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The map label for this gene is gcvPA

Identifier: 18978371

GI number: 18978371

Start: 1846588

End: 1847934

Strand: Direct

Name: gcvPA

Synonym: PF1999

Alternate gene names: 18978371

Gene position: 1846588-1847934 (Clockwise)

Preceding gene: 18978370

Following gene: 18978372

Centisome position: 96.77

GC content: 44.47

Gene sequence:

>1347_bases
ATGGGAAAGCACTACATTCCTAACTCAGCTCATAAAGAAGAAATGCTAAAGGAAATCGGCTTTTCTTCAATAGAAGAACT
CTTTGCAGATGTTCCAGAGGGATTCATAAGGGAGTTCAACGTTCCAGAAGGAAAAAGTGAATACGAGGTATTCATGGAGA
TGAACGAGATTCTAAGCAAGAACAAGACCGTGCTGGAGATGCCAACATTTCTCGGAGCAGGAACTTATTTCCACTACGTT
CCAGCTCATGTAAAATACCTCATAGAGAGAAGTGAGTTCCTAACTTCTTACACCCCTTACCAGGCCGAGATAAGCCAGGG
AATGCTCCAGGCTCTCTTCGAATATCAAAGCCTGATAGCTGAACTCGTAGGATTGCCCGTTGTCAATTCGTCAATGTACG
ACTGGGGCTCAGCTTTAGGTGAGGCAGCCTTAATGACGGTAAGACTTCACAGAGGAAAGAGATTAAAGTTCGTCGTTCCT
AAGCACACACATCCCGAGAGAATGCAAGTTCTAAAAACCTACACCAGAGGAGCAAATCTGGAAATAGTGGAGGTAAAGTG
GAATGATAGAGGCCAAGTTGATCTTGAAGATTTAAAAGAGAAGGTTAACGATGCTGCTGGAGTTTACGTAGAGATACCAA
ACTTCTTTGGACTTCTTGAAGAAAACATTCAAGAGATTGGAGAGATAGCCCATGAAGCGGGAGCATACTTCGTAGTCGGA
GTTGATCCAACGATTTTAGGAGTAGTAGAGGCCCCGGGAGAATTAGGAGCAGATATAGTTGTTGGAGAAGCTTCATACTT
TGGAAGTCCAATGAACTTTGGGGGGCCCAGGGCCGGAATTTTCGCAACTAGAAACGATCCTAAATTTATCAGACAGATGC
CTGGGAGAATTATAGGAATGACGAAGGACGCAGAAGGAAAGAGAGCCTTCGTGATGACACTCCAGACGAGAGAGCAACAC
ATAAGGAGAGCTAAAGCTACTTCAAACATTTGTTCAAATGAAGCTCTAGTGGCAGTGGCCGCAGCGATCCACATAGCTTC
CCTGGGACCCAAGGGAATGCAAGAGCTTGGGGAAGTAATACTGAAAAATACCGCCTATCTAAAGAAGAGGCTCAGTGAAG
TTGCAGAGATACCTTTTGATGGCGTGAACTTCAAGGACGTTCTTGTAAAATTCGAAAAGCCCTACCAAGAAATCCACGAG
CATCTATTGCAGAAAAATATTCACGGTGGTTACTACGTTAAGCCCCATTTCCCAGAGCTTGGAGAAAGTGCCCTCTTTGC
AGCTACAGAGACTACAAGAAAGGAATGGATTGATGCACTGATAGATGCCCTTAGGGAGGTGTTGTAA

Upstream 100 bases:

>100_bases
TGGAGCCTTCTTGATGTAGTTAAGAATTTGAAATCTAGATAGACAGAAAACAGAAAGGCATATATTTTTCTATGTTAAAA
GATTTTATGAGGGAAAAATT

Downstream 100 bases:

>100_bases
ATGTTCAGACAGGCAAAATGGGATGAACCGCTAATTTTCGAGCTCTCAAGGCCTGGGAGAGTTGGATACACTCTTCCTAA
GCCCATTGAAGACATAAAGG

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MGKHYIPNSAHKEEMLKEIGFSSIEELFADVPEGFIREFNVPEGKSEYEVFMEMNEILSKNKTVLEMPTFLGAGTYFHYV
PAHVKYLIERSEFLTSYTPYQAEISQGMLQALFEYQSLIAELVGLPVVNSSMYDWGSALGEAALMTVRLHRGKRLKFVVP
KHTHPERMQVLKTYTRGANLEIVEVKWNDRGQVDLEDLKEKVNDAAGVYVEIPNFFGLLEENIQEIGEIAHEAGAYFVVG
VDPTILGVVEAPGELGADIVVGEASYFGSPMNFGGPRAGIFATRNDPKFIRQMPGRIIGMTKDAEGKRAFVMTLQTREQH
IRRAKATSNICSNEALVAVAAAIHIASLGPKGMQELGEVILKNTAYLKKRLSEVAEIPFDGVNFKDVLVKFEKPYQEIHE
HLLQKNIHGGYYVKPHFPELGESALFAATETTRKEWIDALIDALREVL

Sequences:

