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The map label for this gene is dapA

Identifier: 190571217

GI number: 190571217

Start: 894877

End: 895758

Strand: Direct

Name: dapA

Synonym: WPa_0816

Alternate gene names: 190571217

Gene position: 894877-895758 (Clockwise)

Preceding gene: 190571216

Following gene: 190571222

Centisome position: 60.36

GC content: 39.57

Gene sequence:

>882_bases
TTGAAATCTACATTTTTATGGACTGCTTGTGTTACTCCTTTTAATTGCAGTGGAGATAGTATAGATTACCAAAGCTTGCA
GCGTTTACTAACAATGCAAGCTGAAACTGAAAATGGTGTAGTGTTGCTAGGTAGCACAGGTGAAAGCTTATCACTTACTG
ATTCTGAAAAGCGCACATTAGTTGAATTTGTATGTGAGCTAAAATTAAATACGAAAATTATAATTGGTGTACCAGGAGTG
AATCTATATCAGACTCTTGAATGGCTTGATTTTTGCAAGGGTATGCCTATTCATGGCTATCTAATGACAACTCCCATTTA
TGCAAAGCCTGGAATCATGGGGCAAACTTTATGGTTTGAAAAGCTGCTTGAAAAAGCACATGTGCCAGCCATGCTTTACA
ATATTCCATCAAGAGCAGGAGTGAGTCTTCACGCTGAAACTGTACGCAACTTATCCAGCCACGAAAAATTTTGGGCTATC
AAAGATTCAAGTGGCACCGTTGATACTTTAACTCAGTATAAGAAAGTTGCACCAAATATTGAGGTCTTTTGCGGAGATGA
TAATATGATACCCGATATGGCTGCTAAGGGTGCGGCTGGTCTGGTTTCTGTTGCTGCCAATGTTTGGCCAAGTGTAGTAC
ATGAATATGTTAAGCAATGCATGAGTGGCGAGAACCCTCAGGCAGACAGTTGGCAACAAGCTTGCAAAACTCTATTTACT
GCCAGCAATCCAATACCTACTAAAGCACTCTTGCATGACATTGGGCTTATAGAACACAAAACTGTTCGTCTACCACTAAG
CACAGAAGACTTGCCTTCTATTGAAACATTGAGGCAAGCTAATAAAATGATTCTTGGATGGAAAGAATTGACTAATAGCT
AA

Upstream 100 bases:

>100_bases
CAAACAAAATGAAACAGAACAAAAAGATAAACACGGAAGTTTTGACAACGATATAAAAGACGAACTAATCGATGATGAAA
TACCATTTTAATAACTTCAA

Downstream 100 bases:

>100_bases
AGCTAGGAACACACATCATCAACTTCTACACCTGCATCAAATAAACTAACTTGTTATAAGAAAACTAACCATGTGAAATT
CTTGTTGATATGACTTAATG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MKSTFLWTACVTPFNCSGDSIDYQSLQRLLTMQAETENGVVLLGSTGESLSLTDSEKRTLVEFVCELKLNTKIIIGVPGV
NLYQTLEWLDFCKGMPIHGYLMTTPIYAKPGIMGQTLWFEKLLEKAHVPAMLYNIPSRAGVSLHAETVRNLSSHEKFWAI
KDSSGTVDTLTQYKKVAPNIEVFCGDDNMIPDMAAKGAAGLVSVAANVWPSVVHEYVKQCMSGENPQADSWQQACKTLFT
ASNPIPTKALLHDIGLIEHKTVRLPLSTEDLPSIETLRQANKMILGWKELTNS

Sequences:

