Click here to switch to the map view.

The map label for this gene is coxA [H]

Identifier: 190570552

GI number: 190570552

Start: 78172

End: 79722

Strand: Reverse

Name: coxA [H]

Synonym: WPa_0082

Alternate gene names: 190570552

Gene position: 79722-78172 (Counterclockwise)

Preceding gene: 190570553

Following gene: 190570551

Centisome position: 5.38

GC content: 37.91

Gene sequence:

>1551_bases
ATGAGTGATGTACCAAAAGGTATAAGACGTTGGCTGCTTTCTACTAATCACAAAGATATAGGGACACTATACATTATTTT
TTCCATATTAGCTGGAATTATTGGTGGATTATTATCGGTAATTATTCGTACTCAGCTAATGCACATTAATATACTTAACA
ATAATTACCAGCTATATAACGTAATGATTACAGGGCATGCGGTAATAATGGTGTTTTTTATGATAATGCCAGCCTTAATG
GGAGGATTTGGTAATTGGTTCGTACCTCTCATGATTGGTGCACCAGATATGGCATTTCCTCGTATGAATAATTTAAGTTT
TTGGTTGTTAGTTTCATCTTTTATTTTGCTTATCCTCTCGGTATTTGCTGGCGAAGGTCCTGGAACAGGATGGACTTTAT
ACCCACCTCTATCGCAAATCATGTCTCACCCAAGTGCAGGAGTTGATCTTGCTATACTTGCACTTCATGTTGCTGGTATG
TCATCAATTGTTGGGGCGATCAACTTTATAGTTACCATATTCAATATGCGTGCAAAAGGTATGTCACTAACTAAGATACC
ACTATTTGTTTGGTCTATTTTACTCACGTCATTTATGTTAATTGTTGCCTTACCGGTACTTGCTGGTGCTATAACTATGC
TGCTCACTGATCGTAATATAGGTACCTCCTTTTTTGATCCTGCTGGTGGTGGTGATCCTGTGTTATTTCAACATCTGTTT
TGGTTTTTTGGTCATCCAGAAGTTTACATAATTATTTTTCCTGCATTTGGTATCATCAGTCAGATTGTGTCAACTTTTTC
TCATAGGCCAGTATTTGGTTATATGGGAATGGTTTATGCCATGATAGGAATAGCAACGTTTGGCTTCATGGTTTGGGCTC
ACCATATGTTTACTGTTGGGCTTAGCGAGGATACTGCTATATTTTTTAGCACTAGCACAATTTTCATTGGTGTTATAACT
GGTGTAAAAGTCTTTAGTTGGATTGCAACTATGTGGGGTGGAGCGATTGAATTGAAGACACCAATGCTGTTTGCATTAGG
TTTTATTTTCATGTTTGTTGGAGGTGGTATAACCGGAATAATTCTTTCTCACGGTGGAATAGATAAGCTTTTGCACGATA
CCTATTATGTCGTTGCTCACTTTCACTATGTCATGTCGCTTGCTGCATTATTTGGAGCTTTCGCCGGTTTTTATTATTGG
ATAGGCAAAATGTCAGGTAAGCAATATAACGAGTGTTTAGGAAAGATACACTTTTGGCTCACTTTTATTAGCACCAATGT
CACTTTCTTACCCCAGCATTTCCTGGGATTAGCAGGTATGCCAAGGCGTATACCTGATTATCCCGACGCGTTTATCCCTT
GGAATTATATATCCTCAATTGGCTCATATATGTCCTTTGTTTCAGTTATGTTTTTTGTATTTATAGTTATACATCTCTTT
AAGTGGGGCAAAAAAAATGGAGATAATCCTTGGGGGGGTGATACCTTAGAGTGGACGGTATCTTCACCACCACCTTTTCA
TACTTTCGAAAAGCCACCAGTGGTAAAATAA

Upstream 100 bases:

>100_bases
TCATGGATTTATGCCAATTGTTGTTGAAGCAGTGAGTAAAGAAGATTTTAATAAGTGGATTGAAGATAAAAAATTAGTAA
GTTAAGTTTGGAGTATAGAT

Downstream 100 bases:

>100_bases
AGTGTATATAAGTGCTTTGTTAAACGTTGAATCGACAATATTGGACTTTTGGCATTTGCTGAAGCCAAGGATAATGTACC
TTGTAGTGTTTACTGCAATT

Product: cytochrome c oxidase, subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MSDVPKGIRRWLLSTNHKDIGTLYIIFSILAGIIGGLLSVIIRTQLMHINILNNNYQLYNVMITGHAVIMVFFMIMPALM
GGFGNWFVPLMIGAPDMAFPRMNNLSFWLLVSSFILLILSVFAGEGPGTGWTLYPPLSQIMSHPSAGVDLAILALHVAGM
SSIVGAINFIVTIFNMRAKGMSLTKIPLFVWSILLTSFMLIVALPVLAGAITMLLTDRNIGTSFFDPAGGGDPVLFQHLF
WFFGHPEVYIIIFPAFGIISQIVSTFSHRPVFGYMGMVYAMIGIATFGFMVWAHHMFTVGLSEDTAIFFSTSTIFIGVIT
GVKVFSWIATMWGGAIELKTPMLFALGFIFMFVGGGITGIILSHGGIDKLLHDTYYVVAHFHYVMSLAALFGAFAGFYYW
IGKMSGKQYNECLGKIHFWLTFISTNVTFLPQHFLGLAGMPRRIPDYPDAFIPWNYISSIGSYMSFVSVMFFVFIVIHLF
KWGKKNGDNPWGGDTLEWTVSSPPPFHTFEKPPVVK

Sequences:

>Translated_516_residues
MSDVPKGIRRWLLSTNHKDIGTLYIIFSILAGIIGGLLSVIIRTQLMHINILNNNYQLYNVMITGHAVIMVFFMIMPALM
GGFGNWFVPLMIGAPDMAFPRMNNLSFWLLVSSFILLILSVFAGEGPGTGWTLYPPLSQIMSHPSAGVDLAILALHVAGM
SSIVGAINFIVTIFNMRAKGMSLTKIPLFVWSILLTSFMLIVALPVLAGAITMLLTDRNIGTSFFDPAGGGDPVLFQHLF
WFFGHPEVYIIIFPAFGIISQIVSTFSHRPVFGYMGMVYAMIGIATFGFMVWAHHMFTVGLSEDTAIFFSTSTIFIGVIT
GVKVFSWIATMWGGAIELKTPMLFALGFIFMFVGGGITGIILSHGGIDKLLHDTYYVVAHFHYVMSLAALFGAFAGFYYW
IGKMSGKQYNECLGKIHFWLTFISTNVTFLPQHFLGLAGMPRRIPDYPDAFIPWNYISSIGSYMSFVSVMFFVFIVIHLF
KWGKKNGDNPWGGDTLEWTVSSPPPFHTFEKPPVVK
>Mature_515_residues
SDVPKGIRRWLLSTNHKDIGTLYIIFSILAGIIGGLLSVIIRTQLMHINILNNNYQLYNVMITGHAVIMVFFMIMPALMG
GFGNWFVPLMIGAPDMAFPRMNNLSFWLLVSSFILLILSVFAGEGPGTGWTLYPPLSQIMSHPSAGVDLAILALHVAGMS
SIVGAINFIVTIFNMRAKGMSLTKIPLFVWSILLTSFMLIVALPVLAGAITMLLTDRNIGTSFFDPAGGGDPVLFQHLFW
FFGHPEVYIIIFPAFGIISQIVSTFSHRPVFGYMGMVYAMIGIATFGFMVWAHHMFTVGLSEDTAIFFSTSTIFIGVITG
VKVFSWIATMWGGAIELKTPMLFALGFIFMFVGGGITGIILSHGGIDKLLHDTYYVVAHFHYVMSLAALFGAFAGFYYWI
GKMSGKQYNECLGKIHFWLTFISTNVTFLPQHFLGLAGMPRRIPDYPDAFIPWNYISSIGSYMSFVSVMFFVFIVIHLFK
WGKKNGDNPWGGDTLEWTVSSPPPFHTFEKPPVVK

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=509, Percent_Identity=56.5815324165029, Blast_Score=561, Evalue=1e-160,
Organism=Escherichia coli, GI1786634, Length=514, Percent_Identity=40.0778210116732, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6226519, Length=531, Percent_Identity=52.165725047081, Blast_Score=567, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6226524, Length=323, Percent_Identity=56.656346749226, Blast_Score=381, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6226523, Length=248, Percent_Identity=52.4193548387097, Blast_Score=251, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 57314; Mature: 57183

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVPKGIRRWLLSTNHKDIGTLYIIFSILAGIIGGLLSVIIRTQLMHINILNNNYQLYN
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEE
VMITGHAVIMVFFMIMPALMGGFGNWFVPLMIGAPDMAFPRMNNLSFWLLVSSFILLILS
EEEHHHHHHHHHHHHHHHHHCCCCCHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
VFAGEGPGTGWTLYPPLSQIMSHPSAGVDLAILALHVAGMSSIVGAINFIVTIFNMRAKG
HHCCCCCCCCCEECCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MSLTKIPLFVWSILLTSFMLIVALPVLAGAITMLLTDRNIGTSFFDPAGGGDPVLFQHLF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
WFFGHPEVYIIIFPAFGIISQIVSTFSHRPVFGYMGMVYAMIGIATFGFMVWAHHMFTVG
HHHCCCEEEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
LSEDTAIFFSTSTIFIGVITGVKVFSWIATMWGGAIELKTPMLFALGFIFMFVGGGITGI
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHCCCCEEE
ILSHGGIDKLLHDTYYVVAHFHYVMSLAALFGAFAGFYYWIGKMSGKQYNECLGKIHFWL
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
TFISTNVTFLPQHFLGLAGMPRRIPDYPDAFIPWNYISSIGSYMSFVSVMFFVFIVIHLF
HHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KWGKKNGDNPWGGDTLEWTVSSPPPFHTFEKPPVVK
HHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDVPKGIRRWLLSTNHKDIGTLYIIFSILAGIIGGLLSVIIRTQLMHINILNNNYQLYN
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEE
VMITGHAVIMVFFMIMPALMGGFGNWFVPLMIGAPDMAFPRMNNLSFWLLVSSFILLILS
EEEHHHHHHHHHHHHHHHHHCCCCCHHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
VFAGEGPGTGWTLYPPLSQIMSHPSAGVDLAILALHVAGMSSIVGAINFIVTIFNMRAKG
HHCCCCCCCCCEECCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MSLTKIPLFVWSILLTSFMLIVALPVLAGAITMLLTDRNIGTSFFDPAGGGDPVLFQHLF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
WFFGHPEVYIIIFPAFGIISQIVSTFSHRPVFGYMGMVYAMIGIATFGFMVWAHHMFTVG
HHHCCCEEEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
LSEDTAIFFSTSTIFIGVITGVKVFSWIATMWGGAIELKTPMLFALGFIFMFVGGGITGI
CCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHCCCCEEE
ILSHGGIDKLLHDTYYVVAHFHYVMSLAALFGAFAGFYYWIGKMSGKQYNECLGKIHFWL
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
TFISTNVTFLPQHFLGLAGMPRRIPDYPDAFIPWNYISSIGSYMSFVSVMFFVFIVIHLF
HHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KWGKKNGDNPWGGDTLEWTVSSPPPFHTFEKPPVVK
HHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]