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The map label for this gene is gcvPB [H]

Identifier: 18978372

GI number: 18978372

Start: 1847935

End: 1849443

Strand: Direct

Name: gcvPB [H]

Synonym: PF2000

Alternate gene names: 18978372

Gene position: 1847935-1849443 (Clockwise)

Preceding gene: 18978371

Following gene: 18978375

Centisome position: 96.84

GC content: 44.47

Gene sequence:

>1509_bases
ATGTTCAGACAGGCAAAATGGGATGAACCGCTAATTTTCGAGCTCTCAAGGCCTGGGAGAGTTGGATACACTCTTCCTAA
GCCCATTGAAGACATAAAGGTTGATATTCCCGAGAAGTTGAGGAGGAAGAGTAAGCTTGAACTTCCAGAGTTAAGCGAGC
CTGAAATAGTTAAGCACTACACAAGGCTAAGCGAGATGAATTACGGCGTTGACTCTGGAATATATCCACTTGGCTCATGT
ACAATGAAGTATAATCCAAAGATAAACGAGGAGATCGCCACTCATCCAAAAGTTGCTTACATTCATCCCTATCAAGATGA
GAGAACAGTTCAAGGTGCACTTGCAATAATGTGGGAGCTCGAGCAGTGGCTTAAGGAGATAACAGGCATGGATCGCTTTA
CTCTCCAACCAGCAGCTGGAGCAAATGGAGAGTTTACTGGAGTGATGATAATTAGAGCCTATCATTTAGACAATGGAGAG
CCCCAGAGAAATGAAATGTTAGTTCCAGACTCAGCTCACGGAACAAATCCAGCATCAGCAGCAATGGCAGGATTCAAAGT
TATTGAAATACCATCCAATGAGAATGGAACAATTGATTTAGAGGCATTAGAAAATGCCGTAAGTGAAAGAACTGCTGGAT
TAATGCTGACAAACCCAAACACCCTGGGAATATTCGAAGATGAGATAGTGGAAATAGCTAAGATAATCCACAAGGCTGGG
GGGTTGCTCTACTACGATGGTGCGAACCTCAATGGAATTCTTGGAAAGATAAGGCCTGGAGACATGGGATTTGACATTGT
GCACCTCAACCTCCACAAGACGTTTTCAACTCCTCACGGTGGAGGAGGTCCAGGGGCTGGGCCCGTAGGAGTTAAAGAGT
TTCTGAAAGATTATCTACCAGTGCCACTGGTGAGTTATGACGAGAAAAGCGGTAGGTATTACCTTGACTACAACGTGCCA
AAGAGCATTGGAAAGGTGAAGGAGCTTTATGGAAACTTTGCAGTTCTTGTGAGGGCATTAACTTACCTTAAGATAATGGG
AAGAGATGGCCTGAGAGAAGTGAGTGAGATAGCAGTTTTAAACGCAAACTATCTAACCCAAAAGCTCAAGGGGACAAGGG
GATATTCTCTCCCAGGGAAAGAGCTCAGGAAGCACGAAGTTGTATTCTCAGCAGAACCCATGAAGAAAGAGACTGGAGTT
AAAGCTCTAGACGTTGCAAAGAGGCTCTTAGACTTTGGAATGCACGCCCCAACCATATACTTCCCCCTAATTGTACATGA
GGCCTTAATGATCGAACCTACTGAAACCGTAAGTAAGGAGGAGCTAGATGCCTACGTTGAGGCTCTAAAGAGGATTAGCG
AAGAGGCCTACACAAACCCAGAGATCGTTAAGAGTGCTCCCCACAACACGGCAGTTAAAAGAGTTGACGATGTTTTAGCA
GCCAAGAAGCCAATTGTTACGTGGAGAATGTACAAGGAGCTAAAAGAGAAAGGAGAAGTTGACTACTAA

Upstream 100 bases:

>100_bases
TTTCCCAGAGCTTGGAGAAAGTGCCCTCTTTGCAGCTACAGAGACTACAAGAAAGGAATGGATTGATGCACTGATAGATG
CCCTTAGGGAGGTGTTGTAA

Downstream 100 bases:

>100_bases
GGTCAGACAGTGCCAGTATCATCACAACTCAGACCGGTAAACGCTCATCATCCCCTTTCTTTTTATCGTTTCTTTTTTAA
AACCAATCCGCCTATTTTAT

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MFRQAKWDEPLIFELSRPGRVGYTLPKPIEDIKVDIPEKLRRKSKLELPELSEPEIVKHYTRLSEMNYGVDSGIYPLGSC
TMKYNPKINEEIATHPKVAYIHPYQDERTVQGALAIMWELEQWLKEITGMDRFTLQPAAGANGEFTGVMIIRAYHLDNGE
PQRNEMLVPDSAHGTNPASAAMAGFKVIEIPSNENGTIDLEALENAVSERTAGLMLTNPNTLGIFEDEIVEIAKIIHKAG
GLLYYDGANLNGILGKIRPGDMGFDIVHLNLHKTFSTPHGGGGPGAGPVGVKEFLKDYLPVPLVSYDEKSGRYYLDYNVP
KSIGKVKELYGNFAVLVRALTYLKIMGRDGLREVSEIAVLNANYLTQKLKGTRGYSLPGKELRKHEVVFSAEPMKKETGV
KALDVAKRLLDFGMHAPTIYFPLIVHEALMIEPTETVSKEELDAYVEALKRISEEAYTNPEIVKSAPHNTAVKRVDDVLA
AKKPIVTWRMYKELKEKGEVDY

Sequences:

>Translated_502_residues
MFRQAKWDEPLIFELSRPGRVGYTLPKPIEDIKVDIPEKLRRKSKLELPELSEPEIVKHYTRLSEMNYGVDSGIYPLGSC
TMKYNPKINEEIATHPKVAYIHPYQDERTVQGALAIMWELEQWLKEITGMDRFTLQPAAGANGEFTGVMIIRAYHLDNGE
PQRNEMLVPDSAHGTNPASAAMAGFKVIEIPSNENGTIDLEALENAVSERTAGLMLTNPNTLGIFEDEIVEIAKIIHKAG
GLLYYDGANLNGILGKIRPGDMGFDIVHLNLHKTFSTPHGGGGPGAGPVGVKEFLKDYLPVPLVSYDEKSGRYYLDYNVP
KSIGKVKELYGNFAVLVRALTYLKIMGRDGLREVSEIAVLNANYLTQKLKGTRGYSLPGKELRKHEVVFSAEPMKKETGV
KALDVAKRLLDFGMHAPTIYFPLIVHEALMIEPTETVSKEELDAYVEALKRISEEAYTNPEIVKSAPHNTAVKRVDDVLA
AKKPIVTWRMYKELKEKGEVDY
>Mature_502_residues
MFRQAKWDEPLIFELSRPGRVGYTLPKPIEDIKVDIPEKLRRKSKLELPELSEPEIVKHYTRLSEMNYGVDSGIYPLGSC
TMKYNPKINEEIATHPKVAYIHPYQDERTVQGALAIMWELEQWLKEITGMDRFTLQPAAGANGEFTGVMIIRAYHLDNGE
PQRNEMLVPDSAHGTNPASAAMAGFKVIEIPSNENGTIDLEALENAVSERTAGLMLTNPNTLGIFEDEIVEIAKIIHKAG
GLLYYDGANLNGILGKIRPGDMGFDIVHLNLHKTFSTPHGGGGPGAGPVGVKEFLKDYLPVPLVSYDEKSGRYYLDYNVP
KSIGKVKELYGNFAVLVRALTYLKIMGRDGLREVSEIAVLNANYLTQKLKGTRGYSLPGKELRKHEVVFSAEPMKKETGV
KALDVAKRLLDFGMHAPTIYFPLIVHEALMIEPTETVSKEELDAYVEALKRISEEAYTNPEIVKSAPHNTAVKRVDDVLA
AKKPIVTWRMYKELKEKGEVDY

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=439, Percent_Identity=40.3189066059225, Blast_Score=280, Evalue=2e-75,
Organism=Escherichia coli, GI1789269, Length=442, Percent_Identity=38.6877828054299, Blast_Score=282, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI17535605, Length=479, Percent_Identity=41.3361169102296, Blast_Score=303, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI32564013, Length=437, Percent_Identity=42.1052631578947, Blast_Score=281, Evalue=6e-76,
Organism=Saccharomyces cerevisiae, GI6323843, Length=459, Percent_Identity=41.1764705882353, Blast_Score=295, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24645648, Length=415, Percent_Identity=42.8915662650602, Blast_Score=293, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 56113; Mature: 56113

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRQAKWDEPLIFELSRPGRVGYTLPKPIEDIKVDIPEKLRRKSKLELPELSEPEIVKHY
CCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHCCCCCHHHHHHHCCCCCCCCCCHHHHHH
TRLSEMNYGVDSGIYPLGSCTMKYNPKINEEIATHPKVAYIHPYQDERTVQGALAIMWEL
HHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHCCCCEEEECCCCCCHHHHHHHHHHHHH
EQWLKEITGMDRFTLQPAAGANGEFTGVMIIRAYHLDNGEPQRNEMLVPDSAHGTNPASA
HHHHHHHCCCCCEEECCCCCCCCCEEEEEEEEEEECCCCCCCCCCEECCCCCCCCCHHHH
AMAGFKVIEIPSNENGTIDLEALENAVSERTAGLMLTNPNTLGIFEDEIVEIAKIIHKAG
HHHCCEEEECCCCCCCCEEHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHC
GLLYYDGANLNGILGKIRPGDMGFDIVHLNLHKTFSTPHGGGGPGAGPVGVKEFLKDYLP
CEEEECCCCCCCEEEECCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCC
VPLVSYDEKSGRYYLDYNVPKSIGKVKELYGNFAVLVRALTYLKIMGRDGLREVSEIAVL
CCEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
NANYLTQKLKGTRGYSLPGKELRKHEVVFSAEPMKKETGVKALDVAKRLLDFGMHAPTIY
CHHHHHHHHCCCCCCCCCHHHHHHHCEEEECCCCHHHCCCHHHHHHHHHHHCCCCCCHHH
FPLIVHEALMIEPTETVSKEELDAYVEALKRISEEAYTNPEIVKSAPHNTAVKRVDDVLA
HHHHHHHHHEECCHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHH
AKKPIVTWRMYKELKEKGEVDY
CCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFRQAKWDEPLIFELSRPGRVGYTLPKPIEDIKVDIPEKLRRKSKLELPELSEPEIVKHY
CCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHCCCCCHHHHHHHCCCCCCCCCCHHHHHH
TRLSEMNYGVDSGIYPLGSCTMKYNPKINEEIATHPKVAYIHPYQDERTVQGALAIMWEL
HHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHCCCCEEEECCCCCCHHHHHHHHHHHHH
EQWLKEITGMDRFTLQPAAGANGEFTGVMIIRAYHLDNGEPQRNEMLVPDSAHGTNPASA
HHHHHHHCCCCCEEECCCCCCCCCEEEEEEEEEEECCCCCCCCCCEECCCCCCCCCHHHH
AMAGFKVIEIPSNENGTIDLEALENAVSERTAGLMLTNPNTLGIFEDEIVEIAKIIHKAG
HHHCCEEEECCCCCCCCEEHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHC
GLLYYDGANLNGILGKIRPGDMGFDIVHLNLHKTFSTPHGGGGPGAGPVGVKEFLKDYLP
CEEEECCCCCCCEEEECCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCC
VPLVSYDEKSGRYYLDYNVPKSIGKVKELYGNFAVLVRALTYLKIMGRDGLREVSEIAVL
CCEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
NANYLTQKLKGTRGYSLPGKELRKHEVVFSAEPMKKETGVKALDVAKRLLDFGMHAPTIY
CHHHHHHHHCCCCCCCCCHHHHHHHCEEEECCCCHHHCCCHHHHHHHHHHHCCCCCCHHH
FPLIVHEALMIEPTETVSKEELDAYVEALKRISEEAYTNPEIVKSAPHNTAVKRVDDVLA
HHHHHHHHHEECCHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHH
AKKPIVTWRMYKELKEKGEVDY
CCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]