>Translated_293_residues
MKSTFLWTACVTPFNCSGDSIDYQSLQRLLTMQAETENGVVLLGSTGESLSLTDSEKRTLVEFVCELKLNTKIIIGVPGV
NLYQTLEWLDFCKGMPIHGYLMTTPIYAKPGIMGQTLWFEKLLEKAHVPAMLYNIPSRAGVSLHAETVRNLSSHEKFWAI
KDSSGTVDTLTQYKKVAPNIEVFCGDDNMIPDMAAKGAAGLVSVAANVWPSVVHEYVKQCMSGENPQADSWQQACKTLFT
ASNPIPTKALLHDIGLIEHKTVRLPLSTEDLPSIETLRQANKMILGWKELTNS
>Mature_293_residues
MKSTFLWTACVTPFNCSGDSIDYQSLQRLLTMQAETENGVVLLGSTGESLSLTDSEKRTLVEFVCELKLNTKIIIGVPGV
NLYQTLEWLDFCKGMPIHGYLMTTPIYAKPGIMGQTLWFEKLLEKAHVPAMLYNIPSRAGVSLHAETVRNLSSHEKFWAI
KDSSGTVDTLTQYKKVAPNIEVFCGDDNMIPDMAAKGAAGLVSVAANVWPSVVHEYVKQCMSGENPQADSWQQACKTLFT
ASNPIPTKALLHDIGLIEHKTVRLPLSTEDLPSIETLRQANKMILGWKELTNS

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=234, Percent_Identity=25.6410256410256, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788823, Length=283, Percent_Identity=30.3886925795053, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1786463, Length=202, Percent_Identity=26.2376237623762, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789620, Length=284, Percent_Identity=23.943661971831, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87082415, Length=181, Percent_Identity=24.8618784530387, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_WOLPP (B3CM06)

Other databases:

- EMBL:   AM999887
- RefSeq:   YP_001975575.1
- ProteinModelPortal:   B3CM06
- EnsemblBacteria:   EBWOLT00000000360
- GeneID:   6384923
- GenomeReviews:   AM999887_GR
- KEGG:   wpi:WPa_0816
- GeneTree:   EBGT00050000031092
- HOGENOM:   HBG358848
- OMA:   WAIKDSS
- ProtClustDB:   PRK03170
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 32381; Mature: 32381

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 161-161

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSTFLWTACVTPFNCSGDSIDYQSLQRLLTMQAETENGVVLLGSTGESLSLTDSEKRTL
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEECCCHHHHHH
VEFVCELKLNTKIIIGVPGVNLYQTLEWLDFCKGMPIHGYLMTTPIYAKPGIMGQTLWFE
HHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCEECCCCCCHHHHHH
KLLEKAHVPAMLYNIPSRAGVSLHAETVRNLSSHEKFWAIKDSSGTVDTLTQYKKVAPNI
HHHHHHCCCEEEEECCCCCCCEEEHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHCCCC
EVFCGDDNMIPDMAAKGAAGLVSVAANVWPSVVHEYVKQCMSGENPQADSWQQACKTLFT
EEEECCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
ASNPIPTKALLHDIGLIEHKTVRLPLSTEDLPSIETLRQANKMILGWKELTNS
CCCCCCHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHEEEHHHHCCC
>Mature Secondary Structure
MKSTFLWTACVTPFNCSGDSIDYQSLQRLLTMQAETENGVVLLGSTGESLSLTDSEKRTL
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEECCCHHHHHH
VEFVCELKLNTKIIIGVPGVNLYQTLEWLDFCKGMPIHGYLMTTPIYAKPGIMGQTLWFE
HHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCEECCCCCCHHHHHH
KLLEKAHVPAMLYNIPSRAGVSLHAETVRNLSSHEKFWAIKDSSGTVDTLTQYKKVAPNI
HHHHHHCCCEEEEECCCCCCCEEEHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHCCCC
EVFCGDDNMIPDMAAKGAAGLVSVAANVWPSVVHEYVKQCMSGENPQADSWQQACKTLFT
EEEECCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
ASNPIPTKALLHDIGLIEHKTVRLPLSTEDLPSIETLRQANKMILGWKELTNS
CCCCCCHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA