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The map label for this gene is hyfD [H]

Identifier: 190570591

GI number: 190570591

Start: 135670

End: 137157

Strand: Direct

Name: hyfD [H]

Synonym: WPa_0129

Alternate gene names: 190570591

Gene position: 135670-137157 (Clockwise)

Preceding gene: 190570590

Following gene: 190570597

Centisome position: 9.15

GC content: 33.06

Gene sequence:

>1488_bases
ATGGATTTTGTTTTAATATCTCTTTCCTTGCCACTTTTTATTACTGAGAATTATTTGTTAATTACTGCGTTGATCCCACT
TTTAAGTGCATTAGCTATTTCTTTTACTAGTAAATGGCCCAGAGTGAACAATAGCATTACTGTTGTTTCTTCTATGCTTC
TATTTGCGTATACATCTCTATGCACTTTATATTTGGTGTATGGTGATCATTCTCAATTTATTCTCATGGACTTTGGTAAT
AATTTGCATATTAGTTTAAAGTTAGAGTCTAGTGGAGCAATATTCAGTTTATTAATATCATTTTTGTGGGTACTAACCAG
TATATATGCAATATGTTATATGCGAAATAACTATGCTGATAGTAACTACTCGAGTTTTCTATGCTTTTTTTCAATAGCGA
TTAGCTGTGCAATGTTTATTGCTTTTTCTGGAGATTTGCTCACTACATTTGTCTTTTACGAGCTTCTAACTATTAGTACA
TACCCTCTGATTACTCACAACTCAACAAATGAATCAGTAATTGCAGGACGCTATTACTTTGGTTTACTATTTTTCTCTTC
TTTAGTGTTATTTTTTCCTGCAATAGGTCTCTTATATAATGAATTCCATACTTTAGACTTTGTAAGAGGTGGAATATTCA
AGTTTGATACTTCGTTCATAACTTTTATTGCAGTGTGTTTTGCTATGCTGATTTATGGAATAGGAAAAGCTGCATTAATG
CCAATGCATTTTTGGTTGCCAAAAGCAATGGTTGCACCAACTCCTGTAAGCGCACTACTACATGCTGTTGCTGTTGTGAA
ATCAGGAGTGTTCATCATCATCAAAGTTATATTATACACTTTTGGCATCGATAATATGCAACGTTTTGCACAGCAAAGTT
GGTTTGCTGGAGGATGGCTTCCGTACGCTGCTGGATTTACTATTATTACTGCATCGTTAATTGCATTAAAGCAAAAGGAA
TTAAAGAAATTGCTTGCTTATTCTACTATCTCTCAGTTGTCATATATTATATTGTTCGCTTCAATTTTTAGTGAATTTAG
CATGAGGATTGCAATTTTTCAATTAGTTTGCCACGCATTTGCAAAAATCACTTTATTTTTCACTGCTGGAGCAATAATAA
CGAAAACAGGTGAGAAATACATAGATAGAATTCACGGTATAGGACGTAGTATGCCAATTAGTATGATAGCATTTACTATA
GGTGCATTGTCCATGATAGGGGTACCACCTGCTCCGACTTTTTGGAGCAAATTTTTCATTTTTCAAGCTGTTTTTAACTC
TAGTAATGTAACACTTTCTGTATTTGTAGCTCTGGTGTTAATTGTCAGTACTATACTCAACGCTCTATACTTCTTACCGA
TAATTTACAATGCCTTTTTCTTAAAACCTTCTAGAAATTATTTTATTAAAAAGACACCAATGCTTCTAATTTTACCTCCA
GTTGTTACTGCTGTATGCACTTTAGTTATTTTTTTAGCTACCAAGTAA

Upstream 100 bases:

>100_bases
TGGTTTATTTAACATTTCCGATATACAACTAAAAAATAGCAAATTCTCTATAACTTGAATATAATTTTAGCTTTACCTAA
ACAGAAAGATGAATTACTTA

Downstream 100 bases:

>100_bases
TTTTTTAAATGTAATCAGCTGTATTTATAGCCGTTAACAATAAATTTAAATGGTATTATACCAGTTAGAGTTGCTTTCAT
GTTTGATAAAGTAAAGCTAA

Product: putative monovalent cation/H+ antiporter subunit D

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MDFVLISLSLPLFITENYLLITALIPLLSALAISFTSKWPRVNNSITVVSSMLLFAYTSLCTLYLVYGDHSQFILMDFGN
NLHISLKLESSGAIFSLLISFLWVLTSIYAICYMRNNYADSNYSSFLCFFSIAISCAMFIAFSGDLLTTFVFYELLTIST
YPLITHNSTNESVIAGRYYFGLLFFSSLVLFFPAIGLLYNEFHTLDFVRGGIFKFDTSFITFIAVCFAMLIYGIGKAALM
PMHFWLPKAMVAPTPVSALLHAVAVVKSGVFIIIKVILYTFGIDNMQRFAQQSWFAGGWLPYAAGFTIITASLIALKQKE
LKKLLAYSTISQLSYIILFASIFSEFSMRIAIFQLVCHAFAKITLFFTAGAIITKTGEKYIDRIHGIGRSMPISMIAFTI
GALSMIGVPPAPTFWSKFFIFQAVFNSSNVTLSVFVALVLIVSTILNALYFLPIIYNAFFLKPSRNYFIKKTPMLLILPP
VVTAVCTLVIFLATK

Sequences:

>Translated_495_residues
MDFVLISLSLPLFITENYLLITALIPLLSALAISFTSKWPRVNNSITVVSSMLLFAYTSLCTLYLVYGDHSQFILMDFGN
NLHISLKLESSGAIFSLLISFLWVLTSIYAICYMRNNYADSNYSSFLCFFSIAISCAMFIAFSGDLLTTFVFYELLTIST
YPLITHNSTNESVIAGRYYFGLLFFSSLVLFFPAIGLLYNEFHTLDFVRGGIFKFDTSFITFIAVCFAMLIYGIGKAALM
PMHFWLPKAMVAPTPVSALLHAVAVVKSGVFIIIKVILYTFGIDNMQRFAQQSWFAGGWLPYAAGFTIITASLIALKQKE
LKKLLAYSTISQLSYIILFASIFSEFSMRIAIFQLVCHAFAKITLFFTAGAIITKTGEKYIDRIHGIGRSMPISMIAFTI
GALSMIGVPPAPTFWSKFFIFQAVFNSSNVTLSVFVALVLIVSTILNALYFLPIIYNAFFLKPSRNYFIKKTPMLLILPP
VVTAVCTLVIFLATK
>Mature_495_residues
MDFVLISLSLPLFITENYLLITALIPLLSALAISFTSKWPRVNNSITVVSSMLLFAYTSLCTLYLVYGDHSQFILMDFGN
NLHISLKLESSGAIFSLLISFLWVLTSIYAICYMRNNYADSNYSSFLCFFSIAISCAMFIAFSGDLLTTFVFYELLTIST
YPLITHNSTNESVIAGRYYFGLLFFSSLVLFFPAIGLLYNEFHTLDFVRGGIFKFDTSFITFIAVCFAMLIYGIGKAALM
PMHFWLPKAMVAPTPVSALLHAVAVVKSGVFIIIKVILYTFGIDNMQRFAQQSWFAGGWLPYAAGFTIITASLIALKQKE
LKKLLAYSTISQLSYIILFASIFSEFSMRIAIFQLVCHAFAKITLFFTAGAIITKTGEKYIDRIHGIGRSMPISMIAFTI
GALSMIGVPPAPTFWSKFFIFQAVFNSSNVTLSVFVALVLIVSTILNALYFLPIIYNAFFLKPSRNYFIKKTPMLLILPP
VVTAVCTLVIFLATK

Specific function: Unknown

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=188, Percent_Identity=32.9787234042553, Blast_Score=99, Evalue=9e-21,
Organism=Escherichia coli, GI1788829, Length=430, Percent_Identity=28.6046511627907, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1788614, Length=471, Percent_Identity=26.1146496815287, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788827, Length=362, Percent_Identity=29.0055248618785, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788831, Length=354, Percent_Identity=26.5536723163842, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI2367154, Length=421, Percent_Identity=23.2779097387173, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI145693160, Length=314, Percent_Identity=25.796178343949, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 55293; Mature: 55293

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFVLISLSLPLFITENYLLITALIPLLSALAISFTSKWPRVNNSITVVSSMLLFAYTSL
CCEEEEEECCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
CTLYLVYGDHSQFILMDFGNNLHISLKLESSGAIFSLLISFLWVLTSIYAICYMRNNYAD
HHEEEEECCCCCEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
SNYSSFLCFFSIAISCAMFIAFSGDLLTTFVFYELLTISTYPLITHNSTNESVIAGRYYF
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCCCCEEHHHHHH
GLLFFSSLVLFFPAIGLLYNEFHTLDFVRGGIFKFDTSFITFIAVCFAMLIYGIGKAALM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCHHHHH
PMHFWLPKAMVAPTPVSALLHAVAVVKSGVFIIIKVILYTFGIDNMQRFAQQSWFAGGWL
HHHHHCCHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCH
PYAAGFTIITASLIALKQKELKKLLAYSTISQLSYIILFASIFSEFSMRIAIFQLVCHAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKITLFFTAGAIITKTGEKYIDRIHGIGRSMPISMIAFTIGALSMIGVPPAPTFWSKFFI
HHHHHHHCCCHHEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
FQAVFNSSNVTLSVFVALVLIVSTILNALYFLPIIYNAFFLKPSRNYFIKKTPMLLILPP
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEECCCEEEEEHH
VVTAVCTLVIFLATK
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MDFVLISLSLPLFITENYLLITALIPLLSALAISFTSKWPRVNNSITVVSSMLLFAYTSL
CCEEEEEECCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
CTLYLVYGDHSQFILMDFGNNLHISLKLESSGAIFSLLISFLWVLTSIYAICYMRNNYAD
HHEEEEECCCCCEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
SNYSSFLCFFSIAISCAMFIAFSGDLLTTFVFYELLTISTYPLITHNSTNESVIAGRYYF
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCCCCEEHHHHHH
GLLFFSSLVLFFPAIGLLYNEFHTLDFVRGGIFKFDTSFITFIAVCFAMLIYGIGKAALM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCHHHHH
PMHFWLPKAMVAPTPVSALLHAVAVVKSGVFIIIKVILYTFGIDNMQRFAQQSWFAGGWL
HHHHHCCHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCH
PYAAGFTIITASLIALKQKELKKLLAYSTISQLSYIILFASIFSEFSMRIAIFQLVCHAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKITLFFTAGAIITKTGEKYIDRIHGIGRSMPISMIAFTIGALSMIGVPPAPTFWSKFFI
HHHHHHHCCCHHEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
FQAVFNSSNVTLSVFVALVLIVSTILNALYFLPIIYNAFFLKPSRNYFIKKTPMLLILPP
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEECCCEEEEEHH
VVTAVCTLVIFLATK
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]