse

Name: virB11c [H]

Synonym: RHECIAT_PC0000900

Alternate gene names: 190895227

Gene position: 991859-990864 (Counterclockwise)

Preceding gene: 190895228

Following gene: 190895223

Centisome position: 90.87

GC content: 59.64

Gene sequence:

>996_bases
ATGACCGAAGCTCCGGACTCCGCAGTCGTGCGCGAATTGCTTTCGCCTCTCTCGCCGTTCCTTCGCGACAAGACGTTCTA
TGAGGTCATCGTCAATCGACCCGGGCAAGTCGTCACGGAGGGCGGGGAGGGATGGCAGACCTACGACATGGCGGAACTAT
CCTACGACAGGCTGATGCGTCTCGCGCGGGCGGTCGCGAGTTTTTCCAATCAATCGATCGACGAGACACGGCCGATCCTG
TCGGCGACCTTGCCGGATGGCGAGCGGATCCAGATCGTCATTCCGCCGGCAACGACGAAGGGAACCGTCAGCATCACCAT
ACGCAAGCCATCCTCCGTGTCGCTGACCCTCGAGGATCTCGACCATGGAGGATTGTTCGCCGATGTCGCGCTGGCCGAAG
GCGACGGAGGGCGATGGGACAAAAGCCTGTTGGATTACTATCGGGTCGGCGCCTATAAGGCGTTTCTCCGGGAGGCGGTG
TTTGCAAGAAAGAACATCATCATTTCCGGCGCCACGGGCTCTGGAAAGACCACCCTGTCGAAAGCGCTGATCCGTTATAT
TCCGCAAAGCGAGCGGATCATTTCGATCGAAGACACACCGGAGCTGGTGGTCCCGCAGCCCAATCACGTTCGGCTCTTTT
ATTCCAAGGGCGGGCAGGGGCTCGCCAAAGTCGGCGCCAAGGACCTGCTCGAATCCTGTCTGCGCATGCGGCCCGACCGC
ATCCTGCTGCAGGAGCTGCGAGACGGCACGGCTTTCTACTACATTCGCAACATCAACTCCGGCCATCCGGGCTCGATCAC
GACGGTTCACGCCGATTCCACCCGGCTCGCCTTCGAGCAACTGACATTGCTGGTCAAGGAGTCGGAAGGCGGCGGGGACC
TCGAGCGGCACGACATCCGCGAGATGCTGACGATTGCTGTCGATATCATTGTTCAATGCAAGCGGATTGATGGCCGCTTT
CGGGTAAGCGAGATCTACTATCGAGATGCCGAATGA

Upstream 100 bases:

>100_bases
ACCGGCTTCGCGTAACGGAGCCCGGCAACCGCATCTACGACCGCGCCGTGCTCGGAGATTTCGCGCCGACGTCGAAGATC
GTGACAAAATAGGTTCGACG

Downstream 100 bases:

>100_bases
TCCGTAACATCCGTCCCGTCATTTGCTCTTCGCAGGCTTGTTGTCATACTCCACCAAGAGCGGTGGATCTCTGAACGGGC
CGAGACATGGTACCCGAAAG

Product: transport secretion system IV protein, VirB11

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MTEAPDSAVVRELLSPLSPFLRDKTFYEVIVNRPGQVVTEGGEGWQTYDMAELSYDRLMRLARAVASFSNQSIDETRPIL
SATLPDGERIQIVIPPATTKGTVSITIRKPSSVSLTLEDLDHGGLFADVALAEGDGGRWDKSLLDYYRVGAYKAFLREAV
FARKNIIISGATGSGKTTLSKALIRYIPQSERIISIEDTPELVVPQPNHVRLFYSKGGQGLAKVGAKDLLESCLRMRPDR
ILLQELRDGTAFYYIRNINSGHPGSITTVHADSTRLAFEQLTLLVKESEGGGDLERHDIREMLTIAVDIIVQCKRIDGRF
RVSEIYYRDAE

Sequences:

>Translated_331_residues
MTEAPDSAVVRELLSPLSPFLRDKTFYEVIVNRPGQVVTEGGEGWQTYDMAELSYDRLMRLARAVASFSNQSIDETRPIL
SATLPDGERIQIVIPPATTKGTVSITIRKPSSVSLTLEDLDHGGLFADVALAEGDGGRWDKSLLDYYRVGAYKAFLREAV
FARKNIIISGATGSGKTTLSKALIRYIPQSERIISIEDTPELVVPQPNHVRLFYSKGGQGLAKVGAKDLLESCLRMRPDR
ILLQELRDGTAFYYIRNINSGHPGSITTVHADSTRLAFEQLTLLVKESEGGGDLERHDIREMLTIAVDIIVQCKRIDGRF
RVSEIYYRDAE
>Mature_330_residues
TEAPDSAVVRELLSPLSPFLRDKTFYEVIVNRPGQVVTEGGEGWQTYDMAELSYDRLMRLARAVASFSNQSIDETRPILS
ATLPDGERIQIVIPPATTKGTVSITIRKPSSVSLTLEDLDHGGLFADVALAEGDGGRWDKSLLDYYRVGAYKAFLREAVF
ARKNIIISGATGSGKTTLSKALIRYIPQSERIISIEDTPELVVPQPNHVRLFYSKGGQGLAKVGAKDLLESCLRMRPDRI
LLQELRDGTAFYYIRNINSGHPGSITTVHADSTRLAFEQLTLLVKESEGGGDLERHDIREMLTIAVDIIVQCKRIDGRFR
VSEIYYRDAE

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG0630

COG function: function code NU; Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis

Gene ontology:

Cell location: Cell inner membrane (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP E family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR014155
- InterPro:   IPR001482 [H]

Pfam domain/function: PF00437 GSPII_E [H]

EC number: NA

Molecular weight: Translated: 36792; Mature: 36661

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAPDSAVVRELLSPLSPFLRDKTFYEVIVNRPGQVVTEGGEGWQTYDMAELSYDRLMR
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEECCCCCCEEEHHHHHHHHHHHH
LARAVASFSNQSIDETRPILSATLPDGERIQIVIPPATTKGTVSITIRKPSSVSLTLEDL
HHHHHHHHCCCCCHHHCCHHEEECCCCCEEEEEECCCCCCCEEEEEEECCCCEEEEEEEC
DHGGLFADVALAEGDGGRWDKSLLDYYRVGAYKAFLREAVFARKNIIISGATGSGKTTLS
CCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHH
KALIRYIPQSERIISIEDTPELVVPQPNHVRLFYSKGGQGLAKVGAKDLLESCLRMRPDR
HHHHHHCCCCCCEEEECCCCCEECCCCCCEEEEEECCCCCHHHHCHHHHHHHHHHCCCHH
ILLQELRDGTAFYYIRNINSGHPGSITTVHADSTRLAFEQLTLLVKESEGGGDLERHDIR
HHHHHHCCCEEEEEEEECCCCCCCCEEEEECCCHHHHHHHHEEEEEECCCCCCCHHHHHH
EMLTIAVDIIVQCKRIDGRFRVSEIYYRDAE
HHHHHHHHHHHHHHHCCCEEEEEEEEEECCC
>Mature Secondary Structure 
TEAPDSAVVRELLSPLSPFLRDKTFYEVIVNRPGQVVTEGGEGWQTYDMAELSYDRLMR
CCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEECCCCCCEEEHHHHHHHHHHHH
LARAVASFSNQSIDETRPILSATLPDGERIQIVIPPATTKGTVSITIRKPSSVSLTLEDL
HHHHHHHHCCCCCHHHCCHHEEECCCCCEEEEEECCCCCCCEEEEEEECCCCEEEEEEEC
DHGGLFADVALAEGDGGRWDKSLLDYYRVGAYKAFLREAVFARKNIIISGATGSGKTTLS
CCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHH
KALIRYIPQSERIISIEDTPELVVPQPNHVRLFYSKGGQGLAKVGAKDLLESCLRMRPDR
HHHHHHCCCCCCEEEECCCCCEECCCCCCEEEEEECCCCCHHHHCHHHHHHHHHHCCCHH
ILLQELRDGTAFYYIRNINSGHPGSITTVHADSTRLAFEQLTLLVKESEGGGDLERHDIR
HHHHHHCCCEEEEEEEECCCCCCCCEEEEECCCHHHHHHHHEEEEEECCCCCCCHHHHHH
EMLTIAVDIIVQCKRIDGRFRVSEIYYRDAE
HHHHHHHHHHHHHHHCCCEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]