>Translated_448_residues
MGKHYIPNSAHKEEMLKEIGFSSIEELFADVPEGFIREFNVPEGKSEYEVFMEMNEILSKNKTVLEMPTFLGAGTYFHYV
PAHVKYLIERSEFLTSYTPYQAEISQGMLQALFEYQSLIAELVGLPVVNSSMYDWGSALGEAALMTVRLHRGKRLKFVVP
KHTHPERMQVLKTYTRGANLEIVEVKWNDRGQVDLEDLKEKVNDAAGVYVEIPNFFGLLEENIQEIGEIAHEAGAYFVVG
VDPTILGVVEAPGELGADIVVGEASYFGSPMNFGGPRAGIFATRNDPKFIRQMPGRIIGMTKDAEGKRAFVMTLQTREQH
IRRAKATSNICSNEALVAVAAAIHIASLGPKGMQELGEVILKNTAYLKKRLSEVAEIPFDGVNFKDVLVKFEKPYQEIHE
HLLQKNIHGGYYVKPHFPELGESALFAATETTRKEWIDALIDALREVL
>Mature_447_residues
GKHYIPNSAHKEEMLKEIGFSSIEELFADVPEGFIREFNVPEGKSEYEVFMEMNEILSKNKTVLEMPTFLGAGTYFHYVP
AHVKYLIERSEFLTSYTPYQAEISQGMLQALFEYQSLIAELVGLPVVNSSMYDWGSALGEAALMTVRLHRGKRLKFVVPK
HTHPERMQVLKTYTRGANLEIVEVKWNDRGQVDLEDLKEKVNDAAGVYVEIPNFFGLLEENIQEIGEIAHEAGAYFVVGV
DPTILGVVEAPGELGADIVVGEASYFGSPMNFGGPRAGIFATRNDPKFIRQMPGRIIGMTKDAEGKRAFVMTLQTREQHI
RRAKATSNICSNEALVAVAAAIHIASLGPKGMQELGEVILKNTAYLKKRLSEVAEIPFDGVNFKDVLVKFEKPYQEIHEH
LLQKNIHGGYYVKPHFPELGESALFAATETTRKEWIDALIDALREVL

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=401, Percent_Identity=34.1645885286783, Blast_Score=224, Evalue=2e-58,
Organism=Escherichia coli, GI1789269, Length=386, Percent_Identity=34.1968911917098, Blast_Score=197, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17535605, Length=376, Percent_Identity=37.7659574468085, Blast_Score=224, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6323843, Length=398, Percent_Identity=36.9346733668342, Blast_Score=246, Evalue=7e-66,
Organism=Drosophila melanogaster, GI24645648, Length=371, Percent_Identity=35.5795148247978, Blast_Score=226, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPA_PYRFU (Q8TZJ3)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_579728.1
- ProteinModelPortal:   Q8TZJ3
- SMR:   Q8TZJ3
- EnsemblBacteria:   EBPYRT00000004600
- GeneID:   1469883
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1999
- NMPDR:   fig|186497.1.peg.2053
- GeneTree:   EBGT00050000022496
- HOGENOM:   HBG288345
- OMA:   VTEKRTK
- ProtClustDB:   PRK00451
- BRENDA:   1.4.4.2
- HAMAP:   MF_00712
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 50200; Mature: 50069

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKHYIPNSAHKEEMLKEIGFSSIEELFADVPEGFIREFNVPEGKSEYEVFMEMNEILSK
CCCCCCCCCHHHHHHHHHHCHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHCC
NKTVLEMPTFLGAGTYFHYVPAHVKYLIERSEFLTSYTPYQAEISQGMLQALFEYQSLIA
CCCEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
ELVGLPVVNSSMYDWGSALGEAALMTVRLHRGKRLKFVVPKHTHPERMQVLKTYTRGANL
HHHCCCCCCCCHHHHHHHHHHHHHHHHEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCE
EIVEVKWNDRGQVDLEDLKEKVNDAAGVYVEIPNFFGLLEENIQEIGEIAHEAGAYFVVG
EEEEEEECCCCCCCHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEE
VDPTILGVVEAPGELGADIVVGEASYFGSPMNFGGPRAGIFATRNDPKFIRQMPGRIIGM
CCCEEEEEEECCCCCCCCEEEECHHHCCCCCCCCCCCCCEEEECCCHHHHHHCCCCEEEE
TKDAEGKRAFVMTLQTREQHIRRAKATSNICSNEALVAVAAAIHIASLGPKGMQELGEVI
CCCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
LKNTAYLKKRLSEVAEIPFDGVNFKDVLVKFEKPYQEIHEHLLQKNIHGGYYVKPHFPEL
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCC
GESALFAATETTRKEWIDALIDALREVL
CCCCEEEHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
GKHYIPNSAHKEEMLKEIGFSSIEELFADVPEGFIREFNVPEGKSEYEVFMEMNEILSK
CCCCCCCCHHHHHHHHHHCHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHCC
NKTVLEMPTFLGAGTYFHYVPAHVKYLIERSEFLTSYTPYQAEISQGMLQALFEYQSLIA
CCCEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
ELVGLPVVNSSMYDWGSALGEAALMTVRLHRGKRLKFVVPKHTHPERMQVLKTYTRGANL
HHHCCCCCCCCHHHHHHHHHHHHHHHHEECCCCEEEEECCCCCCHHHHHHHHHHHCCCCE
EIVEVKWNDRGQVDLEDLKEKVNDAAGVYVEIPNFFGLLEENIQEIGEIAHEAGAYFVVG
EEEEEEECCCCCCCHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEE
VDPTILGVVEAPGELGADIVVGEASYFGSPMNFGGPRAGIFATRNDPKFIRQMPGRIIGM
CCCEEEEEEECCCCCCCCEEEECHHHCCCCCCCCCCCCCEEEECCCHHHHHHCCCCEEEE
TKDAEGKRAFVMTLQTREQHIRRAKATSNICSNEALVAVAAAIHIASLGPKGMQELGEVI
CCCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
LKNTAYLKKRLSEVAEIPFDGVNFKDVLVKFEKPYQEIHEHLLQKNIHGGYYVKPHFPEL
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCC
GESALFAATETTRKEWIDALIDALREVL
CCCCEEEHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA